JP4194233B2 - シース液供給装置および供給方法並びに試料分析装置 - Google Patents
シース液供給装置および供給方法並びに試料分析装置 Download PDFInfo
- Publication number
- JP4194233B2 JP4194233B2 JP2000248689A JP2000248689A JP4194233B2 JP 4194233 B2 JP4194233 B2 JP 4194233B2 JP 2000248689 A JP2000248689 A JP 2000248689A JP 2000248689 A JP2000248689 A JP 2000248689A JP 4194233 B2 JP4194233 B2 JP 4194233B2
- Authority
- JP
- Japan
- Prior art keywords
- sheath
- cylinder
- piston
- flow cell
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 title claims description 131
- 238000000034 method Methods 0.000 title claims description 26
- 239000012530 fluid Substances 0.000 claims description 20
- 238000002347 injection Methods 0.000 claims description 15
- 239000007924 injection Substances 0.000 claims description 15
- 230000010349 pulsation Effects 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 8
- 230000003287 optical effect Effects 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 description 37
- 239000000523 sample Substances 0.000 description 35
- 210000002700 urine Anatomy 0.000 description 12
- 238000005259 measurement Methods 0.000 description 11
- 239000002245 particle Substances 0.000 description 8
- 238000010586 diagram Methods 0.000 description 6
- 239000013049 sediment Substances 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 5
- 210000002445 nipple Anatomy 0.000 description 5
- 230000007613 environmental effect Effects 0.000 description 3
- 230000000737 periodic effect Effects 0.000 description 3
- 230000002411 adverse Effects 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003219 hemolytic agent Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000012192 staining solution Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
- G01P21/00—Testing or calibrating of apparatus or devices covered by the preceding groups
- G01P21/02—Testing or calibrating of apparatus or devices covered by the preceding groups of speedometers
- G01P21/025—Testing or calibrating of apparatus or devices covered by the preceding groups of speedometers for measuring speed of fluids; for measuring speed of bodies relative to fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
- B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N15/1409—Handling samples, e.g. injecting samples
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000248689A JP4194233B2 (ja) | 2000-08-18 | 2000-08-18 | シース液供給装置および供給方法並びに試料分析装置 |
| US09/930,967 US20020020207A1 (en) | 2000-08-18 | 2001-08-17 | Sheath liquid supplying apparatus, sheath liquid supplying method, and evaluating method of sheath liquid supplying condition |
| US10/336,789 US6804984B2 (en) | 2000-08-18 | 2003-01-06 | Sheath liquid supplying apparatus, sheath liquid supplying method, and evaluating method of sheath liquid supplying condition |
| US10/336,790 US20030110826A1 (en) | 2000-08-18 | 2003-01-06 | Sheath liquid supplying apparatus, sheath liquid supplying method, and evaluating method of sheath liquid supplying condition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000248689A JP4194233B2 (ja) | 2000-08-18 | 2000-08-18 | シース液供給装置および供給方法並びに試料分析装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002062250A JP2002062250A (ja) | 2002-02-28 |
| JP2002062250A5 JP2002062250A5 (enExample) | 2005-11-04 |
| JP4194233B2 true JP4194233B2 (ja) | 2008-12-10 |
Family
ID=18738550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000248689A Expired - Lifetime JP4194233B2 (ja) | 2000-08-18 | 2000-08-18 | シース液供給装置および供給方法並びに試料分析装置 |
Country Status (2)
| Country | Link |
|---|---|
| US (3) | US20020020207A1 (enExample) |
| JP (1) | JP4194233B2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1348943A3 (en) * | 2002-03-25 | 2003-12-17 | Sysmex Corporation | Sheath liquid for particle analyzer |
| KR101166180B1 (ko) * | 2003-08-13 | 2012-07-18 | 루미넥스 코포레이션 | 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법 |
| JP4027872B2 (ja) * | 2003-10-03 | 2007-12-26 | シスメックス株式会社 | シースフロー形成装置およびそれを備えた試料分析装置 |
| CN102494985A (zh) * | 2011-12-26 | 2012-06-13 | 山东兰桥医学科技有限公司 | 一种小型负压装置 |
| US10022720B2 (en) | 2015-06-12 | 2018-07-17 | Cytochip Inc. | Fluidic units and cartridges for multi-analyte analysis |
| US10634602B2 (en) | 2015-06-12 | 2020-04-28 | Cytochip Inc. | Fluidic cartridge for cytometry and additional analysis |
| CN108027310B (zh) | 2015-07-14 | 2020-12-22 | 芯易诊有限公司 | 流体盒中的体积感测 |
| CN110234442A (zh) * | 2016-11-19 | 2019-09-13 | 厦泰生物科技公司 | 具有步进流量控制阀的流式细胞术系统 |
| WO2019000459A1 (zh) * | 2017-06-30 | 2019-01-03 | 深圳迈瑞生物医疗电子股份有限公司 | 供液装置、样本分析仪及供液方法 |
| BR102018075954A2 (pt) * | 2017-09-15 | 2019-11-12 | Horiba Ltd | aparelho de análise de partículas |
| US11491487B2 (en) | 2017-10-23 | 2022-11-08 | Cytochip Inc. | Devices and methods for measuring analytes and target particles |
| CN111751265A (zh) * | 2020-06-30 | 2020-10-09 | 深圳市科曼医疗设备有限公司 | 一种鞘流液路系统及控制方法 |
| CN115963050B (zh) * | 2023-03-16 | 2023-07-21 | 赛默飞世尔(上海)仪器有限公司 | 鞘液供应系统、流式细胞仪及用于供应鞘液的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3788744A (en) * | 1970-01-14 | 1974-01-29 | Bio Physics Systems Inc | Method and apparatus for photoanalysis |
| US3831618A (en) * | 1972-12-22 | 1974-08-27 | Abbott Lab | Apparatus for the precision metering of fluids |
| US4111051A (en) * | 1975-02-20 | 1978-09-05 | Bodenseewerk Perkin-Elmer & Co., Gmbh | Sampling procedure and device for flameless atomic absorption spectroscopy |
| US4476734A (en) * | 1983-03-07 | 1984-10-16 | International Business Machines Corporation | Wet needle sampler for use with a gas chromatograph |
| US4736732A (en) * | 1985-09-03 | 1988-04-12 | Olympus Optical Co., Ltd. | Endoscopic fluid changing device |
| US5215714A (en) | 1988-04-08 | 1993-06-01 | Toa Medical Electronics Co., Ltd. | Immunoagglutination measurement apparatus |
| JPH0353164A (ja) * | 1989-07-20 | 1991-03-07 | Canon Inc | サンプル供給装置及びこれを用いたサンプル測定装置 |
| JP2808321B2 (ja) * | 1989-09-19 | 1998-10-08 | 東亜医用電子株式会社 | 細胞分析方法及び装置 |
| JP2965688B2 (ja) * | 1990-11-30 | 1999-10-18 | シスメックス株式会社 | 粒子検出装置 |
| JP3075367B2 (ja) | 1991-04-05 | 2000-08-14 | シスメックス株式会社 | 粒子分析方法及び装置 |
| JP3115641B2 (ja) * | 1991-04-24 | 2000-12-11 | シスメックス株式会社 | 粒子計数方法 |
| US5603700A (en) | 1993-12-27 | 1997-02-18 | Daneshvar; Yousef | Suction and injection system |
| JP3158929B2 (ja) | 1995-01-27 | 2001-04-23 | 株式会社日立製作所 | 粒子分析装置 |
| JP2001059839A (ja) | 1995-10-16 | 2001-03-06 | Takeda Chem Ind Ltd | 自動精製装置 |
| SE507956C2 (sv) * | 1996-11-20 | 1998-08-03 | Medonic Ab | Utspädnings- och mätanordning för partikelräkning |
| JP3681252B2 (ja) | 1997-03-18 | 2005-08-10 | シスメックス株式会社 | 粒子計数方法および粒子計数装置 |
| JP2000214070A (ja) * | 1999-01-21 | 2000-08-04 | Sysmex Corp | シ―スフロ―セルとそれを用いた血液分析装置 |
-
2000
- 2000-08-18 JP JP2000248689A patent/JP4194233B2/ja not_active Expired - Lifetime
-
2001
- 2001-08-17 US US09/930,967 patent/US20020020207A1/en not_active Abandoned
-
2003
- 2003-01-06 US US10/336,789 patent/US6804984B2/en not_active Expired - Lifetime
- 2003-01-06 US US10/336,790 patent/US20030110826A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002062250A (ja) | 2002-02-28 |
| US20020020207A1 (en) | 2002-02-21 |
| US20030110826A1 (en) | 2003-06-19 |
| US6804984B2 (en) | 2004-10-19 |
| US20030107725A1 (en) | 2003-06-12 |
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