JP3908270B2 - アシルフルベン類似体およびその医薬組成物 - Google Patents

アシルフルベン類似体およびその医薬組成物 Download PDF

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JP3908270B2
JP3908270B2 JP51820894A JP51820894A JP3908270B2 JP 3908270 B2 JP3908270 B2 JP 3908270B2 JP 51820894 A JP51820894 A JP 51820894A JP 51820894 A JP51820894 A JP 51820894A JP 3908270 B2 JP3908270 B2 JP 3908270B2
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compound
tumor
alkyl
antitumor agent
cell
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JPH08506812A (ja
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ジェイ. ケルナー,マイケル
シー. マクモリス,トレバー
タエトル,レイモンド
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THE REGENTS OF THE UNIVERSITY OF CARIFORNIA
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    • C07ORGANIC CHEMISTRY
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    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
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    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02Antineoplastic agents specific for leukemia
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
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    • C07C45/65Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
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    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
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    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
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  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
JP51820894A 1993-02-09 1994-02-02 アシルフルベン類似体およびその医薬組成物 Expired - Fee Related JP3908270B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/015,179 1993-02-09
US08/015,179 US5439936A (en) 1989-10-03 1993-02-09 Method of treating certain tumors using illudin analogs
PCT/US1994/001232 WO1994018151A1 (en) 1993-02-09 1994-02-02 Acylfulvene analogues as antitumor agents

Publications (2)

Publication Number Publication Date
JPH08506812A JPH08506812A (ja) 1996-07-23
JP3908270B2 true JP3908270B2 (ja) 2007-04-25

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JP51820894A Expired - Fee Related JP3908270B2 (ja) 1993-02-09 1994-02-02 アシルフルベン類似体およびその医薬組成物

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US (3) US5439936A (zh)
EP (1) EP0683762B1 (zh)
JP (1) JP3908270B2 (zh)
KR (1) KR100311327B1 (zh)
CN (1) CN1046934C (zh)
AT (1) ATE174894T1 (zh)
AU (1) AU676889B2 (zh)
BR (1) BR9405689A (zh)
CA (1) CA2155329C (zh)
CZ (1) CZ288596B6 (zh)
DE (1) DE69415507T2 (zh)
DK (1) DK0683762T3 (zh)
ES (1) ES2125441T3 (zh)
GR (1) GR3029736T3 (zh)
HU (1) HU220059B (zh)
MD (1) MD1418G2 (zh)
NO (1) NO318648B1 (zh)
NZ (1) NZ262282A (zh)
PL (1) PL175024B1 (zh)
RU (1) RU2145849C1 (zh)
TJ (1) TJ266B (zh)
WO (1) WO1994018151A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503714A (ja) * 1998-02-20 2002-02-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗腫瘍剤
US7655695B2 (en) 2005-08-03 2010-02-02 The Regents Of The University Of California Illudin analogs useful as anticancer agents
US7713939B2 (en) 1996-07-18 2010-05-11 The Regents Of The University Of California Illudin analogs useful as antitumor agents

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723632A (en) * 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
US7141603B2 (en) * 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US6436916B1 (en) 2000-10-12 2002-08-20 Alvin Guttag Ibuprofen-aspirin and hydroxymethylacylfulvene analogs
US7015247B2 (en) * 2000-10-12 2006-03-21 Alvin Guttag Ibuprofen-aspirin, hydroxymethylacylfulvene analogs and L-sugar illudin analogs
EP1765313A2 (en) 2004-06-24 2007-03-28 Novartis Vaccines and Diagnostics, Inc. Compounds for immunopotentiation
EP2389171B1 (en) * 2009-01-26 2016-03-30 Taipei Medical University Use of pterosin compounds for treating diabetes and obesity
US10285955B2 (en) 2014-04-10 2019-05-14 Af Chemicals, Llc Affinity medicant conjugate
US11135182B2 (en) 2014-04-10 2021-10-05 Af Chemicals, Llc Affinity medicant conjugates
KR20160142885A (ko) 2014-04-10 2016-12-13 에이에프 케미칼스, 엘엘씨 친화성 약제 컨쥬게이트
CN106083953A (zh) * 2016-06-15 2016-11-09 成都医学院 一种从蕨菜中提取原蕨苷以及制备高纯度原蕨苷的方法
US20210137850A1 (en) * 2017-03-15 2021-05-13 Memorial Sloan Kettering Cancer Center Diagnosis & treatment of ercc3-mutant cancer
WO2020051222A1 (en) * 2018-09-04 2020-03-12 Lantern Pharma Inc. Illudin analogs, uses thereof, and methods for synthesizing the same
EP3667323A1 (en) 2018-12-11 2020-06-17 Kelner, Michael Methods, compositions and devices for treating cancer with illudofulvenes
RU2738848C1 (ru) * 2019-10-24 2020-12-17 Общество с ограниченной ответственностью "Научно-исследовательский институт ХимРар" (ООО "НИИ ХимРар") Ингибитор вируса гепатита В (ВГВ), представляющий собой производные N-{ 3-[6-(диалкиламино)пиридазин-3-ил]фенил} арилсульфонамида и производные N-{ 4-[6-(диалкиламино)пиридазин-3-ил]фенил} арилсульфонамида
US11591295B2 (en) 2019-11-25 2023-02-28 Af Chemicals Llc Affinity illudofulvene conjugates
EP4035684A1 (en) 2019-11-25 2022-08-03 AF Chemical LLC Affinity illudofulvene conjugates
CN112972443A (zh) * 2021-03-29 2021-06-18 杭州添帆生物科技有限公司 一种抗癌药物及其应用
WO2023239821A2 (en) * 2022-06-07 2023-12-14 Lantern Pharma Inc. Treating cancers with combinations of acylfulvenes with ibrutinib or bortezomib
WO2024016014A2 (en) * 2022-07-15 2024-01-18 Lantern Pharma Inc. Method for treating breast cancers and parp resistant breast cancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05503077A (ja) * 1989-10-03 1993-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗腫瘍剤としてのイルージンアナログ
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents
FI85318C (fi) * 1990-08-14 1992-03-25 Tecnomen Oy Kompensering av felet i en klockas gaong.
JPH06223404A (ja) * 1993-01-25 1994-08-12 Mitsubishi Kasei Corp 光学的情報記録用媒体

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713939B2 (en) 1996-07-18 2010-05-11 The Regents Of The University Of California Illudin analogs useful as antitumor agents
JP2002503714A (ja) * 1998-02-20 2002-02-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗腫瘍剤
US7655695B2 (en) 2005-08-03 2010-02-02 The Regents Of The University Of California Illudin analogs useful as anticancer agents

Also Published As

Publication number Publication date
US5563176A (en) 1996-10-08
CZ288596B6 (cs) 2001-07-11
HU9502358D0 (en) 1995-10-30
BR9405689A (pt) 1995-11-21
CN1046934C (zh) 1999-12-01
MD1418G2 (ro) 2000-10-31
MD1418F2 (en) 2000-02-29
HU220059B (hu) 2001-10-28
KR100311327B1 (ko) 2001-12-28
ATE174894T1 (de) 1999-01-15
DE69415507T2 (de) 1999-08-12
GR3029736T3 (en) 1999-06-30
WO1994018151A1 (en) 1994-08-18
DE69415507D1 (de) 1999-02-04
NO318648B1 (no) 2005-04-25
EP0683762B1 (en) 1998-12-23
CA2155329A1 (en) 1994-08-18
NO953099L (no) 1995-10-09
AU676889B2 (en) 1997-03-27
ES2125441T3 (es) 1999-03-01
US5523490A (en) 1996-06-04
US5439936A (en) 1995-08-08
RU2145849C1 (ru) 2000-02-27
DK0683762T3 (da) 1999-08-23
AU6170094A (en) 1994-08-29
PL310159A1 (en) 1995-11-27
CA2155329C (en) 2006-08-15
NO953099D0 (no) 1995-08-07
NZ262282A (en) 1997-06-24
EP0683762A1 (en) 1995-11-29
CZ198695A3 (en) 1996-01-17
JPH08506812A (ja) 1996-07-23
MD960212A (en) 1999-01-31
CN1119854A (zh) 1996-04-03
TJ266B (en) 2000-08-07
HUT72450A (en) 1996-04-29
PL175024B1 (pl) 1998-10-30

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