JP4274581B2 - キメラヘテロ多量体接着体 - Google Patents

キメラヘテロ多量体接着体 Download PDF

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Publication number
JP4274581B2
JP4274581B2 JP50608998A JP50608998A JP4274581B2 JP 4274581 B2 JP4274581 B2 JP 4274581B2 JP 50608998 A JP50608998 A JP 50608998A JP 50608998 A JP50608998 A JP 50608998A JP 4274581 B2 JP4274581 B2 JP 4274581B2
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JP
Japan
Prior art keywords
chimeric
receptor
erbb2
heteromultimeric
igg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP50608998A
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English (en)
Japanese (ja)
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JP2000515372A (ja
Inventor
ビンセント ダニアル フィッツパトリック，
マーク スリウコウスキ，
リチャード， エル． ヴァンドレン，
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Genentech Inc
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Genentech Inc
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Publication of JP2000515372A publication Critical patent/JP2000515372A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP50608998A 1996-07-12 1997-07-08 キメラヘテロ多量体接着体 Expired - Lifetime JP4274581B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2164096P 1996-07-12 1996-07-12
US60/021,640 1996-07-12
US79832697A 1997-02-10 1997-02-10
US08/798,326 1997-02-10
PCT/US1997/011825 WO1998002540A1 (en) 1996-07-12 1997-07-08 Chimeric heteromultimer adhesins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007321420A Division JP2008115187A (ja) 1996-07-12 2007-12-12 キメラヘテロ多量体接着体

Publications (2)

Publication Number Publication Date
JP2000515372A JP2000515372A (ja) 2000-11-21
JP4274581B2 true JP4274581B2 (ja) 2009-06-10

Family

ID=26694954

Family Applications (2)

Application Number Title Priority Date Filing Date
JP50608998A Expired - Lifetime JP4274581B2 (ja) 1996-07-12 1997-07-08 キメラヘテロ多量体接着体
JP2007321420A Withdrawn JP2008115187A (ja) 1996-07-12 2007-12-12 キメラヘテロ多量体接着体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007321420A Withdrawn JP2008115187A (ja) 1996-07-12 2007-12-12 キメラヘテロ多量体接着体

Country Status (13)

Country Link
US (3) US6696290B2 (enExample)
EP (2) EP0938556B1 (enExample)
JP (2) JP4274581B2 (enExample)
CN (1) CN1202247C (enExample)
AT (1) ATE486937T1 (enExample)
AU (1) AU722178B2 (enExample)
BR (1) BR9710357A (enExample)
CA (1) CA2258721C (enExample)
DE (1) DE69740038D1 (enExample)
DK (1) DK0912734T3 (enExample)
IL (1) IL127891A0 (enExample)
NZ (1) NZ333325A (enExample)
WO (1) WO1998002540A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016523930A (ja) * 2013-07-05 2016-08-12 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 骨髄異形成症候群（ｍｄｓ）を治療するための可溶性ｃｄ３３

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US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
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US20030133939A1 (en) * 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
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CN100424175C (zh) * 2002-03-26 2008-10-08 上海泽生科技开发有限公司 ErbB-3 用于肿瘤治疗的方法和组合物
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EP2248899B8 (en) * 2003-03-19 2015-07-15 Biogen MA Inc. NOGO receptor binding protein
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KR20090057936A (ko) * 2006-02-08 2009-06-08 타게티드 몰레큘라 다이아그노스틱스, 엘엘씨 2가 ｅｒｂｂ 리간드 결합 분자 및 그의 제조 방법 및 사용방법
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Publication number Priority date Publication date Assignee Title
JP2016523930A (ja) * 2013-07-05 2016-08-12 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 骨髄異形成症候群（ｍｄｓ）を治療するための可溶性ｃｄ３３

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DK0912734T3 (da) 2011-02-07
DE69740038D1 (enExample) 2010-12-16
CA2258721C (en) 2014-09-09
NZ333325A (en) 2000-06-23
EP0938556A1 (en) 1999-09-01
AU722178B2 (en) 2000-07-27
JP2000515372A (ja) 2000-11-21
US6696290B2 (en) 2004-02-24
ATE486937T1 (de) 2010-11-15
CN1225129A (zh) 1999-08-04
JP2008115187A (ja) 2008-05-22
US20040138417A1 (en) 2004-07-15
US20030199020A1 (en) 2003-10-23
BR9710357A (pt) 1999-08-17
EP0938556B1 (en) 2005-03-09
AU3596297A (en) 1998-02-09
WO1998002540A1 (en) 1998-01-22
EP0912734A1 (en) 1999-05-06
US7659368B2 (en) 2010-02-09
IL127891A0 (en) 1999-10-28
CN1202247C (zh) 2005-05-18
US20070081994A1 (en) 2007-04-12
CA2258721A1 (en) 1998-01-22
EP0912734B1 (en) 2010-11-03

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