JP2000356738A - Solution for contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a solution which improves surface wettability and has washing, preserving and disinfecting functions by preparing the solution by compounding specific ratios of a specific compound and one or two kinds of sodium chloride and potassium chloride and preparing the solution equivalently to an aqueous sodium chloride solution of a specific ratio in an isotonic property. SOLUTION: This solution is prepared by compounding compounds expressed by formula. In the formula, R1 to R3 denote alkyl groups. While coconut oil, betaine alkyldimethylaminoacetate, betaine stearyldimethylaminoacetate and betaine lauryldimethylaminoacetate, etc., can be exemplified as these compounds, the betaine lauryldimethylaminoacetate is more preferable in terms of the stimulus to the mucous membranes of the eyes. The solution is prepared equivalently to the aqueous sodium chloride solution of 0.5 to 1.0% in the isotonic property. The preparation is executed by compounding one or two kinds of the sodium chloride and the potassium chloride within a range of 0.01 to 1.2% in the total thereof.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a solution for contact lenses. More specifically, the present invention relates to a contact lens solution capable of improving the wettability of a contact lens.

[0002]

2. Description of the Related Art Contact lenses include hard contact lenses and soft contact lenses. Soft contact lenses are further classified into non-hydrated types and hydrous gel types. When these contact lenses are worn, in some cases, the eyes may feel uncomfortable, such as a foreign body sensation, a dry sensation, and cloudiness. A contact lens with a low frequency of feeling unpleasant can be said to be a contact lens with a good feeling of wearing.

Conventionally, there has been no example of developing a contact lens solution for the purpose of mainly improving such a feeling of wearing a contact lens, and the solution is slightly worn by adding a nonionic surfactant to a washing preservation solution. It has only been found that polyvinyl alcohol used as a thickening agent has the effect of improving the feeling of wearing and the effect of improving the feeling of wearing. These effects are brought about by improving the wettability of the contact lens surface by tears. Improving the feeling of wearing contact lenses is an important problem for contact lens wearers.However, if there is no sufficient means at present and discomfort during wearing is strong, it is necessary to apply artificial tears, etc. Outdoing the way. Therefore, development of a contact lens solution having a function of improving the wettability of a contact lens is strongly desired. On the other hand, hygiene management of contact lenses is also an important issue, and imparting a cleaning and disinfecting effect suitable for this is one of the functions required for contact lens solutions. Similarly, even when such a contact lens solution is accidentally put directly into the eye, a function that the irritation is not large is also required.

[0004]

SUMMARY OF THE INVENTION The present invention aims to provide a contact lens solution which has a function of improving the wettability of a contact lens, has a low irritation property, and further has a washing / disinfecting function. Is what you do.

[0005]

Means for Solving the Problems In order to solve such a problem, the present inventors have conducted intensive studies on various surfactants, and as a result, have found that compounds having the following structural formula (1)

Embedded image The present inventors have found that by immersing a contact lens in an aqueous solution containing the compound, the wettability of the contact lens can be improved, leading to the present invention.

Although such compounds are not particularly novel, they have a function of cleaning and disinfecting contact lenses.
In addition, it is a surprising fact that it has a function of improving even wettability. That is, the present invention is a contact lens solution comprising a compound represented by the formula (1). The compounding amount of these compounds is preferably used in the range of 0.001 to 3% when the contact lens is immersed, and more preferably 0.1 to 3%.
It is used in the range of 01 to 1%. If the compounding amount of these compounds is less than 0.001%, the desired effect can hardly be expected, and if the compounding amount exceeds 3%, the effect does not increase and the isotonicity described later is also secured. It is not preferable from the point of view.

Examples of these compounds include coconut oil alkyldimethylaminoacetate betaine, stearyldimethylaminoacetate betaine, lauryldimethylaminoacetate betaine, and the like. Is preferred. These compounds are commercially available, for example, betaine lauryldimethylaminoacetate can also be obtained by betaine-forming lauryldimethylamine and sodium monochloroacetate in the presence of water or a solvent. Further, the contact lens solution of the present invention is adjusted to be isotonic equivalent to a 0.5 to 1.0% aqueous sodium chloride solution in order to achieve a lower irritation. This adjustment is performed by blending one or two kinds of sodium chloride and potassium chloride in a total amount of 0.01 to 1.2%.

The contact lens solution referred to in the present invention refers to various care products specified in Article 2 of the Voluntary Safety Standards for cleaning agents, preservatives, cleaning preservatives, etc. for contact lenses specified by the Japan Contact Lens Association. , Contact lens cleaning agents, preservatives, cleaning preservatives, dissolving water and quasi-drug disinfectants for soft contact lenses, etc. Some of them contain compounds,
What is included in the scope of the present invention is as described in the above voluntary standards.

The solution of the present invention may contain a chelating agent, a buffer and the like, if desired, without departing from the scope of the present invention. As a chelating agent, EDTA-
Examples thereof include 2Na, trihydroxymethylaminomethane, and sodium hexametaphosphate, which are usually used in the range of 0.005 to 1%. As a buffer, sodium bicarbonate,
Examples thereof include sodium phosphate, sodium hydrogen phosphate, sodium borate, boric acid, and sodium or potassium citrate. Usually, the amount is used in the range of 0.01 to 1%. Also,
If necessary, a compound having a corneal metabolism-activating effect such as saccharides such as trehalose and taurine can be added without departing from the scope of the present invention. These are all used as a compound for improving the wearing feeling of a contact lens. These are all used in the range of 0.0001 to 3%.

Similarly, a surfactant, a preservative, an enzyme, a thickener and the like can be used alone or in combination, if desired, without departing from the scope of the present invention. As the surfactant, anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants and the like can be used alone or in combination, and as the anionic surfactant,
Sodium alkylbenzene sulfonate, sodium alkyl sulfate, sodium α-olefin sulfonate, sodium polyoxyethylene alkyl ether sulfate, sodium alkyloyl methyl taurate, sodium alkyloyl benzalcosin, sodium polyoxyethylene alkyl ether phosphate, di (polyoxyethylene Alkyl ethers) Sodium phosphate, polyoxyethylene alkyl phenyl ether sodium sulfate and the like, cationic surfactants such as alkylamine salts and alkylammonium salts, and non-ionic surfactants as
Poly (oxyethylene) -poly (oxypropylene) block copolymer, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene alkyl ester, polyoxyethylene sorbitan alkyl ester, polyoxyethylene hydrogenated castor oil, etc. Examples of the amphoteric surfactant include N-lauroylaminopropyl-N, N-dimethylglycine, N-cocoylaminopropyl-N, N-dimethylglycine,
-Lauroylaminopropyl-N-carboxymethyl-
N-hydroxyethylglycine, N-oleylaminopropyl-N-carboxymethyl-N-hydroxyethylglycine, N-3-dodecyloxy-2-hydroxypropyl-N, N-dimethylglycine, N-cocoylaminopropyl-N-hydroxy Ethyl-3-amino-propionic acid, tri- [3- (N-cocoylaminoethyl-N
-Hydroxyethyl-N-carboxymethyl) amino-
2-hydroxy-propanol] phosphate, alkyl diaminoethyl glycine hydrochloride (the alkyl group is mainly composed of those containing 12 and 14 carbon atoms) and the like.

Usually, these surfactants are used in an amount of 0.01 to
Although it is used in the range of 2%, nonionic surfactants are preferably used because they cause little irritation to the ocular mucosa. Examples of the preservative include benzalkonium chloride, sorbic acid, alkyltriethanolamine, chlorohexidine gluconate, paraben, polyhexamethylene biguanide, polydronium chloride, polylysine, and the like.
Used in the range of 001 to 1%. As the enzyme, proteolytic enzymes, lipolytic enzymes, polysaccharide degrading enzymes and the like can be used alone or in combination. Microorganism-derived proteases and peptidases, animal-derived trypsin,
As a lipolytic enzyme such as pepsin, Aspergillus,
Lipases derived from microorganisms such as Streptomyces and Bacillus
Examples of zeolites and polysaccharide-degrading enzymes include heparinase, hyaluroninase, amylase, dextranase and the like, which are usually used in the range of 0.005 to 5%. Examples of the thickener include mucopolysaccharides such as sodium hyaluronate, polyvinyl alcohol, methylcellulose and derivatives thereof,
Polyethylene glycol and the like can be exemplified, usually 0.01 to
Use in the range of 5%. In the present invention, the combination with other substances, for example, a fragrance, a dye, and the like is not limited, and these substances can be freely used if desired.

[0012]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described specifically with reference to examples, but the present invention is not limited to these examples.

Examples 1 to 10 Each component was dissolved in purified water according to the formulation shown in Table 1 to prepare various compositions (unit: w / v%, weight: g, volume: ml). With respect to all the compositions, evaluation of water wettability, evaluation of detergency, and measurement of osmotic pressure were performed by the following methods, and Examples 1 and 8 were evaluated for antibacterial properties.

Comparative Examples 1 to 5 Compositions having the formulations shown in Table 2 were prepared and evaluated for water wettability, detergency, and osmotic pressure as in the compositions of Examples 1 to 10.

Evaluation Results of Water Wettability The compositions of Examples 1 to 10 were used as preservation liquids at the time of shipment of Aimi-EX Premium (manufactured by Asahi Kasei Aimie Co., Ltd.). That is, a contact lens after manufacture [AIMI-EX Premium; manufactured by Asahi Kasei AIMY Co., Ltd.]
Was immersed in these compositions. 1 day after immersion, 5 days after immersion,
In each case, gently remove the dipped contact lens with tweezers, lightly rinse with purified water, and then slowly lift the lens out of the purified water. The surface of the lens taken out of the purified water was visually observed. A rank is 60% if the lens surface is 80% or more wet
If it is not less than 80% and it is B rank, if it is 40% or more and less than 60%, it is C rank.
Those having a rank of less than 20% were evaluated as E rank. The lenses observed one day later were discarded after observation, and the lenses observed five days later were lenses immersed continuously for five days.
The results are as shown in Tables 1 and 2. The compositions of Examples 1 to 10 and Comparative Examples 1 and 5 improved the wettability of the contact lens surface. On the other hand, the compositions of Comparative Examples 2 to 4 had no effect of improving the wettability of the contact lens.

Detergency test results: 10 g of beef tallow, 10 g of soybean oil, 0.25 g of monoolein,
0.1 g of oil red was dissolved in 60 ml of chloroform to prepare a liquid for preparing a stained lens. Contact lenses [Manami -O ₂ Fine; Asahi Kasei Manami - KK] washing storage solution for contact lenses; washed with [Manami - - Care Asahi Kasei Manami Ltd.], rinsed with purified water, and air dried . The contact lens is immersed in the dirt lens preparation liquid previously prepared for 1 to 2 seconds, and the contact lens taken out is air-dried. If droplets for making a dirty lens adhere to the contact lens, absorb with a filter paper before air drying.

A set of six dirt lenses thus prepared was immersed in 50 ml of the composition of Example 1,
Wash by stirring for minutes. The lens is taken out, rinsed with purified water for 1 minute, and air-dried for 1 day. 7 ml of 6 lenses (one set)
Immerse in chloroform and stir to dissolve residual stain.
The absorbance of the chloroform solution is measured, and the washing rate is calculated according to the following equation. Cleaning rate = [(amount of dirt before cleaning-amount of dirt after cleaning) / amount of dirt before cleaning] × 100 (%) The cleaning rates of Examples 2 to 10 and Comparative Examples 1 to 5 are obtained in the same manner. The results are shown in Tables 1 and 2. Example 1
-10 and Comparative Examples 3 and 5 showed good detergency. On the other hand, the compositions of Comparative Examples 1, 2, and 4
The cleaning power was poor.

Osmotic Pressure Measurement Results The osmotic pressure was measured by the freezing point depression method. The results are shown in Table 1,
2 is shown. In addition, 0.5% measured by the same method.
The osmotic pressure of 0% aqueous sodium chloride solution is 15
5, 325 (mOsm). Examples 1 to 10 and Comparative Examples 1 to 4 were within the desired range, but Comparative Example 5 was far off.

[0017] showed the antibacterial test result antibacterial test results are shown in Table 3. Five kinds of test bacteria shown in the table were added to the compositions of Examples 1 and 8 so as to obtain a predetermined number of bacteria (the number of initial bacteria, unit; number / ml). The number of surviving bacteria (number / ml) present in the composition was measured over time. 5
It was confirmed that the test bacteria of all species decreased over time.

[0018]

[Table 1]

[0019]

[Table 2]

[0020]

[Table 3]

[0021]

The contact lens solution according to the present invention has low irritation and is effective not only for cleaning and disinfecting the contact lens, but also for improving the surface wettability of the contact lens.

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 2H006 BC00 DA09 4H006 AA03 AB12 AB20 AB70 BS10 BS70 BU32 9A001 BB06 HH35 KK35 KK54

Claims (3)

[Claims] 1. A compound having the following structural formula (1): A solution containing one or two of sodium chloride and potassium chloride in a total amount of 0.01 to 1.2% (w / v%; hereinafter, all percentages are in this unit); A solution for contact lenses, which is equivalent to a 0.5 to 1.0% aqueous solution of sodium chloride. 2. In the structural formula (1), R ₁ , R ₂ , R
The solution of claim 1 wherein at least two of a methyl group of _3. 3. The solution according to claim 1, wherein the compound having the structural formula (1) is betaine lauryldimethylaminoacetate.