JP4179166B2 - 疎水性ゾーン装置 - Google Patents

疎水性ゾーン装置 Download PDF

Info

Publication number
JP4179166B2
JP4179166B2 JP2003584329A JP2003584329A JP4179166B2 JP 4179166 B2 JP4179166 B2 JP 4179166B2 JP 2003584329 A JP2003584329 A JP 2003584329A JP 2003584329 A JP2003584329 A JP 2003584329A JP 4179166 B2 JP4179166 B2 JP 4179166B2
Authority
JP
Japan
Prior art keywords
assay
reagent
zone
hydrophobic
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003584329A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005522219A5 (enExample
JP2005522219A (ja
Inventor
ヤン、シン
Original Assignee
ジーンオーム サイエンシーズ、インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジーンオーム サイエンシーズ、インク． filed Critical ジーンオーム サイエンシーズ、インク．
Publication of JP2005522219A publication Critical patent/JP2005522219A/ja
Publication of JP2005522219A5 publication Critical patent/JP2005522219A5/ja
Application granted granted Critical
Publication of JP4179166B2 publication Critical patent/JP4179166B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/0065—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of liquid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2003584329A 2002-04-10 2003-04-08 疎水性ゾーン装置 Expired - Fee Related JP4179166B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/121,214 US20030194709A1 (en) 2002-04-10 2002-04-10 Hydrophobic zone device
PCT/US2003/011225 WO2003087391A2 (en) 2002-04-10 2003-04-08 Hydrophobic zone device

Publications (3)

Publication Number Publication Date
JP2005522219A JP2005522219A (ja) 2005-07-28
JP2005522219A5 JP2005522219A5 (enExample) 2006-06-08
JP4179166B2 true JP4179166B2 (ja) 2008-11-12

Family

ID=28790270

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003584329A Expired - Fee Related JP4179166B2 (ja) 2002-04-10 2003-04-08 疎水性ゾーン装置

Country Status (6)

Country Link
US (1) US20030194709A1 (enExample)
EP (1) EP1497458A4 (enExample)
JP (1) JP4179166B2 (enExample)
AU (1) AU2003221895B2 (enExample)
CA (1) CA2481355A1 (enExample)
WO (1) WO2003087391A2 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
US20050164402A1 (en) * 2003-07-14 2005-07-28 Belisle Christopher M. Sample presentation device
FR2861609B1 (fr) * 2003-10-31 2006-02-03 Commissariat Energie Atomique Procede de repartition de gouttes d'un liquide d'interet sur une surface
WO2005075995A1 (en) * 2004-02-03 2005-08-18 Sphere Medical Ltd Sensor
JP3860174B2 (ja) * 2004-03-01 2006-12-20 倉敷紡績株式会社 同時多検体ハイブリダイゼーション方法
US7615369B2 (en) * 2004-09-22 2009-11-10 The Regents Of The University Of Michigan Reconfigurable protein patterning using electrowetting microelectrodes
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
US20070034513A1 (en) 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
WO2007024800A2 (en) 2005-08-22 2007-03-01 Applera Corporation Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US7601567B2 (en) * 2005-12-13 2009-10-13 Samsung Mobile Display Co., Ltd. Method of preparing organic thin film transistor, organic thin film transistor, and organic light-emitting display device including the organic thin film transistor
US9152150B1 (en) 2007-02-22 2015-10-06 Applied Biosystems, Llc Compositions, systems, and methods for immiscible fluid discrete volume manipulation
JP2009103582A (ja) * 2007-10-23 2009-05-14 Ulvac Japan Ltd 生体関連物質検出用センサおよびその製造方法
WO2009126916A2 (en) * 2008-04-10 2009-10-15 The Johns Hopkins University Patterning devices using fluorinated compounds
WO2011090793A2 (en) 2010-01-20 2011-07-28 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
US9086338B2 (en) 2010-06-25 2015-07-21 Nihon Dempa Kogyo Co., Ltd. Sensing device
JP5102334B2 (ja) * 2010-06-25 2012-12-19 日本電波工業株式会社 感知装置
CN106198656B (zh) * 2010-08-18 2018-12-11 生命科技股份有限公司 用于电化学检测装置的微孔的化学涂层
US20120156767A1 (en) * 2010-12-17 2012-06-21 Stmicroelectronics S.R.L. Pcr device
JP5899908B2 (ja) * 2011-12-26 2016-04-06 株式会社Ｊｖｃケンウッド 試料分析用ディスク
GB2499428B (en) * 2012-02-16 2014-09-24 Microvisk Ltd Surface patterned micro-sensor based fluid test strip
DK2839295T3 (en) * 2012-04-20 2017-05-15 Hewlett-Packard Dev Company Integrated sensors
DE102013210138A1 (de) * 2013-05-30 2014-12-04 Boehringer Ingelheim Vetmedica Gmbh Verfahren zum Erzeugen einer Vielzahl von Messbereichen auf einem Chip sowie Chip mit Messbereichen
US20160258020A1 (en) * 2013-10-21 2016-09-08 The Regents Of The University Of California Enrichment and detection of nucleic acids with ultra-high sensitivity
JP6205299B2 (ja) * 2014-03-31 2017-09-27 シチズンファインデバイス株式会社 試料積載プレート
US10518241B2 (en) * 2014-04-15 2019-12-31 Agilent Technologies, Inc. Creating and harvesting surface-bound emulsion
JP2016067322A (ja) * 2014-09-30 2016-05-09 富士フイルム株式会社 プラスチック製容器
JP6591160B2 (ja) * 2014-12-25 2019-10-16 シチズンファインデバイス株式会社 試料積載プレート
FR3040895B1 (fr) 2015-09-11 2020-01-10 Elvesys Substrat de support d'echantillon liquide, ensemble comportant un tel substrat et son utilisation
KR20180088722A (ko) * 2015-12-02 2018-08-06 베링거잉겔하임베트메디카게엠베하 칩 상에 다수의 측정 영역들을 제조하는 방법 및 다수의 측정 영역들을 갖는 칩
KR101980863B1 (ko) 2017-02-17 2019-05-23 (주)바이오니아 Maldi 질량분석용 시료 플레이트 및 이의 제조 방법
US11099157B2 (en) * 2018-07-06 2021-08-24 Qorvo Biotechnologies, Llc Sensor with droplet retaining structure
JP7219919B2 (ja) 2019-05-20 2023-02-09 日本航空電子工業株式会社 触媒反応生成物の電気化学的測定方法及びトランスデューサ
JP7229110B2 (ja) 2019-06-25 2023-02-27 株式会社Ｓｃｒｅｅｎホールディングス 細胞電位測定装置
CN112705279B (zh) * 2019-10-25 2022-09-23 成都今是科技有限公司 微流控芯片及其制备方法
US12485415B2 (en) 2019-11-13 2025-12-02 Beijing Boe Technology Development Co., Ltd. Detection chip, method for manufacturing detection chip, method for operating detection chip, and reaction system
JP7469092B2 (ja) * 2020-03-23 2024-04-16 株式会社Ｓｃｒｅｅｎホールディングス 細胞保持容器
JP7474161B2 (ja) * 2020-09-15 2024-04-24 株式会社Ｓｃｒｅｅｎホールディングス 細胞計測プレート
TWI767444B (zh) * 2020-12-11 2022-06-11 吳有榮 具自我對準定位之晶片移載方法及其設備
US20230160794A1 (en) * 2021-11-24 2023-05-25 10X Genomics, Inc. Methods for sample preparation for automated in situ analysis
TWI806366B (zh) * 2022-01-18 2023-06-21 國立臺灣大學 用於辨別水溶液中粒子種類的檢測裝置及檢測方法
CN114235921A (zh) * 2022-02-23 2022-03-25 捷仪科技(北京)有限公司 一种用于生物检测的电极载片
GB2627173A (en) * 2022-12-16 2024-08-21 Univ Tartu Method of producing an analysis device, analysis device, analysis arrangement and analysis method
CN115865035A (zh) * 2022-12-27 2023-03-28 烟台明德亨电子科技有限公司 一种晶振用基座及一种晶振

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225410A (en) * 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5766934A (en) * 1989-03-13 1998-06-16 Guiseppi-Elie; Anthony Chemical and biological sensors having electroactive polymer thin films attached to microfabricated devices and possessing immobilized indicator moieties
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
WO1993008464A1 (en) * 1991-10-21 1993-04-29 Holm Kennedy James W Method and device for biochemical sensing
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US6121048A (en) * 1994-10-18 2000-09-19 Zaffaroni; Alejandro C. Method of conducting a plurality of reactions
CZ299135B6 (cs) * 1995-03-10 2008-04-30 Meso Scale Technologies, Llc. Corporation Servicecompany Kazeta a zarízení pro použití pri detekci analytu, zpusob provádení testu za použití uvedené kazety, kit pro použití pri provádení množiny elektrochemiluminescencních testu a zpusob detekce nebo merení analytu
AUPN366995A0 (en) * 1995-06-20 1995-07-13 Australian Membrane And Biotechnology Research Institute Self-assembly of bilayer membrane sensors
DE19628928A1 (de) * 1996-07-18 1998-01-22 Basf Ag Feste Träger für analytische Meßverfahren, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
US6221586B1 (en) * 1997-04-09 2001-04-24 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
US6093302A (en) * 1998-01-05 2000-07-25 Combimatrix Corporation Electrochemical solid phase synthesis
WO1999039829A1 (en) * 1998-02-04 1999-08-12 Merck & Co., Inc. Virtual wells for use in high throughput screening assays
WO1999051773A1 (en) * 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
US6251595B1 (en) * 1998-06-18 2001-06-26 Agilent Technologies, Inc. Methods and devices for carrying out chemical reactions
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
JP3829491B2 (ja) * 1998-08-27 2006-10-04 株式会社日立製作所 プローブチップ、プローブチップ作成方法、試料検出方法、及び試料検出装置
FR2783179B1 (fr) * 1998-09-16 2000-10-06 Commissariat Energie Atomique Dispositif d'analyse chimique ou biologique comprenant une pluralite de sites d'analyse sur un support, et son procede de fabrication
US6565727B1 (en) * 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6682649B1 (en) * 1999-10-01 2004-01-27 Sophion Bioscience A/S Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
WO2001061054A2 (en) * 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US6720157B2 (en) * 2000-02-23 2004-04-13 Zyomyx, Inc. Chips having elevated sample surfaces
AU2001261145B2 (en) * 2000-05-03 2005-08-11 The United States Government, As Represented By The Department Of The Navy Biological identification system with integrated sensor chip
AU2001287472A1 (en) * 2000-09-19 2002-04-02 Cytion Sa Sample positioning and analysis system
JP4361271B2 (ja) * 2000-10-10 2009-11-11 バイオトローブ・インコーポレイテツド アッセイ、合成、および保存用の器具、ならびに、その作製、使用、および操作の方法

Also Published As

Publication number Publication date
EP1497458A4 (en) 2005-05-11
WO2003087391A2 (en) 2003-10-23
WO2003087391A3 (en) 2004-07-15
US20030194709A1 (en) 2003-10-16
EP1497458A2 (en) 2005-01-19
AU2003221895A1 (en) 2003-10-27
CA2481355A1 (en) 2003-10-23
AU2003221895B2 (en) 2008-11-20
JP2005522219A (ja) 2005-07-28

Similar Documents

Publication Publication Date Title
JP4179166B2 (ja) 疎水性ゾーン装置
US7888109B2 (en) Apparatus and methods for detecting nucleic acid in biological samples
US7332328B2 (en) Microcolumn-platform based array for high-throughput analysis
EP1450156A1 (en) Sensor cell, biosensor, capacitive device manufacturing method, biological reaction detection method, and gene analyzing method
JP2005522219A5 (enExample)
US20150377831A1 (en) Digital microfluidic devices and methods employing integrated nanostructured electrodeposited electrodes
JP2007508554A5 (enExample)
JP2012073269A (ja) 対象液体を捕捉するための局在化区域を備える作業装置
US20040084307A1 (en) Biosensor, biosensor array, and method for manufacturing a plurality of biosensors
JP2005522689A (ja) 分子的に平滑な表面の形成方法
US7829271B2 (en) Process for distributing drops of a liquid of interest onto a surface
KR101165860B1 (ko) 생물학적 샘플에서 핵산을 검출하는 장치 및 방법
HK1098177B (en) Apparatus and methods for detecting nucleic acid in biological samples
US20050106583A1 (en) Porous device

Legal Events

Date Code Title Description
A072 Dismissal of procedure [no reply to invitation to correct request for examination]

Free format text: JAPANESE INTERMEDIATE CODE: A073

Effective date: 20050510

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20050415

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060330

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20060330

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060330

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070625

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070918

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071012

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080108

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080222

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080613

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20080708

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20080729

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20080818

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20080818

R150 Certificate of patent or registration of utility model

Ref document number: 4179166

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110905

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110905

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120905

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130905

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313111

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees