JP3204971B2 - 阻害剤 - Google Patents
阻害剤Info
- Publication number
- JP3204971B2 JP3204971B2 JP50198592A JP50198592A JP3204971B2 JP 3204971 B2 JP3204971 B2 JP 3204971B2 JP 50198592 A JP50198592 A JP 50198592A JP 50198592 A JP50198592 A JP 50198592A JP 3204971 B2 JP3204971 B2 JP 3204971B2
- Authority
- JP
- Japan
- Prior art keywords
- tnf
- formula
- hiv
- compound
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dentistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pest Control & Pesticides (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61647990A | 1990-11-21 | 1990-11-21 | |
| US616,479 | 1990-11-21 | ||
| PCT/US1991/008734 WO1992009203A1 (en) | 1990-11-21 | 1991-11-20 | Tnf inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH06506192A JPH06506192A (ja) | 1994-07-14 |
| JP3204971B2 true JP3204971B2 (ja) | 2001-09-04 |
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ID=24469639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50198592A Expired - Lifetime JP3204971B2 (ja) | 1990-11-21 | 1991-11-20 | 阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0558659A4 (ref) |
| JP (1) | JP3204971B2 (ref) |
| KR (1) | KR930702896A (ref) |
| AP (1) | AP259A (ref) |
| AU (1) | AU656938B2 (ref) |
| CA (1) | CA2096623A1 (ref) |
| HU (1) | HUT65838A (ref) |
| IE (1) | IE914034A1 (ref) |
| IL (1) | IL100088A (ref) |
| MX (1) | MX9102173A (ref) |
| NZ (1) | NZ240644A (ref) |
| TW (1) | TW222001B (ref) |
| WO (1) | WO1992009203A1 (ref) |
| ZA (1) | ZA919178B (ref) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1531492A (en) * | 1991-02-14 | 1992-09-15 | Rockefeller University, The | Method for controlling abnormal concentration tnf alpha in human tissues |
| AU7376394A (en) * | 1993-08-04 | 1995-02-28 | Andrulis Pharmaceuticals Corporation | Use of tumor necrosis factor inhibitors together with antiviral agents and therapeutic compositions thereof against hiv infection |
| US5504090A (en) * | 1994-03-30 | 1996-04-02 | Trustees Of The University Of Pennsylvania | Compositions and methods for the prevention and treatment of ischemia-reperfusion organ injury |
| US7608262B2 (en) * | 1996-02-16 | 2009-10-27 | The Kennedy Institute Of Rheumatology | Methods of preventing or treating thrombosis with tumor necrosis factor antagonists |
| GB9703044D0 (en) | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| GB9817623D0 (en) | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| CA2506949A1 (en) * | 2002-11-27 | 2004-06-10 | Altana Pharma Ag | Pde4 and pde3/4 inhibitors for use in the treatment of cachexia |
| HRP20130406T1 (hr) | 2004-02-14 | 2013-06-30 | Glaxosmithkline Intellectual Property Development Limited | Medikamenti s aktivnošä†u prema receptoru hm74a |
| RU2395511C2 (ru) * | 2004-02-14 | 2010-07-27 | Смитклайн Бичам Корпорейшн | Новые соединения |
| JP5112316B2 (ja) | 2005-08-10 | 2013-01-09 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 選択的ｈｍ７４ａアゴニストとしてのキサンチン誘導体 |
| CN107001371B (zh) | 2014-10-09 | 2019-07-05 | 广东众生睿创生物科技有限公司 | 羟基嘌呤类化合物及其应用 |
| EP3369733B1 (en) * | 2015-10-29 | 2020-01-15 | Guangdong Raynovent Biotech Co., Ltd. | Crystal form of 4h-pyrazolo[1,5- ]benzoimidazole compound, preparation method therefor and intermediate thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US757328A (en) * | 1903-02-07 | 1904-04-12 | Boehringer & Soehne | Art of preparing xanthin derivatives. |
| US2517410A (en) * | 1947-08-15 | 1950-08-01 | Searle & Co | Hydroxy alkyl xanthines and the production thereof |
| US4120947A (en) * | 1976-03-31 | 1978-10-17 | Cooper Laboratories, Inc. | Xanthine compounds and method of treating bronchospastic and allergic diseases |
| CH654008A5 (fr) * | 1979-05-22 | 1986-01-31 | Nestle Sa | Procede de preparation de 1,3,7-trialkylxanthines. |
| DE2944568A1 (de) * | 1979-11-05 | 1981-05-14 | Institut für industrielle Pharmazie F + E GmbH, 8750 Aschaffenburg | Pharmazeutische zubereitung |
| IT1200944B (it) * | 1982-08-10 | 1989-01-27 | Malesci Sas | Derivati xantinici,procedimento per la loro preparazione,composizione farmaceutiche che il contengono e loro impiego terapeutico |
| US4593095A (en) * | 1983-02-18 | 1986-06-03 | The Johns Hopkins University | Xanthine derivatives |
| US4636507A (en) * | 1984-04-30 | 1987-01-13 | Hoechst-Roussel Pharmaceuticals Inc. | Host defense mechanism enhancement |
| GB8610136D0 (en) * | 1986-04-25 | 1986-05-29 | Wellcome Found | Compounds |
| IT1197516B (it) * | 1986-12-24 | 1988-11-30 | Abc Ist Biolog Chem Spa | Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono |
| US4965271A (en) * | 1986-12-31 | 1990-10-23 | Hoechst Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| US5015647A (en) * | 1987-04-24 | 1991-05-14 | Burroughs Wellcome Co. | Method for treating viral infections |
| DE3817955A1 (de) * | 1988-05-27 | 1989-11-30 | Hoechst Ag | Tnf-inhibitor enthaltendes arzneimittel |
| GB8906792D0 (en) * | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
| FI891419A7 (fi) * | 1989-03-23 | 1990-09-24 | Tampella Oy Ab | Anordning i en gaengoeppningsanordning foer borrmaskineri. |
-
1991
- 1991-11-19 NZ NZ240644A patent/NZ240644A/en unknown
- 1991-11-19 IL IL10008891A patent/IL100088A/en not_active IP Right Cessation
- 1991-11-20 AU AU91159/91A patent/AU656938B2/en not_active Ceased
- 1991-11-20 JP JP50198592A patent/JP3204971B2/ja not_active Expired - Lifetime
- 1991-11-20 HU HU9301509A patent/HUT65838A/hu unknown
- 1991-11-20 CA CA002096623A patent/CA2096623A1/en not_active Abandoned
- 1991-11-20 WO PCT/US1991/008734 patent/WO1992009203A1/en not_active Ceased
- 1991-11-20 EP EP19920901819 patent/EP0558659A4/en not_active Withdrawn
- 1991-11-20 ZA ZA919178A patent/ZA919178B/xx unknown
- 1991-11-20 IE IE403491A patent/IE914034A1/en not_active Application Discontinuation
- 1991-11-21 AP APAP/P/1991/000335A patent/AP259A/en active
- 1991-11-21 MX MX9102173A patent/MX9102173A/es unknown
- 1991-12-30 TW TW080110250A patent/TW222001B/zh active
-
1993
- 1993-05-21 KR KR1019930701529A patent/KR930702896A/ko not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| Ａｌｌｅｒｇｏｌ．Ｉｍｍｕｎｏｐａｔｈｏｌ．，Ｖｏｌ．１１，Ｎｏ．５（１９８３）ｐ．３２１−３２７ |
| Ｂｉｏｃｈｅｍ．Ｂｉｏｐｈｙｓ．Ｒｅｓ．Ｃｏｍｍｕｎ．，Ｖｏｌ．１５５，Ｎｏ．３（１９８８）ｐ．１２３０−１２３６ |
Also Published As
| Publication number | Publication date |
|---|---|
| MX9102173A (es) | 1992-06-01 |
| ZA919178B (en) | 1992-10-28 |
| HUT65838A (en) | 1994-07-28 |
| EP0558659A1 (en) | 1993-09-08 |
| AU656938B2 (en) | 1995-02-23 |
| IL100088A0 (en) | 1992-08-18 |
| AP9100335A0 (en) | 1992-01-31 |
| KR930702896A (ko) | 1993-11-29 |
| WO1992009203A1 (en) | 1992-06-11 |
| IL100088A (en) | 1995-07-31 |
| HU9301509D0 (en) | 1993-11-29 |
| NZ240644A (en) | 1994-08-26 |
| TW222001B (ref) | 1994-04-01 |
| CA2096623A1 (en) | 1992-05-22 |
| IE914034A1 (en) | 1992-06-03 |
| AU9115991A (en) | 1992-06-25 |
| AP259A (en) | 1993-06-03 |
| JPH06506192A (ja) | 1994-07-14 |
| EP0558659A4 (en) | 1993-10-20 |
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