JP4317816B2 - 材料取り扱い工具 - Google Patents
材料取り扱い工具 Download PDFInfo
- Publication number
- JP4317816B2 JP4317816B2 JP2004523509A JP2004523509A JP4317816B2 JP 4317816 B2 JP4317816 B2 JP 4317816B2 JP 2004523509 A JP2004523509 A JP 2004523509A JP 2004523509 A JP2004523509 A JP 2004523509A JP 4317816 B2 JP4317816 B2 JP 4317816B2
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- JP
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- Prior art keywords
- needle
- tool
- valve
- valves
- plunger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
- B01L3/022—Capillary pipettes, i.e. having very small bore
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
- B01L2300/049—Valves integrated in closure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1072—Multiple transfer devices with provision for selective pipetting of individual channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Description
本発明の各種態様を、例示的実施形態を参照しながら以下に説明する。しかしながら、本発明は以下の実施形態に限定されるものではなく、あらゆる適性のあるシステム又は装置にも使用できる旨理解頂きたい。
Claims (10)
- 材料取り扱い工具において、
工具の本体であり、上部分と下部分とを有し上部分が下部分に相対的に動くようになっており、下部分には複数の流路が設けられてる、本体と、
前記本体の下部分に取り付けられた複数の針であって、各前記針は、材料を作業域から取り出し、材料を作業域に置くように構成配置されている複数の針と、
前記本体の上部分に固定されまた前記下部分の対応する流路内で動かすことのできる複数のプランジャであって、各前記プランジャは、前記複数の針の対応する1つと関係付けられ、前記プランジャを通して流体が流れることを許容する通路を有している複数のプランジャと、
各前記通路に個別にアドレスして各前記通路内の流れを個別に制御できるように構成配置されている制御装置と、を備えており、
前記制御装置は、複数のアクチュエータを備え、各前記複数のアクチュエータは対応する通路に関し流体の流れを制御しまた該通路を開閉することができる薄膜弁を有し、
前記制御装置は複数の第1弁を含み、各前記弁は、対応する薄膜弁の群に空気圧信号を供給し、前記薄膜弁を開状態と閉状態の間で制御して、対応する通路を開閉するようになっており、また、
前記制御装置は複数の第2弁を含み、各前記第2弁は、対応する薄膜弁に流体の流れを供給するようになっている、工具。 - プランジャの通路を閉じると、前記プランジャが前記本体の下部分の流路内で動くときに、対応する針に流体を吸引すること及び対応する針から流体を排出することの内の一方が起こることになる、請求項1に記載の工具。
- 前記本体の上部分が該本体の下部分に対して移動すると、通路が閉じられているプランジャに対応する流路に圧力変化が生じることになる、請求項1に記載の工具。
- ロボット操作式材料取り扱い工具において、
工具の本体であり、上部分と下部分とを有し上部分が下部分に相対的に動くようになっており、下部分には複数の流路が設けられてる、本体と、
前記本体の下部分に取り付けられた第1の個数の針であって、各前記針は、材料を作業域から取り出し、材料を作業域に置くように構成配置されている第1の個数の針と、
前記本体の上部分に固定されまた前記下部分の対応する流路内で動かすことのできる複数のプランジャであって、各前記プランジャは、前記複数の針の対応する1つと関係付けられ、前記プランジャを通して流体が流れることを許容する通路を有している複数のプランジャと、
それぞれが対応するプランジャと関係付けられ、前記プランジャ内の通路に対して流れを制御する第1の個数の薄膜弁と、
前記薄膜弁に信号を供給することにより各前記薄膜弁を制御するように構成配置されている弁制御装置と、を備えており、
前記弁制御装置は、前記薄膜弁を制御して、各前記通路の流れを個別に制御するようになっており、
前記複数の針と、対応する薄膜弁とは、MxNの配列に配置されており、
前記弁制御装置はM個の弁を含み、各前記弁は、対応する行の薄膜弁に空気圧力信号を供給するようになっており、また、
前記弁制御装置はN個の弁を含み、各前記弁は、対応する列の薄膜弁に流体の流れを供給するようになっている、工具。 - プランジャの通路を閉じると、前記プランジャが前記本体の下部分の対応する流路内で動くときに、対応する針に流体を吸引すること及び対応する針から流体を排出することの内の一方が起こることになる、請求項4に記載の工具。
- 前記弁制御装置は、工具の前記本体に取り付けられている、請求項4に記載の工具。
- 前記弁制御装置は、複数の通路に関して流れを同時に制御するために、薄膜弁を制御する、請求項4に記載の工具。
- ロボット操作式材料取り扱い工具において、
工具の本体であり、上部分と下部分とを有し上部分が下部分に相対的に動くようになっており、下部分には複数の流路が設けられてる、本体と、
前記本体の下部分にM列N行に取り付けられた複数の針であって、各前記針が、材料を作業域から取り出し、材料を作業域に置くように構成配置されている複数の針と、
前記本体の上部分に固定されまた前記下部分の対応する流路内で動かすことのできる複数のプランジャであって、各前記プランジャは、前記複数の針の対応する1つと関係付けられ、前記プランジャを通して流体が流れることを許容する通路を有している複数のプランジャと、
少なくとも1つのアドレス弁が対応する通路に関係付けられ、前記通路の流れを制御する複数のアドレス弁と、
前記アドレス弁に信号を供給する、M+Nに等しい個数の複数のスイッチと、を備えており、
前記複数のスイッチは、各針毎に流れを個別に制御するために、信号を前記アドレス弁に供給するようになっており、
前記複数のスイッチは、M列の針に関係付けられたM個のスイッチを含んでおり、各前記M個のスイッチは、対応する列の弁に対応しており、当該弁に流体圧信号を供給し、前記複数のスイッチは、更にN行の針に関係付けられたN個のスイッチを含んでおり、各前記N個のスイッチは、対応する行の弁に対応しており、当該弁に流体信号を供給するようになっている、工具。 - 前記複数のスイッチは工具の前記本体に取り付けられている、請求項8に記載の工具。
- 前記複数のスイッチは、複数の針の流れを同時に制御するために前記アドレス弁に信号を供給する、請求項8に記載の工具。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39798902P | 2002-07-23 | 2002-07-23 | |
PCT/US2003/022376 WO2004009238A1 (en) | 2002-07-23 | 2003-07-18 | Liquid handling tool having hollow plunger |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005534015A JP2005534015A (ja) | 2005-11-10 |
JP4317816B2 true JP4317816B2 (ja) | 2009-08-19 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004523509A Expired - Fee Related JP4317816B2 (ja) | 2002-07-23 | 2003-07-18 | 材料取り扱い工具 |
Country Status (8)
Country | Link |
---|---|
US (1) | US7438857B2 (ja) |
EP (1) | EP1539352B1 (ja) |
JP (1) | JP4317816B2 (ja) |
AT (1) | ATE452704T1 (ja) |
AU (1) | AU2003251996A1 (ja) |
DE (1) | DE60330681D1 (ja) |
DK (1) | DK1539352T3 (ja) |
WO (1) | WO2004009238A1 (ja) |
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-
2003
- 2003-07-18 US US10/622,414 patent/US7438857B2/en not_active Expired - Fee Related
- 2003-07-18 EP EP03765666A patent/EP1539352B1/en not_active Expired - Lifetime
- 2003-07-18 AU AU2003251996A patent/AU2003251996A1/en not_active Abandoned
- 2003-07-18 JP JP2004523509A patent/JP4317816B2/ja not_active Expired - Fee Related
- 2003-07-18 DK DK03765666.7T patent/DK1539352T3/da active
- 2003-07-18 AT AT03765666T patent/ATE452704T1/de not_active IP Right Cessation
- 2003-07-18 DE DE60330681T patent/DE60330681D1/de not_active Expired - Lifetime
- 2003-07-18 WO PCT/US2003/022376 patent/WO2004009238A1/en active Application Filing
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US7438857B2 (en) | 2008-10-21 |
ATE452704T1 (de) | 2010-01-15 |
US20040018119A1 (en) | 2004-01-29 |
AU2003251996A1 (en) | 2004-02-09 |
EP1539352A1 (en) | 2005-06-15 |
DE60330681D1 (de) | 2010-02-04 |
EP1539352B1 (en) | 2009-12-23 |
DK1539352T3 (da) | 2010-04-19 |
JP2005534015A (ja) | 2005-11-10 |
WO2004009238A1 (en) | 2004-01-29 |
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