JP3636363B2 - 新規デオキシガラクトノジリマイシン誘導体 - Google Patents
新規デオキシガラクトノジリマイシン誘導体 Download PDFInfo
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- JP3636363B2 JP3636363B2 JP52554194A JP52554194A JP3636363B2 JP 3636363 B2 JP3636363 B2 JP 3636363B2 JP 52554194 A JP52554194 A JP 52554194A JP 52554194 A JP52554194 A JP 52554194A JP 3636363 B2 JP3636363 B2 JP 3636363B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US08/061,645 | 1993-05-13 | ||
| US08/061,645 US5399567A (en) | 1993-05-13 | 1993-05-13 | Method of treating cholera |
| US08/102,654 US6291657B1 (en) | 1993-05-13 | 1993-08-05 | Deoxygalactonojirimycin derivatives |
| US08/102,654 | 1993-08-05 | ||
| PCT/US1994/004974 WO1994026714A1 (en) | 1993-05-13 | 1994-05-11 | Novel deoxygalactonojirimycin derivatives |
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| JPH08510244A JPH08510244A (ja) | 1996-10-29 |
| JP3636363B2 true JP3636363B2 (ja) | 2005-04-06 |
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| JP (1) | JP3636363B2 (https=) |
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| AU (1) | AU6783294A (https=) |
| CA (1) | CA2159988C (https=) |
| DE (1) | DE69401658T2 (https=) |
| DK (1) | DK0698012T3 (https=) |
| ES (1) | ES2097653T3 (https=) |
| GR (1) | GR3022554T3 (https=) |
| WO (1) | WO1994026714A1 (https=) |
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| US5798366A (en) * | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
| US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
| US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
| WO2000029556A2 (en) * | 1998-11-17 | 2000-05-25 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Identification of glycosphingolipids that promote hiv-1 entry into cells |
| US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
| ATE234626T1 (de) | 1999-07-26 | 2003-04-15 | Searle & Co | Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten |
| AU1840101A (en) | 1999-08-10 | 2001-03-05 | Chancellor, Masters And Scholars Of The University Of Oxford, The | Long chain n-alkyl compounds and oxo-derivatives thereof |
| US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| AU2003248960B2 (en) | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
| AU2003246942B2 (en) | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| GB0229476D0 (en) * | 2002-12-17 | 2003-01-22 | Oxford Glycosciences Uk Ltd | Novel process |
| PT2441467E (pt) | 2003-01-31 | 2015-10-12 | Sinai School Medicine | Terapia combinada para o tratamento de transtornos associados a uma deficiência proteica |
| GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| EP1682504B1 (en) * | 2003-11-12 | 2012-12-26 | Amicus Therapeutics Inc. | Hydroxy piperidine derivatives to treat gaucher disease |
| US20050256168A1 (en) * | 2004-04-28 | 2005-11-17 | Block Timothy M | Compositions for oral administration for the treatment of interferon-responsive disorders |
| WO2005123055A2 (en) * | 2004-06-14 | 2005-12-29 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
| EP2932982B1 (en) | 2005-05-17 | 2018-10-03 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| JP2009545621A (ja) | 2006-08-02 | 2009-12-24 | ユナイテッド セラピューティクス コーポレーション | ウィルス感染症のリポソーム処置 |
| US20090252785A1 (en) * | 2008-03-26 | 2009-10-08 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
| KR20120059447A (ko) * | 2009-03-27 | 2012-06-08 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 콜레스테롤 수준 저하 리포좀 |
| CA2793276A1 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | Ganglioside biosynthesis modulators |
| RU2609210C2 (ru) | 2010-12-23 | 2017-01-31 | Алектос Терапьютикс Инк. | Селективные ингибиторы гликозидазы и их применение |
| EP2691407B1 (en) | 2011-03-31 | 2017-02-22 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| US9701693B2 (en) | 2011-06-27 | 2017-07-11 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| US9522883B2 (en) * | 2012-08-31 | 2016-12-20 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| EP2890675A4 (en) | 2012-08-31 | 2016-01-13 | Alectos Therapeutics Inc | GLYCOSIDASE INHIBITORS AND USES THEREOF |
| EP2890676B1 (en) | 2012-08-31 | 2018-12-05 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| KR20150079711A (ko) | 2012-10-31 | 2015-07-08 | 알렉토스 테라퓨틱스 인크. | 글리코시다아제 저해제 및 이의 용도 |
| MX2015008837A (es) * | 2013-01-09 | 2015-10-14 | Amicus Therapeutics Inc | Composiciones parenterales estables de dnj. |
| AU2018278247B2 (en) * | 2017-06-01 | 2022-07-28 | Idorsia Pharmaceuticals Ltd | Crystalline form of N-butyldeoxygalactonojirimycin |
| EP4034256B1 (en) | 2019-09-25 | 2025-11-19 | Assia Chemical Industries Ltd. | Solid state forms of lucerastat salts and process for preparation thereof |
| WO2022132992A1 (en) | 2020-12-16 | 2022-06-23 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds |
| US11623916B2 (en) * | 2020-12-16 | 2023-04-11 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade migalastat and methods of producing the same |
| WO2025017212A1 (en) | 2023-07-20 | 2025-01-23 | Katholieke Universiteit Leuven | Udp-glucose ceramide glucosyltransferase synthase (ugcg) inhibitors in the treatment of cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| US4065562A (en) | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
| NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| GB2020278B (en) | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
| EP0252962B1 (en) | 1985-12-23 | 1995-08-23 | Fred Hutchinson Cancer Research Center | Regulating retroviral replication, infection, and pathogenesis |
| US4849430A (en) | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
| US5011829A (en) * | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
| US5030638A (en) | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
| CA2086413A1 (en) | 1990-06-29 | 1991-12-30 | Yohji Ezure | Piperidine derivatives |
| US5128347A (en) * | 1990-10-18 | 1992-07-07 | Monsanto Company | Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin |
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1993
- 1993-08-05 US US08/102,654 patent/US6291657B1/en not_active Expired - Lifetime
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1994
- 1994-05-11 CA CA002159988A patent/CA2159988C/en not_active Expired - Fee Related
- 1994-05-11 DE DE69401658T patent/DE69401658T2/de not_active Expired - Fee Related
- 1994-05-11 DK DK94916021.2T patent/DK0698012T3/da active
- 1994-05-11 AT AT94916021T patent/ATE148456T1/de not_active IP Right Cessation
- 1994-05-11 WO PCT/US1994/004974 patent/WO1994026714A1/en not_active Ceased
- 1994-05-11 AU AU67832/94A patent/AU6783294A/en not_active Abandoned
- 1994-05-11 EP EP94916021A patent/EP0698012B1/en not_active Expired - Lifetime
- 1994-05-11 JP JP52554194A patent/JP3636363B2/ja not_active Expired - Fee Related
- 1994-05-11 ES ES94916021T patent/ES2097653T3/es not_active Expired - Lifetime
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1995
- 1995-03-01 US US08/396,989 patent/US5580884A/en not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2159988C (en) | 2007-01-09 |
| JPH08510244A (ja) | 1996-10-29 |
| US6291657B1 (en) | 2001-09-18 |
| DK0698012T3 (https=) | 1997-02-17 |
| US5786368A (en) | 1998-07-28 |
| AU6783294A (en) | 1994-12-12 |
| DE69401658D1 (de) | 1997-03-13 |
| US5580884A (en) | 1996-12-03 |
| WO1994026714A1 (en) | 1994-11-24 |
| CA2159988A1 (en) | 1994-11-24 |
| ATE148456T1 (de) | 1997-02-15 |
| DE69401658T2 (de) | 1997-06-12 |
| GR3022554T3 (en) | 1997-05-31 |
| EP0698012B1 (en) | 1997-01-29 |
| ES2097653T3 (es) | 1997-04-01 |
| EP0698012A1 (en) | 1996-02-28 |
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