KR0154371B1 - Contact lens cleaning composition - Google Patents

Abstract

The present invention relates to a contact lens cleaning liquid composition, a stimulation-reducing agent and cleaning power that can prevent side effects that may appear when the eye wears after washing the lens, namely irritation, redness of the cornea, foreign body, etc. Good antiseptic and less stimulation Contact lens cleaning liquid composition and irritant agent, zwitterionic surfactant, which comprises a zwitterionic surfactant with, and does not include a preservative that may be deposited on the lens to discolor the lens or cause side effects when worn. And it relates to a contact lens cleaning liquid composition comprising a polymeric preservative having a large molecular size.

Description

[Name of invention]

Contact Lens Cleaning Liquid Composition

Detailed description of the invention

[Purpose of invention]

The present invention relates to a contact lens cleaning liquid composition, and more particularly, a stimulation-reducing agent and cleaning power that can prevent side effects that may appear when the eye is worn after washing the lens, such as irritation, redness of the cornea, foreign body, etc. A contact lens cleaning liquid composition and irritant agent, both of which contain a small amount of antiseptic cationic surfactant and do not contain a preservative which may be deposited on the lens and discolor the lens or cause side effects when worn. It relates to a contact lens cleaning liquid composition comprising an ionic surfactant and a polymeric preservative having a large molecular size.

[Use Field of the Invention and Prior Art]

Contact lenses are increasingly used in terms of correcting vision and beauty, and accordingly, interest in how to clean lenses is increasing. Contact lenses tend to form deposits on the lens surface due to external factors such as mascara and hair spray and internal factors such as protein, mucus and fatty secretions.

Methods for removing such external and internal factors deposits include US Pat. Nos. 5,169,455, PCT 94/06429, EP 0586741, EP 0141607, US Pat. No. 3,910,296, PCT 88/05073, EP 0140669. Most of the cleaners containing proteolytic enzymes and detergents using various kinds of surfactants such as proteolytic enzymes are generally known to be effective and safe. There is a problem to soak over time.

On the other hand, there is an advantage that the cleaning liquids using nonionic, cationic, anionic and amphoteric surfactants can be used easily and conveniently. Sometimes it acts as an argument.

In particular, in order to prevent deterioration during use, chlorohexidine, thimerosal in US Pat. No. 4,013,576, thimerosal, sorbic acid in US Pat. No. 4,046,706, thimerosal in US Pat. No. 4,356,100, and 5-269181 includes preservatives such as chlorohexidine. These low-molecular weight preservatives are adsorbed on the lens and slowly leak when the lens is worn on the eye, causing side effects to the eyes or cloudiness or discoloration of the lens. do.

Therefore, the present invention solves the problems of the above technique, the preservative is prevented from adsorbing to the lens by using a polymeric preservative having a large molecular size so that the preservative is not adsorbed to the lens and does not flow out when worn, the cleaning power is good and Ocular surfactants with low irritation and antiseptic amphoteric surfactant and the substance itself completely eliminate ocular irritation of the mixture when mixed with other substances suspected of causing irritation without any ocular irritation. It is an object of the present invention to provide a contact lens cleaning liquid composition composed of a light-reducing substance.

In addition, another object of the present invention is to provide a contact lens cleaning liquid composition including the ophthalmic mucosa-reducing substance and no preservative.

[Configuration of Invention]

Hereinafter, the present invention will be described in detail.

The present invention provides a contact lens cleaning composition and a stimulant-reducing agent, a polymeric preservative, and a non-ionic surfactant, characterized in that the composition is composed of a stimulant-reducing agent, a nonionic surfactant and an amphoteric surfactant, and a buffer suitable for the eye. It relates to a contact lens cleaning liquid composition, characterized in that consisting of a warm surfactant and a buffer solution.

Hereinafter, the present invention will be described in more detail.

In the present invention, the stimulant-reducing agent is added to prevent side effects that may occur when the eye is worn after washing the lens, that is, irritation, redness of the cornea, foreign body sensation, etc., polyethyleneglycol-120 methyl glucose dioleate ), Polyvinyl alcohol (polyvinylalcohol), polyvinylpyrrolidone (polyvinylpyrrolidone) and the like can be used, it is preferable to use 0.01 to 10% by weight, particularly preferably to use 0.1 to 5% by weight.

At this time, if the stimulation-reducing agent is used less than 0.01% by weight, the stimulation-reducing effect is insignificant, and when used in excess of 10% by weight, the viscosity is too high, there is a problem such as inconvenience in the preparation and use of cleaning solution.

In addition, in the present invention, as a nonionic surfactant, polyethylene oxide / co-polypropylene oxide, polyoxyethylene sorbitan monolaurate, polyethylene glycol paraisoctylphenyl ether (polyethyleneglycol) Hypoallergenic, water-soluble, nonionic surfactants such as p-isoocty phenylehter), polyoxyethylene monooleate, and polyoxyethylene lauryl ether can be used. .

Polyethylene oxide / polypropylene oxide copolymers have an average molecular weight of 2200 (ethylene oxide content; 47.0 weight percent; poloxamer 124), 8350 (ethylene oxide content; 82.0 weight percent; poloxamer 188), 12000 (ethylene oxide content; 73.0 weight %; Poloxamer 338) and 15000 (ethylene oxide content; 83.0 wt%; poloxamer 407), there are several grades, one of which may use 0.01 to 10 wt%, preferably 0.1 to 8 wt% Good to do.

In this case, when the polyethylene oxide / polypropylene oxide copolymer is used at less than 0.01%, the lens cleaning effect is insufficient, and when the polyethylene oxide / polypropylene oxide copolymer is used at more than 10% by weight, the viscosity becomes too high, resulting in inconveniences in manufacturing and using the cleaning liquid.

Another nonionic surfactant is polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene lauryl ether, polyethyleneglycol paraisooctyl One kind of phenyl ether may be used in an amount of 0.001 to 1% by weight, preferably 0.01 to 0.5% by weight.

Amphoteric surfactants are added because of their low preservation and low precipitating properties. Cocoampho carboxyglycinate sodium lauryl sulfate, cocoampho carboxyglycinate, alkyl beta Phosphorus (alkyl betaine), propyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-lauryl-N-methyl-beta-alanine sodium (N-lauryl-N-methyl-β-alanine sodium), lauryl dimethylamino acetic acid betaine, etc. Addition, 0.001 to 10% by weight can be used, preferably 0.01 to 2% by weight is used.

At this time, when the amphoteric surfactant is added in less than 0.001%, the antiseptic power is weak, and when used in excess of 10% by weight, there is a problem of eye irritation.

In addition, polymeric preservatives include hydrolyzed lauryldimonium hydroxypropyl hydrolyzed collagen, hydrolyzed cocodimonium hydroxypropyl hydrolyzed collagen, and hydrolyzed stearyldimonium hydroxypropyl collagen ( stearyldimonium hydroxypropyl hydrolyzed collagen), poly (oxyethylene (dimethylimino) ethylene (dimethylimino) ethylene dichloride (poly [oxyethylene (dimethylimino) ethylene (dimethylimino) ethylene dichloride

]) And polyquaternium-16 can be used. The polymeric preservative may be used in an amount of 0.001 to 1% by weight, preferably 0.01 to 0.5% by weight. At this time, when the polymeric preservative is used in less than 0.001% by weight, the preservation effect is weak, and when used in excess of 1% by weight, there are problems such as eye irritation.

In addition, in the present invention, a suitable buffer solution for the eye was used, and a borate buffer solution or a phosphate buffer solution was used to adjust the pH to 6.0 to 8.0, and sodium chloride was used as an isotonic solution in an appropriate amount.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to Examples.

Example 1

Dissolve sodium chloride in distilled water with the following composition, add borax, stir well, and dissolve completely by adding boric acid. Next, polyoxyethylene sorbitan monolaurate and alkyl betain were mixed well in order, and then poloxamer 407 was slowly added with stirring to dissolve, and polyethylene glycol-120 methyl glucose dioleate was added and mixed to prepare a washing solution.

Example 2

A cleaning liquid was prepared in the same manner as in Example 1 except that the composition was as follows.

Example 3

Washing liquid similar to Example 1 was manufactured using the following composition.

Example 4

A washing liquid was prepared in the same manner as in Example 1 with the following composition.

Example 5

A washing liquid was prepared in the same manner as in Example 1 with the following composition.

Example 6

In order to determine the cleaning power of the cleaning solution of the present invention, the experiment was carried out as follows. After dissolving 0.02 g of protein lysozyme hydrochloride in 100 ml of saline solution, an unused lens (EDGE III XT, manufactured by ocular) was immersed in 5 ml of this solution and heated to about 90 ° C. for 1 hour to deposit protein and mucus onto the lens and to room temperature. Cooled. This procedure was repeated twice followed by rinsing with physiological saline to remove proteins and mucus that did not deposit on the lens. Place the contaminated lens on the palm of your hand and drop 2 drops of cleaning solution on the front and back of the lens, and then rub it with 10 stops each time. After rinsing with physiological saline, remove the remaining cleaning solution. As a result of the measurement, it can be seen that the effect is good as shown in Table 6 below.

The rating of the Ludco method is as follows.

Ⅰ: Clean.

Ⅱ: 7-time magnification

III: Visual deposits with the lens dry.

Ⅳ: Visually visible deposit with wet lens.

C: Form of deposit is crystalline form.

G: The form of the deposit is granular.

F: The form of deposit is a film form.

a: 0-25% of the deposit of the lens

b: deposits 25-50% of the lens

c: deposits 50-75% of the lens

d: deposit is 75-100% of the lens

Example 7

The retention test for the cleaning liquid of the present invention was carried out by the method according to the US Pharmacopoeia. This experiment is very important in that it prevents side effects caused by corruption when the product is used by consumers. If the strain used is as shown in Table 7 below, the criterion is as follows.

That is, when the viable cell count of all the bacteria used for the test decreased during the test period, the viable cell count of the fungi on the 14th day was less than or equal to the number at the start of the test, when the viable cell number of the bacterium was reduced to 0.1% or less than the number at the start of the test. At the time of 28 days, it was judged that it was effective as a preservative when the number of each bacteria was below the number at the beginning of a test.

As a result of the experiment under the U.S. Pharmacopoeia Law, as shown in Table 8, it was found that the preservative power is effective.

Example 8

The ocular mucosa stimulation test for the cleaning solution of the present invention was carried out as follows. Before the test, the eyes of rabbits were examined by naked eye and an ophthalmoscope, and nine animals without abnormalities were taken as a group, and each test substance was applied to the left eye with 100 µl, and 6 were left as it was. Rinse with saline for about 1 minute. Right eye was evaluated by eye, flashlight and ophthalmoscope after 1 hour 1,2,3,4,5,6,7 days. The test was conducted based on the guidelines published by the National Institute of Health and Safety. The results are shown in Table 9.

M.O.I. (mean occular irritation index)

= Total stimulus / number of test animals (n = 9)

Example 9

Whether the lens was adsorbed to the cleaning liquid of the present invention was confirmed by the following method. This experiment is especially useful for examining the adsorption of lenses with preservatives that are more likely to cause irritation. In the experimental method, the contact lens was immersed in the cleaning solution for 8 hours at room temperature, then the cleaning solution was removed and immersed in physiological saline for 16 hours. Repeat this procedure seven times, cut the contact lens into a pinwheel shape, completely adhered to the medium in which Staphylococcus aureus was cultured, incubated for 48 hours at 35 ° C., and then determined the adsorption by measuring the growth inhibition area. It was.

[Effects of the Invention]

The cleaning solution by the composition of the present invention was found to be very excellent as in the above results, it is a cleaning solution that can prevent the side effects caused by the deterioration in advance because of the excellent preserved effect. In addition, an excellent ocular irritation index of 48 after 48 hours can be obtained an excellent cleaning solution with little irritation to the eye mucosa.

Claims (11)

A contact lens cleaning liquid composition, comprising an irritant, a nonionic surfactant, an amphoteric surfactant, and a buffer solution. The contact lens cleaning liquid composition according to claim 1, wherein the irritant agent is selected from the group consisting of polyethylene glycol-120 methyl glucose dioleate, polyvinyl alcohol and polyvinylpyrrolidone. The contact lens cleaning liquid composition according to claim 1 or 2, wherein the irritant agent is contained in an amount of 0.01 to 10% by weight based on the total weight. The zwitterionic surfactant according to claim 1, wherein the zwitterionic surfactant is cocoampo carboxyglycinate sodium lauryl sulfate, cocoampo carboxyglycinate, propylbetaine, alkyl betaine, 2-alkyl-N-carboxymethyl-N- A contact lens cleaning liquid composition, characterized in that it is selected from the group consisting of hydroxyethyl amidazolinium betaine, lauryl dimethylamino acetic acid betaine and N-lauryl-N-methyl-beta-alline sodium. The contact lens cleaning liquid composition according to claim 1 or 4, wherein the amphoteric surfactant is 0.001 to 10% by weight based on the total weight. The nonionic surfactant of claim 1, wherein the nonionic surfactant is a polyethylene oxide / polypropylene oxide copolymer having an average molecular weight of 2200 (ethylene oxide content; 47.0 wt%; Poloxamer 124), 8350 (ethylene oxide content; 82.0 wt%; poloxamer 188), 12000 (ethylene oxide content; 73.0% by weight; poloxamer 338) and 15000 (ethylene oxide content; 83.0% by weight; poloxamer 407), and in addition to polyoxy At least one selected from group (II) consisting of ethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene lauryl ether and polyethylene glycol paraisooctylphenyl ether A contact lens cleaning liquid composition, which may include. The method according to claim 1 or 6, characterized in that the nonionic surfactant is 0.01 to 10% by weight relative to the total weight for group (I) and 0.001 to 1% by weight relative to the total weight for group (II). Contact lens cleaning liquid composition The contact lens cleaning liquid composition according to claim 1, wherein a polymeric preservative is added to the irritant, nonionic surfactant, amphoteric surfactant, and buffer solution. The method of claim 10 wherein the polymeric preservative is hydrolyzed lauryldimonium hydroxy propyl collagen, hydrolyzed cocodimonium hydroxypropyl collagen, hydrolyzed stearyldimonium hydroxypropyl collagen, poly [oxyethylene (dimethylimino) A contact lens cleaning liquid composition, characterized in that selected from the group consisting of ethylene (dimethylimino) ethylene dichloride and polyquaternium. 12. The contact lens cleaning liquid composition according to claim 10 or 11, wherein the polymeric preservative is 0.001 to 1% by weight based on the total weight. The contact lens cleaning composition according to claim 1, wherein the buffer solution is a borate buffer or phosphate buffer having a pH in the range of 6.0 to 8.0.