JP4463978B2 - 四重極イオンガイド中でイオンを選択的に衝突誘発解離する方法および装置 - Google Patents
四重極イオンガイド中でイオンを選択的に衝突誘発解離する方法および装置 Download PDFInfo
- Publication number
- JP4463978B2 JP4463978B2 JP2000524810A JP2000524810A JP4463978B2 JP 4463978 B2 JP4463978 B2 JP 4463978B2 JP 2000524810 A JP2000524810 A JP 2000524810A JP 2000524810 A JP2000524810 A JP 2000524810A JP 4463978 B2 JP4463978 B2 JP 4463978B2
- Authority
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- Prior art keywords
- ions
- quadrupole
- ion
- electric field
- excitation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002500 ions Chemical class 0.000 title claims abstract description 193
- 238000000034 method Methods 0.000 title claims abstract description 33
- 238000001360 collision-induced dissociation Methods 0.000 title claims abstract description 22
- 230000005284 excitation Effects 0.000 claims abstract description 57
- 239000012634 fragment Substances 0.000 claims abstract description 32
- 239000000126 substance Substances 0.000 claims abstract description 4
- 230000005684 electric field Effects 0.000 claims description 28
- 238000001228 spectrum Methods 0.000 claims description 20
- 238000013467 fragmentation Methods 0.000 claims description 11
- 238000006062 fragmentation reaction Methods 0.000 claims description 11
- 230000003321 amplification Effects 0.000 claims description 8
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 8
- 230000000737 periodic effect Effects 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 2
- 239000007789 gas Substances 0.000 description 17
- 238000005040 ion trap Methods 0.000 description 9
- 230000005405 multipole Effects 0.000 description 9
- 238000004885 tandem mass spectrometry Methods 0.000 description 8
- 238000010884 ion-beam technique Methods 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
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- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
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- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000011410 subtraction method Methods 0.000 description 2
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- 230000005279 excitation period Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000037427 ion transport Effects 0.000 description 1
- 238000005372 isotope separation Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 1
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- 230000005658 nuclear physics Effects 0.000 description 1
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Images
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/0063—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by applying a resonant excitation voltage
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6704597P | 1997-12-04 | 1997-12-04 | |
| US60/067,045 | 1997-12-04 | ||
| PCT/CA1998/001098 WO1999030351A1 (en) | 1997-12-04 | 1998-11-27 | Method of and apparatus for selective collision-induced dissociation of ions in a quadrupole ion guide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001526448A JP2001526448A (ja) | 2001-12-18 |
| JP2001526448A5 JP2001526448A5 (enExample) | 2009-07-02 |
| JP4463978B2 true JP4463978B2 (ja) | 2010-05-19 |
Family
ID=22073366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000524810A Expired - Fee Related JP4463978B2 (ja) | 1997-12-04 | 1998-11-27 | 四重極イオンガイド中でイオンを選択的に衝突誘発解離する方法および装置 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6512226B1 (enExample) |
| EP (1) | EP1051733B1 (enExample) |
| JP (1) | JP4463978B2 (enExample) |
| AT (1) | ATE274235T1 (enExample) |
| AU (1) | AU1329099A (enExample) |
| CA (1) | CA2312754C (enExample) |
| DE (1) | DE69825789T2 (enExample) |
| WO (1) | WO1999030351A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9820210D0 (en) * | 1998-09-16 | 1998-11-11 | Vg Elemental Limited | Means for removing unwanted ions from an ion transport system and mass spectrometer |
| US6124591A (en) * | 1998-10-16 | 2000-09-26 | Finnigan Corporation | Method of ion fragmentation in a quadrupole ion trap |
| US6806463B2 (en) * | 1999-07-21 | 2004-10-19 | The Charles Stark Draper Laboratory, Inc. | Micromachined field asymmetric ion mobility filter and detection system |
| US7157700B2 (en) * | 2001-06-30 | 2007-01-02 | Sionex Corporation | System for collection of data and identification of unknown ion species in an electric field |
| WO2001015201A2 (en) * | 1999-08-26 | 2001-03-01 | University Of New Hampshire | Multiple stage mass spectrometer |
| AU3907401A (en) * | 2000-03-14 | 2001-09-24 | Ca Nat Research Council | Apparatus and method for trandem icp/faims/ms |
| US7041967B2 (en) * | 2001-05-25 | 2006-05-09 | Mds Inc. | Method of mass spectrometry, to enhance separation of ions with different charges |
| US7119328B2 (en) * | 2001-06-30 | 2006-10-10 | Sionex Corporation | System for DMS peak resolution |
| US6946653B2 (en) | 2001-11-27 | 2005-09-20 | Ciphergen Biosystems, Inc. | Methods and apparatus for improved laser desorption ionization tandem mass spectrometry |
| US7122794B1 (en) | 2002-02-21 | 2006-10-17 | Sionex Corporation | Systems and methods for ion mobility control |
| US6630662B1 (en) * | 2002-04-24 | 2003-10-07 | Mds Inc. | Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas |
| GB0210930D0 (en) * | 2002-05-13 | 2002-06-19 | Thermo Electron Corp | Improved mass spectrometer and mass filters therefor |
| US6982417B2 (en) * | 2003-10-09 | 2006-01-03 | Siemens Energy & Automation, Inc. | Method and apparatus for detecting low-mass ions |
| CA2551991A1 (en) * | 2004-01-13 | 2005-07-28 | Sionex Corporation | Methods and apparatus for enhanced sample identification based on combined analytical techniques |
| US8003934B2 (en) | 2004-02-23 | 2011-08-23 | Andreas Hieke | Methods and apparatus for ion sources, ion control and ion measurement for macromolecules |
| US7138642B2 (en) | 2004-02-23 | 2006-11-21 | Gemio Technologies, Inc. | Ion source with controlled superposition of electrostatic and gas flow fields |
| GB0420408D0 (en) * | 2004-09-14 | 2004-10-20 | Micromass Ltd | Mass spectrometer |
| GB0425426D0 (en) | 2004-11-18 | 2004-12-22 | Micromass Ltd | Mass spectrometer |
| GB0427632D0 (en) * | 2004-12-17 | 2005-01-19 | Micromass Ltd | Mass spectrometer |
| GB2441943A (en) | 2005-07-26 | 2008-03-19 | Sionex Corp | Ultra compact ion mobility based analyzer system and method |
| EP2245650A4 (en) * | 2008-01-30 | 2015-11-18 | Dh Technologies Dev Pte Ltd | ION FRAGMENTATION IN MASS SPECTROMETRY |
| JP6126707B2 (ja) | 2013-03-14 | 2017-05-10 | レコ コーポレイションLeco Corporation | タンデム質量分析のための方法及びシステム |
| US8772711B1 (en) | 2013-08-27 | 2014-07-08 | Battelle Memorial Institute | Apparatus and method of dissociating ions in a multipole ion guide |
| CN108376637B (zh) * | 2018-04-19 | 2023-05-26 | 南京信息工程大学 | 实现对自由飞行区解离碎片分辨的离子速度成像仪 |
| CN110729171B (zh) * | 2018-07-17 | 2022-05-17 | 株式会社岛津制作所 | 四极质量分析器及质量分析方法 |
| EP4248482A2 (en) * | 2020-11-19 | 2023-09-27 | DH Technologies Development Pte. Ltd. | Method of performing ms/ms of high intensity ion beams using a bandpass filtering collision cell to enhance mass spectrometry robustness |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4234791A (en) * | 1978-11-13 | 1980-11-18 | Research Corporation | Tandem quadrupole mass spectrometer for selected ion fragmentation studies and low energy collision induced dissociator therefor |
| US5089703A (en) * | 1991-05-16 | 1992-02-18 | Finnigan Corporation | Method and apparatus for mass analysis in a multipole mass spectrometer |
| US5179278A (en) * | 1991-08-23 | 1993-01-12 | Mds Health Group Limited | Multipole inlet system for ion traps |
| US5448061A (en) * | 1992-05-29 | 1995-09-05 | Varian Associates, Inc. | Method of space charge control for improved ion isolation in an ion trap mass spectrometer by dynamically adaptive sampling |
| DE4316737C1 (de) * | 1993-05-19 | 1994-09-01 | Bruker Franzen Analytik Gmbh | Verfahren zur digitalen Erzeugung einer zusätzlichen Wechselspannung für die resonante Anregung von Ionen in Ionenfallen |
| US6011259A (en) * | 1995-08-10 | 2000-01-04 | Analytica Of Branford, Inc. | Multipole ion guide ion trap mass spectrometry with MS/MSN analysis |
| DK0748249T3 (da) | 1994-02-28 | 2009-11-09 | Analytica Of Branford Inc | Multipolionguide for massespektrometri |
| US5420425A (en) | 1994-05-27 | 1995-05-30 | Finnigan Corporation | Ion trap mass spectrometer system and method |
| DE19520319A1 (de) * | 1995-06-02 | 1996-12-12 | Bruker Franzen Analytik Gmbh | Verfahren und Vorrichtung für die Einführung von Ionen in Quadrupol-Ionenfallen |
| US5576540A (en) * | 1995-08-11 | 1996-11-19 | Mds Health Group Limited | Mass spectrometer with radial ejection |
| US5672870A (en) | 1995-12-18 | 1997-09-30 | Hewlett Packard Company | Mass selective notch filter with quadrupole excision fields |
-
1998
- 1998-11-27 AU AU13290/99A patent/AU1329099A/en not_active Abandoned
- 1998-11-27 DE DE69825789T patent/DE69825789T2/de not_active Expired - Lifetime
- 1998-11-27 US US09/555,686 patent/US6512226B1/en not_active Expired - Lifetime
- 1998-11-27 JP JP2000524810A patent/JP4463978B2/ja not_active Expired - Fee Related
- 1998-11-27 AT AT98956740T patent/ATE274235T1/de not_active IP Right Cessation
- 1998-11-27 CA CA002312754A patent/CA2312754C/en not_active Expired - Fee Related
- 1998-11-27 WO PCT/CA1998/001098 patent/WO1999030351A1/en not_active Ceased
- 1998-11-27 EP EP98956740A patent/EP1051733B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001526448A (ja) | 2001-12-18 |
| EP1051733B1 (en) | 2004-08-18 |
| AU1329099A (en) | 1999-06-28 |
| DE69825789D1 (de) | 2004-09-23 |
| DE69825789T2 (de) | 2005-09-01 |
| US6512226B1 (en) | 2003-01-28 |
| ATE274235T1 (de) | 2004-09-15 |
| CA2312754C (en) | 2007-10-09 |
| CA2312754A1 (en) | 1999-06-17 |
| WO1999030351A1 (en) | 1999-06-17 |
| EP1051733A1 (en) | 2000-11-15 |
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