JP4201337B2 - 固相上で分子を固定するための方法とその利用法 - Google Patents

固相上で分子を固定するための方法とその利用法 Download PDF

Info

Publication number
JP4201337B2
JP4201337B2 JP2003517298A JP2003517298A JP4201337B2 JP 4201337 B2 JP4201337 B2 JP 4201337B2 JP 2003517298 A JP2003517298 A JP 2003517298A JP 2003517298 A JP2003517298 A JP 2003517298A JP 4201337 B2 JP4201337 B2 JP 4201337B2
Authority
JP
Japan
Prior art keywords
dna
nucleic acid
acid molecule
solid support
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003517298A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004538456A (ja
JP2004538456A5 (https=
Inventor
ギャグナ,クロード
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2004538456A publication Critical patent/JP2004538456A/ja
Publication of JP2004538456A5 publication Critical patent/JP2004538456A5/ja
Application granted granted Critical
Publication of JP4201337B2 publication Critical patent/JP4201337B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/08Integrated apparatus specially adapted for both creating and screening libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Structural Engineering (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2003517298A 2001-07-31 2002-07-31 固相上で分子を固定するための方法とその利用法 Expired - Fee Related JP4201337B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30893601P 2001-07-31 2001-07-31
PCT/US2002/024377 WO2003012124A2 (en) 2001-07-31 2002-07-31 Methods for immobilizing molecules to a solid phase and uses thereof

Publications (3)

Publication Number Publication Date
JP2004538456A JP2004538456A (ja) 2004-12-24
JP2004538456A5 JP2004538456A5 (https=) 2006-01-05
JP4201337B2 true JP4201337B2 (ja) 2008-12-24

Family

ID=23195986

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003517298A Expired - Fee Related JP4201337B2 (ja) 2001-07-31 2002-07-31 固相上で分子を固定するための方法とその利用法

Country Status (5)

Country Link
US (1) US6936461B2 (https=)
EP (1) EP1421201A4 (https=)
JP (1) JP4201337B2 (https=)
AU (1) AU2002337660A1 (https=)
WO (1) WO2003012124A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3888947B2 (ja) * 2002-02-01 2007-03-07 日清紡績株式会社 生体分子の担体への固定法
FR2842826B1 (fr) * 2002-07-25 2006-01-20 Centre Nat Rech Scient Procede de fabrication de puces biologiques
US9394332B2 (en) 2002-08-29 2016-07-19 Epigenomics Ag Method for bisulfite treatment
US7781163B2 (en) * 2003-01-08 2010-08-24 Lesley Davenport G-quadruplex binding assays and compounds therefor
EP1673478A4 (en) * 2003-10-14 2007-08-22 Cylene Pharmaceuticals Inc COMPETITION ASSAY FOR THE IDENTIFICATION OF MODULATORS OF QUADRUPLEX NUCLEIC ACIDS
GB0424953D0 (en) * 2004-11-11 2004-12-15 Plant Bioscience Ltd Assay
WO2006093104A1 (ja) * 2005-03-03 2006-09-08 Sapporo Breweries Limited アルコール飲料の香味を制御する方法
US9790538B2 (en) * 2013-03-07 2017-10-17 Apdn (B.V.I.) Inc. Alkaline activation for immobilization of DNA taggants
US10741034B2 (en) 2006-05-19 2020-08-11 Apdn (B.V.I.) Inc. Security system and method of marking an inventory item and/or person in the vicinity
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
WO2008154225A2 (en) * 2007-06-06 2008-12-18 Bayer Healthcare Llc Microdeposition system for a biosensor
US9266370B2 (en) 2012-10-10 2016-02-23 Apdn (B.V.I) Inc. DNA marking of previously undistinguished items for traceability
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
EP3058339B1 (en) 2013-10-07 2019-05-22 APDN (B.V.I.) Inc. Multimode image and spectral reader
WO2015142990A1 (en) 2014-03-18 2015-09-24 Apdn (B.V.I.) Inc. Encryped optical markers for security applications
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
US10760182B2 (en) 2014-12-16 2020-09-01 Apdn (B.V.I.) Inc. Method and device for marking fibrous materials
CN114196746A (zh) * 2016-02-10 2022-03-18 密歇根大学董事会 核酸的检测
US10519605B2 (en) 2016-04-11 2019-12-31 APDN (B.V.I.), Inc. Method of marking cellulosic products
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
US10920274B2 (en) 2017-02-21 2021-02-16 Apdn (B.V.I.) Inc. Nucleic acid coated submicron particles for authentication

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4777129A (en) * 1983-12-12 1988-10-11 Molecular Diagnostics, Inc. Nucleic acid probe detectable by specific nucleic acid binding protein
US6022714A (en) * 1985-05-02 2000-02-08 Genetics Institute Methods for attachment of a polynucleotide to a preselected material
US5055316A (en) * 1988-04-20 1991-10-08 Washington Research Foundation Tight binding of proteins to surfaces
US6147198A (en) * 1988-09-15 2000-11-14 New York University Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
US5237016A (en) * 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US5169599A (en) * 1990-08-30 1992-12-08 Teknekron Sensor Development Corporation Method and apparatus for optically detecting presence of immunological components
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5591841A (en) * 1993-01-14 1997-01-07 Ji; Huamin Rapid purification of circular DNA by triplex-mediated affinity capture
AU7839594A (en) * 1993-09-20 1995-04-10 Regents Of The University Of Colorado, The Strategy for the production of rna from immobilized templates
US5624803A (en) * 1993-10-14 1997-04-29 The Regents Of The University Of California In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom
US5514501A (en) * 1994-06-07 1996-05-07 The United States Of America As Represented By The Secretary Of Commerce Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates
US5726050A (en) * 1995-06-20 1998-03-10 Massachusetts Institute Of Technology Z-DNA binding protein and applications
US6096508A (en) * 1995-08-16 2000-08-01 Kirkegaard & Perry Laboratoies, Inc. Method of reducing background in biotin-based assays
WO1998016829A1 (en) * 1996-10-15 1998-04-23 Enteron, L.P. Organism-specific and allergen-specific antibody capture assay and compositions for detection of disease-causing organisms and allergens
GB9622665D0 (en) * 1996-10-31 1997-01-08 Zeneca Ltd Methods
WO1998028626A1 (en) * 1996-12-23 1998-07-02 Cobra Therapeutics Limited Optimization of gene delivery and gene delivery systems
US5763768A (en) * 1997-03-17 1998-06-09 Iowa State University Research Foundation, Inc. Analytical method using modified scanning probes
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US6187537B1 (en) * 1998-04-27 2001-02-13 Donald E. Zinn, Jr. Process and apparatus for forming a dry DNA transfer film, a transfer film product formed thereby and an analyzing process using the same
US5958701A (en) * 1999-01-27 1999-09-28 The United States Of America As Represented By The Secretary Of The Navy Method for measuring intramolecular forces by atomic force
US6420112B2 (en) * 1999-07-21 2002-07-16 The Regents Of The University Of California DNA attachment to support structures
JP2003043037A (ja) * 2001-07-27 2003-02-13 Inst Of Physical & Chemical Res ハイブリダイゼーション用基板、この基板の製造方法及び使用方法

Also Published As

Publication number Publication date
EP1421201A2 (en) 2004-05-26
EP1421201A4 (en) 2005-11-23
AU2002337660A1 (en) 2003-02-17
US6936461B2 (en) 2005-08-30
WO2003012124A3 (en) 2003-11-06
JP2004538456A (ja) 2004-12-24
US20030096273A1 (en) 2003-05-22
WO2003012124A2 (en) 2003-02-13

Similar Documents

Publication Publication Date Title
JP4201337B2 (ja) 固相上で分子を固定するための方法とその利用法
US10648972B2 (en) Multiplexed analyses of test samples
JP6144654B2 (ja) 試験試料の多重化分析
CN102329876B (zh) 一种测定待检测样本中疾病相关核酸分子的核苷酸序列的方法
Rao et al. Biophysical properties of nucleic acids at surfaces relevant to microarray performance
JP2000510710A (ja) ジスルフィド結合による核酸分子の固相への共有結合による固定化
ES2675584T3 (es) Modificación de ADN en perlas magnéticas
CN115244185A (zh) 使用探针对连接的原位rna分析
JP2003515112A (ja) 長鎖オリゴヌクレオチドアレイ
JP2013520980A (ja) 増強マルチプレックスfish
US20240417720A1 (en) Making and using structured nucleic acid particles
CN101573454A (zh) 用于荧光原位杂交和芯片技术的核酸信标
JP2007003439A (ja) バイオセンサの製造方法
CA2397357A1 (en) Recombinase mediated gene chip detection
WO2007025190A2 (en) Novel methods for genome-wide location analysis
JP2003520766A (ja) 固定のポリヌクレオチド
AU2013248169B2 (en) Multiplexed analyses of test samples
Lou et al. Ultrasensitive DNA and protein analysis using molecular beacon probes
HK1217540B (en) Kits comprising aptamers

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050114

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080207

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080502

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080513

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080718

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20080718

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20081002

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20081006

R150 Certificate of patent or registration of utility model

Ref document number: 4201337

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20111017

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121017

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131017

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees