JP4343428B2 - 感熱性分散液または乳濁液を生成する方法 - Google Patents
感熱性分散液または乳濁液を生成する方法 Download PDFInfo
- Publication number
- JP4343428B2 JP4343428B2 JP2000522993A JP2000522993A JP4343428B2 JP 4343428 B2 JP4343428 B2 JP 4343428B2 JP 2000522993 A JP2000522993 A JP 2000522993A JP 2000522993 A JP2000522993 A JP 2000522993A JP 4343428 B2 JP4343428 B2 JP 4343428B2
- Authority
- JP
- Japan
- Prior art keywords
- heat exchanger
- high pressure
- mixing zone
- orifice
- passing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000006185 dispersion Substances 0.000 title description 18
- 239000000839 emulsion Substances 0.000 title description 6
- 238000002156 mixing Methods 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 description 14
- 239000012530 fluid Substances 0.000 description 7
- 239000011230 binding agent Substances 0.000 description 5
- 239000000049 pigment Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- UONOETXJSWQNOL-UHFFFAOYSA-N tungsten carbide Chemical compound [W+]#[C-] UONOETXJSWQNOL-UHFFFAOYSA-N 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 229910010413 TiO 2 Inorganic materials 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000000110 cooling liquid Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000001247 metal acetylides Chemical class 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229920005596 polymer binder Polymers 0.000 description 1
- 239000002491 polymer binding agent Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
- B01F25/4323—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
- B01F25/23—Mixing by intersecting jets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/56—Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Accessories For Mixers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/980,526 US5927852A (en) | 1997-12-01 | 1997-12-01 | Process for production of heat sensitive dispersions or emulsions |
| US08/980,526 | 1997-12-01 | ||
| PCT/US1998/022561 WO1999028020A1 (en) | 1997-12-01 | 1998-10-23 | Process for production of heat sensitive dispersions or emulsions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001524377A JP2001524377A (ja) | 2001-12-04 |
| JP2001524377A5 JP2001524377A5 (https=) | 2006-01-05 |
| JP4343428B2 true JP4343428B2 (ja) | 2009-10-14 |
Family
ID=25527630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000522993A Expired - Fee Related JP4343428B2 (ja) | 1997-12-01 | 1998-10-23 | 感熱性分散液または乳濁液を生成する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5927852A (https=) |
| EP (1) | EP1035911B1 (https=) |
| JP (1) | JP4343428B2 (https=) |
| AU (1) | AU1276099A (https=) |
| DE (1) | DE69810814T2 (https=) |
| WO (1) | WO1999028020A1 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159442A (en) * | 1997-08-05 | 2000-12-12 | Mfic Corporation | Use of multiple stream high pressure mixer/reactor |
| GB2359765B (en) * | 2000-03-02 | 2003-03-05 | Univ Newcastle | Capillary reactor distribution device and method |
| DE10011564C1 (de) * | 2000-03-09 | 2001-09-27 | Goldschmidt Ag Th | Verfahren zur Herstellung von Polyorganosiloxanemulsionen |
| JP2003001079A (ja) * | 2001-06-18 | 2003-01-07 | Karasawa Fine Ltd | 粒子微細化装置 |
| US6827479B1 (en) * | 2001-10-11 | 2004-12-07 | Amphastar Pharmaceuticals Inc. | Uniform small particle homogenizer and homogenizing process |
| US6730214B2 (en) * | 2001-10-26 | 2004-05-04 | Angelo L. Mazzei | System and apparatus for accelerating mass transfer of a gas into a liquid |
| US6923213B2 (en) * | 2002-09-18 | 2005-08-02 | Imation Corp. | Fluid processing device with annular flow paths |
| JP4397014B2 (ja) * | 2002-11-26 | 2010-01-13 | 株式会社スギノマシン | 噴流衝合装置 |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| DE10360766A1 (de) * | 2003-12-23 | 2005-07-28 | Degussa Ag | Verfahren und Vorrichtung zur Herstellung von Dispersionen |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| US20070140046A1 (en) * | 2005-12-20 | 2007-06-21 | Imation Corp. | Multiple-stream annular fluid processor |
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP2530167A1 (en) | 2006-05-11 | 2012-12-05 | Raindance Technologies, Inc. | Microfluidic Devices |
| EP2077912B1 (en) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| US20080105316A1 (en) * | 2006-10-18 | 2008-05-08 | Imation Corp. | Multiple fluid product stream processing |
| US20080144430A1 (en) * | 2006-12-14 | 2008-06-19 | Imation Corp. | Annular fluid processor with different annular path areas |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US20080203199A1 (en) * | 2007-02-07 | 2008-08-28 | Imation Corp. | Processing of a guar dispersion for particle size reduction |
| CA2678227A1 (en) * | 2007-02-13 | 2008-08-21 | Vrtx Technologies, Llc | Systems and methods for treatment of wastewater |
| US7651621B2 (en) * | 2007-04-18 | 2010-01-26 | Vrtx Technologies, Llc | Methods for degassing one or more fluids |
| US20090152212A1 (en) * | 2007-04-18 | 2009-06-18 | Kelsey Robert L | Systems and methods for treatment of groundwater |
| US20080257411A1 (en) * | 2007-04-18 | 2008-10-23 | Kelsey Robert L | Systems and methods for preparation of emulsions |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US20090071544A1 (en) * | 2007-09-14 | 2009-03-19 | Vek Nanotechnologies, Inc. | Fluid conditioning and mixing apparatus and method for using same |
| US8853284B2 (en) | 2008-06-02 | 2014-10-07 | Honeywell International Inc. | Wax dispersion formulations, method of producing same, and uses |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| EP3412778A1 (en) | 2011-02-11 | 2018-12-12 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
| WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| EP3216872B1 (en) | 2011-06-02 | 2020-04-01 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
| US10967372B2 (en) * | 2014-04-16 | 2021-04-06 | International Business Machines Corporation | Electro-fluidic flow probe |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| DE102016101232A1 (de) * | 2016-01-25 | 2017-07-27 | Instillo Gmbh | Verfahren zum Herstellen von Emulsionen |
| US9950328B2 (en) * | 2016-03-23 | 2018-04-24 | Alfa Laval Corporate Ab | Apparatus for dispersing particles in a fluid |
| US10857507B2 (en) * | 2016-03-23 | 2020-12-08 | Alfa Laval Corporate Ab | Apparatus for dispersing particles in a liquid |
| NO346707B1 (en) * | 2019-02-05 | 2022-11-28 | Jagtech As | Method and device for shearing and mixing drilling fluid |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2976024A (en) * | 1954-10-06 | 1961-03-21 | Pure Oil Co | Apparatus for preparing colloidal dispersions |
| US3833718A (en) * | 1971-04-02 | 1974-09-03 | Chevron Res | Method of mixing an aqueous aluminum salt solution and an alkaline base solution in a jet mixer to form a hydroxy-aluminum solution |
| DE2555156C3 (de) * | 1975-12-08 | 1987-07-09 | The Dow Chemical Co. (eine Ges.n.d.Gesetzen d. Staates Delaware), Midland, Mich. | Hochdruck-Mischkopf |
| US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
| US4966466A (en) * | 1987-11-10 | 1990-10-30 | Krauss-Maffei A.G. | Impingement mixing device with pressure controlled nozzle adjustment |
| US5026427A (en) * | 1988-10-12 | 1991-06-25 | E. I. Dupont De Nemours And Company | Process for making pigmented ink jet inks |
| US5423607A (en) * | 1991-05-03 | 1995-06-13 | Dolco Packaging Corp. | Method for blending diverse blowing agents |
| DE4128999A1 (de) * | 1991-08-31 | 1993-03-04 | Adrian Verstallen | Verfahren und vorrichtung zum vermischen schwer mischbarer fluide zur bildung einer dispersion insbesondere emulsion |
| US5635206A (en) * | 1994-01-20 | 1997-06-03 | Hoffmann-La Roche Inc. | Process for liposomes or proliposomes |
| US5843334A (en) * | 1994-06-20 | 1998-12-01 | Nippon Shinyaku Co., Ltd. | Method of producing emulsions and an emulsification apparatus |
| EP0787035B1 (en) * | 1994-11-14 | 2001-08-16 | Minnesota Mining And Manufacturing Company | Process and apparatus for preparing a dispersion of hard particles in solvent |
| WO1996014941A1 (en) * | 1994-11-14 | 1996-05-23 | Minnesota Mining And Manufacturing Company | Magnetic dispersion conditioning process |
| US6135628A (en) * | 1995-10-13 | 2000-10-24 | Boehringer Ingelheim Pharmceuticals, Inc. | Method and apparatus for homogenizing aerosol formulations |
-
1997
- 1997-12-01 US US08/980,526 patent/US5927852A/en not_active Expired - Fee Related
-
1998
- 1998-10-23 JP JP2000522993A patent/JP4343428B2/ja not_active Expired - Fee Related
- 1998-10-23 EP EP98956178A patent/EP1035911B1/en not_active Expired - Lifetime
- 1998-10-23 DE DE69810814T patent/DE69810814T2/de not_active Expired - Fee Related
- 1998-10-23 WO PCT/US1998/022561 patent/WO1999028020A1/en not_active Ceased
- 1998-10-23 AU AU12760/99A patent/AU1276099A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69810814D1 (de) | 2003-02-20 |
| JP2001524377A (ja) | 2001-12-04 |
| WO1999028020A1 (en) | 1999-06-10 |
| US5927852A (en) | 1999-07-27 |
| EP1035911A1 (en) | 2000-09-20 |
| EP1035911B1 (en) | 2003-01-15 |
| DE69810814T2 (de) | 2003-11-06 |
| AU1276099A (en) | 1999-06-16 |
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