JP3822601B2 - 安定多形体のフリバンセリン、その製造方法及び薬剤を製造するためのその使用 - Google Patents
安定多形体のフリバンセリン、その製造方法及び薬剤を製造するためのその使用 Download PDFInfo
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- JP3822601B2 JP3822601B2 JP2003519029A JP2003519029A JP3822601B2 JP 3822601 B2 JP3822601 B2 JP 3822601B2 JP 2003519029 A JP2003519029 A JP 2003519029A JP 2003519029 A JP2003519029 A JP 2003519029A JP 3822601 B2 JP3822601 B2 JP 3822601B2
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- flibanserin
- polymorph
- water
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- pharmaceutical composition
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Classifications
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01118593 | 2001-08-02 | ||
| EP01130180 | 2001-12-19 | ||
| PCT/EP2002/008466 WO2003014079A1 (en) | 2001-08-02 | 2002-07-30 | Stable polymorph of flibanserin, technical process for its preparation and the use thereof for preparing medicaments |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004537597A JP2004537597A (ja) | 2004-12-16 |
| JP2004537597A5 JP2004537597A5 (enExample) | 2006-02-16 |
| JP3822601B2 true JP3822601B2 (ja) | 2006-09-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003519029A Expired - Fee Related JP3822601B2 (ja) | 2001-08-02 | 2002-07-30 | 安定多形体のフリバンセリン、その製造方法及び薬剤を製造するためのその使用 |
Country Status (26)
| Country | Link |
|---|---|
| EP (2) | EP1518858A1 (enExample) |
| JP (1) | JP3822601B2 (enExample) |
| KR (1) | KR100899297B1 (enExample) |
| CN (1) | CN1288147C (enExample) |
| AR (2) | AR036208A1 (enExample) |
| AT (1) | ATE288911T1 (enExample) |
| AU (1) | AU2002331361B2 (enExample) |
| BR (1) | BR0211601A (enExample) |
| CA (1) | CA2450093C (enExample) |
| CO (1) | CO5560572A2 (enExample) |
| DE (1) | DE60202958T2 (enExample) |
| DK (1) | DK1414816T3 (enExample) |
| EA (1) | EA006400B1 (enExample) |
| ES (1) | ES2237694T3 (enExample) |
| HR (1) | HRP20040107B1 (enExample) |
| HU (1) | HU228666B1 (enExample) |
| IL (2) | IL159151A0 (enExample) |
| MX (1) | MXPA04000913A (enExample) |
| MY (1) | MY127294A (enExample) |
| NZ (1) | NZ530510A (enExample) |
| PL (1) | PL210224B1 (enExample) |
| PT (1) | PT1414816E (enExample) |
| RS (1) | RS50742B (enExample) |
| SI (1) | SI1414816T1 (enExample) |
| UA (1) | UA76767C2 (enExample) |
| WO (1) | WO2003014079A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7183410B2 (en) | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
| DE10138273A1 (de) * | 2001-08-10 | 2003-02-27 | Boehringer Ingelheim Pharma | Arzneimittel mit neuroprotektiver Wirkung |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| HRP20041092B1 (hr) * | 2002-05-22 | 2013-05-31 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Novi farmaceutski pripravci flibanserina |
| WO2006119884A2 (en) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug abuse with flibanserin |
| PL1912650T3 (pl) | 2005-08-03 | 2018-01-31 | Sprout Pharmaceuticals Inc | Zastosowanie flibanseryny w leczeniu otyłości |
| CA2626134C (en) | 2005-10-29 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
| US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
| JP2009528322A (ja) * | 2006-02-28 | 2009-08-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | フリバンセリンによる弁膜性心疾患の治療又は予防 |
| EA200802208A1 (ru) * | 2006-05-09 | 2009-04-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Применение флибансерина для лечения расстройств полового влечения в постклимактерический период |
| EP2037927B1 (en) | 2006-06-30 | 2010-01-27 | Boehringer Ingelheim International GmbH | Flibanserin for the treatment of urinary incontinence and related diseases |
| AR062320A1 (es) | 2006-08-14 | 2008-10-29 | Boehringer Ingelheim Int | Formulaciones de flibanserina y metodo para fabricarlas |
| CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
| WO2008022932A2 (en) | 2006-08-25 | 2008-02-28 | Boehringer Ingelheim International Gmbh | Controlled release system and method for manufacturing the same |
| WO2008061966A2 (en) * | 2006-11-22 | 2008-05-29 | Boehringer Ingelheim International Gmbh | New use of flibanserin |
| US8722682B2 (en) | 2006-12-20 | 2014-05-13 | Sprout Pharmaceuticals, Inc. | Sulfated benzimidazolone derivatives having mixed serotonin receptor affinity |
| EP1955699A1 (en) * | 2007-02-08 | 2008-08-13 | Boehringer Ingelheim Pharma GmbH & Co. KG | Use of flibanserin for the treatment of insomnia |
| CL2008002693A1 (es) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
| EP2090297A1 (en) | 2008-02-13 | 2009-08-19 | Boehringer Ingelheim International GmbH | Formulations of flibanserin |
| CA2686480A1 (en) | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | New salts |
| CN104926734B (zh) * | 2015-07-07 | 2017-04-05 | 苏州立新制药有限公司 | 氟班色林的制备方法 |
| WO2017076356A1 (zh) * | 2015-11-05 | 2017-05-11 | 苏州晶云药物科技有限公司 | 氟班色林的新晶型及其制备方法 |
| WO2017128932A1 (zh) * | 2016-01-31 | 2017-08-03 | 孟晓明 | 氟班色林的新晶型及其制备方法及其用途 |
| CN111303043A (zh) * | 2019-04-19 | 2020-06-19 | 武汉万知化工医药有限公司 | 一种氟班色林盐酸盐的制备方法 |
| CN115919860B (zh) | 2022-12-05 | 2023-11-10 | 中国药科大学 | 氟班色林在制备治疗雄激素脱发药物中的用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
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2002
- 2002-07-30 RS YUP-78/04A patent/RS50742B/sr unknown
- 2002-07-30 EP EP04026410A patent/EP1518858A1/en not_active Withdrawn
- 2002-07-30 JP JP2003519029A patent/JP3822601B2/ja not_active Expired - Fee Related
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- 2002-07-30 DK DK02767277T patent/DK1414816T3/da active
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- 2002-07-30 AU AU2002331361A patent/AU2002331361B2/en not_active Expired
- 2002-07-30 WO PCT/EP2002/008466 patent/WO2003014079A1/en not_active Ceased
- 2002-07-30 SI SI200230104T patent/SI1414816T1/xx unknown
- 2002-07-30 UA UA2004031505A patent/UA76767C2/uk unknown
- 2002-07-30 CN CNB028152263A patent/CN1288147C/zh not_active Expired - Fee Related
- 2002-07-30 IL IL15915102A patent/IL159151A0/xx unknown
- 2002-07-30 CA CA002450093A patent/CA2450093C/en not_active Expired - Fee Related
- 2002-07-30 EP EP02767277A patent/EP1414816B1/en not_active Expired - Lifetime
- 2002-07-30 EA EA200400252A patent/EA006400B1/ru not_active IP Right Cessation
- 2002-07-30 PL PL364598A patent/PL210224B1/pl unknown
- 2002-07-30 NZ NZ530510A patent/NZ530510A/en not_active IP Right Cessation
- 2002-07-30 HR HR20040107A patent/HRP20040107B1/xx not_active IP Right Cessation
- 2002-07-30 MX MXPA04000913A patent/MXPA04000913A/es active IP Right Grant
- 2002-07-30 BR BR0211601-4A patent/BR0211601A/pt not_active Application Discontinuation
- 2002-07-30 PT PT02767277T patent/PT1414816E/pt unknown
- 2002-07-31 MY MYPI20022876A patent/MY127294A/en unknown
- 2002-08-02 AR ARP020102942A patent/AR036208A1/es not_active Application Discontinuation
-
2003
- 2003-12-02 IL IL159151A patent/IL159151A/en active IP Right Grant
-
2004
- 2004-02-25 CO CO04016766A patent/CO5560572A2/es unknown
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2010
- 2010-07-15 AR ARP100102577A patent/AR077416A2/es unknown
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