JP4215822B2 - タンパク質分解酵素の基質および阻害剤 - Google Patents

タンパク質分解酵素の基質および阻害剤 Download PDF

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JP4215822B2
JP4215822B2 JP53786497A JP53786497A JP4215822B2 JP 4215822 B2 JP4215822 B2 JP 4215822B2 JP 53786497 A JP53786497 A JP 53786497A JP 53786497 A JP53786497 A JP 53786497A JP 4215822 B2 JP4215822 B2 JP 4215822B2
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library
compounds
components
component
mixture
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JP2001501170A (ja
JP2001501170A5 (enExample
Inventor
マーティン クウィーベル
トニー ジョンソン
テランス ハート
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メディヴァー ユーケイ リミテッド
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Priority claimed from GBGB9608457.9A external-priority patent/GB9608457D0/en
Priority claimed from GBGB9616115.3A external-priority patent/GB9616115D0/en
Priority claimed from GBGB9624584.0A external-priority patent/GB9624584D0/en
Application filed by メディヴァー ユーケイ リミテッド filed Critical メディヴァー ユーケイ リミテッド
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Publication of JP2001501170A5 publication Critical patent/JP2001501170A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00504—Pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
JP53786497A 1996-04-24 1997-04-24 タンパク質分解酵素の基質および阻害剤 Expired - Fee Related JP4215822B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9608457.9 1996-04-24
GBGB9608457.9A GB9608457D0 (en) 1996-04-24 1996-04-24 Inhibitors of proteolytic enzymes
GB9616115.3 1996-07-31
GBGB9616115.3A GB9616115D0 (en) 1996-07-31 1996-07-31 Substrate and inhibitors of proteolytic enzymes
GBGB9624584.0A GB9624584D0 (en) 1996-11-27 1996-11-27 Substances and inhibitors of proteolytic enzymes
GB9624584.0 1996-11-27
PCT/GB1997/001157 WO1997040065A2 (en) 1996-04-24 1997-04-24 Substrates and inhibitors of proteolytic enzymes

Publications (3)

Publication Number Publication Date
JP2001501170A JP2001501170A (ja) 2001-01-30
JP2001501170A5 JP2001501170A5 (enExample) 2005-01-13
JP4215822B2 true JP4215822B2 (ja) 2009-01-28

Family

ID=27268257

Family Applications (2)

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JP53786497A Expired - Fee Related JP4215822B2 (ja) 1996-04-24 1997-04-24 タンパク質分解酵素の基質および阻害剤
JP09539622A Abandoned JP2000512979A (ja) 1996-04-24 1997-04-24 自己デコンボリューション法によるコンビナトリアルライブラリー

Family Applications After (1)

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JP09539622A Abandoned JP2000512979A (ja) 1996-04-24 1997-04-24 自己デコンボリューション法によるコンビナトリアルライブラリー

Country Status (10)

Country Link
US (2) US6528275B1 (enExample)
EP (2) EP0906334A1 (enExample)
JP (2) JP4215822B2 (enExample)
AT (1) ATE203545T1 (enExample)
AU (2) AU728263B2 (enExample)
CA (2) CA2252408A1 (enExample)
DE (1) DE69705838T2 (enExample)
DK (1) DK0906333T3 (enExample)
ES (1) ES2162277T3 (enExample)
WO (2) WO1997040065A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6042789A (en) * 1996-10-23 2000-03-28 Glaxo Group Limited System for parallel synthesis of organic compounds
US6149869A (en) * 1996-10-23 2000-11-21 Glaxo Wellcome Inc. Chemical synthesizers
CA2270394A1 (en) * 1996-10-31 1998-05-07 Novalon Pharmaceutical Corporation Identification of drugs using complementary combinatorial libraries
US6617114B1 (en) 1996-10-31 2003-09-09 Karo Bio Ab Identification of drug complementary combinatorial libraries
US6054325A (en) * 1996-12-02 2000-04-25 Glaxo Wellcom Inc. Method and apparatus for transferring and combining distinct chemical compositions with reagents
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
GB9722818D0 (en) * 1997-10-30 1997-12-24 Peptide Therapeutics Ltd A method for mapping the active sites bound by enzymes that covalently modify substrate molecules
EP1034154A1 (en) * 1997-11-26 2000-09-13 Peptide Therapeutics Limited A solid-phase technology for the preparation of combinatorial libraries through amide-bond anchoring
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6569636B2 (en) * 1998-05-29 2003-05-27 Hawaii Biotechnology Group, Inc. Assay for modulators of metallo-enzyme activity
DE19925402C2 (de) * 1999-06-02 2001-12-20 Molecular Machines & Ind Gmbh Screening von Target-Ligand-Wechselwirkungen
AU2001262906A1 (en) * 2000-02-11 2001-08-20 Cellomics, Inc. Peptide biosensors for anthrax protease
JP2002250730A (ja) * 2001-02-27 2002-09-06 Shinwa Kako Kk 分子センサー及びその製造方法
MY140707A (en) 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
JP2005535710A (ja) * 2002-08-09 2005-11-24 トランス　テック　ファーマ，インコーポレイテッド アリールおよびヘテロアリール化合物ならびに凝固を調節する方法
US7208601B2 (en) 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014532A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
US8015064B2 (en) * 2005-04-20 2011-09-06 At&T Intellectual Property I, Lp System and method of providing advertisements to cellular devices
JP2009502158A (ja) * 2005-07-26 2009-01-29 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ 酵母のストレス耐性を増加させる遺伝子類の同定方法類、およびそれらの遺伝子類の酵母株改良のための使用
EP2364366B1 (en) 2008-11-05 2014-01-08 MorphoSys AG Deconvolution method
EP2189536A1 (en) * 2008-11-20 2010-05-26 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Rapid FRET based anthrax diagnosis
JP5798487B2 (ja) * 2008-11-20 2015-10-21 ネーデルランドセ・オルガニサティ・フォール・トゥーヘパスト−ナトゥールウェテンスハッペライク・オンデルズーク・テーエヌオー Ｆｒｅｔに基づく病原体の迅速診断
EP3608317A1 (en) * 2012-01-12 2020-02-12 Yale University Compounds & methods for the enhanced degradation of targeted proteins & other polypeptides by an e3 ubiquitin ligase
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
RU2018120330A (ru) 2015-11-02 2019-12-04 Йейл Юниверсити Химерные соединения, осуществляющие нацеливание для протеолиза, и способы их получения и применения

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428000A1 (en) 1989-11-03 1991-05-22 Abbott Laboratories Fluorogenic substrates for the detection of proteolytic enzyme activity
US5011910A (en) * 1989-12-28 1991-04-30 Washington University Reagent and method for determining activity of retroviral protease
US5164300A (en) 1989-12-28 1992-11-17 Washington University Method for determining activity of retroviral protease
DK93990D0 (da) * 1990-04-17 1990-04-17 Carlsberg As Fluorogene peptider og deres anvendelse ved bestemmelse af enzymatisk aktivitet
HU9201687D0 (en) 1992-05-21 1992-08-28 Arpad Furka Preparation of sets from peptid mixtures with polycomponents and their use for the identification of biologically active peptides
US5585275A (en) 1992-09-02 1996-12-17 Arris Pharmaceutical Corporation Pilot apparatus for peptide synthesis and screening
EP0734530B1 (en) 1993-12-15 1997-11-12 Combichem, Inc. Combinatorial libraries and methods for their use
US5506115A (en) 1994-04-29 1996-04-09 G. D. Searle & Co. Reagent and method for determining activity of herpes protease
US5738996A (en) 1994-06-15 1998-04-14 Pence, Inc. Combinational library composition and method
JP2000503533A (ja) 1996-01-04 2000-03-28 ネーデルランドセ・オルガニザテイエ・フール・テゲパスト―ナトウールベテンシヤツペリーク・オンデルツエク・テイエヌオー 蛍光消光基質を用いたタンパク質分解酵素のアッセイ方法
US7135288B2 (en) * 2002-09-27 2006-11-14 Ut-Battelle, Llc Combinatorial synthesis of ceramic materials

Also Published As

Publication number Publication date
EP0906334A1 (en) 1999-04-07
DK0906333T3 (da) 2001-11-12
JP2001501170A (ja) 2001-01-30
AU706855B2 (en) 1999-06-24
CA2252508A1 (en) 1997-10-30
DE69705838D1 (de) 2001-08-30
ES2162277T3 (es) 2001-12-16
WO1997040065A2 (en) 1997-10-30
WO1997042216A1 (en) 1997-11-13
US20030092067A1 (en) 2003-05-15
US6528275B1 (en) 2003-03-04
WO1997040065A3 (en) 1997-12-04
DE69705838T2 (de) 2002-04-11
ATE203545T1 (de) 2001-08-15
JP2000512979A (ja) 2000-10-03
EP0906333A2 (en) 1999-04-07
CA2252408A1 (en) 1997-11-13
AU728263B2 (en) 2001-01-04
AU2645097A (en) 1997-11-26
AU2644997A (en) 1997-11-12
EP0906333B1 (en) 2001-07-25

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