HUP0103099A2 - N-Szubsztituált aza-bicikloheptán-származékok, előállításuk és alkalmazásuk - Google Patents
N-Szubsztituált aza-bicikloheptán-származékok, előállításuk és alkalmazásukInfo
- Publication number
- HUP0103099A2 HUP0103099A2 HU0103099A HUP0103099A HUP0103099A2 HU P0103099 A2 HUP0103099 A2 HU P0103099A2 HU 0103099 A HU0103099 A HU 0103099A HU P0103099 A HUP0103099 A HU P0103099A HU P0103099 A2 HUP0103099 A2 HU P0103099A2
- Authority
- HU
- Hungary
- Prior art keywords
- production
- substituted
- fluorine
- chlorine atom
- azabicycloheptane derivatives
- Prior art date
Links
- UUAVYXKRUSVCDJ-UHFFFAOYSA-N 1-cycloheptylazepane Chemical class C1CCCCCC1N1CCCCCC1 UUAVYXKRUSVCDJ-UHFFFAOYSA-N 0.000 title 1
- 229910052801 chlorine Chemical group 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- -1 N-substituted 3-aza-bicyclo[3.2.0]heptane Chemical class 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
Abstract
A találmány tárgyát új általános képletű - ahol R1 fluor- vagyklóratom, R2 alkil- vagy ciklopropilcsoport, és R3 hidrogén-, fluor-vagy klóratom - N-szubsztituált 3-aza-biciklo[3.2.0]heptán-származékokés fiziológiailag elviselhető savakkal képzett sóik képezik. Az újvegyületek különböző idegrendszeri betegségek leküzdésérealkalmazhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19836404A DE19836404A1 (de) | 1998-08-12 | 1998-08-12 | N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| PCT/EP1999/005166 WO2000009499A1 (de) | 1998-08-12 | 1999-07-20 | N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0103099A2 true HUP0103099A2 (hu) | 2002-03-28 |
| HUP0103099A3 HUP0103099A3 (en) | 2002-12-28 |
Family
ID=7877215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0103099A HUP0103099A3 (en) | 1998-08-12 | 1999-07-20 | N-substituted azabicycloheptane derivatives, production and use thereof |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1105388B1 (hu) |
| JP (1) | JP2002522538A (hu) |
| KR (1) | KR20010072407A (hu) |
| CN (1) | CN1312808A (hu) |
| AT (1) | ATE239015T1 (hu) |
| AU (1) | AU5618699A (hu) |
| BG (1) | BG105329A (hu) |
| BR (1) | BR9912888A (hu) |
| CA (1) | CA2340168A1 (hu) |
| CO (1) | CO5130037A1 (hu) |
| CZ (1) | CZ2001465A3 (hu) |
| DE (2) | DE19836404A1 (hu) |
| DK (1) | DK1105388T3 (hu) |
| ES (1) | ES2198947T3 (hu) |
| HK (1) | HK1040082A1 (hu) |
| HR (1) | HRP20010181A2 (hu) |
| HU (1) | HUP0103099A3 (hu) |
| ID (1) | ID27964A (hu) |
| IL (1) | IL140919A0 (hu) |
| MY (1) | MY133139A (hu) |
| NO (1) | NO20010624L (hu) |
| PL (1) | PL346003A1 (hu) |
| PT (1) | PT1105388E (hu) |
| SK (1) | SK812001A3 (hu) |
| TR (1) | TR200100476T2 (hu) |
| WO (1) | WO2000009499A1 (hu) |
| ZA (1) | ZA200101971B (hu) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4254127A (en) * | 1980-04-03 | 1981-03-03 | Janssen Pharmaceutica, N.V. | 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives |
| DE4243287A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| DE4219973A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| DE4427648A1 (de) * | 1994-08-04 | 1996-02-08 | Basf Ag | N-Stubstituierte 3-Azabicyclo[3,2,0,]heptan-Derivate, ihre Herstellung und Verwendung |
| DE4341402A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| DE4427647A1 (de) * | 1994-08-04 | 1996-02-08 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
-
1998
- 1998-08-12 DE DE19836404A patent/DE19836404A1/de not_active Withdrawn
-
1999
- 1999-07-20 CN CN99809525A patent/CN1312808A/zh active Pending
- 1999-07-20 AU AU56186/99A patent/AU5618699A/en not_active Abandoned
- 1999-07-20 DE DE59905342T patent/DE59905342D1/de not_active Expired - Fee Related
- 1999-07-20 ES ES99942792T patent/ES2198947T3/es not_active Expired - Lifetime
- 1999-07-20 ID IDW20010348A patent/ID27964A/id unknown
- 1999-07-20 PL PL99346003A patent/PL346003A1/xx not_active Application Discontinuation
- 1999-07-20 CZ CZ2001465A patent/CZ2001465A3/cs unknown
- 1999-07-20 PT PT99942792T patent/PT1105388E/pt unknown
- 1999-07-20 WO PCT/EP1999/005166 patent/WO2000009499A1/de not_active Application Discontinuation
- 1999-07-20 BR BR9912888-8A patent/BR9912888A/pt not_active IP Right Cessation
- 1999-07-20 CA CA002340168A patent/CA2340168A1/en not_active Abandoned
- 1999-07-20 DK DK99942792T patent/DK1105388T3/da active
- 1999-07-20 EP EP99942792A patent/EP1105388B1/de not_active Expired - Lifetime
- 1999-07-20 IL IL14091999A patent/IL140919A0/xx unknown
- 1999-07-20 KR KR1020017001780A patent/KR20010072407A/ko not_active Application Discontinuation
- 1999-07-20 HU HU0103099A patent/HUP0103099A3/hu unknown
- 1999-07-20 AT AT99942792T patent/ATE239015T1/de not_active IP Right Cessation
- 1999-07-20 JP JP2000564951A patent/JP2002522538A/ja active Pending
- 1999-07-20 TR TR2001/00476T patent/TR200100476T2/xx unknown
- 1999-07-20 SK SK81-2001A patent/SK812001A3/sk unknown
- 1999-08-12 CO CO99051371A patent/CO5130037A1/es unknown
- 1999-08-12 MY MYPI99003450A patent/MY133139A/en unknown
-
2001
- 2001-02-06 NO NO20010624A patent/NO20010624L/no not_active Application Discontinuation
- 2001-03-09 BG BG105329A patent/BG105329A/xx unknown
- 2001-03-09 ZA ZA200101971A patent/ZA200101971B/en unknown
- 2001-03-12 HR HR20010181A patent/HRP20010181A2/hr not_active Application Discontinuation
-
2002
- 2002-03-07 HK HK02101761.3A patent/HK1040082A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1105388E (pt) | 2003-09-30 |
| BG105329A (en) | 2001-12-29 |
| HRP20010181A2 (en) | 2002-04-30 |
| BR9912888A (pt) | 2001-05-08 |
| EP1105388A1 (de) | 2001-06-13 |
| AU5618699A (en) | 2000-03-06 |
| WO2000009499A1 (de) | 2000-02-24 |
| HK1040082A1 (zh) | 2002-05-24 |
| MY133139A (en) | 2007-10-31 |
| SK812001A3 (en) | 2001-08-06 |
| NO20010624D0 (no) | 2001-02-06 |
| CN1312808A (zh) | 2001-09-12 |
| ATE239015T1 (de) | 2003-05-15 |
| DE19836404A1 (de) | 2000-02-17 |
| CA2340168A1 (en) | 2000-02-24 |
| DE59905342D1 (de) | 2003-06-05 |
| KR20010072407A (ko) | 2001-07-31 |
| CO5130037A1 (es) | 2002-02-27 |
| TR200100476T2 (tr) | 2001-07-23 |
| NO20010624L (no) | 2001-02-06 |
| EP1105388B1 (de) | 2003-05-02 |
| ZA200101971B (en) | 2002-03-11 |
| HUP0103099A3 (en) | 2002-12-28 |
| CZ2001465A3 (cs) | 2001-08-15 |
| IL140919A0 (en) | 2002-02-10 |
| PL346003A1 (en) | 2002-01-14 |
| ID27964A (id) | 2001-05-03 |
| DK1105388T3 (da) | 2003-08-18 |
| ES2198947T3 (es) | 2004-02-01 |
| JP2002522538A (ja) | 2002-07-23 |
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