JP3923970B2 - Deodorant composition - Google Patents

Description

  The present invention relates to a deodorant composition that is excellent in deodorant effect, has no white residue on the skin, and has good powder dispersion stability intended to improve antiperspirant action and feel.

Antiperspirant deodorant agents are widely used for the purpose of suppressing body odor, but a sufficient deodorant effect has not yet been obtained.
In order to improve the deodorant effect, attempts have been made to improve the antiperspirant performance of the antiperspirant used (Patent Document 1), masking with a fragrance, and a large amount of a bactericide.

However, biologically, it is impossible to completely stop sweating, and masking does not maintain its effect, and there are odors that cannot be hidden. Moreover, it is desirable that the amount of the bactericide is small in terms of safety and environmental load.
Furthermore, the deodorant agent containing powder also has a problem that a white residue is generated on the skin after application and the appearance is impaired.
JP-T-2002-523347

  An object of the present invention is to provide a deodorant composition which has an excellent deodorant effect, has no white residue of powder on the skin, and has good dispersion stability of the powder.

  By using a specific plant extract in combination with an antiperspirant and / or a fungicide, the inventor has excellent deodorant effect, no white residue on the skin, and powder dispersion stability. It has been found that a good deodorant composition can be obtained.

The present invention includes (A) a hydrophobic fraction obtained by extraction with a hydrophobic solvent from a plant selected from yellowfin, ginkgo, purple, licorice and gardenia or an extract thereof , and (B) an antiperspirant and / or A deodorant composition containing a bactericide is provided.

The deodorant composition of the present invention is excellent in the deodorant effect, has no white residue of the powder on the skin, and has good powder dispersion stability.
Among the plant extracts used in the present invention, yellowfin extract is known to have a bactericidal action (for example, JP 2001-226213 A, JP 2003-113013 A), but a general fungicide. The effect is low compared to. For example, MIC (Minimum Inhibitory Concentration) in Staphylococcus aureus is 0.015% for isopropylmethylphenol, a common fungicide, whereas 0.15-2 for yellowfin extract. 5% (Clinical and Microbiology, Vol. 26, No. 2, p. 219 (1999)).
The specific plant extract used in the present invention has an action of suppressing the degradation of apolipoprotein D, which is a carrier protein of the odor molecule, on the skin surface by microorganisms, and the specific plant extract having such an action Is used in combination with an antiperspirant or bactericidal agent, the effect of inhibiting the degradation of apolipoprotein D is further enhanced, and an excellent deodorant effect can be obtained.

The plant that is the base of the component (A) used in the present invention is selected from yellowfin, ginkgo, purple, licorice and gardenia.
These plants can be used as they are or after pulverizing the whole plant or leaves, roots, rhizomes, fruits, seeds and flowers, but yellowfin is bark, ginkgo is leaf, purple is root. It is preferable to use root for licorice and fruit for gardenia.

  In the present invention, the extract refers to various solvent extractions obtained by extracting from these plants using an appropriate solvent at room temperature or under heating, or using an extraction device such as a Soxhlet extractor. Liquid, its diluted solution, its concentrated solution or its dry powder. Here, the extract may be a mixture obtained from two or more kinds of plants.

  Solvents used for extraction include water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as propylene glycol and butylene glycol; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; Chain and cyclic ethers such as tetrahydrofuran and diethyl ether; Halogenated hydrocarbons such as dichloromethane, chloroform and carbon tetrachloride; Hydrocarbons such as hexane, cyclohexane and petroleum ether; Aromatic hydrocarbons such as benzene and toluene Polyethylene glycol having an average molecular weight of 180 to 1000; pyridine; ester oils such as isopropyl myristate and isopropyl stearate; fats and oils such as olive oil and diacylglycerol; supercritical carbon dioxideThese can be used alone or in combination.

  When used alone, ethanol, acetone, hexane, fats and oils, supercritical carbon dioxide and the like are preferable. When used in combination, a water-alcohol mixture, particularly a water-ethanol mixture is preferred, and the ethanol content is preferably 50 v / v% or more, particularly 80 v / v% or more, and more preferably 95 v / v%.

  Extraction conditions vary depending on the solvent to be used. For example, when extracting with a water-ethanol mixed solution, 70 to 150 mL of solvent is used for 10 g of plant, and the temperature is 15 to 35 ° C, preferably 20 to 25 ° C. 30 hours to 10 days, particularly 5 to 8 days.

  In the present invention, it is preferable to use a hydrophobic fraction of the plant extract, that is, a fraction obtained by extracting the plant or the extract thereof with a hydrophobic solvent. Examples of the hydrophobic solvent used here include esters such as methyl acetate and ethyl acetate; ethers such as diethyl ether; halogenated hydrocarbons such as dichloromethane, chloroform and carbon tetrachloride; hexane, cyclohexane and petroleum ether Hydrocarbons such as squalane; aromatic hydrocarbons such as benzene and toluene; supercritical carbon dioxide; ester oils such as isopropyl myristate and isopropyl stearate; fats and oils such as olive oil and diacylglycerol; and silicone oils It is done. These can be used alone or in combination. Among these, it is preferable to use supercritical carbon dioxide or hexane.

  In addition, it is possible to remove inactive contaminants from the extract by a technique such as liquid-liquid distribution, and it is preferable to use such an extract in the present invention. These may be used after performing treatments such as deodorization and decolorization by a known method if necessary.

  These extracts can be used as they are, but can also be used by diluting the extract or preparing it in a powder or paste form by concentration or lyophilization.

  Component (A) is preferably contained in the total composition in an amount of 0.0001 to 5% by mass, particularly 0.0005 to 2% by mass in terms of solid content.

Among the component (B) used in the present invention, examples of the antiperspirant include aluminum chlorohydrate, aluminum zirconium chlorohydrate, aluminum chloride, aluminum sulfate, basic aluminum bromide, aluminum phenolsulfonic acid, and basic iodide. Aluminum etc. are mentioned, and it is preferable to contain 0.1 to 30%, especially 1 to 25% by mass in the total composition, since the skin feel and the effective antiperspirant effect can be obtained.
Examples of bactericides include 3,4,4-trichlorocarbanilide, triclosan, benzalkonium chloride, benzethonium chloride, alkyltrimethylammonium chloride, resorcin, phenol, sorbic acid, salicylic acid, hexachlorophene, isopropylmethylphenol and the like. It is preferable to contain 0.0001 to 1% by mass, particularly 0.0005 to 0.5% by mass in the total composition, in order to effectively suppress the safety and growth of bacteria.

  As the component (B), one or more kinds can be used, and an antiperspirant and a disinfectant can be used in combination.

The deodorant composition of the present invention can further contain (C) a deodorant powder.
Examples of the deodorant powder include chitosan fine particles, amphoteric porous fine particles, zeolite, antibacterial zeolite, porous silica, zinc oxide, and magnesium oxide.

As the chitosan fine particles, those having an average particle diameter of 0.01 to 50 μm are preferable. For example, those described in JP-A-7-304643 can be used.
As the amphoteric porous fine particles, those having an average particle diameter of 0.01 to 50 μm are preferable. For example, those described in JP-A-7-316203 can be used.

  As the antibacterial zeolite, one holding an antibacterial metal ion in an ion-exchangeable part of the zeolite can be used. As the antibacterial metal ion, ions such as silver, copper, and zinc are preferable, and silver-supported zeolite is particularly preferable. Such antibacterial zeolite can be produced, for example, by the method described in JP-A-8-26955.

As magnesium oxide, in addition to normal magnesium oxide powder, magnesium oxide with enhanced deodorizing effect, for example, specific surface area is 120 to 300 m ² / g, and pore volume is 0.8 to 1.5 mL / g. A certain magnesium oxide powder (Japanese Patent Laid-Open No. 2001-187721) or the like can also be used.

  Further, these powders can be used after being surface-coated on nylon, polyethylene, silica or the like or combined. For example, composite powder made of synthetic resin such as nylon, polyethylene, polypropylene and metal oxide such as zinc oxide, magnesium oxide, calcium oxide (Japanese Patent Laid-Open No. 61-217139), metal such as zinc, silver, copper Or a composite of oxide and silicate thereof (Japanese Patent Laid-Open No. 2000-159602), composite powder containing cosmetic powder and aluminum hydroxide (Japanese Patent Laid-Open No. 2002-146238), amorphous silica In the particles of amorphous silica-alumina or amorphous aluminosilicate coated with a magnesium compound such as magnesium hydroxide, magnesium silicate, magnesium oxide (JP-A-7-138140), A powder supporting magnesium oxide (Japanese Patent Laid-Open No. 10-338621), a porous powder composited of silicon dioxide and magnesium oxide (Japanese Patent Laid-Open No. 2003-73249), and the like can be used.

  As the deodorant powder, inorganic powder is preferable, and zeolite, antibacterial zeolite, porous silica, zinc oxide, and magnesium oxide are particularly preferable.

  One or more deodorant powders of the component (C) can be used, and 0.1 to 10% by mass, particularly 0.5 to 5% by mass is contained in the total composition, and the deodorizing effect and the skin. It is preferable because it is excellent in touch.

  In addition to the above components, the deodorant composition of the present invention includes components used in normal cosmetics, such as oil components, water, various surfactants, polymer compounds, wetting agents, preservatives, antioxidants, medicinal effects. Components, fragrances, powders, propellants and the like can be included.

  The deodorant composition of the present invention can be in the form of, for example, aerosol spray, pump spray, roll-on, powder, stick, cream and the like.

Production Example 1 (Preparation of yellowfin extract)
To 10 g of yellowfin bark, 100 mL of a 95 v / v% aqueous ethanol solution was added, extracted at room temperature for 7 days, and filtered to obtain an extract (yield: 87 mL, evaporation residue: 0.72 w / v%).

Production Example 2 (Preparation of yellowfin extract hydrophobic fraction)
To 10 g of yellowfin bark, 100 mL of a 95 v / v% aqueous ethanol solution was added, extracted at room temperature for 7 days, and then filtered to obtain an extract. The extract was concentrated under reduced pressure, further extracted with 100 mL of hexane, and filtered to obtain an extract. This was concentrated under reduced pressure and further dried under reduced pressure to obtain a yellowfin extract hydrophobic fraction (yield: 0.28 g).

Production Example 3 (Preparation of Ginkgo biloba extract)
100 g of a 95 v / v% ethanol aqueous solution was added to 10 g of ginkgo biloba, extracted at room temperature for 7 days, and then filtered to obtain an extract (yield: 85 mL, evaporation residue: 1.59 w / v%).

Production Example 4 (Preparation of Murasaki Extract)
Hexane root (10 g) was added with hexane (100 mL), extracted at room temperature for 7 days, and filtered to obtain an extract (yield: 84 mL, evaporation residue: 0.12 w / v%).

Production Example 5 (Preparation of licorice extract)
100 g of 50 v / v% aqueous ethanol solution was added to 10 g of licorice roots, extracted at room temperature for 7 days, and filtered to obtain an extract (yield: 78 mL, evaporation residue: 3.07 w / v%).

Production Example 6 (Preparation of gardenia extract)
100 g of 95 v / v% ethanol aqueous solution was added to 10 g of gardenia seeds, extracted at room temperature for 7 days, and filtered to obtain an extract (yield: 93 mL, evaporation residue: 1.69 w / v%).

Test Example 1 (Apolipoprotein D degradation inhibitory action)
(1) Preparation of concentrated sweat:
The operation of wiping the armpits of 8 men with apocrine odor with absorbent cotton containing 1.5 mL of distilled water was performed once a day for 3 days. The liquid (57.5 mL) collected by squeezing these absorbent cottons is filtered through a filter with a pore size of 0.45 μm, concentrated with a Millipore centrifugal filter membrane “Centreprep YM-10”, and distilled water is added again In the same manner, it was concentrated with Centriprep YM-10 to remove low molecular components. This was concentrated sweat.

(2) To 0.04 mL of concentrated sweat prepared by the above method (1), 0.03 mL of 100 mM Tris-HCl buffer, 0.02 mL of distilled water and 0.01 mL of each plant extract (Production Examples 1 and 3) 6) was added. This was inoculated with Brevibacterium epiderumidis washed 3 times with pH 7.2, 20 mM Tris-HCl buffer so that the final cell mass was about 10 ⁸ cfu / mL, and incubated at 37 ° C. for 24 hours. Antibody staining was performed. As a gel of SDS polyacrylamide electrophoresis (SDS-PAGE) of bacterial cell-treated concentrated sweat, Ready Gel J (separated gel concentration: 15%, Bio-Rad) was used. For antibody staining, the protein separated by SDS-PAGE is electrically transferred from the gel onto a PVDF filter (Immobilon transfer membrane, Millipore), then the primary antibody is anti-apolipoprotein D monoclonal mouse antibody (RDI), and the secondary antibody is An apolipoprotein D was detected by an ECL Plus Western blotting detection system (Amersham Pharmacia Biotech) using an anti-mouse Ig antibody labeled with HRP (Amersham Pharmacia Biotech), and image processing was performed. , (Apolipoprotein D amount of sample / Apolipoprotein D amount in untreated sweat) × 100 was calculated.

As a result, the residual rate of apolipoprotein D was 51% when no plant extract was added, whereas it was 85% yellowfin extract, 81% ginkgo extract, 82% purple extract, and licorice extract 72. %, Gardenia extract 80%.
By treating the concentrated sweat with Brevibacterium epiderumidis , apolipoprotein D in the concentrated sweat was decomposed and decreased, whereas the addition of a specific plant extract suppressed the degradation of apolipoprotein D.

Examples 1-3 , Comparative Examples 1-2
A powder spray having the composition shown in Table 1 was produced, and the deodorant effect, the dispersion stability of the powder, and the white residue on the skin were evaluated. The results are also shown in Table 1.

(Production method)
After each plant extract, isopropyl myristate, and decamethylcyclopentasiloxane were uniformly mixed, the solution and powder (aluminum chlorohydrate, zeolite) were filled into an aerosol container, clinched, and then LPG was injected. .

(Evaluation methods)
(1) White residue and deodorant effect on skin:
For each powder spray, 0.5 g of the agent was sprayed under the cocoons of 10 panelists having a strong odor, and the white residue on the skin after spraying was subjected to sensory evaluation according to the following criteria. Further, after 8 hours, the deodorant effect was evaluated according to the following criteria.

(White residue on skin)
Score 4: Does not turn white.
Score 3: Not very white.
Score 2: Slightly white.
Score 1: turns white.

(Deodorant effect)
Score 4: Very high deodorant effect.
Score 3: Deodorant effect is high.
Score 2: Deodorant effect is slightly low.
Score 1: Deodorant effect is low.

The average score was determined and judged according to the following criteria.
A: Average score of 3.5 to 4.0.
A: Average score of 2.5 to 3.4.
(Triangle | delta): Average score 1.5-2.4.
X: Average score of 1.0 to 1.4.

(2) Dispersion stability of powder:
About each powder spray, the agent was filled in the glass bottle, and the dispersion state of the powder when the container was shaken at room temperature was visually evaluated by the following 5 evaluation panelists based on the following criteria. An average score was determined and determined in the same manner as (1).
Score 4: very good.
Score 3: Good.
Score 2: Slightly bad.
Score 1: bad.

Example 4 (powder spray)
A powder spray having the following composition was produced by a conventional method.
(component)
Yellowfin extract hydrophobic fraction (Production Example 2) 0.005 (mass%)
Aluminum chlorohydrate (Rocron P, manufactured by Hoechst AG) 1.50
Magnesium oxide coated silica 1.00
Isopropyl palmitate 2.50
Polyoxyethylene / methylpolysiloxane copolymer (KF-6015, manufactured by Shin-Etsu Chemical Co., Ltd.) 0.02
Isostearyl alcohol 0.50
Oleic acid 0.10
Fragrance 0.30
Decamethylcyclopentasiloxane (SH-245, manufactured by Toray Dow Corning Silicone) 2.075
LPG 92.00

Example 5 (pump spray)
A pump spray having the following composition was produced by a conventional method.
(component)
Purple extract (Production Example 4) 0.20 (% by mass)
Aluminum chlorohydrate (REACH 501 solution, manufactured by REHEIS) 2.00
Isopropylmethylphenol 0.20
Porous silica 2.00
Polyoxyethylene (20EO) coconut oil fatty acid sorbitan (Leodol TW-L120, manufactured by Kao Corporation) 0.20
Isopropyl myristate 0.10
Zinc oxide coated nylon 0.20
Linoleic acid 0.01
Fragrance 0.20
Purified water 7.89
Ethanol 87.00

All of the deodorant compositions obtained in Examples 4 to 5 were excellent in the deodorant effect, had no white residue on the skin, and had good powder stability.

Claims (5)

(A) Hydrophobic fraction obtained by extraction with a hydrophobic solvent from a plant selected from yellowfin, ginkgo, purple, licorice and gardenia or an extract thereof , and (B) containing an antiperspirant and / or a fungicide Deodorant composition. The hydrophobic solvent used in component (A) is selected from esters, ethers, halogenated hydrocarbons, hydrocarbons, aromatic hydrocarbons, supercritical carbon dioxide, oils and fats, and silicone oils Item 2. A deodorant composition according to Item 1.   The deodorant composition according to claim 1, wherein component (A) is a hydrophobic fraction of yellowfin extract.   The deodorant composition according to any one of claims 1 to 3, further comprising (C) a deodorant powder.   (C) The deodorant composition according to claim 4, wherein the deodorant powder is an inorganic powder.