JP3993746B2 - 腫瘍性細胞成長阻害のための組成物及び方法 - Google Patents

腫瘍性細胞成長阻害のための組成物及び方法 Download PDF

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Publication number
JP3993746B2
JP3993746B2 JP2000589692A JP2000589692A JP3993746B2 JP 3993746 B2 JP3993746 B2 JP 3993746B2 JP 2000589692 A JP2000589692 A JP 2000589692A JP 2000589692 A JP2000589692 A JP 2000589692A JP 3993746 B2 JP3993746 B2 JP 3993746B2
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Japan
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acid sequence
amino acid
sequence identity
nucleic acid
seq
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JP2000589692A
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English (en)
Japanese (ja)
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JP2003529317A (ja
JP2003529317A5 (fr
Inventor
アシュケナジ，アヴィ，ジェイ．
ゴダード，オードリー
ジェイ． ゴドスキー，ポール
ガーニー，オースティン，エル．
マースタース，スコット，エー．
ネイピエール，メアリー，エー．
ピッティ，ロバート，エム．
アイ． ウッド，ウィリアム
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Genentech Inc
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Genentech Inc
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Priority claimed from PCT/US1999/005028 external-priority patent/WO1999046281A2/fr
Priority claimed from PCT/US1999/021547 external-priority patent/WO2000015797A2/fr
Priority claimed from PCT/US1999/021090 external-priority patent/WO2000015796A2/fr
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JP2003529317A publication Critical patent/JP2003529317A/ja
Publication of JP2003529317A5 publication Critical patent/JP2003529317A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2000589692A 1998-12-22 1999-12-02 腫瘍性細胞成長阻害のための組成物及び方法 Expired - Fee Related JP3993746B2 (ja)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US11329698P 1998-12-22 1998-12-22
US60/113,296 1998-12-22
PCT/US1999/005028 WO1999046281A2 (fr) 1998-03-10 1999-03-08 Nouveaux polypeptides et acides nucleiques les codant
US9905028 1999-03-08
US13023299P 1999-04-21 1999-04-21
US60/130,232 1999-04-21
US13144599P 1999-04-28 1999-04-28
US60/131,445 1999-04-28
US13428799P 1999-05-14 1999-05-14
US60/134,287 1999-05-14
US14475899P 1999-07-20 1999-07-20
US60/144,758 1999-07-20
US14569899P 1999-07-26 1999-07-26
US60/145,698 1999-07-26
PCT/US1999/021547 WO2000015797A2 (fr) 1998-09-17 1999-09-15 Compositions et methodes de traitement des maladies relatives au syteme immunitaire
PCT/US1999/021090 WO2000015796A2 (fr) 1998-09-16 1999-09-15 Polypeptides secretes et transmembranaires et acides nucleiques codant pour ces polypeptides
US9921547 1999-09-15
US9921090 1999-09-15
PCT/US1999/028565 WO2000037638A2 (fr) 1998-12-22 1999-12-02 Methodes permettant d'inhiber la croissance de cellules neoplasiques

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2005066569A Division JP4037876B2 (ja) 1998-12-22 2005-03-10 腫瘍性細胞成長阻害のための組成物及び方法
JP2005066570A Division JP2005237383A (ja) 1998-12-22 2005-03-10 腫瘍性細胞成長阻害のための組成物及び方法

Publications (3)

Publication Number Publication Date
JP2003529317A JP2003529317A (ja) 2003-10-07
JP2003529317A5 JP2003529317A5 (fr) 2004-12-24
JP3993746B2 true JP3993746B2 (ja) 2007-10-17

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Family Applications (5)

Application Number Title Priority Date Filing Date
JP2000589692A Expired - Fee Related JP3993746B2 (ja) 1998-12-22 1999-12-02 腫瘍性細胞成長阻害のための組成物及び方法
JP2005066569A Expired - Lifetime JP4037876B2 (ja) 1998-12-22 2005-03-10 腫瘍性細胞成長阻害のための組成物及び方法
JP2005066570A Withdrawn JP2005237383A (ja) 1998-12-22 2005-03-10 腫瘍性細胞成長阻害のための組成物及び方法
JP2007138468A Pending JP2007222180A (ja) 1998-12-22 2007-05-24 腫瘍性細胞成長阻害のための組成物及び方法
JP2007138469A Pending JP2007291116A (ja) 1998-12-22 2007-05-24 腫瘍性細胞成長阻害のための組成物及び方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2005066569A Expired - Lifetime JP4037876B2 (ja) 1998-12-22 2005-03-10 腫瘍性細胞成長阻害のための組成物及び方法
JP2005066570A Withdrawn JP2005237383A (ja) 1998-12-22 2005-03-10 腫瘍性細胞成長阻害のための組成物及び方法
JP2007138468A Pending JP2007222180A (ja) 1998-12-22 2007-05-24 腫瘍性細胞成長阻害のための組成物及び方法
JP2007138469A Pending JP2007291116A (ja) 1998-12-22 2007-05-24 腫瘍性細胞成長阻害のための組成物及び方法

Country Status (13)

Country Link
EP (1) EP1141284A2 (fr)
JP (5) JP3993746B2 (fr)
KR (1) KR100499600B1 (fr)
AT (2) ATE432987T1 (fr)
AU (1) AU768230B2 (fr)
CA (1) CA2353799A1 (fr)
DE (2) DE69940964D1 (fr)
DK (1) DK1484338T3 (fr)
ES (2) ES2327785T3 (fr)
IL (3) IL143031A0 (fr)
MX (1) MXPA01006330A (fr)
PT (1) PT1484338E (fr)
WO (1) WO2000037638A2 (fr)

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KR20010104373A (ko) * 1999-03-08 2001-11-24 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
DE60035693T2 (de) * 1999-07-20 2008-05-15 Genentech, Inc., South San Francisco Zusammensetzung und verfahren zur behandlung von immunverwandten krankheiten
CZ20021853A3 (cs) * 1999-12-09 2002-11-13 Sankyo Company, Limited Způsob testování účinku látky, polynukleotid, DNA, protilátka, souprava pro testování, pouľití polynukleotidu, pouľití polypeptidu, pouľití protilátky, RNA a terapeutické činidlo
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WO2001085193A2 (fr) 2000-05-08 2001-11-15 Biogen, Inc. Procede servant a favoriser la neovascularisation
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US20020111302A1 (en) * 2000-11-30 2002-08-15 Y. Tom Tang Novel nucleic acids and polypeptides
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CA2391438A1 (fr) * 2002-05-01 2003-11-01 Procyon Biopharma Inc. Reactifs et methodes diagnostiques a base de psp94
WO2006089095A2 (fr) 2005-02-17 2006-08-24 Biogen Idec Ma Inc. Traitement de troubles neurologiques
EP1885388B1 (fr) 2005-05-10 2013-09-11 Biogen Idec MA Inc. Traitement et evaluation des troubles inflammatoires
WO2006138219A2 (fr) 2005-06-13 2006-12-28 Biogen Idec Ma Inc. Procedes d'evaluation de patients
US7893032B2 (en) 2005-07-07 2011-02-22 Yale University NgR variants and compositions thereof for suppressing axonal growth inhibition
BRPI0619657A2 (pt) 2005-11-04 2011-11-08 Genentech Inc métodos de prevenção ou melhoria de doença ocular, uso de um inibidor de complemento, uso de um sirna especìfico para uma proteìna do sistema complemento e uso de um ácido nucleico que codifica um inibidor do sistema complemento
US9044461B2 (en) 2006-04-07 2015-06-02 The Research Foundation Of State University Of New York Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
EP2010226B1 (fr) * 2006-04-07 2014-01-15 The Research Foundation of State University of New York Polypeptides du récepteur de la transcobalamine, acides nucléiques et modulateurs associés, procédés d'utilisation associés destinés à moduler la croissance cellulaire et à traiter le cancer et la déficience en cobalamine
US7776573B2 (en) 2006-06-01 2010-08-17 Genentech, Inc. Crystal structure of CRIg and C3b:CRIg complex
EP2471818A1 (fr) 2006-11-02 2012-07-04 Genentech, Inc. Anticorps anti-facteur D humanisés et utilisations associées
AR066660A1 (es) 2007-05-23 2009-09-02 Genentech Inc Prevencion y tratamiento de condiciones del ojo asociadas con su complemento
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Publication number Publication date
JP2003529317A (ja) 2003-10-07
JP2007291116A (ja) 2007-11-08
ATE432987T1 (de) 2009-06-15
JP2007222180A (ja) 2007-09-06
EP1141284A2 (fr) 2001-10-10
KR100499600B1 (ko) 2005-07-07
ATE353339T1 (de) 2007-02-15
JP4037876B2 (ja) 2008-01-23
WO2000037638A3 (fr) 2000-11-09
JP2005237383A (ja) 2005-09-08
ES2327785T3 (es) 2009-11-03
CA2353799A1 (fr) 2000-06-29
IL186154A0 (en) 2008-01-20
JP2005245451A (ja) 2005-09-15
PT1484338E (pt) 2007-05-31
MXPA01006330A (es) 2002-07-02
KR20010084882A (ko) 2001-09-06
ES2281704T3 (es) 2007-10-01
AU768230B2 (en) 2003-12-04
AU1749900A (en) 2000-07-12
DK1484338T3 (da) 2007-06-11
DE69940964D1 (de) 2009-07-16
IL186153A0 (en) 2008-01-20
IL143031A0 (en) 2002-04-21
DE69935085D1 (de) 2007-03-22
WO2000037638A2 (fr) 2000-06-29
DE69935085T2 (de) 2007-08-23

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