JP3408760B2 - Contact lens care agent - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a care agent for contact lenses. More specifically, the present invention relates to a contact lens care product that can improve the wearing sensation of a contact lens and a method for improving the wearing sensation of a contact lens.

[0002]

2. Description of the Related Art Contact lenses include hard contact lenses and soft contact lenses, and soft contact lenses are classified into non-hydrous type and hydrous gel type. When these contact lenses are worn, the eyes may sometimes feel discomfort such as foreign body sensation, dryness, cloudiness, and itchiness. A contact lens that is less likely to cause such discomfort can be referred to as a contact lens having a good wearing feeling.

Conventionally, there are still few examples in which a contact lens agent has been developed mainly for the purpose of improving such wearing feeling of contact lenses. It has only been found that a solution of methyl cellulose, polyvinyl alcohol, hydroxyethyl cellulose, or hyaluronic acid has the effect of improving the wearing sensation. It is said that these effects are brought about by improving the wettability of the contact lens surface due to the thickening effect, but it is not clear. However, as described above, improving the wearing sensation of contact lenses is an important issue, and particularly, as seen in the recent spread of disposable contact lenses, hydrous soft lenses have been widely used, and dry lenses have been dried. The number of wearers who feel the feeling is increasing, and improvement thereof is strongly desired.

[0004]

That is, the present invention is intended to provide a care agent for contact lenses, which can improve the wearing feeling of contact lenses.

[0005]

Means for Solving the Problems As a result of intensive studies to solve such a problem, the present inventor has found that the contact lens is worn by immersing the contact lens in a solution containing trimethylglycine. It was found that the feeling can be improved, and the present invention has been achieved.
That is, the present invention provides a contact lens care agent containing trimethylglycine and containing no proteolytic enzyme. Furthermore, the present invention provides a method for improving the wearing sensation of a contact lens by immersing the contact lens in a liquid containing trimethylglycine and containing no proteolytic enzyme.

[0006] Trimethylglycine is a natural substance and is contained in a wide range of animals and plants. For example, sugar radish is often contained in malt, mushrooms, fruits, especially plants of the family Chenopodiaceae, and in animals, shrimp, crab, and so on. It is also found in octopus and in human liver. The content of trimethylglycine in the care agent for contact lenses of the present invention is preferably in the range of 0.01% to 50% at the time of dipping the contact lens, and more preferably 0.1% to 30%. It is a range. When the amount of trimethylglycine used is less than 0.01%, the desired effect can hardly be expected, and even when the content exceeds 50%, the effect does not increase.

The term "care agent for contact lenses" as used in the present invention means a detergent, a preservative, a washing preservative, a dissolving water, a conditioning solution, and a rinse sol which are used when wearing, preserving, and cleaning the contact lens. -Solution, lubrication solution, disinfectant, etc. Furthermore, granules, powders, tablets, gels, etc. for adjustment at the time of use, which contain trimethylglycine in advance, are also included in the scope of the present invention. The wearing sensation of a contact lens refers to a foreign body sensation, a feeling of dryness, cloudiness, etc. felt by the wearer when wearing the lens.For example, in addition to the actual wearing test, it should be revealed by a water retention test or water wetting test of the lens. You can also

The contact lens care agent of the present invention comprises:
If desired, a surfactant, a salt, an antiseptic, a chelating agent, a buffer, an enzyme, a thickener, a chemical sterilizer, an abrasive and the like can be present alone or in combination. As a surfactant,
Anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants and the like can be used alone or in combination. Examples of the anionic surfactant include sodium alkylbenzene sulfonate, sodium alkyl sulfate, sodium α-olefin sulfonate, sodium polyoxyethylene alkyl ether sulfate, sodium alkyloylmethyl taurine, sodium alkyloylbenzalcosin, and polyoxyethylene alkyl ether. Examples include sodium phosphate, sodium di (polyoxyethylene alkyl ether) phosphate, sodium polyoxyethylene alkylphenyl ether sulfate, and the like.

Examples of the cationic surfactant include alkylamine salts and alkylammonium salts. As a nonionic surfactant, poly (oxyethylene)
Examples thereof include poly (oxypropylene) block copolymer, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene alkyl ester, polyoxyethylene sorbitan alkyl ester, and polyoxyethylene hydrogenated castor oil.

As the amphoteric surfactant, N-lauroylaminopropyl-N, N-dimethylglycine, N-cocoylaminopropyl-N, N-dimethylglycine, N-
Lauroylaminopropyl-N-carboxymethyl-N
-Hydroxyethylglycine, N-oleylaminopropyl-N-carboxymethyl-N-hydroxyethylglycine, N-3-dodecyloxy-2-hydroxypropyl-N, N-dimethylglycine, N-cocoylaminopropyl-N-hydroxyethyl -3-Amino-propionic acid, tri- [3- (N-cocoylaminoethyl-N-
Hydroxyethyl-N-carboxymethyl) amino-2
-Hydroxy-propanol] phosphate, alkyldiaminoethylglycine hydrochloride (the alkyl group is mainly composed of those containing 12 and 14 carbon atoms) and the like. Usually, these surfactants are used in the range of 0.01 to 20%.

Examples of salts include sodium chloride, potassium chloride and the like, and they are usually used in the range of 0.1 to 1%. Examples of the preservative include benzalkonium chloride, sorbic acid, alkyltriethanolamine, paraben and the like, and they are usually used in the range of 0.0001 to 0.5%.
Examples of the chelating agent include EDTA-2Na, trihydroxymethylaminomethane, soda hexametaphosphate and the like, which is usually used in the range of 0.01 to 5%.

As the buffer, sodium bicarbonate, sodium phosphate, sodium hydrogen phosphate, sodium borate,
Examples thereof include boric acid and sodium or potassium citrate, and they are usually used in the range of 0.01 to 5%. As the enzyme, a lipolytic enzyme, a polysaccharide degrading enzyme or the like can be used alone or in combination, and as the lipolytic enzyme, Aspergillus, Streptomyces, lipase derived from a microorganism such as valacis and the like can be exemplified, and as a polysaccharide degrading enzyme. Can be exemplified by heparinase, hyaluroninase, amylase, dextranase, etc., and is usually used in the range of 0.01% to 5%.

Examples of the thickener include mucopolysaccharide, polyvinyl alcohol, methylcellulose and its derivatives, and they are usually used in the range of 0.1% to 5%. Examples of the chemical sterilizing agent include 3% hydrogen peroxide solution and polyguard (quaternary ammonium salt). Silica as an abrasive,
Examples include inorganic fine particles such as titanium oxide and polymer fine particles. In the present invention, other substances, such as fragrances,
There is no limitation on the combined use with a dye or the like, and it is free to allow these substances to coexist if desired.

[0014]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

Example 1 Each component was dissolved in purified water and Table 1 shows Example 1
A preservative solution for contact lenses having the composition shown below was prepared. On the other hand, a preservative for contact lenses (Comparative Example 1) having a composition obtained by removing only trimethylglycine from Example 1 was prepared. As trimethylglycine, Asahi Chemical Industry Co., Ltd. product (trade name: Aminocoat) was used.

Using both solutions, a monitor test was performed on 10 oxygen permeable hard contact lens wearers. Seven out of ten were Aimi-EX Premium (manufactured by Asahi Kasei Amy Co., Ltd.) wearers, and three were Aimi-O2 Fine (manufactured by the same company) wearers. For these 10 people,
When the contact lens using the preservative solution of Example 1 was worn on the right eye and the contact lens using the preservative solution of Comparative Example 1 was worn on the left eye, the impression after one week was heard.
8 people answered that it was better to use the preservative solution (The breakdown is Aimi-EX Premium wearer 6 people, Aimi-
O2 fine wearers 2), and 2 answered that there was no difference between the two.

[0016]

[Example 2] Soft contact lens (Sureview;
A wearer (Johnson End Johnson Medical Co., Ltd.) was subjected to the same monitor-test as in Example 1 using the preservative solutions having the compositions shown as Example 2 and Comparative Example 2 in Table 1. Eight of the respondents answered that the use of the preservative solution of Example 2 had a better wearing feeling, and two responded that there was no difference between them.

[0017]

[Example 3] For wearers of soft contact lenses (Aimi-Soft Caribbean; manufactured by Asahi Kasei Amy Co., Ltd.), the same preservative solutions as those of Example 1 and Comparative Example 2 in Table 1 were used. Monitor-tested. Seven people answered that the use of the preservation solution of Example 3 was better in wearing comfort, and three people answered that there was no difference between them.

[0018]

[Example 4] In contrast to the monitor of Example 1, the left eye was fitted with the contact lens using the cleaning preservative solution shown as Example 4 in Table 1, and the right eye was evaluated using the cleaning preservative solution of Comparative Example 4. The same monitor test as in Example 1 was conducted by wearing contact lenses. Eight persons answered that the feeling of wearing was better when using the wash preservation solution of Example 4 (breakdown: 6 Aimi-EX premium wearers, 2 Aimi-O2 fine wearers).
2) who answered that there is no difference between the two.

[0019]

[Example 5] Soft contact lens (Sureview:
Johnson & Johnson Medical Co., Ltd.
Was immersed in a liquid having the composition shown as Example 5 in Table 1 for 2 days, the adhered water was wiped off with clean paper (clean wipe), and the mixture was left at room temperature for 8 hours, and the change in lens weight was measured. The weight loss due to standing was 48%. Comparative Example 5 and Comparative Example 6
The weight reduction of the lens immersed in the above solution is 5
6% and 55%, showing the water retention effect of trimethylglycine. An attempt was made to prepare a 10% sodium hyaluronate solution with the composition of Comparative Example 5, which resulted in a gel and a transparent liquid was not obtained.

[0020]

[Table 1]

[0021]

EFFECT OF THE INVENTION The use of the contact lens care product according to the present invention has the effect of enhancing the wearing sensation of contact lenses.

Claims (3)

(57) [Claims] 1. A protein containing trimethylglycine and containing trimethylglycine
Care product for contact lenses that does not contain white matter-degrading enzymes . 2. The agent for care for contact lenses according to claim 1, which is a liquid agent. 3. A method of improving the wearing sensation of a contact lens by immersing the contact lens in a liquid containing trimethylglycine and containing no proteolytic enzyme .