JP4054431B2 - Non-adsorbent packaging material and non-adsorbent packaging bag - Google Patents

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a packaging material and packaging bag for packaging and storing medicines such as haptics and poultices containing volatile components, foods and fragrances containing a large amount of fragrances.
[0002]
[Prior art]
Conventionally, an acrylonitrile-based resin with little adsorption of medicinal ingredients has been frequently used as the innermost layer (thermoplastic resin) of pharmaceutical packaging materials, particularly haptic packaging materials. Acrylic nitrile resins are superior in that they have little adsorption of medicinal ingredients, but have the following problems in practice.
[0003]
1. Poor flexibility and difficult to take out contents (medicine) from the bag. Further, when the opening is bent after use, it is difficult to bend and difficult to seal.
2. Mounting (thermal bonding) of a polyolefin resin chuck tape (for example, trade name Zip Lock), which is widely used, is virtually impossible and cannot be manufactured.
3. The price is higher than that of general-purpose resins, leading to an increase in drug prices.
[0004]
Conventionally, those using acrylonitrile-based resins cannot be attached with a chuck tape, and there is no method for preserving them other than forcibly bending the openings and fastening them with clips or the like. Some were sold with a zippered bag for storage, but this was not preferable because it took time and effort to move the contents in addition to increasing the cost. It was made of a curable resin and could not be stored for a long time.
[0005]
As described above, the conventional packaging materials have various problems, particularly inconvenient for the elderly, and cannot cope with an aging society.
[0006]
[Problems of the Invention]
SUMMARY OF THE INVENTION An object of the present invention is to provide a packaging material in which an active ingredient contained in a medicine or the like is less adsorbed and a packaging bag on which a chuck tape can be attached.
[0007]
[Means for solving problems]
In order to solve the above problems, in the packaging material of the present invention, an outer surface layer, a barrier intermediate layer, and an inner surface thermal adhesive layer having a coating amount of 0.8 to 3 g / m ² including a modified polyolefin resin are laminated. The laminated body had an oxygen permeability of 1.0 cc / m ² · 24 hours or less, a moisture permeability of 1.0 g / m ² · 24 hours or less, and an ultraviolet transmittance of 0.5% or less.
[0008]
It is preferable that the outer surface layer is formed of a paper having a tear strength of 15 gf or more, a material mainly composed of paper, a synthetic resin film having a thickness of 8 to 50 μm, or a composite thereof.
[0009]
The barrier intermediate layer is preferably formed of at least one of a metal foil layer, a metal vapor deposition layer, an inorganic oxide layer, and a metal oxide layer.
[0010]
When the packaging material as described above is heat-sealed to form a bag, a non-adsorbing packaging bag is formed. When a chuck tape is attached to the inner surface of the opening of the packaging bag, a sealed bag that can be re-sealed is obtained.
[0011]
Embodiment
Embodiments of the present invention will be described below with reference to the accompanying drawings. As shown in FIG. 1, the packaging material 1 includes an outer surface layer 2 that appears on the surface when formed into a bag, a barrier intermediate layer 3, and an inner surface thermal adhesive layer 4.
[0012]
As the outer surface layer 2, paper or a material containing paper as a main component (for example, coated paper), a single synthetic resin film, or a laminate of paper and synthetic resin film is used. Of course, it goes without saying that a printed layer or a colored layer can be provided on the outer or inner surface of the layer 2. When paper or a material mainly composed of paper is used for the outer surface layer 2, the tear strength (JIS P8116) needs to be 15 gf or more, preferably about 20 to 50 gf. If it is less than 15 gf, the strength of the bag body is low, and there is a risk of breakage during handling. The upper limit is not particularly defined but is preferably 70 gf or less. If this value is exceeded, it will be difficult to break by hand when the bag is opened. Specifically, pure white roll paper, coated paper, craft paper, and the like can be used as the paper to be used. When using a resin film, it is good to use resin films, such as an expanded polypropylene resin (henceforth OPP) whose thickness is 8-50 micrometers, a polyester resin, and a nylon resin. When the thickness is less than 8 μm, the strength of the bag body is lowered as in the case of paper, and there is a risk of breakage during handling and transportation. If it exceeds 50 μm, the flexibility of the bag is lost and the cost is increased, which is not preferable. As described above, paper and a resin film may be used in combination with the outer surface layer 2.
[0013]
The intermediate layer 3 located in the middle is required to have a shielding property to prevent ingress of moisture and oxygen, and a sealing property to prevent volatilization / evaporation of chemical volatile components / medicinal components, metal foil layer, metal vapor deposition layer, inorganic oxidation What is necessary is just to use at least 1 sort (s) chosen from a physical layer and a metal oxide layer. In the case of using a metal foil, a metal foil such as aluminum, steel, copper, stainless steel, titanium, tin can be used, but it is preferable to use an aluminum foil of 4 to 50 μm in consideration of cost, weight and hygiene. . If it is less than 4 μm, pinholes and the like are increased, which is not preferable in terms of shielding properties and sealing properties. On the other hand, when the thickness exceeds 50 μm, the cost is increased and flexibility is lost. Metal deposition layer, the inorganic oxide layer and the metal oxide layer, Al, Ag, Ti, Al 2 O 3, can be used SiO _2, TiO _2, etc., in particular Al ₂ O _3, SiO ₂ is preferable. One or more of these may be deposited on the outer surface layer 2 with a thickness of generally 300 to 2000 angstroms. In this case, it is more effective to use a resin film for the outer surface layer 2. Furthermore, in order to completely cut off ultraviolet rays, it is preferable to print a white colored layer containing at least 10% by weight of TiO ₂ , preferably 30 to 50% by weight.
[0014]
The thermal adhesive layer 4 which is the inner side in the case of a bag body may be coated with a resin containing at least 10% by weight of a modified polyolefin resin in a solid content (weight after drying) of 0.8 to 3 g / m ² . Preferably, carboxyl-modified polyethylene (for example, Toray Morton Co., Ltd., Olivevine THS3402) or carboxyl-modified polypropylene (for example, Mitsui Petrochemical Co., Ltd., Unistal 100) may be used. Further, a saturated linear polyester resin (for example, X-PET-37 manufactured by T & K Co., Ltd.) containing 20% by weight of a carboxyl-modified polyolefin resin can be used. When the content of the modified polyolefin resin is less than 10% by weight, the non-adsorption performance is inferior. On the other hand, if the coating amount is less than 0.8 g / m ² , the thermal adhesive force is insufficient and there is a risk of adhesion failure or peeling. If it exceeds 3 g / m ² , the adsorption amount of volatile components and medicinal components may increase, which is not preferable.
[0015]
A known method may be employed for laminating the layers 2, 3, and 4. A lamination method using an extrusion coater, a dry lamination method using a known adhesive, and the like can be employed. Moreover, you may perform use of an anchor coat agent, or a corona discharge process as needed.
[0016]
The performance of the packaging material 1 must be an oxygen permeability of 1.0 cc / m ² · 24 hours or less, a moisture permeability of 1.0 g / m ² · 24 hours or less, and an ultraviolet transmittance of 0.5% or less. . This is because if these values exceed these values, the stored items such as haps and poultices will be deteriorated and the medicinal components will be permeated.
[0017]
If the packaging material 1 obtained by laminating | stacking the said layers 2, 3, and 4 is formed in a bag by heat bonding (heat seal), a non-adsorptive packaging bag can be obtained. The form of the bag is not particularly limited. For example, it can be formed into a known bag shape such as a three-sided (seal portion 11) or four-side sealed flat bag 10 as shown in FIG. 2, a gusset type square bag (not shown), or a self-standing bag having a lower surface. The heat seal temperature is usually about 140 to 240 ° C.
[0018]
When the plastic zipper tape 12 is thermally bonded to the inside of the planned opening (on the side of the bag body) before or before forming the bag, the inside of the bag can be easily resealed. it can. As the chuck tape 12, a polyethylene (hereinafter referred to as PE) chuck tape or a polypropylene (hereinafter referred to as PP) chuck tape can be used.
[0019]
Examples and comparative examples are given below.
[0020]
Example 1 and Comparative Examples 1, 11, 12
In order to produce a pouch for ship agent packaging using a resin extrusion coater, 30 g / m ² of pure white roll paper (manufactured by Mishima Paper Co., Ltd.) and 7μ soft aluminum foil are used with PE resin (thickness after drying 20μ). Extrusion lamination is then performed, and then, using a gravure coloring machine, carboxyl-modified polyethylene (Olivein THS3402 manufactured by Toyo Morton Co., Ltd.) is produced at various coating amounts as shown in FIG. The bag was made into a predetermined size (75 mm × 95 mm) by three-way sealing (210 ° C.) while inserting a PE chuck with a machine.
[0021]
Examples 4 and 7 and Comparative Example 4
In order to produce a pouch for ship agent packaging using a resin extrusion coater, PE resin (thickness 20 μm after drying) with 30 g / m ² pure white roll paper (made by Mishima Paper Co., Ltd.) and 7 μm soft aluminum foil is used. Extrusion lamination is then performed, and then, using a gravure coloring machine, carboxyl-modified polypropylene (Mitsui Petrochemical Co., Ltd., Unistall 100) is produced with various coating amounts as shown in FIG. The bag was made into a predetermined size (75 mm × 95 mm) by three-way sealing (210 ° C.) while inserting a PP chuck with a bag making machine.
[0022]
Examples 2, 3, 5, 6, 8, 9 and Comparative Examples 2, 3, 5, 6, 13-15
In order to produce a pouch for salve using a gravure coloring machine, as shown in FIG. 3, aluminum-deposited 12 μm PET (manufactured by Oike Industry Co., Ltd., aluminum-deposited layer is 600 Å), and silica-deposited 12 μm PET (Oike Industry Co., Ltd.) Company-made, silica-deposited layer is 700 Å), or alumina-deposited 12 μm PET (Toyo Metallizing Co., Ltd., alumina-deposited layer is 1000 Å). Carboxyl-modified polypropylene (Mitsui Petrochemical Co., Ltd., Unistal 100) or polyester resin blended with 20% by weight of carboxyl-modified polyolefin resin (T & K Co., Ltd., abbreviated as X-PET-37 and PET37) Applying with the coating amount shown in FIG. 3, various pouch originals are manufactured, and the originals are sealed in three directions while inserting a PP or PE chuck with a bag making machine, and a predetermined size (75 mm × 95 mm). ).
[0023]
[Comparative Example 7]
Low density polyethylene resin (Sumitomo Chemical Co., Ltd.) using a T-die extruder on one side of 30 g / m ² pure white roll paper (manufactured by Mishima Paper Co., Ltd.) to produce a pouch for shipping agent packaging using a resin extrusion coater. Kogyo Co., Ltd., Sumikasen 705) was extruded and coated (thickness 20 μm after drying), and then, with a gravure coloring machine, carboxyl-modified polyethylene (Olivein THS3402 manufactured by Toyo Morton Co., Ltd.) was shown in FIG. A pouch original fabric was produced at a coating amount, and the original fabric was sealed in a three-way seal (210 ° C.) while inserting a PE chuck with a bag making machine to form a bag with a predetermined size (75 mm × 95 mm).
[0024]
[Comparative Examples 8, 9, 10]
In order to produce a salve pouch using a gravure coloring machine, as shown in FIG. 3, a carboxyl modification is applied to a corona-treated surface of 20 μm PET (manufactured by Teijin Ltd.) or a corona-treated surface of 20 μm OPP (manufactured by Toyobo Co., Ltd.). Polypropylene (Mitsui Petrochemical Co., Ltd., Unistor 100) or PET37 (T & K Co., Ltd., X-PET-37) is applied at the coating amount shown in FIG. The opposite side was sealed in three directions while inserting a PP or PE chuck with a bag making machine, and the bag was made into a predetermined size (75 mm × 95 mm).
[0025]
[Comparative Example 16]
Extrude 30 g / m ² pure white roll paper (manufactured by Mishima Paper Co., Ltd.) and 7 μm soft aluminum foil using PE resin (thickness 20 μ) to produce a pouch for shipping agent packaging using a resin extrusion coater. Lamination is performed, and then a dry laminator is used to apply a two-component reaction type urethane-based dry laminate adhesive (coating amount after drying: 3 to 6 g / m ² ) to the aluminum foil surface, and 20 μm PAN (polyacrylonitrile) A film (manufactured by Tamapoly Co., Ltd.) is pasted and aged in a 40 ° C atmosphere for 72 hours to produce a pouch original fabric, and the original fabric is three-sided sealed (thermal bonding temperature 210 ° C) with a bag making machine. A bag was made to a predetermined size (75 mm x 95 mm) (initially a PP or PE chuck was inserted, but it was broken due to poor adhesion. )
[0026]
[Comparative Example 17]
To produce a salve pouch using a gravure coloring machine, a two-component reaction type urethane-based dry laminating adhesive on a corona-treated surface of 12 μm PET (manufactured by Teijin Limited) (coating amount after drying: 3 to 6 g) / M ² ), 20 μm PAN film (manufactured by Tamapoly Co., Ltd.) is bonded, and aging is performed in an atmosphere of 40 ° C. for 72 hours to produce a pouch original fabric. The bag was sealed (thermal bonding temperature 210 ° C.) and made into a predetermined size (75 mm × 95 mm).
[0027]
[Comparative Examples 18 and 19]
Using a two-stand type resin extrusion coater, PE with 30 g / m ² pure white roll paper (manufactured by Mishima Paper Co., Ltd.) and 7 μm soft aluminum foil was used to produce a pouch for shipping agent packaging. Extrusion lamination is performed using a resin (thickness 20 μm after drying), and then a polyethylene (PE) resin is extruded 20 μm on the aluminum foil surface at the second stand, or an EAA resin (ethylene-acrylic acid copolymer) is extruded 20 μm. A pouch original fabric was manufactured by carrying out the above process, and the original fabric was sealed in three directions while inserting a PE chuck with a bag making machine to produce a bag having a predetermined size (75 mm × 95 mm). In the above Examples and Comparative Examples, when the outer surface layer was a resin film, white coloring ink (containing 33% by weight of TiO ₂ ) was further applied to the outer surface.
[0028]
The following methods were used to evaluate the medicinal components, adsorption amount, barrier properties, thermal adhesiveness, flexible plastic chuck mounting property and cost of each bag product obtained in the above Examples and Comparative Examples. Is shown in FIG.
[0029]
[Adsorption amount of medicinal components]
After inserting 20 Salon Pass A (43 mm x 65 mm) (manufactured by Hisamitsu Pharmaceutical Co., Ltd.) from the opening into the three-side sealed bag-making product (75 mm x 95 mm) of each Example and Comparative Example, the opening was completely heated. After sealing and leaving in an atmosphere of 60 ° C. × 75% relative humidity for one week, the adsorbed amounts of d-camphor, L-menthol and methyl salicylate as bag-making materials were measured with an ion gas chromatograph, and unit area (1 m ² ) To obtain the result of adsorption amount. In addition, as the evaluation, the adsorbent total was 80 mg / m ² or less, and it was judged as acceptable 、, and the others were regarded as unacceptable x.
[0030]
[Weight change rate (residual%) test]
After inserting 20 Salon Pass A (43 mm x 65 mm) (manufactured by Hisamitsu Pharmaceutical Co., Ltd.) from the opening into the three-side sealed bag-making product (75 mm x 95 mm) of each example and comparative example, the opening is completely heat-sealed. Then, the weight change (change per 20 salon passes) after being left in a 60 ° C. atmosphere for one week was measured, and the result was the weight residual ratio (%). In addition, as evaluation, the pass ◎ when the weight residual ratio was 99.0% or more, and the failure X otherwise.
[0031]
[Thermal bonding strength (conforms to JIS Z1707)]
In order to confirm the thermal bonding strength of the inner layer surfaces of the materials of each of the above examples and comparative examples, a lever type heat sealer (manufactured by Toyo Seiki Co., Ltd.) was used, and the inner layer surfaces were thermally bonded based on the following conditions. The strength of the heat-bonded portion was measured and evaluated based on the following conditions using an autograph (manufactured by Shimadzu Corporation). A value of 200 g / 15 mm width or more was regarded as a non-defective product ◎ as the value having no practical problem.
Thermal bonding conditions Thermal bonding strength measurement conditions Thermal bonding temperature: 150 ° C. Peeling angle: 180 degrees Thermal bonding time: 1 second Peeling speed: 200 mm / min
Thermal bonding pressure: 3 kg / cm ² .
[0032]
[Flexibility]
The bag-making materials of the above Examples and Comparative Examples were cut into a flat size of 200 mm × 200 mm, and the flexibility was judged based on the tactile sensation when the flat plate was folded by hand.
A: Can be easily folded.
○: Can be folded with some squeezing.
X: Since it repels and returns, it is difficult to fold.
[0033]
[Thermal adhesive cost]
The cost of the material of each of the above Examples and Comparative Examples was evaluated based on the following index.
◎: Low price ○: Moderate ×: Expensive
[0034]
[Attachability of chuck tape]
The attachment performance of the chuck tape was evaluated by manually peeling the adhesiveness between the respective chuck tapes of the bag-made products of the above Examples and Comparative Examples and the bag body.
A: Good adhesion (cannot be easily removed by hand)
X: Adhesion is impossible (it peels easily by hand).
[0035]
[Oxygen permeability]
According to ASTM D3985-81 isobaric method.
[0036]
[Moisture permeability]
According to JIS Z0208 cup method.
[0037]
[UV transmittance]
The ultraviolet light shielding rate of each packaging material was measured with a spectrophotometer (manufactured by Shimadzu Corporation, MP-5000).
[0038]
From the results shown in FIGS. 4 and 5, the packaging material of the present invention is excellent in all points of non-adsorption property, thermal adhesive strength, flexibility, cost, chuck mounting property, barrier property, and light shielding property. It turns out that it is suitable for a packaging bag.
[0039]
【The invention's effect】
While conventional non-adsorbing packaging materials have good non-adsorbing performance, they are expensive, have poor flexibility as packaging materials, and cannot be fitted with plastic chucks, but have limited usage. In addition, the non-adsorbing packaging material of the present invention is particularly better in the non-adsorbing performance than the conventional product, and at the same time, the cost is lower than that of the conventional non-adsorbing packaging material, the flexibility as a bag, and the thermal adhesive strength is practical. It possesses performance without problems and can be mounted with a plastic chuck, making it extremely useful as a non-adsorbing packaging material.
[Brief description of the drawings]
FIG. 1 is a cross-sectional view showing an example of a packaging material according to the present invention. FIG. 2 is a front view showing an example of a packaging bag according to the present invention. 4] Table showing test results [Figure 5] Table showing test results [Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Packaging material 2 Outer surface layer 3 Barrier property intermediate layer 4 Inner surface heat bonding layer 10 Packaging bag 11 Sealing part 12 Chuck tape

Claims (6)

An outer surface layer, a barrier intermediate layer, and an inner surface thermal adhesive layer having a coating amount of 0.8 to 3 g / m ² containing a modified polyolefin resin are laminated, and the oxygen permeability is 1.0 cc / m ² · 24 hours or less, A non-adsorbing packaging material having a moisture permeability of 1.0 g / m ² · 24 hours or less and an ultraviolet transmittance of 0.5% or less. Paper having a tear strength of 15 gf or more as a main component, a synthetic resin film having a thickness of 8 to 50 μm, a composite of the material having the paper or paper as a main component and the synthetic resin film. The non-adsorbent packaging material according to claim 1, which is any one of the above. The non-adsorptive packaging material according to claim 1 or 2, wherein the barrier intermediate layer comprises at least one selected from a metal foil layer, a metal vapor deposition layer, an inorganic oxide layer, and a metal oxide layer. The non-adsorbing packaging material according to claim 1, wherein a white colored layer containing at least TiO ₂ is laminated on the outer surface layer. A non-adsorptive packaging bag in which the non-adsorptive packaging material according to claim 1 is formed on a bag body by heat sealing. The non-adsorptive packaging bag according to claim 5, wherein a zipper tape made of synthetic resin is attached to the inner surface of the opening of the bag body.

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