JP4278866B2 - 平面クロマトグラフィー用多孔質薄膜 - Google Patents
平面クロマトグラフィー用多孔質薄膜 Download PDFInfo
- Publication number
- JP4278866B2 JP4278866B2 JP2000531734A JP2000531734A JP4278866B2 JP 4278866 B2 JP4278866 B2 JP 4278866B2 JP 2000531734 A JP2000531734 A JP 2000531734A JP 2000531734 A JP2000531734 A JP 2000531734A JP 4278866 B2 JP4278866 B2 JP 4278866B2
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- JP
- Japan
- Prior art keywords
- support
- separation
- film
- liquid
- thin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000010409 thin film Substances 0.000 title claims description 11
- 238000001292 planar chromatography Methods 0.000 title description 2
- 238000000926 separation method Methods 0.000 claims description 52
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 24
- 239000012528 membrane Substances 0.000 claims description 23
- 150000002148 esters Chemical class 0.000 claims description 22
- 239000010408 film Substances 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 17
- 238000004809 thin layer chromatography Methods 0.000 claims description 15
- 238000006116 polymerization reaction Methods 0.000 claims description 12
- 239000000377 silicon dioxide Substances 0.000 claims description 11
- 230000007062 hydrolysis Effects 0.000 claims description 10
- 238000006460 hydrolysis reaction Methods 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 9
- 239000000741 silica gel Substances 0.000 claims description 9
- 229910002027 silica gel Inorganic materials 0.000 claims description 9
- 238000005406 washing Methods 0.000 claims description 9
- 239000012636 effector Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000002955 isolation Methods 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 239000011521 glass Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 239000000975 dye Substances 0.000 description 5
- 238000010828 elution Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000004378 air conditioning Methods 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 238000013375 chromatographic separation Methods 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 239000003269 fluorescent indicator Substances 0.000 description 2
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 238000004438 BET method Methods 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- MCMNRKCIXSYSNV-UHFFFAOYSA-N ZrO2 Inorganic materials O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910000416 bismuth oxide Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- TYIXMATWDRGMPF-UHFFFAOYSA-N dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Bi+3].[Bi+3] TYIXMATWDRGMPF-UHFFFAOYSA-N 0.000 description 1
- GYWBHBXGYTYXRG-UHFFFAOYSA-N dichloro-methyl-octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[Si](C)(Cl)Cl GYWBHBXGYTYXRG-UHFFFAOYSA-N 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229910003437 indium oxide Inorganic materials 0.000 description 1
- PJXISJQVUVHSOJ-UHFFFAOYSA-N indium(iii) oxide Chemical compound [O-2].[O-2].[O-2].[In+3].[In+3] PJXISJQVUVHSOJ-UHFFFAOYSA-N 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 125000003010 ionic group Chemical group 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- -1 nitro blue 2B Chemical compound 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920006327 polystyrene foam Polymers 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 1
- 229910001887 tin oxide Inorganic materials 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 229910052845 zircon Inorganic materials 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
- G01N30/92—Construction of the plate
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19805395A DE19805395A1 (de) | 1998-02-11 | 1998-02-11 | Dünne poröse Schichten für die planare Chromatographie |
| DE19805395.9 | 1998-02-11 | ||
| PCT/EP1999/000284 WO1999041602A1 (de) | 1998-02-11 | 1999-01-19 | Dünne poröse schichten für die planare chromatographie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002503809A JP2002503809A (ja) | 2002-02-05 |
| JP2002503809A5 JP2002503809A5 (https=) | 2006-03-09 |
| JP4278866B2 true JP4278866B2 (ja) | 2009-06-17 |
Family
ID=7857275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000531734A Expired - Lifetime JP4278866B2 (ja) | 1998-02-11 | 1999-01-19 | 平面クロマトグラフィー用多孔質薄膜 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6395178B1 (https=) |
| EP (1) | EP1055120B1 (https=) |
| JP (1) | JP4278866B2 (https=) |
| DE (2) | DE19805395A1 (https=) |
| WO (1) | WO1999041602A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050019335A1 (en) * | 2001-11-12 | 2005-01-27 | Lowery David E | Salmonella vaccine |
| WO2003041834A1 (de) | 2001-11-13 | 2003-05-22 | Metanomics Gmbh & Co. Kgaa | Verfahren zur extraktion von inhaltsstoffen aus organischem material |
| US20070224590A1 (en) * | 2006-03-22 | 2007-09-27 | The Regents Of The University Of California | Single cell planar chromatography |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH493847A (de) * | 1968-08-28 | 1970-07-15 | Balzers Patent Beteilig Ag | Verfahren zur chromatographischen Trennung von Stoffen |
| DE1908695C3 (de) | 1969-02-21 | 1980-12-11 | Merck Patent Gmbh, 6100 Darmstadt | Folie für die Schichtchromatographie |
| US4095950A (en) * | 1976-06-11 | 1978-06-20 | Bio-Dynamics, Inc. | Method for the chromatographic analysis of a technetium-containing mixture |
| FR2383690A1 (fr) * | 1977-03-19 | 1978-10-13 | Merck Patent Gmbh | Matiere de separation pour chromatographie en couche mince et procede pour sa preparation |
| DE2712113C2 (de) * | 1977-03-19 | 1983-11-17 | Merck Patent Gmbh, 6100 Darmstadt | Trennmaterial für die Dünnschichtchromatographie und Verfahren zu dessen Herstellung |
| US4276061A (en) * | 1979-07-31 | 1981-06-30 | The Dow Chemical Company | Chromatographic column packing having a bonded organosiloxane coating |
| DD232031B1 (de) * | 1984-07-13 | 1987-08-12 | Leuna Werke Veb | Verfahren zur herstellung poroeser sphaerischer silikagele |
| DE3427923A1 (de) * | 1984-07-28 | 1986-01-30 | Merck Patent Gmbh, 6100 Darmstadt | Trennmaterial fuer die duennschichtchromatographie |
| DE19509949A1 (de) * | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Trennmittel für die DC-FTIR-Kopplung |
| US5935862A (en) * | 1996-01-19 | 1999-08-10 | The United States Of America As Represented By The Secretary Of The Army | Microspot test methods and field test kit for on-site inspections of chemical agents |
-
1998
- 1998-02-11 DE DE19805395A patent/DE19805395A1/de not_active Withdrawn
-
1999
- 1999-01-19 WO PCT/EP1999/000284 patent/WO1999041602A1/de not_active Ceased
- 1999-01-19 JP JP2000531734A patent/JP4278866B2/ja not_active Expired - Lifetime
- 1999-01-19 US US09/601,617 patent/US6395178B1/en not_active Expired - Lifetime
- 1999-01-19 DE DE59915220T patent/DE59915220D1/de not_active Expired - Lifetime
- 1999-01-19 EP EP99907383A patent/EP1055120B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999041602A1 (de) | 1999-08-19 |
| EP1055120B1 (de) | 2010-11-17 |
| DE19805395A1 (de) | 1999-08-12 |
| US6395178B1 (en) | 2002-05-28 |
| DE59915220D1 (de) | 2010-12-30 |
| JP2002503809A (ja) | 2002-02-05 |
| EP1055120A1 (de) | 2000-11-29 |
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