JP4009671B2 - 不連続向流クロマトグラフィーの方法および装置 - Google Patents

不連続向流クロマトグラフィーの方法および装置 Download PDF

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JP4009671B2
JP4009671B2 JP52010597A JP52010597A JP4009671B2 JP 4009671 B2 JP4009671 B2 JP 4009671B2 JP 52010597 A JP52010597 A JP 52010597A JP 52010597 A JP52010597 A JP 52010597A JP 4009671 B2 JP4009671 B2 JP 4009671B2
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pump
sample
chromatography
solvent
cycle
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JP2000503112A (ja
JP2000503112A5 (cg-RX-API-DMAC7.html
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グリル，エム．チャールズ
ハンプトン，ダブリュ．トーマス
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ノヴァセップ
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/44—Flow patterns using recycling of the fraction to be distributed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1857—Reactive simulated moving beds

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sustainable Development (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
JP52010597A 1995-11-30 1996-11-12 不連続向流クロマトグラフィーの方法および装置 Expired - Fee Related JP4009671B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/566,425 1995-11-30
US08/566,425 US5630943A (en) 1995-11-30 1995-11-30 Discontinuous countercurrent chromatographic process and apparatus
PCT/EP1996/004937 WO1997020206A1 (en) 1995-11-30 1996-11-12 Discontinuous countercurrent chromatographic process and apparatus

Publications (3)

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JP2000503112A JP2000503112A (ja) 2000-03-14
JP2000503112A5 JP2000503112A5 (cg-RX-API-DMAC7.html) 2004-10-28
JP4009671B2 true JP4009671B2 (ja) 2007-11-21

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US (1) US5630943A (cg-RX-API-DMAC7.html)
EP (1) EP0877936B1 (cg-RX-API-DMAC7.html)
JP (1) JP4009671B2 (cg-RX-API-DMAC7.html)
CA (1) CA2238954A1 (cg-RX-API-DMAC7.html)
DE (1) DE69631903T2 (cg-RX-API-DMAC7.html)
WO (1) WO1997020206A1 (cg-RX-API-DMAC7.html)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063284A (en) * 1997-05-15 2000-05-16 Em Industries, Inc. Single column closed-loop recycling with periodic intra-profile injection
JPH1190106A (ja) * 1997-09-26 1999-04-06 Daicel Chem Ind Ltd 擬似移動床式クロマト分離装置
DK1073618T3 (da) * 1998-05-01 2004-03-15 Pfizer Prod Inc Fremgangsmåde til fremstilling af enantiomerisk ren eller optisk beriget sertralin-tetralon under anvendelse af kontinuerlig kromatografi
US6136197A (en) * 1998-05-27 2000-10-24 Battelle Memorial Institute Systems for column-based separations, methods of forming packed columns, and methods of purifying sample components
FR2781860B1 (fr) * 1998-07-31 2000-09-01 Inst Francais Du Petrole Systeme de mise en communication alternee d'au moins quatre fluides et son application dans un procede de separation en lit mobile simule
DE19858892A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
AU2986400A (en) * 1999-02-08 2000-08-25 Admetric Biochem Inc. Chromatographic system with pre-detector eluent switching
ATE419911T1 (de) 1999-04-23 2009-01-15 Advion Biosystems Inc Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz
JP4176240B2 (ja) * 1999-07-02 2008-11-05 オルガノ株式会社 クロマト分離装置
FR2809490B1 (fr) * 2000-05-23 2002-11-29 Hocer Installation et procede pour la preparation automatique d'echantillons
JP3476417B2 (ja) * 2000-06-05 2003-12-10 株式会社島津製作所 液体クロマトグラフによる分析方法
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
US6812030B2 (en) * 2001-04-25 2004-11-02 Biotrove, Inc. System and method for high throughput sample preparation and analysis using column chromatography
US8414774B2 (en) * 2001-04-25 2013-04-09 Agilent Technologies, Inc. Systems and methods for high-throughput screening of fluidic samples
US7588725B2 (en) * 2001-04-25 2009-09-15 Biotrove, Inc. High throughput autosampler
US20050123970A1 (en) * 2001-04-25 2005-06-09 Can Ozbal High throughput autosampler
JP3693324B2 (ja) * 2001-10-30 2005-09-07 ダイセル化学工業株式会社 擬似移動床式クロマトグラフィー用試料供給装置
US7530257B2 (en) * 2002-09-27 2009-05-12 Honeywell International Inc. Phased micro analyzer VIII
US7104112B2 (en) * 2002-09-27 2006-09-12 Honeywell International Inc. Phased micro analyzer IV
EP1544612A1 (en) * 2003-12-09 2005-06-22 Agilent Technologies, Inc. Chromatography system and method for operating the same
CA2574363A1 (en) * 2004-07-23 2006-02-02 Pharmacia & Upjohn Company Llc Enantioselective method for separating sustituted 2-trifluoromethyl-2h-chromene-3-carboxylic acid derivatives
US20060086667A1 (en) * 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides
US8802035B2 (en) * 2005-06-21 2014-08-12 Waters Technologies Corporation Apparatus and methods for performing steps of a multi-step process in parallel
FR2889077B1 (fr) * 2005-07-26 2007-10-12 Novasep Soc Par Actions Simpli Procede et dispositif de separation chromatographique de fractions d'un melange
US8123394B2 (en) * 2005-10-17 2012-02-28 Evonik Degussa Gmbh Mixer for liquid colorants and method for mixing liquid colorants
SI2455382T1 (sl) 2005-12-13 2017-03-31 Incyte Holdings Corporation S heteroarilom substituirani pirolo(2,3b)piridini in pirolo(2,3-b)pirimidini kot zaviralci janus kinaze
WO2008025887A1 (fr) * 2006-08-28 2008-03-06 Novasep Procede d'enrichissement d'un ou plusieurs composes d'un melange utilisant une phase mobile liquide contenant un gaz
US20080053908A1 (en) * 2006-09-01 2008-03-06 Lalit Chordia High pressure flash chromatography
FR2907687B1 (fr) * 2006-10-30 2008-12-26 Applexion Procede de purification de sialyllactose par chromatographie
ES2467665T5 (es) 2007-06-13 2022-11-03 Incyte Holdings Corp Sales del inhibidor de cinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo
JP5571552B2 (ja) * 2007-06-15 2014-08-13 ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー クロマトグラフィー法
EP2217356B1 (en) * 2007-11-02 2018-10-17 Biocius Life Sciences, Inc. Devices and methods for coupling mass spectrometry devices with chromatography systems
FR2929533B1 (fr) * 2008-04-03 2010-04-30 Novasep Procede de separation multicolonnes a gradient.
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
JOP20190230A1 (ar) 2009-01-15 2017-06-16 Incyte Corp طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
WO2010124159A1 (en) * 2009-04-23 2010-10-28 Xcellerex, Inc. System and method for variable speed feedback control chromatography loading
PT2432472T (pt) * 2009-05-22 2019-12-09 Incyte Holdings Corp 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octano- ou heptano-nitrilo como inibidores de jak
MY156727A (en) * 2009-05-22 2016-03-15 Incyte Corp N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
WO2011028685A1 (en) * 2009-09-01 2011-03-10 Incyte Corporation Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
MX354212B (es) 2010-03-10 2018-02-19 Incyte Corp Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
US20110288107A1 (en) 2010-05-21 2011-11-24 Bhavnish Parikh Topical formulation for a jak inhibitor
EP2640725B1 (en) 2010-11-19 2015-01-07 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
CA2818542A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
WO2012177606A1 (en) 2011-06-20 2012-12-27 Incyte Corporation Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
EP2578286A1 (en) * 2011-10-04 2013-04-10 Merck Patent GmbH Method and apparatus for chromatographic purification
WO2013083482A1 (en) * 2011-12-05 2013-06-13 Chromacon Ag Chromatographic method for the separation of fatty acid mixtures
WO2013173720A1 (en) 2012-05-18 2013-11-21 Incyte Corporation Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
ES2880814T3 (es) 2012-11-15 2021-11-25 Incyte Holdings Corp Formas de dosificación de liberación sostenida de ruxolitinib
EP2772289B1 (en) * 2013-03-01 2015-05-06 ChromaCon AG Chromatographic process for enrichment and isolation
EP3489239B1 (en) 2013-03-06 2021-09-15 Incyte Holdings Corporation Processes and intermediates for making a jak inhibitor
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP2801604B1 (en) 2013-05-07 2017-04-12 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
CN109679768A (zh) 2013-05-07 2019-04-26 诺瓦塞普集团 用于生产高度纯化的多不饱和脂肪酸的色谱方法
TWI789516B (zh) 2013-08-07 2023-01-11 美商英塞特公司 Jak1抑制劑之持續釋放劑型
CN103424488B (zh) * 2013-08-21 2015-04-01 利穗科技(苏州)有限公司 一种双柱或多柱串联的色谱系统
FR3014436B1 (fr) * 2013-12-11 2016-10-21 Novasep Process Procede de purification chromatographique d'un acide gras
EP3118186B1 (fr) 2013-12-11 2022-02-09 Novasep Process Installation chromatographique de production d acides gras polyinsatures
FR3014435B1 (fr) * 2013-12-11 2016-10-21 Novasep Process Purification d'acides gras par un procede chromatographique
EP3082991B1 (en) * 2013-12-19 2024-05-08 Cytiva Sweden AB A chromatography system and method
JP6303017B2 (ja) 2014-01-07 2018-03-28 ノヴァセプ プロセスＮｏｖａｓｅｐ Ｐｒｏｃｅｓｓ 芳香族アミノ酸を精製する方法
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
CH709709A1 (de) * 2014-05-30 2015-11-30 Werner Döbelin Systemkonfiguration für die Injektion von Proben mit automatischer Festphasenextraktion mit nur einem binären Pumpensystem für den Betrieb im Bereich der HPLC, ultra-, mikro- und nano- HPLC.
CN106053689B (zh) * 2016-07-18 2017-10-20 华南理工大学 可精确获取采样时间的手动停流型二维液相色谱及其应用
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
HRP20220510T1 (hr) 2018-01-30 2022-05-27 Incyte Corporation Postupci za pripravu (1-(3-fluoro-2-(trifluorometil)izonikotinil) piperidin-4-ona)
US11119076B2 (en) * 2018-02-26 2021-09-14 Valco Instruments Company, L.P. System and valve for liquid chromatography
CN108254475A (zh) * 2018-03-09 2018-07-06 山东省分析测试中心 一种用于复杂样品循环分离的高速逆流色谱仪及工作方法
HUE067471T2 (hu) 2018-03-30 2024-10-28 Incyte Corp Gennyes verejtékmirigy-gyulladás kezelése jak inhibitorok alkalmazásával
US11285403B2 (en) * 2018-05-31 2022-03-29 Waters Technologies Corporation High resolution and semi-preparative recycling chromatography system for isolation and preparation of unknown trace impurities in pharmaceutical products
US11324718B2 (en) 2018-10-09 2022-05-10 Sartorius Chromatography Equipment Method for purifying cannabinoids
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
US20250179466A1 (en) 2022-03-03 2025-06-05 Chromacon Ag Chromatographic purification method and uses thereof
CA3250933A1 (en) * 2022-03-27 2023-10-05 Purdue Research Foundation MULTI-DIMENSIONAL MULTIMODE CHROMATOGRAPHY PROCESSES FOR PRODUCING HIGH-PURITY, HIGH-YIELD LITHIUM, COBALT, NICKEL, AND MANGANESE SALTS FROM USED LITHIUM-ION BATTERIES AND OTHER FEEDING MATERIALS

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001112A (en) * 1972-06-14 1977-01-04 Philip Edwin Barker Method of operating a chromatographic apparatus
US3992175A (en) * 1974-02-11 1976-11-16 Toe Jokhannesovich Klementi Method of and device for chromatographic separation of fluid mixtures into fractions
JPS6055162B2 (ja) * 1977-05-26 1985-12-04 参松工業株式会社 カラムクロマト分離法
US4359323A (en) * 1980-10-31 1982-11-16 W. R. Grace & Co. Single pump liquid chromatograph analytical system for amines
US4412866A (en) * 1981-05-26 1983-11-01 The Amalgamated Sugar Company Method and apparatus for the sorption and separation of dissolved constituents
JPS5838857A (ja) * 1981-08-31 1983-03-07 Shimadzu Corp ガスクロマトグラフ用カラム切換コツク
FR2527934A1 (fr) * 1982-06-03 1983-12-09 Elf Aquitaine Procede de fractionnement de melanges par chromatographie d'elution avec fluide en etat supercritique et installation pour sa mise en oeuvre
JPS59222764A (ja) * 1983-06-01 1984-12-14 Yokogawa Hokushin Electric Corp ガスクロマトグラフ
EP0127926B1 (en) * 1983-06-03 1986-11-26 Hewlett-Packard Company Chromatographic separation
US4530234A (en) * 1983-06-30 1985-07-23 Mobil Oil Corporation Method and system for measuring properties of fluids
US4528101A (en) * 1983-09-09 1985-07-09 Illinois Water Treatment Company Method of separating acid from salt by adsorption with recycling
US4536199A (en) * 1984-01-05 1985-08-20 Mobil Oil Corporation Gas chromatograph for reseparating a sampel into pure components
US4498991A (en) * 1984-06-18 1985-02-12 Uop Inc. Serial flow continuous separation process
US5122275A (en) * 1986-05-08 1992-06-16 A. E. Staley Manufacturing Company Simulated moving bed chromatographic separation
US4840730A (en) * 1986-07-25 1989-06-20 Sepragen Corporation Chromatography system using horizontal flow columns
JPH0669521B2 (ja) * 1986-12-23 1994-09-07 三菱化成エンジニアリング株式会社 クロマト分離法
US4919595A (en) * 1987-03-03 1990-04-24 Beckman Instruments, Inc. Fluid delivery system with deficit flow compensation
US5180487A (en) * 1987-09-25 1993-01-19 Nihon Bunko Kogyo Kabushiki Kaisha Pump apparatus for transferring a liquified gas used in a recycle chromatograph
DE3735814A1 (de) * 1987-10-22 1989-05-11 Siemens Ag Einrichtung und verfahren zum dosieren von proben fuer die gaschromatographische analyse
JPH0746097B2 (ja) * 1988-05-17 1995-05-17 三菱化成エンジニアリング株式会社 クロマト分離法
JP2845909B2 (ja) * 1988-12-09 1999-01-13 株式会社日立製作所 液体クロマトグラフおよびそれを用いる方法
US4990259A (en) * 1988-12-16 1991-02-05 The Amalgamated Sugar Company Chromatographic separator sorbent bed preparation
US5089126A (en) * 1989-03-31 1992-02-18 Lehigh University Method and apparatus for capillary hydrodynamic fractionation
FR2651148B1 (fr) * 1989-08-28 1992-05-07 Inst Francais Du Petrole Procede continu et dispositif de separation chromatographique d'un melange d'au moins trois constituants en trois effluents purifies au moyen de deux solvants.
FR2651149B1 (fr) * 1989-08-28 1992-06-05 Inst Francais Du Petrole Procede continu et dispositif de separation chromatographique d'un melange d'au moins trois constituants en trois effluents purifies au moyen d'un seul solvant a deux temperatures et/ou a deux pressions differentes.
US5071547A (en) * 1990-03-23 1991-12-10 Separations Technology, Inc. Column chromatographic column apparatus with switching capability
US5108466A (en) * 1990-12-21 1992-04-28 Hewlett-Packard Company Apparatus and methods for controlling fluids provided to a chromatographic detector
US5196039A (en) * 1991-01-30 1993-03-23 Southern Illinois University At Carbondale Apparatus and method of multi-dimensional chemical separation
US5253981A (en) * 1992-03-05 1993-10-19 Frank Ji-Ann Fu Yang Multichannel pump apparatus with microflow rate capability
DE4231149C1 (de) * 1992-09-17 1993-12-16 Amino Gmbh Verfahren zur Weiterverarbeitung von technischen Restabläufen der melasseverarbeitenden Industrie
US5415489A (en) * 1993-01-11 1995-05-16 Zymark Corporation Reciprocating driver apparatus
US5398539A (en) * 1993-08-02 1995-03-21 Hewlett-Packard Company Correlated multi-dimensional chromatography with confirmatory hybrid run

Also Published As

Publication number Publication date
JP2000503112A (ja) 2000-03-14
DE69631903D1 (de) 2004-04-22
EP0877936A1 (en) 1998-11-18
US5630943A (en) 1997-05-20
CA2238954A1 (en) 1997-06-05
WO1997020206A1 (en) 1997-06-05
EP0877936B1 (en) 2004-03-17
DE69631903T2 (de) 2004-08-19

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