JP4391597B2 - 抗糖尿病性、低脂質性及び抗高血圧性を有するチアゾリンジオンとオキサゾリジンジオン誘導体 - Google Patents
抗糖尿病性、低脂質性及び抗高血圧性を有するチアゾリンジオンとオキサゾリジンジオン誘導体 Download PDFInfo
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- JP4391597B2 JP4391597B2 JP54317398A JP54317398A JP4391597B2 JP 4391597 B2 JP4391597 B2 JP 4391597B2 JP 54317398 A JP54317398 A JP 54317398A JP 54317398 A JP54317398 A JP 54317398A JP 4391597 B2 JP4391597 B2 JP 4391597B2
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- 239000003472 antidiabetic agent Substances 0.000 title abstract description 5
- 230000003178 anti-diabetic effect Effects 0.000 title abstract description 4
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- 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 6
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
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- COWNFYYYZFRNOY-UHFFFAOYSA-N oxazolidinedione Chemical compound O=C1COC(=O)N1 COWNFYYYZFRNOY-UHFFFAOYSA-N 0.000 claims description 4
- DOJMKGYWVKQRNI-UHFFFAOYSA-N 5-[[4-[(3-methyl-4-oxophthalazin-1-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C12=CC=CC=C2C(=O)N(C)N=C1COC(C=C1)=CC=C1CC1SC(=O)NC1=O DOJMKGYWVKQRNI-UHFFFAOYSA-N 0.000 claims description 3
- AZQBBQQYUFIZDL-UHFFFAOYSA-N 5-[[4-[(3-methyl-4-oxophthalazin-1-yl)methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound C12=CC=CC=C2C(=O)N(C)N=C1COC(C=C1)=CC=C1C=C1SC(=O)NC1=O AZQBBQQYUFIZDL-UHFFFAOYSA-N 0.000 claims description 3
- SQXKUKDJRRMGDV-UHFFFAOYSA-N 5-[[4-[2-(1,4-dioxo-3h-phthalazin-2-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound O=C1C2=CC=CC=C2C(O)=NN1CCOC(C=C1)=CC=C1C=C1SC(=O)NC1=O SQXKUKDJRRMGDV-UHFFFAOYSA-N 0.000 claims description 3
- ZOEGSOBAHONJKF-UHFFFAOYSA-N 5-[[4-[2-(1-oxo-4-phenylphthalazin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1CC(C=C1)=CC=C1OCCN1C(=O)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1 ZOEGSOBAHONJKF-UHFFFAOYSA-N 0.000 claims description 3
- SSOWJXNHFJYAIY-UHFFFAOYSA-N 5-[[4-[2-(1-oxo-4-phenylphthalazin-2-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1=CC(C=C1)=CC=C1OCCN1C(=O)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1 SSOWJXNHFJYAIY-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/982,962 | 1997-12-02 | ||
| US08/982,962 US6011036A (en) | 1997-04-15 | 1997-12-02 | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them |
| PCT/US1998/007285 WO1998045292A1 (en) | 1997-12-02 | 1998-04-10 | Thiazolidinedione and oxazolidinedione derivatives having antidiabetic, hypolipidaemic and antihypertensive properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002508745A JP2002508745A (ja) | 2002-03-19 |
| JP2002508745A5 JP2002508745A5 (https=) | 2005-11-24 |
| JP4391597B2 true JP4391597B2 (ja) | 2009-12-24 |
Family
ID=25529696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54317398A Expired - Fee Related JP4391597B2 (ja) | 1997-12-02 | 1998-04-10 | 抗糖尿病性、低脂質性及び抗高血圧性を有するチアゾリンジオンとオキサゾリジンジオン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0971917B1 (https=) |
| JP (1) | JP4391597B2 (https=) |
| AT (1) | ATE212991T1 (https=) |
| AU (1) | AU6966498A (https=) |
| DE (1) | DE69803750T2 (https=) |
| WO (1) | WO1998045292A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19921567A1 (de) * | 1999-05-11 | 2000-11-16 | Basf Ag | Verwendung von Phthalazine-Derivaten |
| ES2253353T3 (es) | 2000-03-08 | 2006-06-01 | Novo Nordisk A/S | Reduccion del colesterol serico. |
| WO2003031432A1 (en) | 2001-10-12 | 2003-04-17 | Novo Nordisk A/S | Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor |
| PL370989A1 (en) | 2001-12-21 | 2005-06-13 | Novo Nordisk A/S | Amide derivatives as gk activators |
| DE60335359D1 (de) * | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
| AU2003243921B2 (en) | 2002-06-27 | 2009-05-07 | Novo Nordisk A/S | Aryl carbonyl derivatives as therapeutic agents |
| EP1670815A2 (en) | 2003-09-30 | 2006-06-21 | Novo Nordisk A/S | Melanocortin receptor agonists |
| EP2298337B1 (en) | 2003-12-09 | 2017-02-22 | Novo Nordisk A/S | Regulation of food preference using GLP-1 agonists |
| BRPI0506662B8 (pt) | 2004-01-06 | 2021-05-25 | Novo Nordisk As | compostos ativadores de glucoquinase |
| US20080113944A1 (en) | 2004-05-04 | 2008-05-15 | Novo Nordisk A/S | Novel Indole Derivatives |
| EP1758575A1 (en) | 2004-06-11 | 2007-03-07 | Novo Nordisk A/S | Counteracting drug-induced obesity using glp-1 agonists |
| US8263551B2 (en) | 2004-11-22 | 2012-09-11 | Novo Nordisk A/S | Soluble, stable insulin-containing formulations with a protamine salt |
| EP1824835A1 (en) | 2004-12-03 | 2007-08-29 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
| MX2007015675A (es) | 2005-07-04 | 2008-02-20 | Novo Nordisk As | Antagonistas del receptor de histamina h3. |
| EP1904467B1 (en) | 2005-07-14 | 2013-05-01 | Novo Nordisk A/S | Urea glucokinase activators |
| EP1910317B1 (en) | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino linked compounds |
| ES2393757T3 (es) | 2005-11-17 | 2012-12-27 | Eli Lilly & Company | Antagonistas de receptor de glucagón, preparación y usos terapéuticos |
| CN101410385B (zh) | 2006-03-28 | 2011-08-24 | 高点制药有限责任公司 | 具有组胺h3受体活性的苯并噻唑类 |
| EP2402324A1 (en) | 2006-05-29 | 2012-01-04 | High Point Pharmaceuticals, LLC | Benzodioxolylcyclopropylpiperazinylpyridazines |
| ATE523497T1 (de) | 2006-11-15 | 2011-09-15 | High Point Pharmaceuticals Llc | Neue 2-(2-hydroxyphenyl)benzimidazole, die sich für die behandlung von obesitas und diabetes eignen |
| EP2086951B1 (en) | 2006-11-15 | 2011-12-21 | High Point Pharmaceuticals, LLC | Novel 2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes |
| JP5226008B2 (ja) | 2007-01-11 | 2013-07-03 | ノボ・ノルデイスク・エー／エス | ウレアグルコキナーゼアクチベーター |
| BR112012021231A2 (pt) | 2010-02-26 | 2015-09-08 | Basf Plant Science Co Gmbh | método para acentuar o rendimento em plantas, planta, construto, uso de um construto, método para a produção de uma planta transgênica, partes coletáveis de uma planta, produtos derivados de uma planta, uso de um ácido nucleíco e método para a produção de um produto |
| EP2539364A1 (en) | 2010-02-26 | 2013-01-02 | Novo Nordisk A/S | Peptides for treatment of obesity |
| EP2552951A1 (en) | 2010-03-26 | 2013-02-06 | Novo Nordisk A/S | Novel glucagon analogues |
| WO2012104834A1 (en) | 2011-02-03 | 2012-08-09 | Pharmedica Ltd. | New oral dissolving films for insulin administration, for treating diabetes |
| RU2013145013A (ru) | 2011-03-28 | 2015-05-10 | Ново Нордиск А/С | Новые аналоги глюкагона |
| AU2012311484B2 (en) | 2011-09-23 | 2017-04-13 | Novo Nordisk A/S | Novel glucagon analogues |
| EP2986313B1 (en) | 2013-04-18 | 2019-06-12 | Novo Nordisk A/S | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
| US10570184B2 (en) | 2014-06-04 | 2020-02-25 | Novo Nordisk A/S | GLP-1/glucagon receptor co-agonists for medical use |
| US20200223889A1 (en) | 2017-03-15 | 2020-07-16 | Novo Nordisk A/S | Bicyclic Compounds Capable of Binding to Melanocortin 4 Receptor |
| WO2019219714A1 (en) | 2018-05-15 | 2019-11-21 | Novo Nordisk A/S | Compounds capable of binding to melanocortin 4 receptor |
| WO2020053414A1 (en) | 2018-09-14 | 2020-03-19 | Novo Nordisk A/S | Bicyclic compounds capable of acting as melanocortin 4 receptor agonists |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0842925A1 (en) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
| GB8919417D0 (en) * | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
| GB9023583D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
-
1998
- 1998-04-10 EP EP98915492A patent/EP0971917B1/en not_active Expired - Lifetime
- 1998-04-10 WO PCT/US1998/007285 patent/WO1998045292A1/en not_active Ceased
- 1998-04-10 AU AU69664/98A patent/AU6966498A/en not_active Abandoned
- 1998-04-10 DE DE69803750T patent/DE69803750T2/de not_active Expired - Fee Related
- 1998-04-10 AT AT98915492T patent/ATE212991T1/de active
- 1998-04-10 JP JP54317398A patent/JP4391597B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE212991T1 (de) | 2002-02-15 |
| AU6966498A (en) | 1998-10-30 |
| JP2002508745A (ja) | 2002-03-19 |
| WO1998045292A1 (en) | 1998-10-15 |
| DE69803750D1 (de) | 2002-03-21 |
| DE69803750T2 (de) | 2002-09-12 |
| EP0971917B1 (en) | 2002-02-06 |
| EP0971917A1 (en) | 2000-01-19 |
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