JP4422103B2 - 疲労を回復又は軽減するための組成物、および当該組成物を備える医用デバイス - Google Patents
疲労を回復又は軽減するための組成物、および当該組成物を備える医用デバイス Download PDFInfo
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- JP4422103B2 JP4422103B2 JP2005511060A JP2005511060A JP4422103B2 JP 4422103 B2 JP4422103 B2 JP 4422103B2 JP 2005511060 A JP2005511060 A JP 2005511060A JP 2005511060 A JP2005511060 A JP 2005511060A JP 4422103 B2 JP4422103 B2 JP 4422103B2
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Description
[特許文献1]
特開平11−292756号公報(平成11年10月26日公開)
[非特許文献1]
Foods&Food Ingred J Jpn JN No.185、57−59(2000年)
[非特許文献2]
第76回日本生理学会講演要旨、第258頁、1999年
本発明は、疲労を回復又は軽減する効果、すなわち抗疲労効果を有する組成物、具体的には慢性疲労症候群の症状の緩和のためおよび/または過労死の予防のための組成物を提供することを目的とする。
以下の表1に示す原材料を適宜混合し、芳香性を有する組成物を調製した。同様に対照となる比較製剤1も調製した。比較製剤1は、トランス−2−ヘキセナールおよびシス−3−ヘキセノールを含まない点を除き、本発明の組成物と同じ組成を有する。
(1)試験対象
被験者としての20歳代の男性健常者6名に対して改良したATMT(Advanced Trail Making Test)によって精神作業負荷をあたえ、ATMT前後での疲労を評価した。上記作業負荷の間、上記被験者は、実施例1に示した本発明の組成物または比較製剤1を含むメッシュ袋を挟んだ医療用マスクを用い、本発明の組成物または比較製剤1を吸引しながら作業を行った。同一被験者に対して、一週間以内の異なる二日において盲検法を実施した。喫煙者、および検査日にアレルギー性鼻炎などによる鼻症状を呈した被験者を、本試験から除外した。カフェイン含有食品(コーヒー、ドリンク剤、ガムなど)や抗アレルギー剤などの中枢神経に作用する可能性のある薬剤を常用する被験者および試験当日に使用した被験者もまた除外した。
ATMTは、加齢現象の評価および初期痴呆のスクリーニングに利用される試験である。ATMTでは、タッチディスプレイ上に提示された1〜25までの数字を即座に押すという視覚探索反応課題を行なう。従来、A4紙で行っていたTMT(ランダムに配置された1〜25の数字を一筆書きの要領で線を引く課題)とは異なり、標的となる数字ごとの探索反応時間を測定することが可能であり、また反応ごとに全ての標的数字を再配置させたり、反応済の標的数字を消して新たに標的数字を追加発生させることが可能である。これらの工程を遂行することによって、課題遂行中に観察される精神疲労の増大、または探索効率を高めるためのワーキングメモリー活用度などを評価することが可能である。
疲労の評価方法として、上述した改良ATMT(開始直後および最終間際の3セット分の平均反応時間)および加速度脈波の2方法を採用した。
精神作業負荷の前後において、ATMTの課題のうちC課題のみを行い、これを1セットとし、作業にかかった時間を測定した。
加速度脈波は、血管の老化または体調評価に利用されている(特開2002−238867(平成14年8月27日公開)を参照のこと)。加速度脈波は、脈波の解析を補助する目的で波形の一次微分波形をさらに微分したものである(佐野祐司、片岡幸雄、生山匡、和田光明、今野廣隆、川村協平、渡辺剛、西田明子、および小山内博:加速度脈波による血液循環の評価とその応用、労働科学、61(3)、129−143(1985)を参照のこと)。加速度脈波は、脈波を2回微分することによって、変曲点を強調して波形の評価を容易にし、その結果、血液循環動態を示すと考えられている。原波形の変曲点が鋭角であればあるほど、二次微分波形の変曲点の振幅も大きくなる(鈴木明祐:生理機能検査法脈波、加速度脈波、現代医療、23(1)、61−65(1991)を参照のこと)。よって、加速度脈波は、変曲点による波形のパターンの認識や測定が容易となり、それ故に生理機能との関連や血行動態の研究にさらに適していると考えられている。加速度脈波形は心臓の収縮期の波形であり、a波、b波、c波、d波、およびe波の5つの成分波が観察される(図1)。図1の縦軸は波高(振幅(mV))を表し、疲労またはストレスを負荷することにより変化すると考えられている(横軸は時間(秒))。この加速度脈波の成分のうち、特にa波の波高の変化が疲労度評価に利用できると考え、精神作業負荷の前後における加速度脈波を測定して、a波の波高の変化を評価した。
ATMTの平均反応時間の検討では、比較製剤1を用いると、開始直後に3.03秒であったものが、作業終了間際には3.38秒に延長していた(約1.11倍)。一方、本発明の組成物を用いると、開始直後に3.13秒であったものが、作業終了間際でも3.13秒であり、全く延長しなかった(データは示さず)。このデータに基づいて平均反応時間の遅延をグラフに示した(図2)。比較製剤1における遅延時間が0.348秒であるのに対して、本発明の組成物における遅延時間は0.001秒であり、本発明の組成物と比較製剤1との間で有意な差が認められた(P<0.05)(図2)。
(1)対象患者
慢性疲労症候群と診断された患者(CFS患者)8名に対して実施例1にて調製した本発明の組成物を適用して、各症状の変化について検討した。
(2−1)慢性疲労症候群の専門医による診察に基づいて、臨床症状を評価した。
ヘパリン添加末梢血を比重遠心分離法(Conray−Ficll:d−1.077)を用いてエフェクター細胞を分離し、PBSを用いて細胞を洗浄し(2回)、次いで、10%FBSを補充したRPMI1640培養液をこの細胞に添加して、細胞数を1×106個/mlに調整した。
浮遊継代培養細胞(K−562細胞)を遠心分離して収集し、この細胞に50〜100μCiの51Cr−クロム酸ナトリウムを添加し、次いで、この細胞を37℃で1時間培養し、PBSを用いて洗浄し(2回)、10%FBSを補充したRPMI1640培養液を添加して、細胞数を1×106個/mlに調整した。
マイクロタイタープレートの各ウェルに標的細胞を分注し、全てのウェルにおける遊離値(上記B値)を得るために1N塩酸を、天然の遊離値(対照)を得るために10%FBSを補充したRPMI1640培養液を、そして実験遊離値を得るためにエフェクター細胞(E/T=20)をそれぞれ分注した。次いで、プレート遠心器にて800rpmで5分間遠心し、5%CO2培養器中で3.5時間培養した。
培養したプレートより、各ウェルから培養上清を採取し、γ−シンチレーションカウンターを用いて遊離した51Cr値を測定し、次の式を用いてNK活性を算出した。
(3−1)臨床症状について
本発明の組成物の適用開始2週間目ごろに、全身倦怠感の軽減とともに、不安感や緊張感の緩和、筋肉痛、関節痛の軽減などが認められ、本発明の組成物の適用開始12週目には、8症例全てにおいて臨床症状の改善が認められた。
本発明の組成物の適用開始前のスコアは7.3±1.4であったが、本発明の組成物の適用開始後12週間目において6.6±2.1となり、慢性疲労の症状の緩和が認められた(図5)。
本発明の組成物の適用開始前と比較して、本発明の組成物の適用開始12週間後では、どの細胞比の条件下においても明らかにNK活性の増加が認められた(図6)。これは、トランス−2−ヘキセナールおよびシス−3−ヘキセノールが慢性疲労症候群の症状を緩和する機能があることを示している。
本発明の組成物の適用開始前に比べ、本発明の組成物の適用開始12週間後では、血中DHEAS濃度が増加した(図7)。これは、トランス−2−ヘキセナールおよびシス−3−ヘキセノールが慢性疲労症候群の症状を緩和する機能があることを示している。
産業上の利用の可能性
Claims (12)
- トランス−2−ヘキセナールおよびシス−3−ヘキセノールを含有することを特徴とする慢性疲労症候群の症状を緩和するための組成物(ただし、食品および食品添加物を除く。)。
- 長期間のビタミン剤投与または漢方薬投与の治療によって症状が緩和されない慢性疲労症候群の患者が適用対象であることを特徴とする請求項1に記載の組成物。
- 芳香性であり、その芳香が抗疲労効果をもたらすことを特徴とする請求項1または2に記載の組成物。
- 芳香剤、液体洗浄剤、固体洗浄剤、化粧料、浴用組成物、保健衛生材料類、または口腔用組成物であることを特徴とする請求項3に記載の組成物。
- 経口摂取できることを特徴とする請求項1〜4のいずれか1項に記載の組成物。
- 点眼または点鼻が可能な形態であることを特徴とする請求項1に記載の組成物。
- 吸入可能な形態であることを特徴とする請求項1に記載の組成物。
- 請求項1に記載の組成物を備えることを特徴とする医用デバイス。
- 医療用マスクであることを特徴とする請求項8に記載の医用デバイス。
- 上記医療用マスクが花粉症を患う患者に適用されることを特徴とする請求項9に記載の医用デバイス。
- 上記組成物が0.5重量%以下のトランス−2−ヘキセナールおよびシス−3−ヘキセノールを含有することを特徴とする請求項8に記載の医用デバイス。
- 気道疾患の処置に用いられる吸入用エアロゾルのためのデバイスであることを特徴とする請求項8に記載の医用デバイス。
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JP2003185152 | 2003-06-27 | ||
PCT/JP2004/009020 WO2005000286A1 (ja) | 2003-06-27 | 2004-06-25 | 疲労を回復又は軽減するための組成物、および当該組成物を備える医用デバイス |
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JP2006036726A (ja) * | 2004-07-29 | 2006-02-09 | Akikazu Hatanaka | トイレタリー製品 |
JP2006248921A (ja) * | 2005-03-08 | 2006-09-21 | Nivea Kao Kk | 発汗抑制剤 |
JP2007162188A (ja) * | 2005-12-16 | 2007-06-28 | Chuo System Giken:Kk | 睡眠導入剤及び睡眠導入具 |
JP2007308435A (ja) * | 2006-05-19 | 2007-11-29 | Pokka Corp | 脳機能改善剤及びそれを含有する脳機能改善組成物 |
JP5300244B2 (ja) * | 2007-10-31 | 2013-09-25 | 淳司 淀井 | 抗酸化酵素誘導剤 |
JP6253529B2 (ja) * | 2014-06-26 | 2017-12-27 | 花王株式会社 | 疲労抑制剤の探索方法 |
JP2018179603A (ja) * | 2017-04-06 | 2018-11-15 | 高砂香料工業株式会社 | 心理、神経、内分泌、免疫指標を用いた香りの生理心理効果の評価方法 |
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JP3590274B2 (ja) * | 1998-09-11 | 2004-11-17 | 株式会社資生堂 | 気化吸引用鎮静剤及びそれを有効成分とする鎮静香料組成物 |
JP2001000141A (ja) * | 1999-03-01 | 2001-01-09 | Success:Kk | 杉葉抽出液の製法 |
JP2000355545A (ja) * | 1999-06-10 | 2000-12-26 | Karita Takahisa | 睡眠補充および/または導入用精油組成物および睡眠補充および/または導入剤 |
JP5053472B2 (ja) * | 1999-07-09 | 2012-10-17 | 株式会社 資生堂 | 高揚香料組成物 |
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