ATE287404T1 - Diazabicyclo (2.2.1) heptanderivate - Google Patents

Diazabicyclo (2.2.1) heptanderivate

Info

Publication number
ATE287404T1
ATE287404T1 AT02700189T AT02700189T ATE287404T1 AT E287404 T1 ATE287404 T1 AT E287404T1 AT 02700189 T AT02700189 T AT 02700189T AT 02700189 T AT02700189 T AT 02700189T AT E287404 T1 ATE287404 T1 AT E287404T1
Authority
AT
Austria
Prior art keywords
diseases
disorders
diazabicyclo
nervous system
heptane derivatives
Prior art date
Application number
AT02700189T
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Elsebet Ostergaard Nielsen
Philip K Ahring
Tino Dyhring Jorgensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE287404T1 publication Critical patent/ATE287404T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02700189T 2001-03-02 2002-02-28 Diazabicyclo (2.2.1) heptanderivate ATE287404T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200100344 2001-03-02
PCT/DK2002/000133 WO2002070522A1 (en) 2001-03-02 2002-02-28 Novel 2,5-diazabicyclo[2.2.1]heptane derivatives

Publications (1)

Publication Number Publication Date
ATE287404T1 true ATE287404T1 (de) 2005-02-15

Family

ID=8160337

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02700189T ATE287404T1 (de) 2001-03-02 2002-02-28 Diazabicyclo (2.2.1) heptanderivate

Country Status (13)

Country Link
US (1) US7329754B2 (de)
EP (1) EP1368348B1 (de)
JP (1) JP4294958B2 (de)
CN (1) CN1331864C (de)
AT (1) ATE287404T1 (de)
AU (1) AU2002233181B2 (de)
CA (1) CA2438815A1 (de)
DE (1) DE60202667T2 (de)
DK (1) DK1368348T3 (de)
HK (1) HK1068878A1 (de)
MX (1) MXPA03007895A (de)
NZ (1) NZ527006A (de)
WO (1) WO2002070522A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002352878B2 (en) * 2001-11-27 2007-11-22 Merck Sharp & Dohme Corp. 2-Aminoquinoline compounds
CN101952278A (zh) * 2008-02-15 2011-01-19 弗·哈夫曼-拉罗切有限公司 3-烷基-哌嗪衍生物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN166416B (de) * 1985-09-18 1990-05-05 Pfizer
US5196548A (en) 1989-05-11 1993-03-23 Pfizer Inc. Preparation of diazabicyclic Intermediates
JPH06228138A (ja) 1993-02-03 1994-08-16 Fujisawa Pharmaceut Co Ltd ピリドシンノリン化合物またはその塩及びこれを含有する抗菌剤
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
US5561127A (en) 1994-12-19 1996-10-01 Allelix Biopharmaceuticals, Inc. Muscarinic receptor ligands
FR2786769B1 (fr) 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
DE60038823D1 (de) * 1999-01-29 2008-06-19 Abbott Lab Diazabicycloderivate als Nikotin-Acetylcholin-Rezeptorliganden
EP1289996B1 (de) 2000-05-25 2005-04-06 Targacept, Inc. Heteroaryldiazabicycloalkane als liganden für den nikotinischen acetylcholin-rezeptor
US6552015B2 (en) 2000-08-03 2003-04-22 Pfizer Inc. Azabicycloalkane derivatives and therapeutic uses thereof

Also Published As

Publication number Publication date
CN1535273A (zh) 2004-10-06
DE60202667T2 (de) 2005-06-16
US7329754B2 (en) 2008-02-12
CN1331864C (zh) 2007-08-15
JP2004529901A (ja) 2004-09-30
AU2002233181B2 (en) 2007-06-07
JP4294958B2 (ja) 2009-07-15
HK1068878A1 (en) 2005-05-06
MXPA03007895A (es) 2003-12-04
DK1368348T3 (da) 2005-05-23
US20040181069A1 (en) 2004-09-16
NZ527006A (en) 2005-02-25
EP1368348A1 (de) 2003-12-10
WO2002070522A1 (en) 2002-09-12
EP1368348B1 (de) 2005-01-19
DE60202667D1 (de) 2005-02-24
CA2438815A1 (en) 2002-09-12

Similar Documents

Publication Publication Date Title
HK1080860A1 (en) Novel quinuclidine derivatives and their use
HK1068628A1 (en) Nicotinic acetyl-choline receptors inhibitor compounds, their preparation and use
PL375025A1 (en) Novel 1,4-diazabicycloalkane derivatives, their preparation and use
AU2002220517A1 (en) 3-substituted quinuclidines and their use as nicotinic agonists
AU6583101A (en) Aryl and heteroaryl diazabicycloalkanes, their preparation and use
ATE348831T1 (de) Diazabicyclische biarylderivate
AU2003280309A1 (en) 1,4-diazabicyclo (3,2,2)nonane derivatives, preparation and therapeutical use thereof
ATE289310T1 (de) Heteroaryl-diazabicycloalkanderivaten als cns- modulatoren
ATE437880T1 (de) Dimere azacyclische verbindungen und deren verwendung
HK1079528A1 (en) Azacyclic ethynyl derivatives
MXPA05006861A (es) Derivados arildiazabiciclicos novedosos.
DE60307102D1 (de) 3-substituierte chinuklidine und deren verwendung
HK1068878A1 (en) Novel 2, 5-diazabicyclo Ä2.2.1Üheptane derivatives
DE602004031124D1 (de) Neue chinuklidinderivative und deren pharmazeutische verwendung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1368348

Country of ref document: EP

REN Ceased due to non-payment of the annual fee