JP3961479B2 - Liquid oral composition - Google Patents
Liquid oral composition Download PDFInfo
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- JP3961479B2 JP3961479B2 JP2003434727A JP2003434727A JP3961479B2 JP 3961479 B2 JP3961479 B2 JP 3961479B2 JP 2003434727 A JP2003434727 A JP 2003434727A JP 2003434727 A JP2003434727 A JP 2003434727A JP 3961479 B2 JP3961479 B2 JP 3961479B2
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- 239000000203 mixture Substances 0.000 title claims description 33
- 239000007788 liquid Substances 0.000 title claims description 19
- -1 alkyl sulfate ester salts Chemical class 0.000 claims description 25
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 22
- 229910001424 calcium ion Inorganic materials 0.000 claims description 22
- 239000003945 anionic surfactant Substances 0.000 claims description 19
- 239000002736 nonionic surfactant Substances 0.000 claims description 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 13
- 239000000194 fatty acid Substances 0.000 claims description 13
- 229930195729 fatty acid Natural products 0.000 claims description 13
- 210000000214 mouth Anatomy 0.000 claims description 10
- 239000003205 fragrance Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- 244000024873 Mentha crispa Species 0.000 claims description 2
- 235000014749 Mentha crispa Nutrition 0.000 claims description 2
- 244000246386 Mentha pulegium Species 0.000 claims description 2
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 2
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 2
- 235000007265 Myrrhis odorata Nutrition 0.000 claims description 2
- 240000004760 Pimpinella anisum Species 0.000 claims description 2
- 235000012550 Pimpinella anisum Nutrition 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 235000017803 cinnamon Nutrition 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 235000001050 hortel pimenta Nutrition 0.000 claims description 2
- 229940041616 menthol Drugs 0.000 claims description 2
- 229960001047 methyl salicylate Drugs 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229960005069 calcium Drugs 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 208000002925 dental caries Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 238000005063 solubilization Methods 0.000 description 4
- 230000007928 solubilization Effects 0.000 description 4
- 235000019640 taste Nutrition 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 241000519995 Stachys sylvatica Species 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 229960002401 calcium lactate Drugs 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002324 mouth wash Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- 229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 description 1
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 1
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 235000010237 calcium benzoate Nutrition 0.000 description 1
- 239000004301 calcium benzoate Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229960002713 calcium chloride Drugs 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 235000019255 calcium formate Nutrition 0.000 description 1
- 239000004281 calcium formate Substances 0.000 description 1
- 229940044172 calcium formate Drugs 0.000 description 1
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 1
- 229940095618 calcium glycerophosphate Drugs 0.000 description 1
- 235000019299 calcium glycerylphosphate Nutrition 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 229940095643 calcium hydroxide Drugs 0.000 description 1
- 235000011116 calcium hydroxide Nutrition 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000010331 calcium propionate Nutrition 0.000 description 1
- 239000004330 calcium propionate Substances 0.000 description 1
- AVVIDTZRJBSXML-UHFFFAOYSA-L calcium;2-carboxyphenolate;dihydrate Chemical compound O.O.[Ca+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O AVVIDTZRJBSXML-UHFFFAOYSA-L 0.000 description 1
- BVTQVYBMHFSYPL-UHFFFAOYSA-L calcium;2-methylpropanoate Chemical compound [Ca+2].CC(C)C([O-])=O.CC(C)C([O-])=O BVTQVYBMHFSYPL-UHFFFAOYSA-L 0.000 description 1
- HZQXCUSDXIKLGS-UHFFFAOYSA-L calcium;dibenzoate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 HZQXCUSDXIKLGS-UHFFFAOYSA-L 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 229940071089 sarcosinate Drugs 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、優れた洗浄力とむし歯予防効果を有する液体口腔用組成物に関する。 The present invention relates to a liquid oral composition having excellent detergency and a cavity prevention effect.
歯質の主成分はハイドロキシアパタイト(Ca10(PO4)6(OH)2)であり、口中においては通常、リン酸イオンやカルシウムイオンの溶出(脱灰)と、リン酸カルシウムやハイドロキシアパタイトへの結晶化(再石灰化)が平衡状態にある。ここでむし歯の原因菌が産生する酸は、脱灰を促進することが知られている(非特許文献1)。すなわち、むし歯は、歯垢を構成するストレプトコッカス・ミュータンス(Streptococcus mutans)等の細菌がショ糖等を分解して乳酸を主とする有機酸を産生し、これがpHを低下させてカルシウム等を溶出させることにより生じる。 The main component of tooth is hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), and in the mouth, phosphate ions and calcium ions are usually eluted (decalcified) and crystallized into calcium phosphate and hydroxyapatite. The calcification (remineralization) is in equilibrium. Here, it is known that the acid produced by the causative bacteria of the cavity promotes decalcification (Non-patent Document 1). In other words, in bacteria, bacteria such as Streptococcus mutans, which constitutes plaque, decomposes sucrose to produce organic acids, mainly lactic acid, which lowers the pH and elutes calcium and the like Caused by
ところでむし歯の初期においては、通常透明なエナメル質に白斑(ホワイトスポット)が生じるが、カルシウムイオンは再石灰化を促進し、かかる白斑を消失させ、エナメル質を再透明化することが知られている(非特許文献2)。このためカルシウムイオンは、再石灰化促進を目的に多くの口腔用組成物に配合されている。 By the way, in the early stages of caries, white spots are usually generated in transparent enamel, but calcium ions are known to promote remineralization, eliminate such white spots, and re-enamelize enamel. (Non-Patent Document 2). For this reason, calcium ions are blended in many oral compositions for the purpose of promoting remineralization.
しかしながら、組成物中においては、様々な他の配合成分との相互作用によって、カルシウムイオンの不活化がおこり、該カルシウムイオンの性質が十分に発揮されないことがある。例えば、洗浄力の高さの点からラウリル硫酸ナトリウムに代表される陰イオン界面活性剤が口腔用組成物の多くには使用されているが、この陰イオン界面活性剤はカルシウムイオンと不溶性のカルシウム塩を形成する。特に液体口腔用組成物では、このような問題は解決されておらず、陰イオン界面活性剤とカルシウムイオンとを同時に含有する液体口腔用組成物は無いのが現状である。
本発明の目的は、カルシウムイオンを安定に共存させ優れたむし歯予防効果を発揮し、且つ、陰イオン界面活性剤による優れた洗浄力を有する液体口腔用組成物を提供することである。 An object of the present invention is to provide a liquid oral composition that exhibits an excellent caries prevention effect by stably coexisting calcium ions and has an excellent detergency with an anionic surfactant.
本発明者は、陰イオン界面活性剤を含有する液体口腔用組成物中でカルシウムイオンを安定させるべく鋭意研究を行った結果、非イオン性界面活性剤を陰イオン界面活性剤に対して特定比率で配合することで、上記目的を達成することを見出し、本発明を完成するに至った。 As a result of intensive studies to stabilize calcium ions in a liquid oral composition containing an anionic surfactant, the present inventor has found that a specific ratio of nonionic surfactant to anionic surfactant It was found that the above-mentioned purpose was achieved by blending with, and the present invention was completed.
すなわち、本発明は、下記成分(A)、(B)、(C)及び(D):
(A)カルシウムイオン供給化合物 0.005〜1.0質量%
(B)陰イオン界面活性剤 0.01〜10質量%
(C)非イオン界面活性剤 30質量%以下であって、成分(B)1質量部に対し2.5〜8質量部
(D)水 60〜99質量%
を含有する液体口腔用組成物を提供するものである。
That is, the present invention includes the following components (A), (B), (C) and (D):
(A) Calcium ion supply compound 0.005-1.0 mass%
(B) Anionic surfactant 0.01 to 10% by mass
(C) Nonionic surfactant is 30% by mass or less, and 2.5 to 8 parts by mass (D) water 60 to 99% by mass with respect to 1 part by mass of component (B).
The liquid oral cavity composition containing this is provided.
本発明により、洗浄力の高い陰イオン界面活性剤とカルシウムイオンを同時に配合した、優れたむし歯予防効果を発揮する液体口腔用組成物が提供できる。 INDUSTRIAL APPLICABILITY According to the present invention, a liquid oral composition that exhibits an excellent caries prevention effect, in which an anionic surfactant having high detergency and calcium ions are simultaneously blended can be provided.
本発明に用いられる(A)カルシウムイオン供給化合物とは、水に溶けてカルシウムイオンを放出する化合物であり、例えば、水酸化カルシウム、塩化カルシウム、酢酸カルシウム、ギ酸カルシウム、乳酸カルシウム、硝酸カルシウム、グルコン酸カルシウム、安息香酸カルシウム、イソ酪酸カルシウム、プロピオン酸カルシウム、サリチル酸カルシウム、グリセロリン酸カルシウム及びそれらの混合物が挙げられる。その配合量は、口腔用組成物全体に対してカルシウム換算で0.005〜1.0質量%、特に0.01〜0.5質量%が好ましい。 The (A) calcium ion supply compound used in the present invention is a compound that dissolves in water and releases calcium ions. For example, calcium hydroxide, calcium chloride, calcium acetate, calcium formate, calcium lactate, calcium nitrate, glucone Calcium acid, calcium benzoate, calcium isobutyrate, calcium propionate, calcium salicylate, calcium glycerophosphate and mixtures thereof. The blending amount is preferably 0.005 to 1.0% by mass, particularly 0.01 to 0.5% by mass in terms of calcium with respect to the whole oral cavity composition.
本発明で用いられる(B)陰イオン界面活性剤は、口腔用組成物に一般に用いられる陰イオン界面活性剤であれば良く、例えばラウリル硫酸ナトリウム等のアルキル硫酸エステル塩、N−アシルサルコシネートナトリウム等のN−アシルアミノ酸塩、ポリオキシエチレンラウリルエーテル硫酸ナトリウム等のポリオキシエチレンアルキルエーテル硫酸塩、、高級脂肪酸ナトリウム塩の高級脂肪酸塩等が挙げられる。これらの陰イオン界面活性剤のアルキル部分は炭素数6〜18が好ましい。好ましくは炭素数6〜18のアルキル硫酸エステル塩、特に好ましくは炭素数10〜14のアルキル硫酸エステル塩である。その配合量は、通常、口腔用組成物全体に対して0.01〜10質量%、好ましくは0.05〜10質量%である。 The anionic surfactant (B) used in the present invention may be any anionic surfactant generally used in oral compositions, such as alkyl sulfate salts such as sodium lauryl sulfate, N-acyl sarcosinate. Examples thereof include N-acyl amino acid salts such as sodium, polyoxyethylene alkyl ether sulfates such as sodium polyoxyethylene lauryl ether sulfate, and higher fatty acid salts of higher fatty acid sodium salts. The alkyl part of these anionic surfactants preferably has 6 to 18 carbon atoms. Preferred are alkyl sulfate salts having 6 to 18 carbon atoms, and particularly preferred are alkyl sulfate salts having 10 to 14 carbon atoms. The compounding quantity is 0.01-10 mass% normally with respect to the whole composition for oral cavity, Preferably it is 0.05-10 mass%.
(C)非イオン界面活性剤は、口腔用組成物に一般に用いられる非イオン界面活性剤であれば良く、例えばショ糖脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレン硬化ひまし油等が挙げられる。可溶化力の点でショ糖脂肪酸エステルが好ましく、また、HLB価(Griffin)は12〜20であることが好ましく、さらに好ましくは18〜20である。
HLB価=20(1−S/A)
(S:けん化価、A:使用脂肪酸の酸価)
これらの非イオン界面活性剤の脂肪酸部は炭素数6〜18が好ましい。その配合量は、通常、口腔用組成物全体に対して0.01〜30質量%、好ましくは0.1〜10質量%である。
(C) Nonionic surfactant should just be a nonionic surfactant generally used for an oral composition, for example, sucrose fatty acid ester, glycerol fatty acid ester, polyglycerol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, Examples include polyoxyethylene hydrogenated castor oil. A sucrose fatty acid ester is preferable in terms of solubilizing power, and the HLB value (Griffin) is preferably 12 to 20, and more preferably 18 to 20.
HLB value = 20 (1-S / A)
(S: Saponification value, A: Acid value of fatty acid used)
The fatty acid part of these nonionic surfactants preferably has 6 to 18 carbon atoms. The compounding quantity is 0.01-30 mass% normally with respect to the whole composition for oral cavity, Preferably it is 0.1-10 mass%.
(B)陰イオン界面活性剤の少なくとも1種類と(C)非イオン界面活性剤の少なくとも1種類とを含有することで油溶性香料を可溶化でき、なおかつカルシウムイオンを安定に配合することができる。陰イオン界面活性剤と非イオン界面活性剤の比率は、陰イオン界面活性剤1質量部に対し、カルシウムイオンの安定化効果の点から1質量部以上が好ましく、口腔用組成物の味の点から10質量部以下が好ましく、さらに好ましくは4〜8質量部である。 (B) By containing at least one anionic surfactant and (C) at least one nonionic surfactant, the oil-soluble fragrance can be solubilized, and calcium ions can be blended stably. . The ratio of the anionic surfactant to the nonionic surfactant is preferably 1 part by mass or more with respect to 1 part by mass of the anionic surfactant from the viewpoint of the stabilizing effect of calcium ions. To 10 parts by mass or less, more preferably 4 to 8 parts by mass.
また、本発明の液体口腔用組成物中の(D)水の含有量は、60〜99質量%であるが、さらに好ましくは65〜85質量%である。 Moreover, although content of (D) water in the composition for liquid oral cavity of this invention is 60-99 mass%, More preferably, it is 65-85 mass%.
また、本発明の液体口腔用組成物は、非イオン界面活性剤の苦味を低減するためにさらに(E)香料を配合することが好ましい。
本発明で用いられる香料は、口腔用剤に用いられる香料であればよく、例えばシナモン、スペアミント、ペパーミント、バート、アニス、メントール、サリチル酸メチル及びそれらの混合物が挙げられる。当該香料は組成物中に香気付与に有効な量含有すればよく、例えば0.1〜10重量%、さらに0.5〜5重量%、特に0.8〜3重量%含有するのが好ましい。
In addition, the liquid oral composition of the present invention preferably further contains (E) a fragrance in order to reduce the bitterness of the nonionic surfactant.
The fragrance | flavor used by this invention should just be the fragrance | flavor used for an oral preparation, for example, a cinnamon, spearmint, peppermint, bart, anise, menthol, methyl salicylate, and mixtures thereof are mentioned. The perfume may be contained in the composition in an amount effective for imparting aroma, for example, 0.1 to 10% by weight, more preferably 0.5 to 5% by weight, and particularly preferably 0.8 to 3% by weight.
本発明の液体口腔用組成物中には、これらの成分の他に、エタノール等の溶剤、グリセリン、ポリエチレングリコール、ソルビット、キシリット等の湿潤剤、カルボキシメチルセルロースナトリウム、カラギーナン、キサンタンガム、アルギン酸ナトリウム等の粘結剤、サッカリンナトリウム等の甘味剤、着色剤、パラオキシ安息香酸メチル等の保存剤、塩化ベンゼトニウム、イソプロピルメチルフェノール、トリクロサン等の殺菌剤、消炎剤等を添加することができる。 In the liquid oral composition of the present invention, in addition to these components, a solvent such as ethanol, a wetting agent such as glycerin, polyethylene glycol, sorbit, and xylit, a viscosity such as sodium carboxymethylcellulose, carrageenan, xanthan gum, and sodium alginate. Binders, sweeteners such as sodium saccharin, coloring agents, preservatives such as methyl paraoxybenzoate, bactericides such as benzethonium chloride, isopropylmethylphenol and triclosan, anti-inflammatory agents and the like can be added.
本発明の液体口腔用組成物の形態としては、洗口液、液状歯磨剤等が挙げられる。 Examples of the form of the liquid oral composition of the present invention include mouthwash, liquid dentifrice and the like.
表1の実施例1〜4及び比較例1〜4の洗口液を製造した。 The mouthwashes of Examples 1 to 4 and Comparative Examples 1 to 4 in Table 1 were produced.
カルシウム安定性:
調製した組成物を密閉できるガラス容器に入れ、5℃に1週間保存し沈殿物の生成状態を判断した。
沈殿物あり:×
沈殿物なし:○
Calcium stability:
The prepared composition was put into a glass container that can be sealed, and stored at 5 ° C. for 1 week to determine the state of precipitate formation.
With deposit: ×
No precipitate: ○
香料可溶化:
調製直後の組成物を透明ガラスビーカーに入れ、濁り、及び香料の分離状態を判断した。
濁り、分離あり:×
濁り、分離なし:○
Perfume solubilization:
The composition immediately after preparation was put into a transparent glass beaker, and turbidity and the state of separation of the fragrance were judged.
Turbidity and separation: ×
Turbidity, no separation: ○
味:
調製1日後の組成物を口中に含み30秒漱いだ後の味を判断した。
苦みあり:×
苦みなし:○
taste:
The composition after 1 day from the preparation was included in the mouth, and the taste after brewing for 30 seconds was judged.
There is bitterness: ×
No bitterness: ○
洗浄力:
直径7mmのガラス管を5本並べ接着剤で固定する。パスツールピペット間の溝 に赤い口紅(モデル汚れ)を塗り込む。調製した組成物をパスツールピペット 上に10mL注ぎ60秒間歯ブラシでブラッシングし、その後、水で洗浄する。メタノール100gにパスツールピペットをつけ、10分間超音波洗浄する。540nmで吸光度を測定し残存汚れ量を算出する。水のみでの洗浄に対して
10%以下の効果:×
10%以上の効果:○
Detergency:
Five glass tubes with a diameter of 7 mm are arranged and fixed with an adhesive. Apply red lipstick (model dirt) in the groove between Pasteur pipettes. Pour 10 mL of the prepared composition onto a Pasteur pipette, brush with a toothbrush for 60 seconds, and then wash with water. Place a Pasteur pipette on 100 g of methanol and ultrasonically wash for 10 minutes. Absorbance is measured at 540 nm to calculate the amount of residual dirt. Less than 10% effect on washing with water only: ×
10% or more effect: ○
表1に示すように、カルシウムイオン供給化合物(乳酸カルシウム)と香料を含有する液体口腔用組成物において非イオン界面活性剤と陰イオン界面活性剤の比率が1/1〜10/1にある実施例1〜4の全てにおいてカルシウムイオン安定性、香料可溶化、味の全てが良かった。
これに対し比較例1は、陰イオン界面活性剤単独で0.3質量%含有するものであるが、優れた洗浄力が認めれたものの1週間の保存で沈殿物が生じカルシウムイオン安定性の点で問題があった。比較例2は陰イオン界面活性剤単独で0.05質量%含有するものであるが、カルシウムイオンの安定性の点では問題ないものの洗浄力の点及び香料の可溶化の点で問題があった。
比較例3では陰イオン界面活性剤と非イオン界面活性剤を併用しているが、非イオン界面活性剤の比率が低いためカルシウムイオン安定性が十分ではなかった。比較例4では非イオン界面活性剤単独で1.2質量%含有するものであり、カルシウムイオンの安定性の点、香料の可溶化の点では問題なかったが、味が悪く、洗浄力も低かった。
As shown in Table 1, in the liquid oral composition containing a calcium ion supply compound (calcium lactate) and a fragrance, the ratio of the nonionic surfactant to the anionic surfactant is 1/1 to 10/1. In all of Examples 1 to 4, calcium ion stability, flavor solubilization, and taste were all good.
On the other hand, Comparative Example 1 contains 0.3% by mass of the anionic surfactant alone. However, although excellent detergency was observed, a precipitate was formed after storage for 1 week, and the calcium ion stability was improved. There was a problem. Comparative Example 2 contains 0.05% by mass of the anionic surfactant alone, but there is a problem in terms of detergency and solubilization of the fragrance although there is no problem in terms of calcium ion stability. .
In Comparative Example 3, an anionic surfactant and a nonionic surfactant were used in combination, but the calcium ion stability was not sufficient because the ratio of the nonionic surfactant was low. In Comparative Example 4, the nonionic surfactant alone contained 1.2% by mass, and there was no problem in terms of calcium ion stability and perfume solubilization, but the taste was poor and the detergency was low. .
Claims (5)
(A)カルシウムイオン供給化合物 0.005〜1.0質量%
(B)陰イオン界面活性剤 0.01〜10質量%
(C)非イオン界面活性剤 30質量%以下であって、成分(B)1質量部に対し2.5〜8質量部
(D)水 60〜99質量%
を含有する液体口腔用組成物。 The following components (A), (B), (C) and (D):
(A) Calcium ion supply compound 0.005-1.0 mass%
(B) Anionic surfactant 0.01 to 10% by mass
(C) Nonionic surfactant is 30% by mass or less, and 2.5 to 8 parts by mass (D) water 60 to 99% by mass with respect to 1 part by mass of component (B).
A liquid composition for oral cavity.
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