AU2003221895B2 - Hydrophobic zone device - Google Patents
Hydrophobic zone device Download PDFInfo
- Publication number
- AU2003221895B2 AU2003221895B2 AU2003221895A AU2003221895A AU2003221895B2 AU 2003221895 B2 AU2003221895 B2 AU 2003221895B2 AU 2003221895 A AU2003221895 A AU 2003221895A AU 2003221895 A AU2003221895 A AU 2003221895A AU 2003221895 B2 AU2003221895 B2 AU 2003221895B2
- Authority
- AU
- Australia
- Prior art keywords
- reagent
- zones
- zone
- hydrophobic
- assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000002209 hydrophobic effect Effects 0.000 title claims description 77
- 239000003153 chemical reaction reagent Substances 0.000 claims description 93
- 238000003556 assay Methods 0.000 claims description 88
- 239000000758 substrate Substances 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 29
- 239000000463 material Substances 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 23
- 239000004020 conductor Substances 0.000 claims description 11
- 229920002313 fluoropolymer Polymers 0.000 claims description 9
- 230000003993 interaction Effects 0.000 claims description 9
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 8
- 229910052710 silicon Inorganic materials 0.000 claims description 8
- 239000010703 silicon Substances 0.000 claims description 8
- 239000004811 fluoropolymer Substances 0.000 claims description 7
- 239000012491 analyte Substances 0.000 claims description 6
- 238000005530 etching Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 2
- 230000005660 hydrophilic surface Effects 0.000 claims description 2
- 101150084844 PAFAH1B1 gene Proteins 0.000 claims 1
- 101150006006 nudF gene Proteins 0.000 claims 1
- 101150077839 pac1 gene Proteins 0.000 claims 1
- 239000010410 layer Substances 0.000 description 53
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 22
- 108020004414 DNA Proteins 0.000 description 20
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 16
- 239000010931 gold Substances 0.000 description 16
- 229910052737 gold Inorganic materials 0.000 description 16
- 238000000018 DNA microarray Methods 0.000 description 15
- 235000012239 silicon dioxide Nutrition 0.000 description 11
- 239000000377 silicon dioxide Substances 0.000 description 11
- 239000000523 sample Substances 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 9
- 235000012431 wafers Nutrition 0.000 description 9
- 239000004809 Teflon Substances 0.000 description 5
- 229920006362 Teflon® Polymers 0.000 description 5
- -1 glassy carbon Chemical compound 0.000 description 5
- 239000004065 semiconductor Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- 238000000151 deposition Methods 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000003989 dielectric material Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000012252 genetic analysis Methods 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000009396 hybridization Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002861 polymer material Substances 0.000 description 3
- 108091033319 polynucleotide Proteins 0.000 description 3
- 102000040430 polynucleotide Human genes 0.000 description 3
- 239000002157 polynucleotide Substances 0.000 description 3
- 125000003396 thiol group Chemical class [H]S* 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000027455 binding Effects 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000004518 low pressure chemical vapour deposition Methods 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- 238000000059 patterning Methods 0.000 description 2
- 239000000816 peptidomimetic Substances 0.000 description 2
- 238000000206 photolithography Methods 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229920000052 poly(p-xylylene) Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 229910052703 rhodium Inorganic materials 0.000 description 2
- 239000010948 rhodium Substances 0.000 description 2
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 108700010039 chimeric receptor Proteins 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229920001940 conductive polymer Polymers 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 229910021419 crystalline silicon Inorganic materials 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000000840 electrochemical analysis Methods 0.000 description 1
- 238000000835 electrochemical detection Methods 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 229910021397 glassy carbon Inorganic materials 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910021421 monocrystalline silicon Inorganic materials 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229910021420 polycrystalline silicon Inorganic materials 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
- B01J2219/0065—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of liquid beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/121,214 US20030194709A1 (en) | 2002-04-10 | 2002-04-10 | Hydrophobic zone device |
| US10/121,214 | 2002-04-10 | ||
| PCT/US2003/011225 WO2003087391A2 (en) | 2002-04-10 | 2003-04-08 | Hydrophobic zone device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003221895A1 AU2003221895A1 (en) | 2003-10-27 |
| AU2003221895B2 true AU2003221895B2 (en) | 2008-11-20 |
Family
ID=28790270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003221895A Expired - Fee Related AU2003221895B2 (en) | 2002-04-10 | 2003-04-08 | Hydrophobic zone device |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030194709A1 (enExample) |
| EP (1) | EP1497458A4 (enExample) |
| JP (1) | JP4179166B2 (enExample) |
| AU (1) | AU2003221895B2 (enExample) |
| CA (1) | CA2481355A1 (enExample) |
| WO (1) | WO2003087391A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10539561B1 (en) | 2001-08-30 | 2020-01-21 | Customarray, Inc. | Enzyme-amplified redox microarray detection process |
| US20050164402A1 (en) * | 2003-07-14 | 2005-07-28 | Belisle Christopher M. | Sample presentation device |
| FR2861609B1 (fr) * | 2003-10-31 | 2006-02-03 | Commissariat Energie Atomique | Procede de repartition de gouttes d'un liquide d'interet sur une surface |
| US20070134721A1 (en) * | 2004-02-03 | 2007-06-14 | Laitenberger Peter G | Sensor |
| JP3860174B2 (ja) * | 2004-03-01 | 2006-12-20 | 倉敷紡績株式会社 | 同時多検体ハイブリダイゼーション方法 |
| WO2006137882A2 (en) * | 2004-09-22 | 2006-12-28 | The Regents Of The University Of Michigan | Reconfigurable protein patterning using electrowetting microelectrodes |
| US20060102471A1 (en) | 2004-11-18 | 2006-05-18 | Karl Maurer | Electrode array device having an adsorbed porous reaction layer |
| US20070034513A1 (en) | 2005-03-25 | 2007-02-15 | Combimatrix Corporation | Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array |
| US9394167B2 (en) | 2005-04-15 | 2016-07-19 | Customarray, Inc. | Neutralization and containment of redox species produced by circumferential electrodes |
| EP2660482B1 (en) | 2005-08-22 | 2019-08-07 | Life Technologies Corporation | Vorrichtung, System und Verfahren unter Verwendung von nichtmischbaren Flüssigkeiten mit unterschiedlichen Volumen |
| US20070065877A1 (en) | 2005-09-19 | 2007-03-22 | Combimatrix Corporation | Microarray having a base cleavable succinate linker |
| US7601567B2 (en) * | 2005-12-13 | 2009-10-13 | Samsung Mobile Display Co., Ltd. | Method of preparing organic thin film transistor, organic thin film transistor, and organic light-emitting display device including the organic thin film transistor |
| US9152150B1 (en) | 2007-02-22 | 2015-10-06 | Applied Biosystems, Llc | Compositions, systems, and methods for immiscible fluid discrete volume manipulation |
| JP2009103582A (ja) * | 2007-10-23 | 2009-05-14 | Ulvac Japan Ltd | 生体関連物質検出用センサおよびその製造方法 |
| WO2009126916A2 (en) * | 2008-04-10 | 2009-10-15 | The Johns Hopkins University | Patterning devices using fluorinated compounds |
| US9927434B2 (en) | 2010-01-20 | 2018-03-27 | Customarray, Inc. | Multiplex microarray of serially deposited biomolecules on a microarray |
| JP5102334B2 (ja) * | 2010-06-25 | 2012-12-19 | 日本電波工業株式会社 | 感知装置 |
| US9086338B2 (en) | 2010-06-25 | 2015-07-21 | Nihon Dempa Kogyo Co., Ltd. | Sensing device |
| US20120045368A1 (en) | 2010-08-18 | 2012-02-23 | Life Technologies Corporation | Chemical Coating of Microwell for Electrochemical Detection Device |
| US20120156767A1 (en) * | 2010-12-17 | 2012-06-21 | Stmicroelectronics S.R.L. | Pcr device |
| JP5899908B2 (ja) * | 2011-12-26 | 2016-04-06 | 株式会社Ｊｖｃケンウッド | 試料分析用ディスク |
| GB2499428B (en) * | 2012-02-16 | 2014-09-24 | Microvisk Ltd | Surface patterned micro-sensor based fluid test strip |
| DK2839295T3 (en) * | 2012-04-20 | 2017-05-15 | Hewlett-Packard Dev Company | Integrated sensors |
| DE102013210138A1 (de) * | 2013-05-30 | 2014-12-04 | Boehringer Ingelheim Vetmedica Gmbh | Verfahren zum Erzeugen einer Vielzahl von Messbereichen auf einem Chip sowie Chip mit Messbereichen |
| US20160258020A1 (en) * | 2013-10-21 | 2016-09-08 | The Regents Of The University Of California | Enrichment and detection of nucleic acids with ultra-high sensitivity |
| JP6205299B2 (ja) * | 2014-03-31 | 2017-09-27 | シチズンファインデバイス株式会社 | 試料積載プレート |
| CN106232217B (zh) * | 2014-04-15 | 2020-08-04 | 安捷伦科技有限公司 | 创建并收获表面结合的乳液 |
| JP2016067322A (ja) * | 2014-09-30 | 2016-05-09 | 富士フイルム株式会社 | プラスチック製容器 |
| JP6591160B2 (ja) * | 2014-12-25 | 2019-10-16 | シチズンファインデバイス株式会社 | 試料積載プレート |
| FR3040895B1 (fr) * | 2015-09-11 | 2020-01-10 | Elvesys | Substrat de support d'echantillon liquide, ensemble comportant un tel substrat et son utilisation |
| CA3003767A1 (en) | 2015-12-02 | 2017-06-08 | Boehringer Ingelheim Vetmedica Gmbh | Method for producing a plurality of measurement regions on a chip, and chip having a plurality of measurement regions |
| KR101980863B1 (ko) | 2017-02-17 | 2019-05-23 | (주)바이오니아 | Maldi 질량분석용 시료 플레이트 및 이의 제조 방법 |
| US11099157B2 (en) | 2018-07-06 | 2021-08-24 | Qorvo Biotechnologies, Llc | Sensor with droplet retaining structure |
| JP7219919B2 (ja) * | 2019-05-20 | 2023-02-09 | 日本航空電子工業株式会社 | 触媒反応生成物の電気化学的測定方法及びトランスデューサ |
| JP7229110B2 (ja) | 2019-06-25 | 2023-02-27 | 株式会社Ｓｃｒｅｅｎホールディングス | 細胞電位測定装置 |
| CN112705279B (zh) * | 2019-10-25 | 2022-09-23 | 成都今是科技有限公司 | 微流控芯片及其制备方法 |
| US12485415B2 (en) | 2019-11-13 | 2025-12-02 | Beijing Boe Technology Development Co., Ltd. | Detection chip, method for manufacturing detection chip, method for operating detection chip, and reaction system |
| JP7469092B2 (ja) * | 2020-03-23 | 2024-04-16 | 株式会社Ｓｃｒｅｅｎホールディングス | 細胞保持容器 |
| JP7474161B2 (ja) * | 2020-09-15 | 2024-04-24 | 株式会社Ｓｃｒｅｅｎホールディングス | 細胞計測プレート |
| TWI767444B (zh) * | 2020-12-11 | 2022-06-11 | 吳有榮 | 具自我對準定位之晶片移載方法及其設備 |
| US20230160794A1 (en) * | 2021-11-24 | 2023-05-25 | 10X Genomics, Inc. | Methods for sample preparation for automated in situ analysis |
| TWI806366B (zh) * | 2022-01-18 | 2023-06-21 | 國立臺灣大學 | 用於辨別水溶液中粒子種類的檢測裝置及檢測方法 |
| CN114235921A (zh) * | 2022-02-23 | 2022-03-25 | 捷仪科技(北京)有限公司 | 一种用于生物检测的电极载片 |
| GB2627173A (en) * | 2022-12-16 | 2024-08-21 | Univ Tartu | Method of producing an analysis device, analysis device, analysis arrangement and analysis method |
| CN115865035A (zh) * | 2022-12-27 | 2023-03-28 | 烟台明德亨电子科技有限公司 | 一种晶振用基座及一种晶振 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4225410A (en) * | 1978-12-04 | 1980-09-30 | Technicon Instruments Corporation | Integrated array of electrochemical sensors |
| SE462408B (sv) * | 1988-11-10 | 1990-06-18 | Pharmacia Ab | Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet |
| US5063081A (en) * | 1988-11-14 | 1991-11-05 | I-Stat Corporation | Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor |
| US5200051A (en) * | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
| US5766934A (en) * | 1989-03-13 | 1998-06-16 | Guiseppi-Elie; Anthony | Chemical and biological sensors having electroactive polymer thin films attached to microfabricated devices and possessing immobilized indicator moieties |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5252743A (en) * | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| CA2121797A1 (en) * | 1991-10-21 | 1993-04-29 | James W. Holm-Kennedy | Method and device for biochemical sensing |
| US5849486A (en) * | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
| US5412087A (en) * | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| US5591578A (en) * | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US6121048A (en) * | 1994-10-18 | 2000-09-19 | Zaffaroni; Alejandro C. | Method of conducting a plurality of reactions |
| EP0821726B1 (en) * | 1995-03-10 | 2014-05-07 | Meso Scale Technologies, LLC. | Multi-array, multi-specific electrochemiluminescence testing |
| AUPN366995A0 (en) * | 1995-06-20 | 1995-07-13 | Australian Membrane And Biotechnology Research Institute | Self-assembly of bilayer membrane sensors |
| DE19628928A1 (de) * | 1996-07-18 | 1998-01-22 | Basf Ag | Feste Träger für analytische Meßverfahren, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| US6221586B1 (en) * | 1997-04-09 | 2001-04-24 | California Institute Of Technology | Electrochemical sensor using intercalative, redox-active moieties |
| US5981268A (en) * | 1997-05-30 | 1999-11-09 | Board Of Trustees, Leland Stanford, Jr. University | Hybrid biosensors |
| US6093302A (en) * | 1998-01-05 | 2000-07-25 | Combimatrix Corporation | Electrochemical solid phase synthesis |
| US6565813B1 (en) * | 1998-02-04 | 2003-05-20 | Merck & Co., Inc. | Virtual wells for use in high throughput screening assays |
| CA2323638A1 (en) * | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
| US6251595B1 (en) * | 1998-06-18 | 2001-06-26 | Agilent Technologies, Inc. | Methods and devices for carrying out chemical reactions |
| US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| JP3829491B2 (ja) * | 1998-08-27 | 2006-10-04 | 株式会社日立製作所 | プローブチップ、プローブチップ作成方法、試料検出方法、及び試料検出装置 |
| FR2783179B1 (fr) * | 1998-09-16 | 2000-10-06 | Commissariat Energie Atomique | Dispositif d'analyse chimique ou biologique comprenant une pluralite de sites d'analyse sur un support, et son procede de fabrication |
| US6565727B1 (en) * | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
| US6682649B1 (en) * | 1999-10-01 | 2004-01-27 | Sophion Bioscience A/S | Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels |
| US7332271B2 (en) * | 2000-02-18 | 2008-02-19 | Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
| AU3986501A (en) * | 2000-02-23 | 2001-09-03 | Zyomyx Inc | Chips having elevated sample surfaces |
| JP4949589B2 (ja) * | 2000-05-03 | 2012-06-13 | ガウ，ジェン−ジェイアール | 集積センサ・チップを有する生物学的同定システム |
| AU2001287472A1 (en) * | 2000-09-19 | 2002-04-02 | Cytion Sa | Sample positioning and analysis system |
| CA2425476C (en) * | 2000-10-10 | 2011-02-01 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
-
2002
- 2002-04-10 US US10/121,214 patent/US20030194709A1/en not_active Abandoned
-
2003
- 2003-04-08 WO PCT/US2003/011225 patent/WO2003087391A2/en not_active Ceased
- 2003-04-08 EP EP03718354A patent/EP1497458A4/en not_active Withdrawn
- 2003-04-08 JP JP2003584329A patent/JP4179166B2/ja not_active Expired - Fee Related
- 2003-04-08 CA CA002481355A patent/CA2481355A1/en not_active Abandoned
- 2003-04-08 AU AU2003221895A patent/AU2003221895B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4179166B2 (ja) | 2008-11-12 |
| AU2003221895A1 (en) | 2003-10-27 |
| EP1497458A4 (en) | 2005-05-11 |
| CA2481355A1 (en) | 2003-10-23 |
| US20030194709A1 (en) | 2003-10-16 |
| WO2003087391A2 (en) | 2003-10-23 |
| WO2003087391A3 (en) | 2004-07-15 |
| JP2005522219A (ja) | 2005-07-28 |
| EP1497458A2 (en) | 2005-01-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2003221895B2 (en) | Hydrophobic zone device | |
| US7888109B2 (en) | Apparatus and methods for detecting nucleic acid in biological samples | |
| EP2872892B1 (en) | Flexible dna sensor carrier and method | |
| US20040110277A1 (en) | Sensor cell, bio-sensor, capacitance element manufacturing method, biological reaction detection method and genetic analytical method | |
| US20090186776A1 (en) | Microcolumn-platform based array for high-throughput analysis | |
| JP2012073269A (ja) | 対象液体を捕捉するための局在化区域を備える作業装置 | |
| CN101517403A (zh) | 具有交叉指形微电极和导电聚合物的电化学传感器 | |
| JP2007508554A5 (enExample) | ||
| US6955914B2 (en) | Method for making a molecularly smooth surface | |
| EP1678488A1 (en) | Novel sensor configuration | |
| US7829271B2 (en) | Process for distributing drops of a liquid of interest onto a surface | |
| US20050106583A1 (en) | Porous device | |
| HK1098177B (en) | Apparatus and methods for detecting nucleic acid in biological samples |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 04 DEC 2008. |
|
| MK25 | Application lapsed reg. 22.2i(2) - failure to pay acceptance fee |