JP4774724B2 - Package - Google Patents

Description

The present invention, surface writability, waist (rigidity), the light-shielding property, relates follicle Sokarada you comprising a barrier property, it relates to follicle Sokarada that can suitably used in particular as a patch.

  In general, the packaging material used for packaging pharmaceuticals suppresses the alteration of the active ingredients in the contents, and in order to maintain the efficacy, oxygen, water vapor, and other gases that alter the contents are permeated through the packaging materials. It is necessary to prevent the influence, and it is required to have a gas barrier property that blocks these gases.

  For example, a vapor deposition layer made of an inorganic compound is provided on a polymer resin substrate, and a water-soluble polymer and (a) one or more alkoxides and / or a hydrolyzate thereof or (b) tin chloride are formed on the inorganic vapor deposition layer. A gas barrier laminate film for obtaining a high barrier property by applying a coating agent mainly containing an aqueous solution containing at least one of the above or a water / alcohol mixed solution, followed by drying by heating, and a laminate thereof A packaging material using a film (see, for example, Patent Document 1) has been proposed. However, in this proposal, there is an example of an aluminum oxide vapor deposition film, but the formation on the metal aluminum vapor deposition film is not mentioned. Further, this patent relates to a polymer resin film and does not touch paper.

  Next, regarding a technique for providing a metal vapor deposition layer such as aluminum on paper and imparting a barrier property, a paper wrapping material having good moisture resistance and oxygen barrier property (for example, see Patent Document 2) has been proposed. However, in this proposal, an aqueous solution containing at least one of a water-soluble polymer and (a) one or more alkoxides and / or a hydrolyzate thereof or (b) tin chloride in the metal deposition layer, or water / alcohol There is no mention of forming a gas barrier film formed by applying a coating agent containing a mixed solution as a main component and drying by heating.

Prior art documents are shown below.
Japanese Patent No. 2790054 JP 2002-321307 A

  In particular, as packaging materials for patches such as anti-inflammatory / analgesic patches, taking into account surface writing properties, waist (rigidity), light-shielding properties, and barrier properties, conventionally, for example, “paper / low density polyethylene (LDPE) / aluminum Packaging bags made of “foil / low density polyethylene (LDPE)” are used. However, in recent years, various problems have been pointed out for packaging materials made of a laminate in which aluminum foils are laminated. For example, when incineration processing is performed in disposal after use, problems with so-called disposal such as problems that the aluminum foil remains as a residue and problems that may damage the incinerator have occurred. . In addition, there is a demand for recycling of packaging materials after use in response to a request for resource reuse, and it is desired to separate and reuse them by material. However, in packaging materials that use aluminum foil as described above, paper substrates, aluminum It is extremely difficult to separate and collect materials such as foil and resin film, and it is practically impossible to reuse them.

The present invention is intended to solve the problems of the prior art, in particular so that it can be suitably used as a patch for agents such as anti-inflammatory, analgesic cataplasm, surface writability, waist (rigidity) , and to provide a light shielding property, excellent packaging Sokarada in conjunction with environmental comprises a barrier property.

The present invention has been made to solve the above-mentioned problems. The invention according to claim 1 of the present invention includes at least a paper layer, a metal-deposited thin film layer, a water-soluble polymer, and (a) 1. Gas barrier properties obtained by applying a coating agent mainly composed of an aqueous solution containing at least one of alkoxides of at least one species and / or a hydrolyzate thereof or (b) tin chloride, or a water / alcohol mixed solution, followed by drying by heating. sequentially laminating a coating layer, further a polyester sealant material and an ethylene - using vinyl alcohol copolymer (EVOH) based heat-sealable resin layer provided was wrapped wearing laminate comprising a sealant material, the unsealing mouth seal portion A packaging bag with resealing means made of polychuck or adhesive tape, with active ingredients ketoprofen, flurbibrofen, indomethacin, ferbina A package which is characterized in that a sealed patch containing any one or more.

The invention according to claim 2 of the present invention, in the package of claim 1, wherein the metallized thin film layer (2) is a package which is characterized in that it consists of aluminum.

The invention according to claim 3 of the present invention, in the package of claim 1 or 2, wherein the packaging body, wherein the paper to form the paper layer (1) is a basis weight of 30~300g / m ² It is.

The package according to the present invention includes at least one of a paper layer, a metal-deposited thin film layer, a water-soluble polymer, (a) one or more alkoxides and / or hydrolysates thereof, and (b) tin chloride. Surface coating by applying a coating agent mainly composed of an aqueous solution containing water or a water / alcohol mixed solution, successively laminating a gas barrier coating layer formed by heating and drying, and further providing a heat-bondable resin layer. , Waist (rigidity), light-shielding properties, barrier properties, and environmental friendliness. Further, the packaging body can be stored for a long time without deteriorating contents such as pharmaceuticals by providing a resealing means comprising a polychuck or an adhesive tape at the opening seal part. Further 該包 Sokarada suppresses deterioration of the active ingredient in the adhesive patch can be maintained efficacy, it is easy disposal after use.

  An embodiment of the present invention will be described in detail with reference to FIGS.

FIG. 1 is a side sectional view showing an embodiment of a layer structure of a packaging laminate (A) according to the present invention, and FIG. 2 shows an opening seal part (10) of a packaging bag (B) according to the present invention. It is a top view which shows one Example of the state which provided the resealing means (11), FIG. 3 provides resealing means (11) in the opening seal part (10) of the packaging bag (B) based on this invention. FIG. 4 is a plan view showing an embodiment of the package (C) according to the present invention.

  As shown in FIG. 1, the laminate (A) for packaging according to the present invention comprises at least a paper layer (1), a metal-deposited thin film layer (2), a water-soluble polymer, and (a) one or more alkoxides. Or / and a hydrolyzate thereof; or (b) a gas barrier coating layer (3) obtained by applying a coating agent mainly containing an aqueous solution containing at least one of tin chloride or a water / alcohol mixed solution, followed by heating and drying. ), And a resin layer (4) that can be heat-sealed.

Paper for forming the paper layer (1) is bleached kraft paper, pure white roll paper, fine paper, art paper manufactured from pulp in which cellulose is extracted by chemically or mechanically treating plant materials such as wood. Coated paper can be used. It is preferable that the basic weight in that case is 30-300 g / m < ² >. If the basis weight is smaller than this, sufficient waist (rigidity) and strength required for the packaging bag (B) cannot be obtained. Moreover, when larger than this, it is inferior to the handleability as a packaging bag (B).

  The metal forming the metal-deposited thin film layer (2) is not particularly limited as long as it is a metal that can be used for vapor deposition, such as aluminum, nickel, and chromium, but aluminum is preferable in consideration of cost and the like.

  As a method for forming such a metal vapor-deposited thin film layer (2), a vacuum vapor deposition method, a sputtering method or the like can be used. However, in consideration of productivity, the vacuum vapor deposition method is preferable.

  There are three types of vacuum deposition methods depending on the form of the body to be deposited: 1) Batch method: Molded product deposition method, 2) Rewinding type semi-continuous method: roll paper or plastic film (hereinafter referred to as web) 3) Rewinding type complete continuous method: Unrolling the roll web. A winder (unwinding device) and a rewinder (winding device) are arranged in an atmospheric system, and a vapor deposition drum and an evaporation source are arranged in a vacuum system to deposit an evaporating substance on a roll-shaped web. This is a completely continuous method called an air-to-air method, which is characterized by high productivity.

  When evaporating evaporated material on a roll-shaped web, the take-up semi-continuous method is particularly popular, and the components of the take-up vacuum deposition device and the outline of the work process, as well as the internal structure of the vacuum deposition device Describe. First, the constituent elements are a roll-shaped web, an evaporation source, an evaporation substance, a vapor deposition drum, a vacuum system, an unwinder (unwinding device), a rewinder (winding device), a guide roll, and the like.

Next, the outline of the work process will be described. First, as a preparation, the door of the vacuum vapor deposition device is opened, the roll-shaped web is set in the unwinder (unwinding device), and the guide disposed between the unwinder and the vapor deposition drum. The web is caused to travel to the vapor deposition drum through a roll, and is further wound around a rewinder (winding device) via a guide roll disposed between the rewinder (winding device) and evaporated onto the web. Preparation for material deposition is completed. Next, the door of the vacuum deposition apparatus is closed, and the vacuum suction chamber in the vacuum deposition apparatus and the vacuum deposition chamber divided by the partition walls are set to a predetermined vacuum environment by a vacuum pump, and the web is unwound from the unwinder. The evaporating substance is evaporated on the web by evaporating the evaporating substance from the evaporation source disposed at the lower part of the evaporating drum on the web that has been run through the guide roll. Since the vapor deposition drum is cooled, the vaporized substance is recrystallized and fixed on the web, and the vapor deposited on the rewinder side guide roll is wound around the rewinder.

The internal structure of the vacuum deposition apparatus is divided into a vacuum suction constant pressure chamber and a vacuum deposition chamber by partition walls. The vacuum suction constant pressure chamber is composed of an unwinder, guide roll, tension control device, speed control device, position control device, and vapor deposition drum. Some rewinders are arranged. In the vacuum deposition chamber, a part of the deposition drum, the evaporation source, its heating device, and the like are arranged, and for example, the vacuum suction constant pressure chamber has a degree of vacuum by a vacuum pump arranged around the vacuum deposition device body. Is about 1 × 10 ⁰ MPa, and the vacuum deposition chamber provided through the partition is set to about 1 × 10 ⁻² MPa (SI unit). Since the two chambers are divided by the partition walls, impurities (dust) such as gas generated from the web in the vacuum suction constant pressure chamber are unlikely to adversely affect the deposition in the vacuum deposition chamber. On the contrary, the radiant heat from the evaporation source arranged in the vacuum deposition chamber has little influence on the vacuum suction constant pressure chamber, so that the influence of the heat on the web is small.

  In addition, the vacuum deposition method is also a heating method: 1) indirect resistance method, 2) direct resistance heating method (wire feed method), 3) high-frequency induction heating method, 4) electron beam method (EB method for short) The electron beam method with high energy conversion efficiency that can be used for refractory metals other than aluminum, insulating metal oxides, and the like is the most suitable. The wound-up electron beam vacuum deposition method is a method in which the evaporative material is directly irradiated with an electron beam and scanned on the surface of the evaporative material, and the surface of the evaporative material is heated. And evaporating the evaporated substance.

  Although the thickness of this metal vapor deposition thin film layer (2) is suitably selected by the end use of vapor deposition paper, it is preferable to exist in the range of 20-200 nm. If the film thickness is less than 20 nm, a uniform film cannot be provided, so that sufficient gas barrier properties and light shielding properties cannot be obtained. If the film thickness exceeds 200 nm, flexibility is lost, and due to external factors such as bending and tension, Since it becomes easy to generate | occur | produce a crack and peeling in a vapor deposition film, it is not preferable.

  In addition, when a sealing layer (not shown) is provided on the vapor deposition surface side of the paper layer (1), the paper layer (1) surface becomes smooth and the suitability for forming the metal vapor deposition thin film layer (2) is improved. To do. As the sealing agent (anchor coating agent) for forming the sealing layer, a thermosetting resin such as amino alkyd or an acrylic resin is used.

  The gas barrier coating layer (3) is an aqueous solution containing at least one of a water-soluble polymer and (a) an alkoxide such as one or more metals or / and a hydrolyzate thereof, or (b) tin chloride, or It consists of a coating agent mainly composed of a water / alcohol mixed solution.

  That is, a solution in which a water-soluble polymer and tin chloride are dissolved in an aqueous (water or water / alcohol mixed) solvent, or a solution in which an alkoxide such as a metal is directly or previously hydrolyzed is mixed. When a gas barrier film layer (3) formed by applying a solution onto the metal vapor-deposited thin film layer (2) and heating and drying is provided, pinholes, cracks, grain boundaries, etc. generated in the metal vapor-deposited thin film layer (2) By filling and reinforcing defects or micropores, a dense structure is formed, so that the gas barrier property is further improved and volatilization of the active ingredient of the happing agent, which is a packaged body, can be prevented. In addition, the flexibility is improved so that it can withstand deformation.

  Next, each component contained in the coating agent will be described in detail below. Examples of the water-soluble polymer include polyvinyl alcohol (PVA), polyvinyl pyrrolidone, starch, methyl cellulose, carboxymethyl cellulose, and sodium alginate. In particular, polyvinyl alcohol (PVA) is preferable because of its excellent gas barrier properties. The polyvinyl alcohol (PVA) here is generally obtained by saponifying polyvinyl acetate.

  Examples of the polyvinyl alcohol (PVA) include fully saponified polyvinyl alcohol (PVA) in which only a few percent of acetic acid groups remain from so-called partially saponified polyvinyl alcohol (PVA) in which several tens of percent of acetate groups remain. There is no particular limitation.

The alkoxide is an alkoxide such as a metal. Represented by a general formula, M (OR) n (wherein M: a metal element such as Si, Zr, Ti, and Al, R: an alkyl group such as CH ₃ and C ₂ H ₅ , n: an oxidation number of the metal element) For example, an alkoxysilane compound, a zirconium alkoxide compound, a titanium alkoxide compound, an aluminum alkoxide compound, and the like can be used.

Specifically, tetramethoxysilane [Si (O—CH ₃ ) ₄ ], tetraethoxysilane [Si (O—C ₂ H ₅ ) ₄ ], tetraisopropoxysilane [Si (O—iso—C ₃ H _{7). 4} ], tetrabutoxysilane [Si (O—C ₄ H ₉ ) ₄ ], dimethyldimethoxysilane [(H ₃ C) ₂ Si (O—CH ₃ ) ₂ ], trimethoxymethylsilane [H ₃ CSi (O -CH _{3) 3],} dimethyldiethoxysilane _{[(H 3 C) 2 Si} (O-C 2 H 5) 2] alkoxysilane compounds such as tetramethoxysilane zirconium _{[Zr (O-CH 3)} 4], tetra Ethoxyzirconium [Zr (O—C ₂ H ₅ ) ₄ ], tetraisopropoxyzirconium [Zr (O-iso-C ₃ H ₇ ) ₄ ], tetrabutoxyzirconium [Zr (O—C ₄ H ₉ ) ₄ ] and the like Zirconi Arm alkoxide compounds, tetramethoxysilane titanium _{[Ti (O-CH 3)} 4], tetraethoxysilane titanium _{[Ti (O-C 2 H} 5) 4], tetraisopropoxy titanium [Ti (O-iso-C 3 H 7) ₄ ], titanium alkoxide compounds such as tetrabutoxy titanium [Ti (O—C ₄ H ₉ ) ₄ ], trimethoxy aluminum [Al (O—CH ₃ ) ₃ ], triethoxy aluminum [Al (O—C ₂ H _5). ) _3], triisopropoxyaluminum [Al (O-iso-C 3 H 7) 3], tributoxy aluminum _{[Al (O-C 4 H} 9) 3] and the like of aluminum alkoxide compounds such as. Among these, tetraethoxysilane, triisopropoxyaluminum, and the like that are relatively stable in an aqueous solvent after hydrolysis are preferable.

  The tin chloride is stannous chloride, stannic chloride, or a mixture thereof, and anhydrides and hydrates of these tin chlorides can also be used.

  Each of the aforementioned components can be added to the coating agent alone or in combination, and further within the range that does not impair the gas barrier properties of the coating agent, the isocyanate compound, silane coupling agent, or dispersant, stabilizer, viscosity. Known additives such as a regulator and a colorant can be added as necessary.

  For example, the isocyanate compound added to the coating agent has two or more isocyanate groups (NCO groups) in the molecule, such as tolylene diisocyanate, triphenylmethane triisocyanate, tetramethylxylene diisocyanate, etc. Monomers and their polymers and derivatives are exemplified.

  The coating agent is formed on the metal vapor-deposited thin film layer (2) by applying a known method such as a gravure roll coating method, reverse roll coating method, air knife coating method, etc., followed by heating and drying. In this case, the thickness of the gas barrier coating layer (3) is preferably in the range of 0.01 to 50 μm after drying. When the thickness is 0.01 μm or less, sufficient gas barrier properties cannot be obtained, and when the thickness is 50 μm or more, the coating film is liable to crack and adversely affects the gas barrier properties.

Next, the heat-sealable resin layer (4) is not particularly limited, and examples thereof include polyolefin resins such as low density polyethylene (LDPE), medium density polyethylene (MDPE), and high density polyethylene (HDPE). Linear low density polyethylene (L-LDPE), unstretched polypropylene (CPP), ethylene-vinyl acetate copolymer (EVA), ionomer, cyclic polyolefin, and the like can be used. Furthermore, when a polyester sealant material or an ethylene-vinyl alcohol copolymer (EVOH) sealant material is used, it is possible to prevent adsorption of a permeable component in a patch such as menthol to the sealant material. The thickness of the resin layer (4) is preferably in the range of 15 to 200 μm, more preferably in the range of 30 to 60 μm, considering the strength and workability.

  As a method of forming the resin layer (4) on the gas barrier coating layer (3), for example, a known method such as an extrusion lamination method, a dry lamination method, a non-solvent dry lamination method, or a hot melt lamination method is used. can do.

  The extrusion lamination method involves heating a thermoplastic resin such as polyethylene or polypropylene, melting it in a cylinder called a cylinder, extruding it by applying pressure with a screw, and forming a narrow slit called a T die at the tip of the cylinder. The resin melted in the form of a curtain is extruded and laminated into a film.

  The dry lamination method is composed of three sections: a coating part for applying an adhesive on a body to be laminated, a drying device, and a nip roller part, and an unwinding, winding and tension control system. The coating portion generally employs a gravure roll coating method or a reverse roll coating method.

  The lamination adhesive may be a polyurethane, polyester, epoxy, polyacryl, polyvinyl acetate, cellulose, or other laminate adhesive. As the adhesive, a solvent type adhesive or a solventless type adhesive is used, but when a solventless type adhesive is used, a drying device is not necessary, and this is called a non-solvent dry lamination method. .

  The hot-melt lamination method is a method in which a hot-melt adhesive such as an ethylene-vinyl acetate copolymer (EVA) melted by heating is applied onto a laminated body, and another film is immediately laminated.

  In the packaging laminate (A) of the present invention, a printed layer (not shown) can be provided on the paper layer (1). As the printing ink for forming the printing layer, a color material composed of a pigment or a dye that gives color to the ink, a resin that adheres to the printing medium while dispersing and holding the color material in fine particles, and the resin are used. A vehicle composed of a solvent that can stably dissolve, disperse the pigments and dyes, maintain the fluidity of the ink, and transfer an appropriate amount of ink from the printing plate, and further disperse the coloring material. The pigment is formed from an auxiliary agent such as a surfactant for the purpose of improving color development, preventing precipitation, and improving fluidity. In particular, the colorant is preferably a pigment having good weather resistance.

  As a printing method for providing the printing layer, for example, a known printing method such as a gravure printing method, a silk screen printing method, a flexographic printing method, and an offset printing method can be used, but copper plating is performed on the surface of an iron cylinder (cylinder). Forming a base, providing a release layer on the copper-plated surface, further copper-plating, and creating a recess (cell) by engraving or corrosion method on the polished copper surface of the surface, A gravure printing method in which the printing ink in the cell is transferred to the paper layer (1) and can be printed in a colorful manner and has a high appealing effect is preferable.

The packaging laminate (A) described above is formed into a bag by heat fusion using a sealing method such as heat sealing, and the packaging bag (B) according to the present invention is obtained. As shown in FIGS. 2 and 3, the packaging bag (B) includes a reseal means (11) comprising a polychuck (11a) or an adhesive tape (11b) at the opening seal part (10). (B).

  These packaging bags (B) are filled and packaged with a patch (12) containing any one or more of ketoprofen, flurbibrofen, indomethacin, and felbinac as active ingredients, and as shown in FIG. A package (C) is obtained.

  As described above, the packaging laminate (A) according to the present invention comprises at least a paper layer (1), a metal-deposited thin film layer (2), a water-soluble polymer, and (a) one or more alkoxides or / And a hydrolyzate thereof or (b) an aqueous solution containing at least one of tin chloride, or a coating agent mainly comprising a water / alcohol mixed solution, and a gas barrier coating layer (3) formed by heating and drying. By sequentially laminating and further providing a heat-sealable resin layer (4), it has surface writing properties, waist (rigidity), light shielding properties, barrier properties, and environmental friendliness. Moreover, the packaging bag (B) using this laminated body for packaging (A) is provided with resealing means (11) comprising a polychuck (11a) or an adhesive tape (11b) at the opening seal part (10). Thus, long-term storage is possible without deteriorating the contents of medicines and the like. Further, the package (C) in which the patch (12) is sealed using the packaging bag (B) can suppress the alteration of the active ingredient of the patch (12) and maintain its efficacy. Is easy to dispose of.

  Hereinafter, the laminate for packaging according to the present invention, the packaging bag using the same, and the packaging body using the same will be described in more detail with specific examples.

As shown in FIG. 1, the laminate (A) for packaging according to the present invention uses bleached kraft paper having a basis weight of 84.9 g / m ² for the outermost paper layer (1), and the paper layer (1) An acrylic resin was applied as a sealing layer (not shown) on the top. On the sealing layer, metal aluminum was vapor-deposited by an electron beam method (electron beam heating method) vacuum vapor deposition apparatus, and a metal vapor-deposited thin film layer (2) having a thickness of about 40 nm was laminated. Next, 89.6 g of 0.1N-hydrochloric acid was added to 10.4 g of tetraethoxysilane, stirred for 30 minutes, and hydrolyzed with a hydrolyzed solution having a solid content of 3.0% by weight (in terms of SiO ₂ ) and polyvinyl alcohol ( A coating agent having a composition in which a 3.0 wt% water / isopropyl alcohol (90/10) solution of PVA) was mixed at a blending ratio (wt%) of 60/40 was applied by a gravure roll coating method, and 120 wt. A gas barrier coating layer (3) having a thickness of about 0.3 μm was laminated by drying at 1 ° C. for 1 minute. Subsequently, 3.5 g / m ² (solid content) of polyurethane adhesive (A525 / A52 manufactured by Mitsui Takeda Chemical Co., Ltd.) was applied on the gas barrier coating layer (3), and an adhesive layer (not shown) was applied. The innermost resin layer (4) serving as a sealing surface is provided through the adhesive layer, and a 50 μm-thick linear low density polyethylene film (L-LDPE) (LX-711C manufactured by Idemitsu Unitech Co., Ltd.) Was laminated by a dry lamination method to obtain a laminate (A) for packaging.

  Next, the packaging laminate (A) obtained by slitting the roll-shaped packaging laminate (A) into a predetermined width using a slitter is sealed in a four-way final product form by a heat seal method. A bag that can be resealed by attaching a polychuck (11a) to an opening seal part (10) as shown in FIG. B) was obtained.

  The packaging bag (B) was filled with a sheet-like patch (12) containing ketoprofen as an active ingredient and packaged to obtain a package (C) containing the patch (12) as shown in FIG. .

The thus obtained packaging laminate (A) according to the present invention has a good surface writing property because the surface on which characters and the like are written is a paper surface, and uses thick paper. ), And the metal-deposited thin film layer (2) and the gas barrier film layer (3) were excellent in light shielding properties and oxygen barrier properties. Further, the packaging bag (B) using the laminate for packaging (A) has a resealing means (11) comprising a polychuck (11a) at the opening seal part (10), so Long-term storage is possible without deterioration. Further, the package (C) containing the patch (12) using the packaging bag (B) can suppress the volatilization and alteration of ketoprofen, which is an active ingredient of the patch (12), and maintain its efficacy. did it. Also, disposal after use was easy.

As shown in FIG. 1, the laminate (A) for packaging according to the present invention uses pure white roll paper having a basis weight of 104.7 g / m ² for the outermost paper layer (1). (1) An acrylic resin was applied as a sealing layer (not shown) on the top. Metal aluminum was vapor-deposited on the sealing layer by an electron beam method (electron beam heating method) vacuum vapor deposition apparatus, and a metal vapor-deposited thin film layer (2) having a thickness of about 50 nm was laminated. Next, 89.6 g of 0.1N-hydrochloric acid was added to 10.4 g of tetraethoxysilane, stirred for 30 minutes, and hydrolyzed with a hydrolyzed solution having a solid content of 3.0% by weight (in terms of SiO ₂ ) and first chloride. Tin (anhydride) 3.0 wt% water / ethanol solution (water: ethanol weight ratio 50:50) and polyvinyl alcohol (PVA) 3.0 wt% water / isopropyl alcohol (water / isopropyl alcohol weight) A coating agent comprising a composition obtained by mixing a 90/10) solution at a blending ratio (wt%) of 40/30/30 was applied by a gravure roll coating method, dried at 120 ° C. for 1 minute in a dryer, and a film thickness of about A 0.3 μm gas barrier coating layer (3) was laminated. Subsequently, 3.5 g / m ² (solid content) of polyurethane adhesive (A525 / A52 manufactured by Mitsui Takeda Chemical Co., Ltd.) was applied on the gas barrier coating layer (3), and an adhesive layer (not shown) was applied. The innermost resin layer (4) serving as a sealing surface is provided through the adhesive layer, and a 50 μm-thick linear low density polyethylene film (L-LDPE) (LX-711C manufactured by Idemitsu Unitech Co., Ltd.) Was laminated by a dry lamination method to obtain a laminate (A) for packaging.

  Next, the packaging laminate (A) obtained by slitting the roll-shaped packaging laminate (A) into a predetermined width using a slitter is sealed in a four-way final product form by a heat seal method. A bag that can be resealed by attaching an adhesive tape (11b) to the opening seal part (10) as shown in FIG. B) was obtained.

  The packaging bag (B) is filled with and packed with a sheet-like patch (12) containing ketoprofen and flurbibrofen as active ingredients, and a package (C) containing the patch (12) as shown in FIG. )

  The thus obtained packaging laminate (A) according to the present invention has a good surface writing property because the surface on which characters and the like are written is a paper surface, and uses thick paper. ), And the metal-deposited thin film layer (2) and the gas barrier film layer (3) were excellent in light shielding properties and oxygen barrier properties. Moreover, since the packaging bag (B) using this laminated body (A) is equipped with the re-sealing means (11) which consists of an adhesive tape (11b) in the opening seal part (10), the contents are Long-term storage is possible without deterioration. Furthermore, the packaging body (C) containing the patch (12) using the packaging bag (B) is effective in suppressing volatilization and alteration of ketoprofen and flurbibrofen, which are the active ingredients of the patch (12). Could be maintained. Also, disposal after use was easy.

It is a sectional side view which shows one Example of the laminated constitution of the laminated body for packaging which concerns on this invention. It is a top view which shows one Example of the state which provided the re-sealing means in the opening seal part of the packaging bag which concerns on this invention. It is a top view which shows the other Example of the state which provided the re-sealing means in the opening opening seal part of the packaging bag which concerns on this invention. It is a top view which shows one Example of the package which concerns on this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Paper layer 2 ... Metal vapor deposition thin film layer 3 ... Gas barrier coating layer 4 ... Resin layer 10 ... Opening seal part 11 ... Resealing means 11a ... Poly chuck 11b ... Adhesive tape 12 ... Patch A ... Packaging laminate B ... Packing bag C ... Packaging body

Claims (3)

An aqueous solution containing at least one of at least one of a paper layer, a metal-deposited thin film layer, a water-soluble polymer, (a) one or more alkoxides and / or hydrolysates thereof, and (b) tin chloride, or water / A gas barrier coating layer is formed by applying a coating agent mainly composed of an alcohol mixed solution, followed by heating and drying, and then heat fusion comprising a polyester sealant material or an ethylene-vinyl alcohol copolymer (EVOH) sealant material. using the packaging wearing laminate having a wear resin material layer, in a packaging bag provided with the re-sealing means comprising poly chuck or adhesive tape unsealing mouth sealing portion, ketoprofen as an active ingredient, Flour Vibro Fen, indomethacin, the felbinac A package characterized by sealing a patch containing any one or more of them . The package according to claim 1, wherein the metal-deposited thin film layer is made of aluminum. Package of claim 1 or 2, wherein the paper forming the paper layer is a basis weight of 30~300g / ^{m 2.}

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