JP3181305B2 - 選択的アデノシン受容体アゴニスト及びアンタゴニスト - Google Patents

選択的アデノシン受容体アゴニスト及びアンタゴニスト

Info

Publication number
JP3181305B2
JP3181305B2 JP08451291A JP8451291A JP3181305B2 JP 3181305 B2 JP3181305 B2 JP 3181305B2 JP 08451291 A JP08451291 A JP 08451291A JP 8451291 A JP8451291 A JP 8451291A JP 3181305 B2 JP3181305 B2 JP 3181305B2
Authority
JP
Japan
Prior art keywords
purine
dione
dihydro
dipropyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP08451291A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04221384A (ja
Inventor
ポ−ル ピ−ト ノ−トン
ロ−ウェル レンツ ネルセン
Original Assignee
メレル ファ−マス−ティカルズ インコ−ポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メレル ファ−マス−ティカルズ インコ−ポレイテッド filed Critical メレル ファ−マス−ティカルズ インコ−ポレイテッド
Publication of JPH04221384A publication Critical patent/JPH04221384A/ja
Application granted granted Critical
Publication of JP3181305B2 publication Critical patent/JP3181305B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP08451291A 1990-03-26 1991-03-26 選択的アデノシン受容体アゴニスト及びアンタゴニスト Expired - Fee Related JP3181305B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/499,111 US5047534A (en) 1990-03-26 1990-03-26 Selective adenosine receptor agents
US499,111 1990-03-26

Publications (2)

Publication Number Publication Date
JPH04221384A JPH04221384A (ja) 1992-08-11
JP3181305B2 true JP3181305B2 (ja) 2001-07-03

Family

ID=23983864

Family Applications (1)

Application Number Title Priority Date Filing Date
JP08451291A Expired - Fee Related JP3181305B2 (ja) 1990-03-26 1991-03-26 選択的アデノシン受容体アゴニスト及びアンタゴニスト

Country Status (22)

Country Link
US (1) US5047534A (de)
EP (1) EP0449175B1 (de)
JP (1) JP3181305B2 (de)
KR (1) KR100195368B1 (de)
CN (1) CN1032815C (de)
AR (1) AR247887A1 (de)
AT (1) ATE156130T1 (de)
AU (1) AU632914B2 (de)
CA (1) CA2038747C (de)
DE (1) DE69127010T2 (de)
DK (1) DK0449175T3 (de)
ES (1) ES2107431T3 (de)
FI (1) FI98461C (de)
GR (1) GR3025135T3 (de)
HU (1) HU208824B (de)
IE (1) IE910982A1 (de)
IL (1) IL97656A (de)
NO (1) NO177591C (de)
NZ (1) NZ237484A (de)
PH (1) PH27511A (de)
PT (1) PT97133B (de)
ZA (1) ZA912038B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102060903B1 (ko) * 2018-09-12 2019-12-30 김지훈 다중접합 도마 및 그 제조방법

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208240A (en) * 1991-03-12 1993-05-04 Merrell Dow Pharmaceuticals Inc. 8-substituted purines as selective adenosine receptor agents
JP2928386B2 (ja) * 1992-07-08 1999-08-03 協和醗酵工業株式会社 うつ病治療剤
US5840729A (en) * 1993-02-26 1998-11-24 Merrell Pharmaceuticals Inc. Xanthine derivatives as adenosine A1 receptor antagonists
WO1994025462A1 (en) * 1993-05-03 1994-11-10 The United States Of America, Represented By The 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
CN1043473C (zh) * 1993-05-06 1999-05-26 默里尔多药物公司 8位取代黄嘌呤作为选择性腺苷受体药物
US5629298A (en) * 1995-03-13 1997-05-13 University Of Massachusetts Medical Center Adenosine as a positive inotrop in the compromised heart
GB9819382D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
US6258794B1 (en) 1999-12-14 2001-07-10 The Mclean Hospital Corporation Treatment of mental conditions including depression
CN1787821A (zh) * 2003-06-10 2006-06-14 协和发酵工业株式会社 一种治疗焦虑症的方法
WO2007036491A1 (de) * 2005-09-30 2007-04-05 Basf Aktiengesellschaft Verfahren zur herstellung von alpha-substituierten carbonsäuren
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1435916A (en) * 1972-05-11 1976-05-19 Beecham Group Ltd Pharmaceutical weight-reducing compositions
SE416810C (sv) * 1977-10-14 1982-07-19 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
JPS57198544A (en) * 1981-05-28 1982-12-06 Sony Corp Manufacture of magnetic recording medium
US4593095A (en) * 1983-02-18 1986-06-03 The Johns Hopkins University Xanthine derivatives
US4772607A (en) * 1986-05-20 1988-09-20 Warner-Lambert Company Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor
US4783530A (en) * 1986-11-13 1988-11-08 Marion Laboratories, Inc. 8-arylxanthines
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102060903B1 (ko) * 2018-09-12 2019-12-30 김지훈 다중접합 도마 및 그 제조방법

Also Published As

Publication number Publication date
NO177591B (no) 1995-07-10
IL97656A (en) 1996-06-18
FI98461C (fi) 1997-06-25
NZ237484A (en) 1993-10-26
NO177591C (no) 1995-10-18
CN1055181A (zh) 1991-10-09
CN1032815C (zh) 1996-09-18
FI98461B (fi) 1997-03-14
ZA912038B (en) 1991-12-24
PT97133B (pt) 1998-07-31
HUT56570A (en) 1991-09-30
DE69127010D1 (de) 1997-09-04
AR247887A1 (es) 1995-04-28
DK0449175T3 (da) 1998-02-23
DE69127010T2 (de) 1997-11-13
NO911200L (no) 1991-09-27
CA2038747C (en) 2002-05-28
AU632914B2 (en) 1993-01-14
CA2038747A1 (en) 1991-09-27
KR910016752A (ko) 1991-11-05
FI911420A0 (fi) 1991-03-25
EP0449175B1 (de) 1997-07-30
IE910982A1 (en) 1991-10-09
JPH04221384A (ja) 1992-08-11
ATE156130T1 (de) 1997-08-15
FI911420A (fi) 1991-09-27
ES2107431T3 (es) 1997-12-01
EP0449175A3 (en) 1993-01-20
PH27511A (en) 1993-08-18
US5047534A (en) 1991-09-10
HU208824B (en) 1994-01-28
IL97656A0 (en) 1992-06-21
NO911200D0 (no) 1991-03-25
AU7353791A (en) 1991-10-03
KR100195368B1 (ko) 1999-06-15
EP0449175A2 (de) 1991-10-02
GR3025135T3 (en) 1998-02-27
PT97133A (pt) 1991-12-31

Similar Documents

Publication Publication Date Title
AU746590B2 (en) Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
EP1116722B1 (de) [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
EP1939197A1 (de) 8-Ethinylxanthinderivate als selektive Antagonisten des A2A-Rezeptors
JP3181305B2 (ja) 選択的アデノシン受容体アゴニスト及びアンタゴニスト
JPH05155887A (ja) アゾール誘導体
CA2155130C (en) Xanthine derivatives as adenosine a1 receptor antagonists
JP3937367B2 (ja) 一酸化窒素合成酵素阻害剤
US5734052A (en) 8-substituted xanthines as selective adenosine receptor agents
AU672226B2 (en) 2-substituted adenosines with A-2 receptor affinity
US6949652B2 (en) Crystalline forms of 3-isopropyl-6-[4-(2,5-difluoro-phenyl)-oxazol-5-yl]-[1,2,4]triazolo-[4,3-A]pyridine
US5426101A (en) 2-substituted adenosines with A-2 receptor affinity

Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees