JP4383053B2 - 超小型流体用バルブ、および、超小型バルブ用マイクロアクチュエータ - Google Patents
超小型流体用バルブ、および、超小型バルブ用マイクロアクチュエータ Download PDFInfo
- Publication number
- JP4383053B2 JP4383053B2 JP2002567724A JP2002567724A JP4383053B2 JP 4383053 B2 JP4383053 B2 JP 4383053B2 JP 2002567724 A JP2002567724 A JP 2002567724A JP 2002567724 A JP2002567724 A JP 2002567724A JP 4383053 B2 JP4383053 B2 JP 4383053B2
- Authority
- JP
- Japan
- Prior art keywords
- permeable membrane
- electrode pad
- valve
- current
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
- F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K31/00—Actuating devices; Operating means; Releasing devices
- F16K31/02—Actuating devices; Operating means; Releasing devices electric; magnetic
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
- F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
- F16K7/123—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm the seat being formed on the bottom of the fluid line
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
- F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
- F16K7/14—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0015—Diaphragm or membrane valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
- F16K99/0051—Electric operating means therefor using electrostatic means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/008—Multi-layer fabrications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Computer Hardware Design (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Theoretical Computer Science (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Electrically Driven Valve-Operating Means (AREA)
- Micromachines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/790,530 US6626417B2 (en) | 2001-02-23 | 2001-02-23 | Microfluidic valve and microactuator for a microvalve |
| PCT/US2002/005222 WO2002068849A1 (en) | 2001-02-23 | 2002-02-22 | Microfluidic valve and microactuator for a microvalve |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004526913A JP2004526913A (ja) | 2004-09-02 |
| JP2004526913A5 JP2004526913A5 (cg-RX-API-DMAC7.html) | 2005-12-22 |
| JP4383053B2 true JP4383053B2 (ja) | 2009-12-16 |
Family
ID=25150974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002567724A Expired - Lifetime JP4383053B2 (ja) | 2001-02-23 | 2002-02-22 | 超小型流体用バルブ、および、超小型バルブ用マイクロアクチュエータ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6626417B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1379802A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4383053B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2438810C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002068849A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE363030T1 (de) * | 1999-02-23 | 2007-06-15 | Matsushita Electric Works Ltd | Mikroaktuator |
| WO2002073673A1 (en) | 2001-03-13 | 2002-09-19 | Rochester Institute Of Technology | A micro-electro-mechanical switch and a method of using and making thereof |
| AU2002303933A1 (en) * | 2001-05-31 | 2002-12-09 | Rochester Institute Of Technology | Fluidic valves, agitators, and pumps and methods thereof |
| US7378775B2 (en) | 2001-10-26 | 2008-05-27 | Nth Tech Corporation | Motion based, electrostatic power source and methods thereof |
| US7211923B2 (en) | 2001-10-26 | 2007-05-01 | Nth Tech Corporation | Rotational motion based, electrostatic power source and methods thereof |
| WO2003040541A1 (en) * | 2001-11-08 | 2003-05-15 | Siemens Vdo Automotive Inc. | Electro-active polymer as a fuel vapor control valve actuator |
| TW551387U (en) * | 2002-04-22 | 2003-09-01 | Ind Tech Res Inst | Water gel actuated micro pump |
| US7648619B2 (en) * | 2002-06-04 | 2010-01-19 | Industrial Technology Research | Hydrogel-driven micropump |
| US7287328B2 (en) | 2003-08-29 | 2007-10-30 | Rochester Institute Of Technology | Methods for distributed electrode injection |
| US7217582B2 (en) | 2003-08-29 | 2007-05-15 | Rochester Institute Of Technology | Method for non-damaging charge injection and a system thereof |
| DE102004008009A1 (de) * | 2003-12-23 | 2005-07-28 | Robert Bosch Gmbh | Integriertes Mikroventil und Verfahren zum Herstellen eines Mikroventils |
| US20050211937A1 (en) * | 2003-12-29 | 2005-09-29 | Popadiuc Peter O | Method of sealing machine components |
| US8581308B2 (en) | 2004-02-19 | 2013-11-12 | Rochester Institute Of Technology | High temperature embedded charge devices and methods thereof |
| US20050196321A1 (en) * | 2004-03-03 | 2005-09-08 | Zhili Huang | Fluidic programmable array devices and methods |
| WO2006083833A2 (en) * | 2005-01-31 | 2006-08-10 | President And Fellows Of Harvard College | Valves and reservoirs for microfluidic systems |
| US8628055B2 (en) | 2005-07-27 | 2014-01-14 | The Board Of Trustees Of The University Of Illinois | Bi-direction rapid action electrostatically actuated microvalve |
| KR20080063268A (ko) * | 2005-07-27 | 2008-07-03 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 정전기적으로 작동되는 양방향 고속 동작의 마이크로밸브 |
| US8123834B2 (en) | 2005-10-06 | 2012-02-28 | The Board Of Trustees Of The University Of Illinois | High gain selective metal organic framework preconcentrators |
| WO2007044690A2 (en) * | 2005-10-07 | 2007-04-19 | The General Hospital Corporation | Devices and methods for cell manipulation |
| US7913928B2 (en) | 2005-11-04 | 2011-03-29 | Alliant Techsystems Inc. | Adaptive structures, systems incorporating same and related methods |
| EP2111551A1 (en) * | 2006-12-20 | 2009-10-28 | Applied Biosystems, LLC | Devices and methods for flow control in microfluidic structures |
| US7871570B2 (en) * | 2007-02-23 | 2011-01-18 | Joseph Zhili Huang | Fluidic array devices and systems, and related methods of use and manufacturing |
| WO2008124046A1 (en) * | 2007-04-04 | 2008-10-16 | Micropoint Bioscience Inc.. | Micromachined electrowetting microfluidic valve |
| US8123841B2 (en) | 2008-01-16 | 2012-02-28 | The Board Of Trustees Of The University Of Illinois | Column design for micro gas chromatograph |
| US8269029B2 (en) | 2008-04-08 | 2012-09-18 | The Board Of Trustees Of The University Of Illinois | Water repellent metal-organic frameworks, process for making and uses regarding same |
| US20100059120A1 (en) * | 2008-09-11 | 2010-03-11 | General Electric Company | Microfluidic device and methods for droplet generation and manipulation |
| DE102008048064A1 (de) * | 2008-09-19 | 2010-04-08 | Jobst Technologies Gmbh | Mikrofluidisches Ventil, mikrofluidische Pumpe, mikrofluidisches System und ein Herstellungsverfahren |
| WO2010073020A1 (en) | 2008-12-24 | 2010-07-01 | Heriot-Watt University | A microfluidic system and method |
| IT1398480B1 (it) * | 2009-12-17 | 2013-03-01 | Silicon Biosystems Spa | Sistema microfluidico |
| GB2481425A (en) | 2010-06-23 | 2011-12-28 | Iti Scotland Ltd | Method and device for assembling polynucleic acid sequences |
| DE102010061909A1 (de) * | 2010-11-24 | 2012-05-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Fluidischer Aktor mit verformbarer Verschlussanordnung und langer Lagerfähigkeit |
| US9162226B2 (en) | 2011-05-12 | 2015-10-20 | The United States Of America, As Represented By The Secretary Of Commerce | Foldable microfluidic devices using double-sided tape |
| WO2012170068A2 (en) * | 2011-06-05 | 2012-12-13 | University Of British Columbia | Wireless microactuators and control methods |
| US8975193B2 (en) | 2011-08-02 | 2015-03-10 | Teledyne Dalsa Semiconductor, Inc. | Method of making a microfluidic device |
| US20130032210A1 (en) * | 2011-08-02 | 2013-02-07 | Teledyne Dalsa Semiconductor, Inc. | Integrated microfluidic device with actuator |
| EP2811206A4 (en) * | 2012-01-31 | 2015-10-14 | Jatco Ltd | CONTROL VALVE BODY STRUCTURE FOR AUTOMATIC GEARBOX |
| FR2987282B1 (fr) * | 2012-02-24 | 2017-12-29 | Fonds De L'espci Georges Charpak | Microcanal avec dispositif d'ouverture et/ou fermeture et/ou pompage |
| US9493228B2 (en) * | 2012-11-28 | 2016-11-15 | The Boeing Company | High heat transfer rate reusable thermal protection system |
| WO2014153092A1 (en) | 2013-03-14 | 2014-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Capillary barriers for staged loading of microfluidic devices |
| WO2017046802A1 (en) * | 2015-09-16 | 2017-03-23 | Technion Research & Development Foundation Limited | Dynamic microfluidic devices and use thereof |
| SG11201806190TA (en) | 2016-01-29 | 2018-08-30 | Purigen Biosystems Inc | Isotachophoresis for purification of nucleic acids |
| JP6654951B2 (ja) * | 2016-03-31 | 2020-02-26 | 株式会社エンプラス | 流体取扱装置 |
| US20200039812A1 (en) * | 2016-10-07 | 2020-02-06 | Xinyu Liu | A microfluidic analytical platform for autonomous immunoassays |
| WO2019028197A1 (en) | 2017-08-02 | 2019-02-07 | Purigen Biosystems, Inc. | SYSTEMS, DEVICES AND METHODS FOR ISOTACHOPHORESIS |
| US11331618B2 (en) * | 2018-03-07 | 2022-05-17 | Encite Llc | R2R microelectromechanical gas concentrator |
| JP7071641B2 (ja) * | 2018-10-18 | 2022-05-19 | 日本電信電話株式会社 | 積層体、積層体の製造方法および形状制御デバイス |
| CN109695779B (zh) * | 2019-01-25 | 2020-07-31 | 京东方科技集团股份有限公司 | 流体开关阀及其制备方法、控制方法、微流控器件 |
| US11236846B1 (en) * | 2019-07-11 | 2022-02-01 | Facebook Technologies, Llc | Fluidic control: using exhaust as a control mechanism |
| US12229340B2 (en) * | 2020-06-19 | 2025-02-18 | Meta Platforms Technologies, Llc | Selective laser etching of layered fluidistors |
| US20220061705A1 (en) * | 2020-08-05 | 2022-03-03 | The Regents Of The University Of California | Programmable epidermal microfluidic valving system for wearable biofluid management and contextual biomarker analysis |
| TWI755075B (zh) * | 2020-09-25 | 2022-02-11 | 研能科技股份有限公司 | 微型流體輸送裝置 |
| CN116068047A (zh) * | 2021-10-29 | 2023-05-05 | 中国科学院声学研究所 | 一种具有自除冰功能的乐甫波结冰传感器及制备方法 |
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| US4581624A (en) * | 1984-03-01 | 1986-04-08 | Allied Corporation | Microminiature semiconductor valve |
| US4966646A (en) | 1986-09-24 | 1990-10-30 | Board Of Trustees Of Leland Stanford University | Method of making an integrated, microminiature electric-to-fluidic valve |
| JP3111319B2 (ja) * | 1990-08-31 | 2000-11-20 | ウエストンブリッジ・インターナショナル・リミテッド | 位置検出器を備えた弁及び前記弁を組み込んだマイクロポンプ |
| US5058856A (en) * | 1991-05-08 | 1991-10-22 | Hewlett-Packard Company | Thermally-actuated microminiature valve |
| US6051380A (en) | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
| DE4234237C2 (de) | 1992-10-10 | 2000-11-30 | Bosch Gmbh Robert | Temperaturkompensierter Mikroaktor |
| US5309943A (en) | 1992-12-07 | 1994-05-10 | Ford Motor Company | Micro-valve and method of manufacturing |
| US5378583A (en) | 1992-12-22 | 1995-01-03 | Wisconsin Alumni Research Foundation | Formation of microstructures using a preformed photoresist sheet |
| US5338416A (en) | 1993-02-05 | 1994-08-16 | Massachusetts Institute Of Technology | Electrochemical etching process |
| JP3418741B2 (ja) | 1993-05-27 | 2003-06-23 | フラウンホッファー−ゲゼルシャフト ツァ フェルダールング デァ アンゲヴァンテン フォアシュンク エー.ファオ. | 超小型弁 |
| US6071394A (en) | 1996-09-06 | 2000-06-06 | Nanogen, Inc. | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
| US5788468A (en) | 1994-11-03 | 1998-08-04 | Memstek Products, Llc | Microfabricated fluidic devices |
| AU7671696A (en) * | 1996-01-18 | 1997-08-11 | University Of New Mexico | Soft actuators and artificial muscles |
| US5785295A (en) * | 1996-08-27 | 1998-07-28 | Industrial Technology Research Institute | Thermally buckling control microvalve |
| US5865417A (en) * | 1996-09-27 | 1999-02-02 | Redwood Microsystems, Inc. | Integrated electrically operable normally closed valve |
| US5971355A (en) | 1996-11-27 | 1999-10-26 | Xerox Corporation | Microdevice valve structures to fluid control |
| US6123316A (en) * | 1996-11-27 | 2000-09-26 | Xerox Corporation | Conduit system for a valve array |
| KR100356101B1 (ko) * | 1996-12-04 | 2003-01-14 | 우릴크 로보우 | 육류 또는 야채 또는 농산물 및 사료를 소독 또는 살균하기 위한 방법 및 장치. |
| US5796152A (en) | 1997-01-24 | 1998-08-18 | Roxburgh Ltd. | Cantilevered microstructure |
| US5780748A (en) | 1997-01-29 | 1998-07-14 | Hewlett-Packard Company | Flow device having parallel flow surfaces which move toward and away from one another to adjust the flow channel in proportion to applied force |
| US6072509A (en) * | 1997-06-03 | 2000-06-06 | Eastman Kodak Company | Microfluidic printing with ink volume control |
| US5965410A (en) | 1997-09-02 | 1999-10-12 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
| US5993414A (en) | 1998-04-23 | 1999-11-30 | Medtronic, Inc. | Implantable device |
| US6056269A (en) * | 1999-01-15 | 2000-05-02 | Hewlett-Packard Company | Microminiature valve having silicon diaphragm |
-
2001
- 2001-02-23 US US09/790,530 patent/US6626417B2/en not_active Expired - Fee Related
-
2002
- 2002-02-22 WO PCT/US2002/005222 patent/WO2002068849A1/en not_active Ceased
- 2002-02-22 CA CA002438810A patent/CA2438810C/en not_active Expired - Fee Related
- 2002-02-22 JP JP2002567724A patent/JP4383053B2/ja not_active Expired - Lifetime
- 2002-02-22 EP EP02707838A patent/EP1379802A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002068849A9 (en) | 2003-01-30 |
| CA2438810A1 (en) | 2002-09-06 |
| US6626417B2 (en) | 2003-09-30 |
| WO2002068849A1 (en) | 2002-09-06 |
| US20020117643A1 (en) | 2002-08-29 |
| EP1379802A1 (en) | 2004-01-14 |
| CA2438810C (en) | 2009-06-02 |
| WO2002068849A8 (en) | 2004-05-21 |
| EP1379802A4 (en) | 2005-11-02 |
| JP2004526913A (ja) | 2004-09-02 |
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