JP4294958B2 - 新規２，５−ジアザビシクロ［２．２．１］ヘプタン誘導体 - Google Patents

新規２，５−ジアザビシクロ［２．２．１］ヘプタン誘導体 Download PDF

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Publication number
JP4294958B2
JP4294958B2 JP2002569842A JP2002569842A JP4294958B2 JP 4294958 B2 JP4294958 B2 JP 4294958B2 JP 2002569842 A JP2002569842 A JP 2002569842A JP 2002569842 A JP2002569842 A JP 2002569842A JP 4294958 B2 JP4294958 B2 JP 4294958B2
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JP
Japan
Prior art keywords
diazabicyclo
heptane
group
quinolinyl
alkyl
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Expired - Fee Related
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JP2002569842A
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English (en)
Japanese (ja)
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JP2004529901A5 (https=
JP2004529901A (ja
Inventor
ペータース・ダン
オルゼン・グンナール・エム
ニールセン・エルゼベート・エースターガート
アーリング・フィリップ・コ
イェルゲンセン・チノ・ディーリング
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NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2002569842A 2001-03-02 2002-02-28 新規２，５−ジアザビシクロ［２．２．１］ヘプタン誘導体 Expired - Fee Related JP4294958B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200100344 2001-03-02
PCT/DK2002/000133 WO2002070522A1 (en) 2001-03-02 2002-02-28 Novel 2,5-diazabicyclo[2.2.1]heptane derivatives

Publications (3)

Publication Number Publication Date
JP2004529901A JP2004529901A (ja) 2004-09-30
JP2004529901A5 JP2004529901A5 (https=) 2009-02-05
JP4294958B2 true JP4294958B2 (ja) 2009-07-15

Family

ID=8160337

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002569842A Expired - Fee Related JP4294958B2 (ja) 2001-03-02 2002-02-28 新規２，５−ジアザビシクロ［２．２．１］ヘプタン誘導体

Country Status (12)

Country Link
US (1) US7329754B2 (https=)
EP (1) EP1368348B1 (https=)
JP (1) JP4294958B2 (https=)
CN (1) CN1331864C (https=)
AT (1) ATE287404T1 (https=)
AU (1) AU2002233181B2 (https=)
CA (1) CA2438815A1 (https=)
DE (1) DE60202667T2 (https=)
DK (1) DK1368348T3 (https=)
MX (1) MXPA03007895A (https=)
NZ (1) NZ527006A (https=)
WO (1) WO2002070522A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2468015A1 (en) * 2001-11-27 2003-06-05 Merck & Co., Inc. 2-aminoquinoline compounds
BRPI0908807A2 (pt) * 2008-02-15 2015-07-28 Hoffmann La Roche Derivados de 3-alquil-piperazina e usos dos mesmos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN166416B (https=) * 1985-09-18 1990-05-05 Pfizer
US5196548A (en) * 1989-05-11 1993-03-23 Pfizer Inc. Preparation of diazabicyclic Intermediates
JPH06228138A (ja) * 1993-02-03 1994-08-16 Fujisawa Pharmaceut Co Ltd ピリドシンノリン化合物またはその塩及びこれを含有する抗菌剤
US5478939A (en) 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
US5561127A (en) * 1994-12-19 1996-10-01 Allelix Biopharmaceuticals, Inc. Muscarinic receptor ligands
FR2786769B1 (fr) 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
TR200102162T2 (tr) 1999-01-29 2001-12-21 Abbott Laboratories Nikotinik asetilkolin reseptör ligandları olarak diazabisiklik türevler.
JP2003534344A (ja) * 2000-05-25 2003-11-18 ターガセプト，インコーポレイテッド ニコチン性コリン受容体リガンドとしてのヘテロアリールジアザビシクロアルカン
CA2354606C (en) 2000-08-03 2005-12-06 Pfizer Products Inc. Azabicycloalkane derivatives and therapeutic uses thereof

Also Published As

Publication number Publication date
CN1535273A (zh) 2004-10-06
ATE287404T1 (de) 2005-02-15
DE60202667D1 (de) 2005-02-24
MXPA03007895A (es) 2003-12-04
HK1068878A1 (en) 2005-05-06
JP2004529901A (ja) 2004-09-30
US7329754B2 (en) 2008-02-12
EP1368348B1 (en) 2005-01-19
CN1331864C (zh) 2007-08-15
DK1368348T3 (da) 2005-05-23
NZ527006A (en) 2005-02-25
DE60202667T2 (de) 2005-06-16
EP1368348A1 (en) 2003-12-10
AU2002233181B2 (en) 2007-06-07
WO2002070522A1 (en) 2002-09-12
US20040181069A1 (en) 2004-09-16
CA2438815A1 (en) 2002-09-12

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