JP4397531B2 - 放射線療法のための生体分解性ガラス組成物および方法 - Google Patents
放射線療法のための生体分解性ガラス組成物および方法 Download PDFInfo
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- JP4397531B2 JP4397531B2 JP2000595944A JP2000595944A JP4397531B2 JP 4397531 B2 JP4397531 B2 JP 4397531B2 JP 2000595944 A JP2000595944 A JP 2000595944A JP 2000595944 A JP2000595944 A JP 2000595944A JP 4397531 B2 JP4397531 B2 JP 4397531B2
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/12—Silica-free oxide glass compositions
- C03C3/14—Silica-free oxide glass compositions containing boron
- C03C3/15—Silica-free oxide glass compositions containing boron containing rare earths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/062—Glass compositions containing silica with less than 40% silica by weight
- C03C3/064—Glass compositions containing silica with less than 40% silica by weight containing boron
- C03C3/068—Glass compositions containing silica with less than 40% silica by weight containing boron containing rare earths
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C2213/00—Glass fibres or filaments
- C03C2213/02—Biodegradable glass fibres
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Geochemistry & Mineralogy (AREA)
- Materials Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glass Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24189299A | 1999-02-01 | 1999-02-01 | |
| US09/241,892 | 1999-02-01 | ||
| PCT/US2000/002388 WO2000044682A1 (en) | 1999-02-01 | 2000-01-31 | Biodegradable glass compositions and methods for radiation therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002535237A JP2002535237A (ja) | 2002-10-22 |
| JP2002535237A5 JP2002535237A5 (enExample) | 2005-11-04 |
| JP4397531B2 true JP4397531B2 (ja) | 2010-01-13 |
Family
ID=22912591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000595944A Expired - Lifetime JP4397531B2 (ja) | 1999-02-01 | 2000-01-31 | 放射線療法のための生体分解性ガラス組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6379648B1 (enExample) |
| EP (1) | EP1149057B1 (enExample) |
| JP (1) | JP4397531B2 (enExample) |
| AT (1) | ATE267775T1 (enExample) |
| AU (1) | AU758560B2 (enExample) |
| CA (1) | CA2361573C (enExample) |
| DE (1) | DE60011045T2 (enExample) |
| ES (1) | ES2222892T3 (enExample) |
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Families Citing this family (31)
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| US6616591B1 (en) * | 1999-12-08 | 2003-09-09 | Scimed Life Systems, Inc. | Radioactive compositions and methods of use thereof |
| AUPR098300A0 (en) * | 2000-10-25 | 2000-11-16 | Sirtex Medical Limited | Polymer based radionuclide containing microspheres |
| AUPR098200A0 (en) * | 2000-10-25 | 2000-11-16 | Sirtex Medical Limited | Production of low density radionuclide containing microspheres |
| GB0104383D0 (en) * | 2001-02-22 | 2001-04-11 | Psimedica Ltd | Cancer Treatment |
| US6709744B1 (en) * | 2001-08-13 | 2004-03-23 | The Curators Of The University Of Missouri | Bioactive materials |
| GB2383534A (en) * | 2001-12-28 | 2003-07-02 | Psimei Pharmaceuticals Plc | Delivery of neutron capture elements for neutron capture therapy |
| WO2004065949A1 (en) * | 2003-01-21 | 2004-08-05 | X-Ray Flux Pty Ltd | X-ray fluorescence flux composition |
| US20040220135A1 (en) * | 2003-04-30 | 2004-11-04 | Sirtex Medical Limited | Combination therapy for treatment of neoplasia |
| US20040258614A1 (en) * | 2003-06-20 | 2004-12-23 | University Of Maryland, Baltimore | Microparticles for microarterial imaging and radiotherapy |
| US7959900B2 (en) * | 2004-03-05 | 2011-06-14 | Xl Sci-Tech, Inc. | Particulate materials and compositions for radio therapy |
| US9248034B2 (en) * | 2005-08-23 | 2016-02-02 | Advanced Cardiovascular Systems, Inc. | Controlled disintegrating implantable medical devices |
| US20070170396A1 (en) * | 2006-01-26 | 2007-07-26 | Graham Appleby | Photostimulable glass ceramic |
| US20080038190A1 (en) | 2006-08-11 | 2008-02-14 | Simpson Thomas J | Composition apparatus and method for use in imaging |
| US20080119927A1 (en) * | 2006-11-17 | 2008-05-22 | Medtronic Vascular, Inc. | Stent Coating Including Therapeutic Biodegradable Glass, and Method of Making |
| US8353966B2 (en) * | 2009-01-15 | 2013-01-15 | The Curators Of The University Of Missouri | Scaffold for bone and tissue repair in mammals |
| US9456890B2 (en) | 2009-01-15 | 2016-10-04 | The Curators Of The University Of Missouri | Scaffold for bone and tissue repair in mammals |
| US8481066B2 (en) | 2009-07-16 | 2013-07-09 | The Curators Of The University Of Missouri | Scaffold for tissue regeneration in mammals |
| WO2011015958A2 (en) | 2009-08-06 | 2011-02-10 | Koninklijke Philips Electronics N.V. | Oncology therapies employing radioactive seeds |
| US9849200B2 (en) | 2010-09-16 | 2017-12-26 | Mo-Sci Corporation | Strontium phosphate microparticle for radiological imaging and therapy |
| US9119887B2 (en) | 2010-09-16 | 2015-09-01 | Mo-Sci Corporation | Low-density magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging |
| US8865123B1 (en) | 2010-09-16 | 2014-10-21 | Mo-Sci Corporation | Strontium phosphate microparticle for radiological imaging and therapy |
| EP2457588A1 (en) * | 2010-11-05 | 2012-05-30 | UMC Utrecht Holding B.V. | Microsphere comprising a lanthanide metal complex |
| US9750828B2 (en) * | 2012-03-29 | 2017-09-05 | Basf Corporation | Amorphous carbon supported nanoparticles comprising oxides of lanthanides and method for preparing them |
| EP2968165B1 (en) | 2013-03-13 | 2023-09-13 | Biosphere Medical, Inc. | Compositions and associated methods for radioisotope-binding microparticles |
| CA2937015C (en) | 2014-01-24 | 2022-08-02 | Sirtex Medical Limited | Treatment of neoplasia |
| GB201415005D0 (en) * | 2014-08-22 | 2014-10-08 | Univ Nottingham | Porous and non-pourous bodies |
| US11013836B2 (en) * | 2016-06-16 | 2021-05-25 | The Curators Of The University Of Missouri | Inorganic biodegradable substrates for devices and systems |
| HRP20230566T1 (hr) * | 2017-08-22 | 2023-08-18 | Moebius Medical Ltd. | Liposomalna formulacija za podmazivanje zglobova |
| TWI675669B (zh) * | 2018-03-05 | 2019-11-01 | 白金科技股份有限公司 | 放射微球及其製備方法 |
| NZ774059A (en) * | 2018-09-05 | 2025-11-28 | Ir Scient Inc | Glass composition |
| JP2022547277A (ja) | 2019-09-16 | 2022-11-11 | エービーケー バイオメディカル インコーポレイテッド | 放射性微粒子及び非放射性微粒子の組成物 |
Family Cites Families (4)
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| US3972721A (en) * | 1974-03-01 | 1976-08-03 | Ppg Industries, Inc. | Thermally stable and crush resistant microporous glass catalyst supports and methods of making |
| US5039326A (en) | 1988-01-29 | 1991-08-13 | The Curators Of The University Of Missouri | Composition and method for radiation synovectomy of arthritic joints |
| US4889707A (en) | 1988-01-29 | 1989-12-26 | The Curators Of The University Of Missouri | Composition and method for radiation synovectomy of arthritic joints |
| US5011797A (en) | 1988-01-29 | 1991-04-30 | The Curators Of The University Of Missouri | Composition and method for radiation synovectomy of arthritic joints |
-
1999
- 1999-02-01 US US09/241,892 patent/US6379648B1/en not_active Expired - Lifetime
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2000
- 2000-01-31 DE DE60011045T patent/DE60011045T2/de not_active Expired - Lifetime
- 2000-01-31 JP JP2000595944A patent/JP4397531B2/ja not_active Expired - Lifetime
- 2000-01-31 AU AU28647/00A patent/AU758560B2/en not_active Expired
- 2000-01-31 CA CA2361573A patent/CA2361573C/en not_active Expired - Lifetime
- 2000-01-31 EP EP00907088A patent/EP1149057B1/en not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| DE60011045T2 (de) | 2005-05-25 |
| JP2002535237A (ja) | 2002-10-22 |
| AU758560B2 (en) | 2003-03-27 |
| EP1149057A1 (en) | 2001-10-31 |
| WO2000044682A9 (en) | 2001-08-30 |
| DE60011045D1 (de) | 2004-07-01 |
| WO2000044682A1 (en) | 2000-08-03 |
| ATE267775T1 (de) | 2004-06-15 |
| CA2361573C (en) | 2010-05-25 |
| EP1149057B1 (en) | 2004-05-26 |
| ES2222892T3 (es) | 2005-02-16 |
| CA2361573A1 (en) | 2000-08-03 |
| AU2864700A (en) | 2000-08-18 |
| US6379648B1 (en) | 2002-04-30 |
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