JP3883291B2 - ストレスの鑑別法 - Google Patents
ストレスの鑑別法 Download PDFInfo
- Publication number
- JP3883291B2 JP3883291B2 JP15387498A JP15387498A JP3883291B2 JP 3883291 B2 JP3883291 B2 JP 3883291B2 JP 15387498 A JP15387498 A JP 15387498A JP 15387498 A JP15387498 A JP 15387498A JP 3883291 B2 JP3883291 B2 JP 3883291B2
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- dehydroepiandrosterone
- stress
- saliva
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012850 discrimination method Methods 0.000 title description 3
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 claims description 42
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 claims description 41
- 229960002847 prasterone Drugs 0.000 claims description 41
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 26
- 210000003296 saliva Anatomy 0.000 claims description 26
- 239000008280 blood Substances 0.000 claims description 21
- 210000004369 blood Anatomy 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 14
- 229960000890 hydrocortisone Drugs 0.000 claims description 13
- 230000002485 urinary effect Effects 0.000 claims description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- 210000002700 urine Anatomy 0.000 description 10
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 8
- 238000000605 extraction Methods 0.000 description 7
- 239000002904 solvent Substances 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- CZWCKYRVOZZJNM-USOAJAOKSA-N dehydroepiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 CZWCKYRVOZZJNM-USOAJAOKSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- JYGXADMDTFJGBT-MKIDGPAKSA-N 11alpha-Hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-MKIDGPAKSA-N 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- CZWCKYRVOZZJNM-UHFFFAOYSA-N Prasterone sodium sulfate Natural products C1C(OS(O)(=O)=O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 CZWCKYRVOZZJNM-UHFFFAOYSA-N 0.000 description 1
- 241000473945 Theria <moth genus> Species 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 150000001886 cortisols Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 229950009829 prasterone sulfate Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- -1 these Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15387498A JP3883291B2 (ja) | 1998-05-19 | 1998-05-19 | ストレスの鑑別法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15387498A JP3883291B2 (ja) | 1998-05-19 | 1998-05-19 | ストレスの鑑別法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH11326318A JPH11326318A (ja) | 1999-11-26 |
| JPH11326318A5 JPH11326318A5 (enExample) | 2005-09-02 |
| JP3883291B2 true JP3883291B2 (ja) | 2007-02-21 |
Family
ID=15572009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15387498A Expired - Lifetime JP3883291B2 (ja) | 1998-05-19 | 1998-05-19 | ストレスの鑑別法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3883291B2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6833274B2 (en) | 2002-05-28 | 2004-12-21 | The Johns Hopkins University | Cortisol sensor |
| KR101019506B1 (ko) | 2008-12-15 | 2011-03-07 | 전남대학교산학협력단 | 타액 내 코르티솔과 데히드로이소안드로스테론 농도를 이용한 부신기능 평가 지표 및 상기 지표를 이용한 부신기능 평가 방법 |
| KR101029251B1 (ko) | 2009-06-18 | 2011-04-18 | 전남대학교산학협력단 | 타액내 코티졸 측정을 통한 코티졸의 일주기리듬 평가 지표 및 방법 |
| KR101447091B1 (ko) * | 2012-08-06 | 2014-10-06 | 주식회사 피코팜 | 스트레스 수치화를 이용한 스트레스 측정 방법 |
| JP7442165B2 (ja) * | 2019-08-15 | 2024-03-04 | 学校法人東京薬科大学 | 基材上に保持された乾燥血液を用いたヒトのｃｙｐ３ａ酵素活性の評価方法 |
-
1998
- 1998-05-19 JP JP15387498A patent/JP3883291B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11326318A (ja) | 1999-11-26 |
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