JP4383851B2 - 多糖類生体材料及びその使用 - Google Patents

多糖類生体材料及びその使用 Download PDF

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Publication number
JP4383851B2
JP4383851B2 JP2003506947A JP2003506947A JP4383851B2 JP 4383851 B2 JP4383851 B2 JP 4383851B2 JP 2003506947 A JP2003506947 A JP 2003506947A JP 2003506947 A JP2003506947 A JP 2003506947A JP 4383851 B2 JP4383851 B2 JP 4383851B2
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Prior art keywords
heparin
monomer
group
hydrogel
macromer
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Expired - Fee Related
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JP2003506947A
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Japanese (ja)
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JP2004534579A (ja
JP2004534579A5 (enExample
Inventor
サンドュ、シブパル、シング
ルター、アジェイ、クマー
ハドソン、ジョン、オーバートン
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バイオインターラクションズ リミテッド
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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0011Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0064Hydrogels or hydrocolloids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • DTEXTILES; PAPER
    • D04BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04BKNITTING
    • D04B21/00Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
    • D04B21/20Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes specially adapted for knitting articles of particular configuration
    • D04B21/205Elongated tubular articles of small diameter, e.g. coverings or reinforcements for cables or hoses
    • DTEXTILES; PAPER
    • D10INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10BINDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2403/00Details of fabric structure established in the fabric forming process
    • D10B2403/01Surface features
    • D10B2403/012Alike front and back faces
    • D10B2403/0122Smooth surfaces, e.g. laminated or coated
    • DTEXTILES; PAPER
    • D10INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10BINDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2509/00Medical; Hygiene
    • D10B2509/06Vascular grafts; stents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Textile Engineering (AREA)
  • Materials For Medical Uses (AREA)
JP2003506947A 2001-06-26 2002-06-26 多糖類生体材料及びその使用 Expired - Fee Related JP4383851B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30117601P 2001-06-26 2001-06-26
PCT/GB2002/002940 WO2003000305A2 (en) 2001-06-26 2002-06-26 Polysaccharide biomaterials and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2004534579A JP2004534579A (ja) 2004-11-18
JP2004534579A5 JP2004534579A5 (enExample) 2006-01-05
JP4383851B2 true JP4383851B2 (ja) 2009-12-16

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JP2003506947A Expired - Fee Related JP4383851B2 (ja) 2001-06-26 2002-06-26 多糖類生体材料及びその使用

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US (3) US8101196B2 (enExample)
EP (1) EP1401511A2 (enExample)
JP (1) JP4383851B2 (enExample)
AU (1) AU2002350289B2 (enExample)
CA (1) CA2451255C (enExample)
WO (1) WO2003000305A2 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
US7655038B2 (en) * 2003-02-28 2010-02-02 Biointeractions Ltd. Polymeric network system for medical devices and methods of use
US7978716B2 (en) * 2003-11-24 2011-07-12 Citrix Systems, Inc. Systems and methods for providing a VPN solution
JP4566189B2 (ja) * 2004-03-15 2010-10-20 テルモ株式会社 癒着防止材
US20050208093A1 (en) 2004-03-22 2005-09-22 Thierry Glauser Phosphoryl choline coating compositions
US9561309B2 (en) 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
US20060095121A1 (en) * 2004-10-28 2006-05-04 Medtronic Vascular, Inc. Autologous platelet gel on a stent graft
US9297928B2 (en) 2004-11-22 2016-03-29 Johnson & Johnson Vision Care, Inc. Ophthalmic compositions comprising polyether substituted polymers
US8431226B2 (en) * 2005-03-30 2013-04-30 Biomet Manufacturing Corp. Coated medical device
US11896505B2 (en) 2005-10-31 2024-02-13 Scott M. Epstein Methods for making and using a structural hydrogel polymer device
US8048350B2 (en) * 2005-10-31 2011-11-01 Scott Epstein Structural hydrogel polymer device
US8052714B2 (en) 2005-11-22 2011-11-08 Medtronic Vascular, Inc. Radiopaque fibers and filtration matrices
JP2010511415A (ja) * 2005-12-01 2010-04-15 イノグラフト,リミティド ライアビリティー カンパニー 薄皮膜の施用のためにポリサッカライド物質をイオン架橋する方法及びそれから生成された製品
US20070160743A1 (en) * 2006-01-09 2007-07-12 Babitt John L Method for coating biocompatible material on a substrate
JP2010500917A (ja) 2006-06-15 2010-01-14 マイクロベンション, インコーポレイテッド 膨張性ポリマーで構成される塞栓形成デバイス
US8685430B1 (en) 2006-07-14 2014-04-01 Abbott Cardiovascular Systems Inc. Tailored aliphatic polyesters for stent coatings
US10188826B2 (en) * 2006-09-29 2019-01-29 Covidien Lp Catheters including antimicrobial sleeve and methods of making catheters
US20080114096A1 (en) * 2006-11-09 2008-05-15 Hydromer, Inc. Lubricious biopolymeric network compositions and methods of making same
CA2783363A1 (en) * 2007-03-15 2008-09-18 The Polymer Technology Group Incorporated Functionalized polyvinylpyrrolidone
JP2010529047A (ja) * 2007-06-08 2010-08-26 クィーンズランド ユニバーシティ オブ テクノロジー 創傷修復組成物および方法
US20090136553A1 (en) * 2007-09-25 2009-05-28 Gerlach Jorg C Triggerably dissolvable hollow fibers for controlled delivery
BRPI0821070B1 (pt) 2007-12-21 2018-10-23 Microvention Inc dispositivo para implantação e método para a preparação de um filamento de hidrogel para implantação em um animal
EP2424775B1 (en) 2009-04-30 2016-02-10 Technip France Spar mooring line sharing method and system
WO2011053555A1 (en) 2009-10-26 2011-05-05 Microvention, Inc. Embolization device constructed from expansile polymer
US8448457B2 (en) * 2009-11-23 2013-05-28 Sartorius Stedim North America Inc. Systems and methods for use in freezing, thawing, and storing biopharmaceutical materials
RU2012126318A (ru) * 2009-11-27 2014-01-10 Басф Се Дендритная полимочевина для солюбилизации труднорастворимых действующих веществ
EP2384725B1 (de) * 2010-05-06 2018-07-04 Biotronik AG Biokorrodierbares Implantat, bei dem eine Korrosion nach erfolgter Implantation durch einen externen Stimulus ausgelöst oder beschleunigt werden kann
US10751206B2 (en) 2010-06-26 2020-08-25 Scott M. Epstein Catheter or stent delivery system
US20110319902A1 (en) 2010-06-26 2011-12-29 Scott Epstein Catheter delivery system
US9456823B2 (en) 2011-04-18 2016-10-04 Terumo Corporation Embolic devices
US9567357B2 (en) 2011-06-24 2017-02-14 Biointeractions Ltd. Biocompatible, biomimetic ampholyte materials
DE102012008656A1 (de) * 2011-12-29 2013-07-04 Nonwotecc Medical Gmbh Struktur mit stellenweise miteinander verklebten Fasern
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
EP3984556B8 (en) 2012-06-14 2025-07-09 Microvention, Inc. Polymeric treatment compositions
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
CN104717983B (zh) 2012-10-15 2018-09-18 微仙美国有限公司 聚合治疗组合物
AU2014264335B2 (en) * 2013-03-15 2017-05-11 Valve Medical Ltd. System and method for sealing percutaneous valve
USRE49528E1 (en) 2013-04-26 2023-05-16 Biointeractions Ltd. Bioactive coatings
US10206945B2 (en) 2013-04-26 2019-02-19 Biointeractions Ltd. Bioactive coatings
CN103272280A (zh) * 2013-05-24 2013-09-04 南京大学医学院附属鼓楼医院 一种对脱细胞血管支架或人造血管改性的方法
WO2015073758A1 (en) 2013-11-15 2015-05-21 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
WO2015167752A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers including active agents
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
CA2970010A1 (en) 2014-12-09 2016-06-16 Karen Havenstrite Medical device coating with a biocompatible layer
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
JP6310167B2 (ja) 2016-01-14 2018-04-11 学校法人大阪医科薬科大学 経編地及び医療材料
US9861410B2 (en) 2016-05-06 2018-01-09 Medos International Sarl Methods, devices, and systems for blood flow
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
CN111200976B (zh) 2017-10-09 2023-07-07 微仙美国有限公司 放射性液体栓塞
US11027046B2 (en) 2017-10-31 2021-06-08 Hothouse Medical Limited Textile products having selectively applied sealant or coating and method of manufacture
JP2022528428A (ja) 2019-03-19 2022-06-10 ジェイメドテック・コーティング・テクノロジーズ・プライベイト・リミテッド 共有結合したヘパリン・コーティングを備える医療デバイス

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954583A (en) 1972-05-30 1976-05-04 The Upjohn Company Photochemical process
JPS5250399A (en) * 1975-10-21 1977-04-22 Agency Of Ind Science & Technol Process for preparing anticoagulating organosilicon polymers
US4239664A (en) * 1978-10-31 1980-12-16 Research Corporation Anti-thrombogenic PVP-heparin polymer
US4469827A (en) * 1978-12-15 1984-09-04 Hospal-Sodip Sa Mixtures of polymers for medical use
US4331697A (en) * 1980-09-02 1982-05-25 Teijin Limited Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative
DE3038288C1 (de) 1980-10-10 1982-04-08 Robert Bürkle GmbH & Co, 7290 Freudenstadt Vorrichtung zur Erfassung des Fliesspunktes von Harzlaminaten bei der Herstellung von Mehrschichtleiterplatten
SU1078894A1 (ru) 1982-04-23 1998-01-10 Московский государственный университет им.М.В.Ломоносова Способ получения гемосовместимых полимерных гидрогелей
US4722906A (en) 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
EP0149693B1 (en) 1984-01-20 1988-06-29 Dräger Nederland B.V. Method of forming an antithrombogenic layer on medical devices
CH665954A5 (fr) * 1985-07-08 1988-06-30 Battelle Memorial Institute Substrat dont la surface presente une activite antithrombogenique.
US5047020A (en) * 1987-09-14 1991-09-10 Baxter International Inc. Ionic heparin coating
JP2855224B2 (ja) 1988-07-22 1999-02-10 バイオ―メトリック システムズ,アイエヌシー. 高分子表面の調製
US5270046A (en) * 1988-09-27 1993-12-14 Ube Industries, Ltd. Heparin bound anti-thrombotic material
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
DE4034882A1 (de) * 1990-11-02 1992-05-07 Starchem Gmbh Verfahren zur herstellung von feinteiligen, wasserquellbaren polysaccharid-pfropfpolymeren
CA2063478A1 (en) * 1991-03-22 1992-09-23 Michael F. Novits Scorch extending curing/crosslinking compositions
CA2109960C (en) * 1991-05-31 2000-07-18 Li-Chien Hsu Thromboresistant coating for defoaming applications
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5510016A (en) * 1991-08-15 1996-04-23 Mobil Oil Corporation Gasoline upgrading process
WO1993005825A1 (en) * 1991-09-20 1993-04-01 Baxter International Inc. Processes for reducing the thrombogenicity of biomaterials
US5837747A (en) * 1991-10-29 1998-11-17 Vivorx, Inc. Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
JP2855307B2 (ja) * 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
NZ249770A (en) * 1992-02-28 1996-09-25 Univ Texas Biodegradable, polymerisable, substantially water soluble macromer comprising at least one water soluble region, at least one degradable region and at least two free radical polymerisable regions separated by at least one degradable region
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
EP0623150A4 (en) * 1992-11-19 1999-08-25 Univ Case Western Reserve Nonthrombogenic implant surfaces.
US5864530A (en) 1993-01-04 1999-01-26 U.S. Philips Corporation Multiplane information storage system and record carrier for use in such a system
US5464650A (en) * 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5531715A (en) * 1993-05-12 1996-07-02 Target Therapeutics, Inc. Lubricious catheters
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
US6015429A (en) * 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
US5583213A (en) * 1995-05-12 1996-12-10 Minnesota Mining And Manufacturing Company Process to activate sulfated polysaccharides
US5581588A (en) 1995-06-23 1996-12-03 General Electric Company Insulated protective coating doped with a noble metal for mitigation of stress corrosion cracking
EP0769503A3 (en) 1995-10-17 1997-10-08 Terumo Corp Heparin complex and medical device containing such compound
DE69632996T2 (de) * 1995-12-26 2005-07-21 Toyo Boseki K.K. In organischen Lösungsmitteln lösliche Mucopolysaccharide, antibakterielles antithrombogenes Mittel und medizinisches Material
US5871537A (en) * 1996-02-13 1999-02-16 Scimed Life Systems, Inc. Endovascular apparatus
GB9603146D0 (en) 1996-02-15 1996-04-17 Innovative Tech Ltd Hydrogels
GB9608882D0 (en) * 1996-04-30 1996-07-03 Luthra Ajay K Non-thrombogenic and anti-thrombogenic polymers
US6368356B1 (en) * 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US5854406A (en) * 1996-07-11 1998-12-29 Wako Pure Chemical Industries, Ltd. High molecular weight azoamide compound
US5851229A (en) * 1996-09-13 1998-12-22 Meadox Medicals, Inc. Bioresorbable sealants for porous vascular grafts
US5855618A (en) * 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US5741881A (en) * 1996-11-25 1998-04-21 Meadox Medicals, Inc. Process for preparing covalently bound-heparin containing polyurethane-peo-heparin coating compositions
US5877263A (en) * 1996-11-25 1999-03-02 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
US5728751A (en) * 1996-11-25 1998-03-17 Meadox Medicals, Inc. Bonding bio-active materials to substrate surfaces
US6121027A (en) 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US5975457A (en) * 1998-03-09 1999-11-02 Forbes; Thomas J. Web feeding systems
US6007833A (en) * 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
US6248127B1 (en) * 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
JP2002523476A (ja) 1998-08-27 2002-07-30 エイドゲントシッシュ テクニーシェ ホッシュール チューリッヒ ボロン酸含有ポリマー由来のゲルおよび多層表面構造
US6299980B1 (en) * 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6358557B1 (en) * 1999-09-10 2002-03-19 Sts Biopolymers, Inc. Graft polymerization of substrate surfaces
WO2001068722A1 (en) * 2000-03-13 2001-09-20 Biocure, Inc. Hydrogel biomedical articles
US6630460B2 (en) * 2001-02-09 2003-10-07 Medtronic, Inc. Heparin compositions and methods of making and using the same
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
JP4759858B2 (ja) * 2001-07-04 2011-08-31 和光純薬工業株式会社 粉末アゾ化合物

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US20030021762A1 (en) 2003-01-30
AU2002350289B2 (en) 2008-03-13
US20110274821A1 (en) 2011-11-10
US9127091B2 (en) 2015-09-08
WO2003000305A3 (en) 2003-04-17
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JP2004534579A (ja) 2004-11-18
US20040142016A1 (en) 2004-07-22

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