JP4124377B2 - コードアダプターの連結による配列決定 - Google Patents

コードアダプターの連結による配列決定 Download PDF

Info

Publication number
JP4124377B2
JP4124377B2 JP50075598A JP50075598A JP4124377B2 JP 4124377 B2 JP4124377 B2 JP 4124377B2 JP 50075598 A JP50075598 A JP 50075598A JP 50075598 A JP50075598 A JP 50075598A JP 4124377 B2 JP4124377 B2 JP 4124377B2
Authority
JP
Japan
Prior art keywords
tag
oligonucleotide
polynucleotide
adapter
nucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP50075598A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000515006A5 (index.php
JP2000515006A (ja
Inventor
アルブレッチ,グレン
ブレナー,シドニー
エイチ. ロイド,デイビッド
ビー. ダブリッジ,ロバート
シー. パラス,マイケル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Solexa Inc
Original Assignee
Solexa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/659,453 external-priority patent/US5846719A/en
Application filed by Solexa Inc filed Critical Solexa Inc
Publication of JP2000515006A publication Critical patent/JP2000515006A/ja
Publication of JP2000515006A5 publication Critical patent/JP2000515006A5/ja
Application granted granted Critical
Publication of JP4124377B2 publication Critical patent/JP4124377B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855Ligating adaptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP50075598A 1996-06-06 1997-06-02 コードアダプターの連結による配列決定 Expired - Lifetime JP4124377B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/659,453 1996-06-06
US08/659,453 US5846719A (en) 1994-10-13 1996-06-06 Oligonucleotide tags for sorting and identification
US68958796A 1996-08-12 1996-08-12
US08/689,587 1996-08-12
PCT/US1997/009472 WO1997046704A1 (en) 1996-06-06 1997-06-02 Sequencing by ligation of encoded adaptors

Publications (3)

Publication Number Publication Date
JP2000515006A JP2000515006A (ja) 2000-11-14
JP2000515006A5 JP2000515006A5 (index.php) 2004-12-09
JP4124377B2 true JP4124377B2 (ja) 2008-07-23

Family

ID=27097828

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50075598A Expired - Lifetime JP4124377B2 (ja) 1996-06-06 1997-06-02 コードアダプターの連結による配列決定

Country Status (12)

Country Link
EP (1) EP0923650B1 (index.php)
JP (1) JP4124377B2 (index.php)
CN (1) CN1195872C (index.php)
AT (1) ATE356221T1 (index.php)
AU (1) AU733782B2 (index.php)
CA (1) CA2256700A1 (index.php)
CZ (1) CZ397998A3 (index.php)
DE (1) DE69737450T2 (index.php)
HU (1) HUP0003944A3 (index.php)
NO (1) NO985698L (index.php)
PL (1) PL331513A1 (index.php)
WO (1) WO1997046704A1 (index.php)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160111947A (ko) * 2014-01-28 2016-09-27 란자테크 뉴질랜드 리미티드 재조합 미생물의 생산 방법
KR20160115938A (ko) * 2014-01-31 2016-10-06 스위프트 바이오사이언시스 인코포레이티드 Dna 기질을 처리하는 개선 방법

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053300A2 (en) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparaus for sequential processing of analytes
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
DE69638179D1 (de) * 1995-06-07 2010-06-10 Solexa Inc Verfahren zur Verbesserung der Effizienz der Polynukleotidsequenzierung
GB9620769D0 (en) * 1996-10-04 1996-11-20 Brax Genomics Ltd Nucleic acid sequencing
US5888737A (en) * 1997-04-15 1999-03-30 Lynx Therapeutics, Inc. Adaptor-based sequence analysis
US6607878B2 (en) * 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
US6265163B1 (en) 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes
JP3944996B2 (ja) 1998-03-05 2007-07-18 株式会社日立製作所 Dnaプローブアレー
CA2335951C (en) 1998-06-24 2013-07-30 Mark S. Chee Decoding of array sensors with microspheres
US6480791B1 (en) * 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
NO986133D0 (no) * 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
WO2000039333A1 (en) * 1998-12-23 2000-07-06 Jones Elizabeth Louise Sequencing method using magnifying tags
JP2002540802A (ja) * 1999-04-06 2002-12-03 イェール ユニバーシティ 配列標識の固定されたアドレス分析
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
CA2374390A1 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
AU6770800A (en) * 1999-08-13 2001-03-13 Yale University Analysis of sequence tags with hairpin primers
ATE542916T1 (de) 1999-08-18 2012-02-15 Illumina Inc Methoden zur erzeugung von oligonukleotidlösungen
AU3806701A (en) 2000-02-07 2001-08-14 Illumina Inc Nucleic acid detection methods using universal priming
DE60136166D1 (de) 2000-02-07 2008-11-27 Illumina Inc Nukleinsäure-nachweisverfahren mit universellem priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
DE60136335D1 (de) 2000-02-16 2008-12-11 Illumina Inc Parallele genotypisierung mehrerer patientenproben
US7291460B2 (en) * 2002-05-31 2007-11-06 Verenium Corporation Multiplexed systems for nucleic acid sequencing
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
JP4480715B2 (ja) * 2003-01-29 2010-06-16 454 コーポレーション 二重末端シーケンシング
GB0308852D0 (en) * 2003-04-16 2003-05-21 Lingvitae As Method
WO2005010184A1 (ja) * 2003-07-25 2005-02-03 Takara Bio Inc. 変異の検出方法
GB0324456D0 (en) 2003-10-20 2003-11-19 Isis Innovation Parallel DNA sequencing methods
US7622281B2 (en) 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
WO2006084132A2 (en) 2005-02-01 2006-08-10 Agencourt Bioscience Corp. Reagents, methods, and libraries for bead-based squencing
GB0524069D0 (en) 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
DK1987159T4 (da) * 2006-02-08 2020-11-16 Illumina Cambridge Ltd Fremgangsmåde til sekventering af en polynukleotidtemplate
US7951536B2 (en) 2006-02-20 2011-05-31 National University Corporation Hokkaido University Method for determining base sequence of DNA
EP2007907A2 (en) * 2006-04-19 2008-12-31 Applera Corporation Reagents, methods, and libraries for gel-free bead-based sequencing
WO2007146158A1 (en) 2006-06-07 2007-12-21 The Trustees Of Columbia University In The City Of New York Dna sequencing by nanopore using modified nucleotides
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US9121059B2 (en) 2010-12-22 2015-09-01 Genia Technologies, Inc. Nanopore-based single molecule characterization
US9581563B2 (en) 2011-01-24 2017-02-28 Genia Technologies, Inc. System for communicating information from an array of sensors
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
EP2710172B1 (en) * 2011-05-20 2017-03-29 Fluidigm Corporation Nucleic acid encoding reactions
US10501791B2 (en) 2011-10-14 2019-12-10 President And Fellows Of Harvard College Sequencing by structure assembly
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
ES2952728T3 (es) 2011-12-22 2023-11-03 Harvard College Métodos para la detección de analitos
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
CN102766689B (zh) * 2012-04-17 2015-07-22 盛司潼 一种增加测序读长的测序方法
WO2013163263A2 (en) * 2012-04-24 2013-10-31 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
CN108018343B (zh) * 2012-05-10 2023-01-03 通用医疗公司 用于测定核苷酸序列的方法
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
CA2876095A1 (en) 2012-06-15 2013-12-19 Genia Technologies, Inc. Chip set-up and high-accuracy nucleic acid sequencing
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
US10648026B2 (en) 2013-03-15 2020-05-12 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
CA3176690A1 (en) 2013-06-04 2014-12-11 President And Fellows Of Harvard College Rna-guided transcriptional regulation
CN105579592B (zh) * 2013-09-30 2020-12-15 凯杰有限公司 用于制备dna文库的dna接头分子以及生产它们的方法和用途
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
US9322062B2 (en) 2013-10-23 2016-04-26 Genia Technologies, Inc. Process for biosensor well formation
CA2926138A1 (en) 2013-10-23 2015-04-30 Genia Technologies, Inc. High speed molecular sensing with nanopores
WO2016007839A1 (en) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
EP3842544A1 (en) * 2014-09-05 2021-06-30 QIAGEN GmbH Preparation of adapter-ligated amplicons
CN107075513B (zh) 2014-09-12 2020-11-03 深圳华大智造科技有限公司 分离的寡核苷酸及其在核酸测序中的用途
WO2016058136A1 (zh) * 2014-10-14 2016-04-21 深圳华大基因科技有限公司 一种接头元件和使用其构建测序文库的方法
WO2016058517A1 (en) * 2014-10-14 2016-04-21 Bgi Shenzhen Co., Limited Mate pair library construction
US10221448B2 (en) 2015-03-06 2019-03-05 Pillar Biosciences Inc. Selective amplification of overlapping amplicons
US10689690B2 (en) * 2015-08-13 2020-06-23 Centrillion Technology Holdings Corporation Library construction using Y-adapters and vanishing restriction sites
MX2018005611A (es) 2015-11-03 2018-11-09 Harvard College Metodo y aparato para la formacion de imagenes volumetricas de una matriz tridimensional que contiene acido nucleico.
WO2017106777A1 (en) 2015-12-16 2017-06-22 Fluidigm Corporation High-level multiplex amplification
EP3868879A1 (en) * 2016-03-10 2021-08-25 The Board of Trustees of the Leland Stanford Junior University Transposase-mediated imaging of the accessible genome
CN116200465A (zh) 2016-04-25 2023-06-02 哈佛学院董事及会员团体 用于原位分子检测的杂交链反应方法
WO2018013837A1 (en) * 2016-07-15 2018-01-18 The Regents Of The University Of California Methods of producing nucleic acid libraries
WO2018045181A1 (en) 2016-08-31 2018-03-08 President And Fellows Of Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
CN109923216B (zh) 2016-08-31 2024-08-02 哈佛学院董事及会员团体 将生物分子的检测组合到使用荧光原位测序的单个试验的方法
US10550425B2 (en) 2016-11-14 2020-02-04 Agilent Technologies, Inc. Composition and method for improving signal-to-noise in hybridization to oligonucleotide arrays
US11783918B2 (en) 2016-11-30 2023-10-10 Microsoft Technology Licensing, Llc DNA random access storage system via ligation
CA3019250A1 (en) 2017-04-14 2019-10-13 President And Fellows Of Harvard College Methods for generation of cell-derived microfilament network
CN107299151B (zh) * 2017-08-28 2020-06-09 华中农业大学 用于鉴别稻米脂肪酸品质的dna分子标记及其应用
CA3087001A1 (en) 2018-01-12 2019-07-18 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
WO2019152108A1 (en) 2018-02-05 2019-08-08 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for multiplexed measurements in single and ensemble cells
EP3802864A1 (en) 2018-06-06 2021-04-14 The Regents Of The University Of California Methods of producing nucleic acid libraries and compositions and kits for practicing same
CN112770776B (zh) 2018-07-30 2025-08-19 瑞德库尔有限责任公司 用于样品处理或分析的方法和系统
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102785A (en) * 1987-09-28 1992-04-07 E. I. Du Pont De Nemours And Company Method of gene mapping
JPH02299598A (ja) * 1989-04-14 1990-12-11 Ro Inst For Molecular Genetics & Geneteic Res 微視的サイズの別個の粒子と結合している核酸試料中のごく短い配列の全部または一部のオリゴヌクレチドプローブとのハイブリダイゼーションによる決定法
US5650274A (en) * 1993-06-25 1997-07-22 Hitachi, Ltd. DNA analyzing method
GB9401200D0 (en) * 1994-01-21 1994-03-16 Medical Res Council Sequencing of nucleic acids
US5552278A (en) * 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
HUP9900910A2 (hu) * 1995-06-07 1999-07-28 Lynx Therapeutics, Inc. Oligonukleotid jelzések osztályozáshoz és azonosításhoz

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160111947A (ko) * 2014-01-28 2016-09-27 란자테크 뉴질랜드 리미티드 재조합 미생물의 생산 방법
KR102320074B1 (ko) 2014-01-28 2021-11-03 란자테크 뉴질랜드 리미티드 재조합 미생물의 생산 방법
KR20160115938A (ko) * 2014-01-31 2016-10-06 스위프트 바이오사이언시스 인코포레이티드 Dna 기질을 처리하는 개선 방법
KR102321956B1 (ko) * 2014-01-31 2021-11-08 스위프트 바이오사이언시스 인코포레이티드 Dna 기질을 처리하는 개선 방법
KR20210135343A (ko) * 2014-01-31 2021-11-12 스위프트 바이오사이언시스 인코포레이티드 Dna 기질을 처리하는 개선 방법
KR102482592B1 (ko) * 2014-01-31 2022-12-30 인티그레이티드 디엔에이 테크놀로지스 아이엔씨. Dna 기질을 처리하는 개선 방법

Also Published As

Publication number Publication date
HUP0003944A3 (en) 2003-08-28
EP0923650B1 (en) 2007-03-07
AU733782B2 (en) 2001-05-24
CN1230226A (zh) 1999-09-29
NO985698D0 (no) 1998-12-04
ATE356221T1 (de) 2007-03-15
JP2000515006A (ja) 2000-11-14
HUP0003944A2 (en) 2001-03-28
DE69737450D1 (de) 2007-04-19
EP0923650A1 (en) 1999-06-23
HK1021206A1 (en) 2000-06-02
WO1997046704A1 (en) 1997-12-11
CZ397998A3 (cs) 1999-07-14
DE69737450T2 (de) 2007-11-29
CA2256700A1 (en) 1997-12-11
NO985698L (no) 1999-02-08
AU3374097A (en) 1998-01-05
CN1195872C (zh) 2005-04-06
PL331513A1 (en) 1999-07-19

Similar Documents

Publication Publication Date Title
JP4124377B2 (ja) コードアダプターの連結による配列決定
US6013445A (en) Massively parallel signature sequencing by ligation of encoded adaptors
US5888737A (en) Adaptor-based sequence analysis
US5962228A (en) DNA extension and analysis with rolling primers
JP4293634B2 (ja) 分類および同定のためのオリゴヌクレオチドタグ
JP4712822B2 (ja) 分子タグ化システム
US5780231A (en) DNA extension and analysis with rolling primers
US5763175A (en) Simultaneous sequencing of tagged polynucleotides
USRE43097E1 (en) Massively parallel signature sequencing by ligation of encoded adaptors
AU7063898A (en) Characterising dna
CN118434882A (zh) 一种生成标记的核酸分子群的方法及其试剂盒
EP1017847B1 (en) Method of mapping restriction sites in polynucleotides
EP0840803B1 (en) Simultaneous sequencing of tagged polynucleotides
HK1021206B (en) Sequencing by ligation of encoded adaptors
JPH11151092A (ja) ローリングプライマーを用いたdna伸長および分析

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040401

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040401

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060221

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060519

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20080401

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20080327

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20080327

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20080501

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

A72 Notification of change in name of applicant

Free format text: JAPANESE INTERMEDIATE CODE: A721

Effective date: 20080327

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110516

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110516

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120516

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130516

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130516

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term