JP4469283B2 - 物質を生産するために細胞を培養する方法 - Google Patents

物質を生産するために細胞を培養する方法 Download PDF

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Publication number
JP4469283B2
JP4469283B2 JP2004554195A JP2004554195A JP4469283B2 JP 4469283 B2 JP4469283 B2 JP 4469283B2 JP 2004554195 A JP2004554195 A JP 2004554195A JP 2004554195 A JP2004554195 A JP 2004554195A JP 4469283 B2 JP4469283 B2 JP 4469283B2
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glucose
cells
dgl
qglc
maintenance
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Japanese (ja)
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JP2006507821A (ja
Inventor
トーマス リンク
ルース エッセルス
カースティン ゾーナー
ヨッヒェン ゲッテゲンス
トーマス ノール
クリスチャン ワンドリー
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2004554195A 2002-11-27 2003-11-07 物質を生産するために細胞を培養する方法 Expired - Lifetime JP4469283B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10255508A DE10255508A1 (de) 2002-11-27 2002-11-27 Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen
PCT/DE2003/003693 WO2004048556A1 (de) 2002-11-27 2003-11-07 Verfahren zur kultivierung von zellen zur produktion von substanzen

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010009094A Division JP5221573B2 (ja) 2002-11-27 2010-01-19 物質を生産するために細胞を培養する方法

Publications (2)

Publication Number Publication Date
JP2006507821A JP2006507821A (ja) 2006-03-09
JP4469283B2 true JP4469283B2 (ja) 2010-05-26

Family

ID=32318751

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004554195A Expired - Lifetime JP4469283B2 (ja) 2002-11-27 2003-11-07 物質を生産するために細胞を培養する方法
JP2010009094A Expired - Lifetime JP5221573B2 (ja) 2002-11-27 2010-01-19 物質を生産するために細胞を培養する方法

Family Applications After (1)

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JP2010009094A Expired - Lifetime JP5221573B2 (ja) 2002-11-27 2010-01-19 物質を生産するために細胞を培養する方法

Country Status (12)

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US (2) US20060127975A1 (enrdf_load_stackoverflow)
EP (3) EP2226381B1 (enrdf_load_stackoverflow)
JP (2) JP4469283B2 (enrdf_load_stackoverflow)
AT (1) ATE462013T1 (enrdf_load_stackoverflow)
CY (2) CY1110267T1 (enrdf_load_stackoverflow)
DE (2) DE10255508A1 (enrdf_load_stackoverflow)
DK (2) DK1585810T3 (enrdf_load_stackoverflow)
ES (3) ES2749217T3 (enrdf_load_stackoverflow)
HU (1) HUE028862T2 (enrdf_load_stackoverflow)
PT (1) PT1585810E (enrdf_load_stackoverflow)
SI (3) SI2275530T1 (enrdf_load_stackoverflow)
WO (1) WO2004048556A1 (enrdf_load_stackoverflow)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2382488T3 (es) 1997-03-21 2012-06-08 Chugai Seiyaku Kabushiki Kaisha Un agente preventivo o terapéutico para enfermedades mediadas por células t sensibilizadas que comprende un antagonista de il-6 como ingrediente activo
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
DE602004027905D1 (de) 2003-05-15 2010-08-12 Wyeth Llc Kontrollierte glukosezufuhr für tierzellkultur
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
DE102008002210A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Erythropoietin
MX2012004682A (es) * 2009-10-26 2012-09-07 Hoffmann La Roche Metodo para la produccion de una inmunoglobulina glicosilada.
AU2016210748B2 (en) * 2009-10-26 2018-03-01 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
AU2015203309B2 (en) * 2009-10-26 2016-05-05 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
TWI537386B (zh) * 2009-12-22 2016-06-11 Ｄｓｍ智慧財產有限公司 由發酵法獲得的６－胺己酸製備己內醯胺
EP3351559A3 (en) 2010-11-08 2018-10-31 F. Hoffmann-La Roche AG Subcutaneously administered anti-il-6 receptor antibody
MX363403B (es) 2013-07-04 2019-03-22 Hoffmann La Roche Inmumoensayo con interferencia suprimida para la deteccion de anticuerpos anti-farmacos en muestras de suero.
EP3119876B1 (en) 2014-03-19 2024-12-18 Pfizer Inc. Method of cell culture
CA2999224C (en) 2015-09-23 2023-10-24 Pfizer Inc. Cells and method of cell culture
WO2020115655A1 (en) 2018-12-06 2020-06-11 Pfizer Inc. Cells with reduced inhibitor production and methods of use thereof
WO2025088516A1 (en) 2023-10-26 2025-05-01 Pfizer Inc. Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657863A (en) * 1982-07-02 1987-04-14 Celanese Corporation Stabilization of a mutant microorganism population
JPH066054B2 (ja) * 1987-10-15 1994-01-26 帝人株式会社 動物細胞の培養方法
ATE125157T1 (de) * 1990-04-03 1995-08-15 Genentech Inc Methoden und zusammensetzungen zur impfung gegen hiv.
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification
CA2111561A1 (en) 1992-05-01 1993-11-11 Yoshiharu Takazawa Fed batch culture method for protein secreting cells
GB9506249D0 (en) * 1995-03-27 1995-05-17 Karobio Ab Media for insect cell cultures
WO1998041611A1 (en) * 1997-03-20 1998-09-24 Regents Of The University Of Minnesota Process for the continuous culture of cells
US6338964B1 (en) * 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration

Also Published As

Publication number Publication date
EP1585810A1 (de) 2005-10-19
PT1585810E (pt) 2010-05-05
JP2010110331A (ja) 2010-05-20
DK2226381T3 (en) 2016-04-11
SI2275530T1 (sl) 2019-11-29
US20060127975A1 (en) 2006-06-15
SI2226381T1 (sl) 2016-05-31
WO2004048556A1 (de) 2004-06-10
EP2275530A3 (de) 2012-05-23
ES2567161T3 (es) 2016-04-20
US20140329277A1 (en) 2014-11-06
EP1585810B1 (de) 2010-03-24
JP5221573B2 (ja) 2013-06-26
DE50312554D1 (de) 2010-05-06
CY1117558T1 (el) 2017-04-26
CY1110267T1 (el) 2015-01-14
ES2340377T3 (es) 2010-06-02
DK1585810T3 (da) 2010-06-07
DE10255508A1 (de) 2004-06-17
ES2749217T3 (es) 2020-03-19
EP2275530A2 (de) 2011-01-19
ATE462013T1 (de) 2010-04-15
SI1585810T1 (sl) 2010-06-30
EP2275530B1 (de) 2019-08-07
HUE028862T2 (en) 2017-01-30
JP2006507821A (ja) 2006-03-09
EP2226381B1 (de) 2016-03-09
EP2226381A1 (de) 2010-09-08

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