AU2002350289B2 - Polysaccharide biomaterials and methods of use thereof - Google Patents

Polysaccharide biomaterials and methods of use thereof Download PDF

Info

Publication number
AU2002350289B2
AU2002350289B2 AU2002350289A AU2002350289A AU2002350289B2 AU 2002350289 B2 AU2002350289 B2 AU 2002350289B2 AU 2002350289 A AU2002350289 A AU 2002350289A AU 2002350289 A AU2002350289 A AU 2002350289A AU 2002350289 B2 AU2002350289 B2 AU 2002350289B2
Authority
AU
Australia
Prior art keywords
monomers
groups
hydrogel
macromers
heparin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002350289A
Other languages
English (en)
Other versions
AU2002350289A1 (en
Inventor
John Overton Hudson
Ajay Kumar Luthra
Shivpal Singh Sandhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BioInteractions Ltd
Original Assignee
BioInteractions Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioInteractions Ltd filed Critical BioInteractions Ltd
Publication of AU2002350289A1 publication Critical patent/AU2002350289A1/en
Application granted granted Critical
Publication of AU2002350289B2 publication Critical patent/AU2002350289B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0011Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005Use of materials characterised by their function or physical properties
    • A61L33/0064Hydrogels or hydrocolloids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • DTEXTILES; PAPER
    • D04BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04BKNITTING
    • D04B21/00Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
    • D04B21/20Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes specially adapted for knitting articles of particular configuration
    • D04B21/205Elongated tubular articles of small diameter, e.g. coverings or reinforcements for cables or hoses
    • DTEXTILES; PAPER
    • D10INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10BINDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2403/00Details of fabric structure established in the fabric forming process
    • D10B2403/01Surface features
    • D10B2403/012Alike front and back faces
    • D10B2403/0122Smooth surfaces, e.g. laminated or coated
    • DTEXTILES; PAPER
    • D10INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10BINDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2509/00Medical; Hygiene
    • D10B2509/06Vascular grafts; stents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Textile Engineering (AREA)
  • Materials For Medical Uses (AREA)
AU2002350289A 2001-06-26 2002-06-26 Polysaccharide biomaterials and methods of use thereof Ceased AU2002350289B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30117601P 2001-06-26 2001-06-26
US60/301,176 2001-06-26
PCT/GB2002/002940 WO2003000305A2 (en) 2001-06-26 2002-06-26 Polysaccharide biomaterials and methods of use thereof

Publications (2)

Publication Number Publication Date
AU2002350289A1 AU2002350289A1 (en) 2003-06-19
AU2002350289B2 true AU2002350289B2 (en) 2008-03-13

Family

ID=23162274

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002350289A Ceased AU2002350289B2 (en) 2001-06-26 2002-06-26 Polysaccharide biomaterials and methods of use thereof

Country Status (6)

Country Link
US (3) US8101196B2 (enExample)
EP (1) EP1401511A2 (enExample)
JP (1) JP4383851B2 (enExample)
AU (1) AU2002350289B2 (enExample)
CA (1) CA2451255C (enExample)
WO (1) WO2003000305A2 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
US7655038B2 (en) * 2003-02-28 2010-02-02 Biointeractions Ltd. Polymeric network system for medical devices and methods of use
US7978716B2 (en) * 2003-11-24 2011-07-12 Citrix Systems, Inc. Systems and methods for providing a VPN solution
US7737214B2 (en) * 2004-03-15 2010-06-15 Terumo Kabushiki Kaisha Adhesion preventive material
US20050208093A1 (en) * 2004-03-22 2005-09-22 Thierry Glauser Phosphoryl choline coating compositions
US9561309B2 (en) 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
US20060095121A1 (en) * 2004-10-28 2006-05-04 Medtronic Vascular, Inc. Autologous platelet gel on a stent graft
US9297928B2 (en) 2004-11-22 2016-03-29 Johnson & Johnson Vision Care, Inc. Ophthalmic compositions comprising polyether substituted polymers
EP1863404A2 (en) * 2005-03-30 2007-12-12 Cartilix, Inc. Coated medical device
US11896505B2 (en) 2005-10-31 2024-02-13 Scott M. Epstein Methods for making and using a structural hydrogel polymer device
US8048350B2 (en) 2005-10-31 2011-11-01 Scott Epstein Structural hydrogel polymer device
US8052714B2 (en) 2005-11-22 2011-11-08 Medtronic Vascular, Inc. Radiopaque fibers and filtration matrices
EP1954327A4 (en) * 2005-12-01 2012-03-28 Innograft Llc METHOD FOR IONIC RETICULATION OF POLYSACCHARIDE MATERIAL FOR THIN FILM APPLICATIONS AND PRODUCTS OBTAINED THEREBY
US20070160743A1 (en) * 2006-01-09 2007-07-12 Babitt John L Method for coating biocompatible material on a substrate
KR101443926B1 (ko) 2006-06-15 2014-10-02 마이크로벤션, 인코포레이티드 팽창성 중합체로 제조된 색전술용 장치
US8685430B1 (en) 2006-07-14 2014-04-01 Abbott Cardiovascular Systems Inc. Tailored aliphatic polyesters for stent coatings
US10188826B2 (en) * 2006-09-29 2019-01-29 Covidien Lp Catheters including antimicrobial sleeve and methods of making catheters
US20080114096A1 (en) * 2006-11-09 2008-05-15 Hydromer, Inc. Lubricious biopolymeric network compositions and methods of making same
EP2132242B1 (en) 2007-03-15 2017-01-11 DSM IP Assets B.V. Novel pdms-pvp block copolymers
WO2008148174A1 (en) * 2007-06-08 2008-12-11 Queensland University Of Technology Wound repair composition and method
US20090136553A1 (en) * 2007-09-25 2009-05-28 Gerlach Jorg C Triggerably dissolvable hollow fibers for controlled delivery
WO2009086208A2 (en) 2007-12-21 2009-07-09 Microvention, Inc. Hydrogel filaments for biomedical uses
US8757077B2 (en) 2009-04-30 2014-06-24 Technip France Spar mooring line sharing method and system
CA2777171C (en) 2009-10-26 2017-09-19 Microvention, Inc. Embolization device constructed from expansile polymer
US8448457B2 (en) * 2009-11-23 2013-05-28 Sartorius Stedim North America Inc. Systems and methods for use in freezing, thawing, and storing biopharmaceutical materials
CA2781637A1 (en) * 2009-11-27 2011-06-03 Basf Se Dendritic polyurea for solubilizing active substances of low solubility
US9072618B2 (en) * 2010-05-06 2015-07-07 Biotronik Ag Biocorrodable implant in which corrosion may be triggered or accelerated after implantation by means of an external stimulus
US10751206B2 (en) 2010-06-26 2020-08-25 Scott M. Epstein Catheter or stent delivery system
US20110319902A1 (en) 2010-06-26 2011-12-29 Scott Epstein Catheter delivery system
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
US9567357B2 (en) 2011-06-24 2017-02-14 Biointeractions Ltd. Biocompatible, biomimetic ampholyte materials
DE102012008656A1 (de) * 2011-12-29 2013-07-04 Nonwotecc Medical Gmbh Struktur mit stellenweise miteinander verklebten Fasern
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
CA2876474C (en) 2012-06-14 2021-06-22 Microvention, Inc. Polymeric treatment compositions
US9395468B2 (en) * 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
AU2013331439B2 (en) 2012-10-15 2016-05-12 Microvention, Inc. Polymeric treatment compositions
HK1212583A1 (zh) * 2013-03-15 2016-06-17 Valve Medical Ltd. 用於密封经皮瓣膜的系统和方法
USRE49528E1 (en) 2013-04-26 2023-05-16 Biointeractions Ltd. Bioactive coatings
CA2910000C (en) 2013-04-26 2023-01-03 Biointeractions Limited Bioactive coating comprising a polymer having both guandine and heparin covalently bonded thereto as pendant groups
CN103272280A (zh) * 2013-05-24 2013-09-04 南京大学医学院附属鼓楼医院 一种对脱细胞血管支架或人造血管改性的方法
WO2015073758A1 (en) 2013-11-15 2015-05-21 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
JP6599361B2 (ja) 2014-04-29 2019-10-30 マイクロベンション インコーポレイテッド 活性剤を含むポリマー
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
JP6774947B2 (ja) 2014-12-09 2020-10-28 タンジブル サイエンス インコーポレイテッド 生体適合性層を有する医療デバイスコーティング
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
KR102625923B1 (ko) 2016-01-14 2024-01-16 데이진 가부시키가이샤 경편지 및 의료 재료
US9861410B2 (en) 2016-05-06 2018-01-09 Medos International Sarl Methods, devices, and systems for blood flow
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
EP3694422A4 (en) 2017-10-09 2021-06-30 Microvention, Inc. EMBOLIC RADIOACTIVE LIQUID
US11027046B2 (en) 2017-10-31 2021-06-08 Hothouse Medical Limited Textile products having selectively applied sealant or coating and method of manufacture
CN113795282A (zh) 2019-03-19 2021-12-14 杰美特涂层科技(厦门)有限公司 包含共价键合肝素涂层的医疗装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041164A1 (en) * 1996-04-30 1997-11-06 Ajay Kumar Luthra Non-thrombogenic and anti-thrombogenic polymers
US5834274A (en) * 1992-04-20 1998-11-10 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5846530A (en) * 1991-10-29 1998-12-08 Vivorx, Inc. Macrocapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor
US5851229A (en) * 1996-09-13 1998-12-22 Meadox Medicals, Inc. Bioresorbable sealants for porous vascular grafts
US6007833A (en) * 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
WO2000012146A1 (en) * 1998-08-27 2000-03-09 Eidgenössisch Technische Hochschule Zurich Gels and multilayer surface structures from boronic acid containing polymers

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954583A (en) 1972-05-30 1976-05-04 The Upjohn Company Photochemical process
JPS5250399A (en) * 1975-10-21 1977-04-22 Agency Of Ind Science & Technol Process for preparing anticoagulating organosilicon polymers
US4239664A (en) * 1978-10-31 1980-12-16 Research Corporation Anti-thrombogenic PVP-heparin polymer
US4469827A (en) * 1978-12-15 1984-09-04 Hospal-Sodip Sa Mixtures of polymers for medical use
US4331697A (en) * 1980-09-02 1982-05-25 Teijin Limited Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative
DE3038288C1 (de) 1980-10-10 1982-04-08 Robert Bürkle GmbH & Co, 7290 Freudenstadt Vorrichtung zur Erfassung des Fliesspunktes von Harzlaminaten bei der Herstellung von Mehrschichtleiterplatten
SU1078894A1 (ru) 1982-04-23 1998-01-10 Московский государственный университет им.М.В.Ломоносова Способ получения гемосовместимых полимерных гидрогелей
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US4722906A (en) 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
EP0149693B1 (en) 1984-01-20 1988-06-29 Dräger Nederland B.V. Method of forming an antithrombogenic layer on medical devices
CH665954A5 (fr) * 1985-07-08 1988-06-30 Battelle Memorial Institute Substrat dont la surface presente une activite antithrombogenique.
US5047020A (en) * 1987-09-14 1991-09-10 Baxter International Inc. Ionic heparin coating
EP0425485B1 (en) 1988-07-22 2000-10-04 SurModics, Inc. Preparation of polymeric surfaces
US5270046A (en) * 1988-09-27 1993-12-14 Ube Industries, Ltd. Heparin bound anti-thrombotic material
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
DE4034882A1 (de) * 1990-11-02 1992-05-07 Starchem Gmbh Verfahren zur herstellung von feinteiligen, wasserquellbaren polysaccharid-pfropfpolymeren
CA2063478A1 (en) * 1991-03-22 1992-09-23 Michael F. Novits Scorch extending curing/crosslinking compositions
EP0588895B1 (en) * 1991-05-31 1995-01-11 Baxter International Inc. Thromboresistant coating for defoaming applications
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5510016A (en) * 1991-08-15 1996-04-23 Mobil Oil Corporation Gasoline upgrading process
WO1993005825A1 (en) * 1991-09-20 1993-04-01 Baxter International Inc. Processes for reducing the thrombogenicity of biomaterials
JP2855307B2 (ja) * 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
BR9306038A (pt) * 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
WO1994011411A1 (en) * 1992-11-19 1994-05-26 Case Western Reserve University Nonthrombogenic implant surfaces
US5864530A (en) 1993-01-04 1999-01-26 U.S. Philips Corporation Multiplane information storage system and record carrier for use in such a system
US5464650A (en) * 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5531715A (en) * 1993-05-12 1996-07-02 Target Therapeutics, Inc. Lubricious catheters
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
US6015429A (en) * 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
US5583213A (en) * 1995-05-12 1996-12-10 Minnesota Mining And Manufacturing Company Process to activate sulfated polysaccharides
US5581588A (en) 1995-06-23 1996-12-03 General Electric Company Insulated protective coating doped with a noble metal for mitigation of stress corrosion cracking
EP0769503A3 (en) 1995-10-17 1997-10-08 Terumo Corp Heparin complex and medical device containing such compound
DE69632996T2 (de) * 1995-12-26 2005-07-21 Toyo Boseki K.K. In organischen Lösungsmitteln lösliche Mucopolysaccharide, antibakterielles antithrombogenes Mittel und medizinisches Material
US5871537A (en) * 1996-02-13 1999-02-16 Scimed Life Systems, Inc. Endovascular apparatus
GB9603146D0 (en) 1996-02-15 1996-04-17 Innovative Tech Ltd Hydrogels
US6368356B1 (en) * 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US5854406A (en) * 1996-07-11 1998-12-29 Wako Pure Chemical Industries, Ltd. High molecular weight azoamide compound
US5855618A (en) * 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US5728751A (en) * 1996-11-25 1998-03-17 Meadox Medicals, Inc. Bonding bio-active materials to substrate surfaces
US5877263A (en) * 1996-11-25 1999-03-02 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
US5741881A (en) * 1996-11-25 1998-04-21 Meadox Medicals, Inc. Process for preparing covalently bound-heparin containing polyurethane-peo-heparin coating compositions
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US5975457A (en) * 1998-03-09 1999-11-02 Forbes; Thomas J. Web feeding systems
US6248127B1 (en) * 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
US6299980B1 (en) * 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6358557B1 (en) * 1999-09-10 2002-03-19 Sts Biopolymers, Inc. Graft polymerization of substrate surfaces
EP1263802B1 (en) * 2000-03-13 2005-11-23 BioCure, Inc. Hydrogel biomedical articles
US6630460B2 (en) * 2001-02-09 2003-10-07 Medtronic, Inc. Heparin compositions and methods of making and using the same
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
JP4759858B2 (ja) * 2001-07-04 2011-08-31 和光純薬工業株式会社 粉末アゾ化合物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846530A (en) * 1991-10-29 1998-12-08 Vivorx, Inc. Macrocapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor
US5834274A (en) * 1992-04-20 1998-11-10 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
WO1997041164A1 (en) * 1996-04-30 1997-11-06 Ajay Kumar Luthra Non-thrombogenic and anti-thrombogenic polymers
US5851229A (en) * 1996-09-13 1998-12-22 Meadox Medicals, Inc. Bioresorbable sealants for porous vascular grafts
US6007833A (en) * 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
WO2000012146A1 (en) * 1998-08-27 2000-03-09 Eidgenössisch Technische Hochschule Zurich Gels and multilayer surface structures from boronic acid containing polymers

Also Published As

Publication number Publication date
WO2003000305A3 (en) 2003-04-17
US9127091B2 (en) 2015-09-08
EP1401511A2 (en) 2004-03-31
CA2451255A1 (en) 2003-01-03
US8101196B2 (en) 2012-01-24
US20110274821A1 (en) 2011-11-10
WO2003000305A2 (en) 2003-01-03
US20040142016A1 (en) 2004-07-22
US20030021762A1 (en) 2003-01-30
JP4383851B2 (ja) 2009-12-16
CA2451255C (en) 2012-11-27
JP2004534579A (ja) 2004-11-18

Similar Documents

Publication Publication Date Title
AU2002350289B2 (en) Polysaccharide biomaterials and methods of use thereof
Ratner et al. Synthetic hydrogels for biomedical applications
JP2992556B2 (ja) 表面改質した医療器具
US6231605B1 (en) Poly(vinyl alcohol) hydrogel
US5290548A (en) Surface modified ocular implants, surgical instruments, devices, prostheses, contact lenses and the like
US7857849B2 (en) Artificial corneal implant
US5100689A (en) Surface modified surgical instruments, devices, implants, contact lenses and the like
EP0241838B1 (en) Antithrombogenic material
US5718862A (en) Secondary shaping of ionically crosslinked polymer compositions for medical devices
US20030008396A1 (en) Poly(vinyl alcohol) hydrogel
JP2018099543A (ja) 固定された生物学的実体
WO1992009312A1 (en) Implant material
JP2003519280A (ja) ヒドロゲル
WO2009135068A1 (en) Artificial cornea
Ai et al. Gelatin-glutaraldehyde cross-linking on silicone rubber to increase endothelial cell adhesion and growth
Aleyamma et al. Polyvinyl alcohol as a biomaterial
Wilson Hemocompatible polymers: preparation and properties
CA1299937C (en) Antithrombogenic material
JPS61263448A (ja) 血管補綴物
JP2620378B2 (ja) 生体適合性に優れた表面を有する医療用具の製造方法
JPS6158196B2 (enExample)
KR100748038B1 (ko) 생리활성물질 고정화 인공혈관
RU2139017C1 (ru) Способ получения биосовместимого материала
JPH09103481A (ja) 生体適合性に優れた表面を有する医療用具およびその製造方法
JPS6320552B2 (enExample)

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired