JP4383446B2 - 微細構造化基板を接着する方法 - Google Patents
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C3/00—Assembling of devices or systems from individually processed components
- B81C3/001—Bonding of two components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/4805—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the type of adhesives
- B29C65/483—Reactive adhesives, e.g. chemically curing adhesives
- B29C65/4835—Heat curing adhesives
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/4805—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the type of adhesives
- B29C65/483—Reactive adhesives, e.g. chemically curing adhesives
- B29C65/484—Moisture curing adhesives
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/4805—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the type of adhesives
- B29C65/483—Reactive adhesives, e.g. chemically curing adhesives
- B29C65/4845—Radiation curing adhesives, e.g. UV light curing adhesives
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/4805—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the type of adhesives
- B29C65/483—Reactive adhesives, e.g. chemically curing adhesives
- B29C65/485—Multi-component adhesives, i.e. chemically curing as a result of the mixing of said multi-components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
- B29C65/526—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive by printing or by transfer from the surfaces of elements carrying the adhesive, e.g. using brushes, pads, rollers, stencils or silk screens
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/02—Preparation of the material, in the area to be joined, prior to joining or welding
- B29C66/026—Chemical pre-treatments
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/02—Preparation of the material, in the area to be joined, prior to joining or welding
- B29C66/028—Non-mechanical surface pre-treatments, i.e. by flame treatment, electric discharge treatment, plasma treatment, wave energy or particle radiation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/05—Particular design of joint configurations
- B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
- B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
- B29C66/112—Single lapped joints
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/05—Particular design of joint configurations
- B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
- B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
- B29C66/112—Single lapped joints
- B29C66/1122—Single lap to lap joints, i.e. overlap joints
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/05—Particular design of joint configurations
- B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
- B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
- B29C66/114—Single butt joints
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/53—Joining single elements to tubular articles, hollow articles or bars
- B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
- B29C66/5346—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/756—Microarticles, nanoarticles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/05—Microfluidics
- B81B2201/058—Microfluidics not provided for in B81B2201/051 - B81B2201/054
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- Micromachines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Lining Or Joining Of Plastics Or The Like (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Particle Formation And Scattering Control In Inkjet Printers (AREA)
Description
−シリコンを用いた、化学またはイオンエッチング、
−ガラスを用いた、化学エッチングまたは超音波もしくはレーザーによる機械加工、
−高分子を用いた、射出成形による複製化、必要なパターンを有する型からの高温スタンプ処理もしくは注入、機械加工、レーザーアブレーションまたはレーザー成長(立体写真転写)である。
[1]米国特許出願第5 842 787A号(Kopf−Sillら)。
[2]国際公開第WO99/56954A号(Caliper Technologies社)。
同じ部品に多数のプローブを設置することや、プローブが付与される領域を幾何学的に配置することは不可能である。
[3]国際公開第WO00/77509A号(Merck Patent Gmbhら)。
前記基板上にグリッドを設置するステップと、
前記グリッドに押し圧を加え、該グリッドを局部的に、上部同一平面領域に接触させる手段を用いて、前記グリッドに接着剤を塗布するステップであって、接着剤の小滴の膜が、前記上部同一平面領域に設置されるステップと、
前記グリッドを除去するステップと、
を有し、
上部同一平面領域は、接着剤の小滴の膜が設置される前に、処理され、該処理は、前記上部同一平面領域の接着剤に対する濡れ性を最適化するように定められることを特徴とする方法によって解決される。
−選定するスクリーン印刷グリッドによって定めることができる、小滴の体積、および設置された小滴配列の密度、
−塗布される支持体のエネルギーおよび表面張力、接着剤の粘度、
−ドクターブレード処理のパラメータ、すなわちドクターブレードの材質および硬度、ドクターブレード処理速度および荷重、ならびにグリッドと基板間の距離である。
−本発明では、幅が50μm以下の、極めて微細な寸法の孔を有する構造化基板の組立体であって、これらの孔が接着剤膜で閉塞されず、あるいは被覆されない組立体を得ることができる。
−本発明は、組み立て前に、基板に局部的に多数の生物プローブを形成する方法と、共存し得る接着技術である。
−本発明は、例えば高温挙動や、接着剤に含まれる成分など、各種機能的な使用に適した特徴を有する多くの接着剤に適用することができる。例えば、シリコン系、アクリル系、エポキシ系、または陽イオン接着剤、熱、紫外線または湿度によって重合化する接着剤、1または2以上の成分を含む接着剤等を用いることが可能である。
−本発明は、半導体ウェハ上のチップをまとめて密閉することに利用することができ、この技術では、いかなる基板寸法に対しても極めて高精度に適合することができる(スクリーン印刷法の場合、1m2以上のスクリーンが用いられる)。
−また本発明は、部品を個々に密閉することに用いることもできる。
−可撓性のあるエポキシ接着剤(例えば、ジュポン1891として市販されている)、
−陽イオン接着剤(例えば、デロカチオボンド(Delo Katiobond)45952市販されている)、
−シリコン接着剤(例えば、東芝GE TSE 399またはTSE 397として市販されている)、
−シリコン接着剤(例えば、ダウコーニング社(Dow Coring)からDC866として市販されている)、
−PDMS(例えば、ダウコーニング社からSylgard 184として市販されている)。
Claims (10)
- 上部同一平面領域と、該同一平面領域間に凹部とを有する、少なくとも一つの微細構造化基板を、前記上部同一平面領域に設置される接着剤によって、接着する方法であって、当該方法は、
前記基板上にマスクの無いグリッドを設置するステップと、
前記グリッドに押し圧を加え、該グリッドを局部的に、上部同一平面領域に接触させる手段を用いて、前記グリッドに接着剤を塗布するステップであって、接着剤の小滴の膜が、前記上部同一平面領域に設置されるステップと、
前記グリッドを除去するステップと、
を有し、
上部同一平面領域は、接着剤の小滴の膜が設置される前に、処理され、該処理は、前記上部同一平面領域の接着剤に対する濡れ性を最適化するように定められることを特徴とする方法。 - 前記手段は、ドクターブレードであることを特徴とする請求項1に記載の方法。
- 前記処理は、上部同一平面領域での接着剤の小滴の広がりを制御するように定められることを特徴とする請求項1または2に記載の方法。
- 微細構造化基板は、密閉基板で密閉され、該密閉基板は、上部同一平面領域に設置された接着剤によって、上部同一平面領域に固定されることを特徴とする請求項1乃至3のいずれか一つに記載の方法。
- 微細構造化基板の凹部は、生物プローブが設置される領域を有することを特徴とする請求項4に記載の方法。
- 前記密閉基板は、生物プローブが設置される領域を有し、該領域は、微細構造化基板が密閉されたとき、該微細構造化基板の凹部と面するように定められることを特徴とする請求項4に記載の方法。
- 前記密閉基板は、流体を微細構造化基板の凹部に添加する際に使用される開口を有することを特徴とする請求項4乃至6のいずれか一つに記載の方法。
- 微細構造化基板組は、予め同一基板にまとめて製作され、全ての微細構造化基板の上部平面領域は、同一平面にあり、接着剤の小滴の膜は、全ての上部平面領域に設置され、全ての微細構造化基板が、同一の密閉基板によって密閉されることにより、密閉された微細構造化基板は、相互に分離されることを特徴とする請求項4乃至7のいずれか一つに記載の方法。
- 微細構造化基板組は、予め同一基板にまとめて製作され、全ての微細構造化基板の上部平面領域は、同一平面にあり、密閉基板組は、予め別の基板にまとめて製作され、各微細構造化基板の上部同一平面領域に接着剤の小滴の膜が設置されてから、微細構造化基板と密閉基板の各々が、相互に分離され、微細構造化基板は、密閉基板によって密閉されることを特徴とする請求項4乃至7のいずれか一つに記載の方法。
- 各基板は、ガラス、シリコンおよび高分子の中から選定される材料であることを特徴とする請求項4乃至7のいずれか一つに記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0350218A FR2856047B1 (fr) | 2003-06-16 | 2003-06-16 | Procede de collage de substrats micro-structures |
PCT/FR2004/050274 WO2004112961A1 (fr) | 2003-06-16 | 2004-06-14 | Procede de collage de substrats micro-structures |
Publications (2)
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JP2007527505A JP2007527505A (ja) | 2007-09-27 |
JP4383446B2 true JP4383446B2 (ja) | 2009-12-16 |
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Application Number | Title | Priority Date | Filing Date |
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JP2006516348A Expired - Fee Related JP4383446B2 (ja) | 2003-06-16 | 2004-06-14 | 微細構造化基板を接着する方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US8647465B2 (ja) |
EP (1) | EP1633480B1 (ja) |
JP (1) | JP4383446B2 (ja) |
AT (1) | ATE504353T1 (ja) |
DE (1) | DE602004032134D1 (ja) |
FR (1) | FR2856047B1 (ja) |
WO (1) | WO2004112961A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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US7578167B2 (en) * | 2005-05-17 | 2009-08-25 | Honeywell International Inc. | Three-wafer channel structure for a fluid analyzer |
FR2906237B1 (fr) | 2006-09-22 | 2008-12-19 | Commissariat Energie Atomique | Composants fluidiques double-face |
FR2929860B1 (fr) | 2008-04-11 | 2010-12-17 | Commissariat Energie Atomique | Dispositif d'extraction de particules de l'haleine expiree |
FR2938063B1 (fr) | 2008-11-05 | 2014-09-19 | Commissariat Energie Atomique | Dispositif de preparation et/ou de traitement d'un echantillon biologique |
FR2946658B1 (fr) | 2009-06-11 | 2011-08-05 | Commissariat Energie Atomique | Dispositif microfluidique comportant deux couches hydrophobes assemblees l'une a l'autre et procede d'assemblage |
FR2961519B1 (fr) * | 2010-06-18 | 2012-07-06 | Commissariat Energie Atomique | Procede de collage calibre en epaisseur entre au moins deux substrats |
EP2548645A1 (en) * | 2011-07-08 | 2013-01-23 | PHD Nordic Oy | Device for handling microfluids and method for manufacturing a device suitable for handling microfluids |
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US20050173059A1 (en) * | 2004-02-11 | 2005-08-11 | Nalge Nunc International Corporation | Methods of making a multi-well test plate having an adhesively secured transparent bottom panel |
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JP2007527505A (ja) | 2007-09-27 |
FR2856047B1 (fr) | 2005-07-15 |
DE602004032134D1 (de) | 2011-05-19 |
US8647465B2 (en) | 2014-02-11 |
EP1633480A1 (fr) | 2006-03-15 |
WO2004112961A1 (fr) | 2004-12-29 |
US20060124230A1 (en) | 2006-06-15 |
FR2856047A1 (fr) | 2004-12-17 |
EP1633480B1 (fr) | 2011-04-06 |
ATE504353T1 (de) | 2011-04-15 |
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