JP4391597B2 - 抗糖尿病性、低脂質性及び抗高血圧性を有するチアゾリンジオンとオキサゾリジンジオン誘導体 - Google Patents
抗糖尿病性、低脂質性及び抗高血圧性を有するチアゾリンジオンとオキサゾリジンジオン誘導体 Download PDFInfo
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- JP4391597B2 JP4391597B2 JP54317398A JP54317398A JP4391597B2 JP 4391597 B2 JP4391597 B2 JP 4391597B2 JP 54317398 A JP54317398 A JP 54317398A JP 54317398 A JP54317398 A JP 54317398A JP 4391597 B2 JP4391597 B2 JP 4391597B2
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- 239000003472 antidiabetic agent Substances 0.000 title abstract description 5
- 230000003178 anti-diabetic effect Effects 0.000 title abstract description 4
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- 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 6
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
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- COWNFYYYZFRNOY-UHFFFAOYSA-N oxazolidinedione Chemical compound O=C1COC(=O)N1 COWNFYYYZFRNOY-UHFFFAOYSA-N 0.000 claims description 4
- DOJMKGYWVKQRNI-UHFFFAOYSA-N 5-[[4-[(3-methyl-4-oxophthalazin-1-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C12=CC=CC=C2C(=O)N(C)N=C1COC(C=C1)=CC=C1CC1SC(=O)NC1=O DOJMKGYWVKQRNI-UHFFFAOYSA-N 0.000 claims description 3
- AZQBBQQYUFIZDL-UHFFFAOYSA-N 5-[[4-[(3-methyl-4-oxophthalazin-1-yl)methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound C12=CC=CC=C2C(=O)N(C)N=C1COC(C=C1)=CC=C1C=C1SC(=O)NC1=O AZQBBQQYUFIZDL-UHFFFAOYSA-N 0.000 claims description 3
- SQXKUKDJRRMGDV-UHFFFAOYSA-N 5-[[4-[2-(1,4-dioxo-3h-phthalazin-2-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound O=C1C2=CC=CC=C2C(O)=NN1CCOC(C=C1)=CC=C1C=C1SC(=O)NC1=O SQXKUKDJRRMGDV-UHFFFAOYSA-N 0.000 claims description 3
- ZOEGSOBAHONJKF-UHFFFAOYSA-N 5-[[4-[2-(1-oxo-4-phenylphthalazin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1CC(C=C1)=CC=C1OCCN1C(=O)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1 ZOEGSOBAHONJKF-UHFFFAOYSA-N 0.000 claims description 3
- SSOWJXNHFJYAIY-UHFFFAOYSA-N 5-[[4-[2-(1-oxo-4-phenylphthalazin-2-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1=CC(C=C1)=CC=C1OCCN1C(=O)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1 SSOWJXNHFJYAIY-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/982,962 US6011036A (en) | 1997-04-15 | 1997-12-02 | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them |
| US08/982,962 | 1997-12-02 | ||
| PCT/US1998/007285 WO1998045292A1 (en) | 1997-12-02 | 1998-04-10 | Thiazolidinedione and oxazolidinedione derivatives having antidiabetic, hypolipidaemic and antihypertensive properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002508745A JP2002508745A (ja) | 2002-03-19 |
| JP2002508745A5 JP2002508745A5 (https=) | 2005-11-24 |
| JP4391597B2 true JP4391597B2 (ja) | 2009-12-24 |
Family
ID=25529696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54317398A Expired - Fee Related JP4391597B2 (ja) | 1997-12-02 | 1998-04-10 | 抗糖尿病性、低脂質性及び抗高血圧性を有するチアゾリンジオンとオキサゾリジンジオン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0971917B1 (https=) |
| JP (1) | JP4391597B2 (https=) |
| AT (1) | ATE212991T1 (https=) |
| AU (1) | AU6966498A (https=) |
| DE (1) | DE69803750T2 (https=) |
| WO (1) | WO1998045292A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19921567A1 (de) * | 1999-05-11 | 2000-11-16 | Basf Ag | Verwendung von Phthalazine-Derivaten |
| JP2003525908A (ja) | 2000-03-08 | 2003-09-02 | ノボ ノルディスク アクティーゼルスカブ | 血清脂質の低下 |
| EP2243776A1 (en) | 2001-10-12 | 2010-10-27 | High Point Pharmaceuticals, LLC | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor |
| WO2003055482A1 (en) | 2001-12-21 | 2003-07-10 | Novo Nordisk A/S | Amide derivatives as gk activators |
| DE60335359D1 (de) * | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
| BR0312023A (pt) | 2002-06-27 | 2005-03-22 | Novo Nordisk As | Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica |
| EP1670815A2 (en) | 2003-09-30 | 2006-06-21 | Novo Nordisk A/S | Melanocortin receptor agonists |
| ATE498404T1 (de) | 2003-12-09 | 2011-03-15 | Novo Nordisk As | Regulierung der nahrungspräferenz mit glp-1- agonisten |
| JP4834840B2 (ja) | 2004-01-06 | 2011-12-14 | ノヴォ ノルディスク アー／エス | ヘテロアリール尿素およびグルコキナーゼ活性化剤としてのその使用 |
| EP1758856A2 (en) | 2004-05-04 | 2007-03-07 | Novo Nordisk A/S | Indole derivatives for the treatment of obesity |
| JP2008501765A (ja) | 2004-06-11 | 2008-01-24 | ノボ ノルディスク アクティーゼルスカブ | Ｇｌｐ−１アゴニストを用いた薬剤誘発性肥満の中和 |
| ES2391776T3 (es) | 2004-11-22 | 2012-11-29 | Novo Nordisk A/S | Formulaciones solubles, estables conteniendo insulina con una sal de protamina |
| CN101137631A (zh) | 2004-12-03 | 2008-03-05 | 转化技术制药公司 | 杂芳族葡糖激酶激活剂 |
| RU2499795C2 (ru) | 2005-07-04 | 2013-11-27 | Хай Пойнт Фармасьютикалс, ЛЛС | Антагонисты гистаминовых н3-рецепторов |
| US7884210B2 (en) | 2005-07-14 | 2011-02-08 | Novo Nordisk A/S | Ureido-thiazole glucokinase activators |
| EP1910317B1 (en) | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino linked compounds |
| ES2393757T3 (es) | 2005-11-17 | 2012-12-27 | Eli Lilly & Company | Antagonistas de receptor de glucagón, preparación y usos terapéuticos |
| MX2008011123A (es) | 2006-03-28 | 2008-09-30 | High Point Pharmaceuticals Llc | Benzotiazoles que tienen actividad de receptor h3 de histamina. |
| SG163547A1 (en) | 2006-05-29 | 2010-08-30 | High Point Pharmaceuticals Llc | 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
| ES2377322T3 (es) | 2006-11-15 | 2012-03-26 | High Point Pharmaceuticals, Llc | Nuevas 2-(2-hidroxifenil)benzotiadiazinas útiles para el tratamiento de la obesidad y la diabetes |
| US7915299B2 (en) | 2006-11-15 | 2011-03-29 | High Point Pharmaceuticals, Llc | 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes |
| WO2008084044A1 (en) | 2007-01-11 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
| EP2539364A1 (en) | 2010-02-26 | 2013-01-02 | Novo Nordisk A/S | Peptides for treatment of obesity |
| BR112012021231A2 (pt) | 2010-02-26 | 2015-09-08 | Basf Plant Science Co Gmbh | método para acentuar o rendimento em plantas, planta, construto, uso de um construto, método para a produção de uma planta transgênica, partes coletáveis de uma planta, produtos derivados de uma planta, uso de um ácido nucleíco e método para a produção de um produto |
| EP2552950A1 (en) | 2010-03-26 | 2013-02-06 | Novo Nordisk A/S | Novel glucagon analogues |
| WO2012104834A1 (en) | 2011-02-03 | 2012-08-09 | Pharmedica Ltd. | New oral dissolving films for insulin administration, for treating diabetes |
| JP2014510739A (ja) | 2011-03-28 | 2014-05-01 | ノヴォ ノルディスク アー／エス | 新規のグルカゴン類似体 |
| RU2610175C2 (ru) | 2011-09-23 | 2017-02-08 | Ново Нордиск А/С | Новые аналоги глюкагона |
| SI2986313T1 (sl) | 2013-04-18 | 2019-09-30 | Novo Nordisk A/S | Stabilni koagonisti GLP-1 / glukagonskega receptorja z dolgotrajnim učinkom za medicinsko uporabo |
| US10570184B2 (en) | 2014-06-04 | 2020-02-25 | Novo Nordisk A/S | GLP-1/glucagon receptor co-agonists for medical use |
| JP2020514365A (ja) | 2017-03-15 | 2020-05-21 | ノヴォ ノルディスク アー／エス | メラノコルチン４受容体に結合可能な二環式化合物 |
| WO2019219714A1 (en) | 2018-05-15 | 2019-11-21 | Novo Nordisk A/S | Compounds capable of binding to melanocortin 4 receptor |
| WO2020053414A1 (en) | 2018-09-14 | 2020-03-19 | Novo Nordisk A/S | Bicyclic compounds capable of acting as melanocortin 4 receptor agonists |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG59988A1 (en) * | 1987-09-04 | 1999-02-22 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
| GB8919417D0 (en) * | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
| GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| GB9023583D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
-
1998
- 1998-04-10 AU AU69664/98A patent/AU6966498A/en not_active Abandoned
- 1998-04-10 AT AT98915492T patent/ATE212991T1/de active
- 1998-04-10 WO PCT/US1998/007285 patent/WO1998045292A1/en not_active Ceased
- 1998-04-10 DE DE69803750T patent/DE69803750T2/de not_active Expired - Fee Related
- 1998-04-10 EP EP98915492A patent/EP0971917B1/en not_active Expired - Lifetime
- 1998-04-10 JP JP54317398A patent/JP4391597B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU6966498A (en) | 1998-10-30 |
| EP0971917A1 (en) | 2000-01-19 |
| DE69803750D1 (de) | 2002-03-21 |
| JP2002508745A (ja) | 2002-03-19 |
| ATE212991T1 (de) | 2002-02-15 |
| DE69803750T2 (de) | 2002-09-12 |
| WO1998045292A1 (en) | 1998-10-15 |
| EP0971917B1 (en) | 2002-02-06 |
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