JP3164015U - Tea bag containing pumpkin seeds - Google Patents

Abstract

[PROBLEMS] Using genus pumpkin seeds, dysuria due to benign prostatic hyperplasia, frequent urination / urinary incontinence due to menopause in women, stress urinary incontinence observed in many women, excess observed in both men and women Provided is a tea bag that is effective for urination disorders derived from active bladder and urinary tract infections, and that can be taken easily, safely and continuously for a long time. The tea bag is configured so that the contents are stored in the bag, and the water-soluble components effective in the prevention and / or treatment of urological diseases are eluted from the contents by immersing the bag in water. To do. Further, the contents are made from the seeds of the genus Cucurbita. [Selection] Figure 1

Description

  The present invention relates to a tea bag in which contents effective for prevention and / or treatment of urological diseases are stored.

  The number of patients suffering from urination disorders in an aging society is increasing, and urination disorders are considered to be a potential social problem regardless of gender. The cause of the disease is not always clear and is often regarded as an aging phenomenon associated with aging rather than a disease. Although frequent urination and urinary incontinence do not present life-threatening symptoms, the patient's quality of life (QOL) is significantly reduced, resulting in mental and physical distress.

  Urination disorders include urine storage dysfunction and urine output dysfunction. Urinary dysfunction includes frequent urination and urinary incontinence (mainly urge incontinence and stress urinary incontinence). Urinary drainage dysfunction includes difficulty urinating, residual urine, urinary retention and the like. Although any pathogenic mechanism is classified into neurogenic and non-neurogenic, it is a pathological condition that ultimately shows excessive or incomplete contraction of bladder smooth muscle.

  Overactive bladder (immediate urinary incontinence) affects high morbidity and quality of life in both elderly men and women with dysuria in the elderly, prostate hypertrophy, a disease specific to elderly men, middle-aged and overwhelming women after menopause There are many cases of stress urinary incontinence. The number of overactive bladder patients is estimated to be approximately 8.1 million in Japan according to the 2002 Japan Urological Function Society survey. If stress urinary incontinence patients, which account for 70% of female urinary incontinence patients, are added to this, it is estimated that the number of patients suffering from dysuria is considerable.

  Examples of frequent urinary / urinary incontinence drug (urine accumulation dysfunction improving drug) include pharmaceuticals such as anticholinergic agents, bladder smooth muscle direct acting drugs, and various Chinese medicine preparations. Examples of low-activity bladder therapeutic agents (improving dysuria) include distigmine bromide and neostigmine bromide having cholinesterase inhibitory action, bethanechol chloride having muscarinic receptor activating action, and α1 adrenergic receptor antagonistic action. And uravidil.

  However, many side effects have been reported for any of these pharmaceuticals or Chinese medicine preparations. In addition, it is necessary to pay close attention to the interaction with medicines in Chinese medicine preparations. These pharmaceuticals or herbal medicines sometimes have serious side effects and are difficult to obtain and take easily because they are drugs that require a doctor's prescription. Many patients are hesitant to visit medical institutions because dysuria has no direct impact on life compared to other diseases. On the other hand, as a feature of the disease, it is important to take the drug continuously for a long period of time. In general, symptoms are reversed when the administration is stopped.

  Therefore, as a drug for preventing or improving urination disorder, a drug that can be surely expected to be effective, easily available, and can be safely taken for a long time is desired.

  Pepo Pumpkin Seed Formulation is on the market as one of the health supplements aimed at preventing or improving frequent urination and urinary incontinence. Containing components include those using seed oil, those using 60% alcohol extraction powder, or those using a mixture of both.

  As such a health food, for example, JP-A-2000-290192 contains a dried extract of pumpkin seeds and isoflavones as active ingredients, and the blending ratio of dried extract of pumpkin seeds: isoflavones is 99: 1-80. : A therapeutic agent for dysuria characterized by a weight ratio of 20 (patent document 1). Japanese Patent Laid-Open No. 2005-343809 describes an inhibitor of urinary intention during sleep, which is obtained by blending 0.1 to 1 peppo pumpkin extract by weight (Patent Document 2). Furthermore, JP-A-2001-342142 discloses a composition for preventing and treating urinary system diseases comprising (A) cranberry or an extract thereof and (B) pumpkin seed or an extract thereof. In addition to being excellent in improving urination abnormalities and urinary incontinence caused by symptoms, it is described that side effects such as stomach sag are reduced and the feeling of taking is good (Patent Document 3).

  As a typical preparation, a product using a dry extract (60% ethanol extract of peppo pumpkin seeds) is marketed by Tervis Co., Ltd. (manufactured and sold) (Non-patent Document 1).

  In German Commission E monographs, etc., Pepo Pumpkin Seed is approved as an effective drug for hypersensitive bladder (frequent urination, urge urinary incontinence, residual urinary sensation), particularly female dysuria (Non-patent Documents 2 and 3) .

JP 2000-290192 A JP-A-2005-343809 JP 2001-342142 A

Sogabe Hitoshi, Terado Takashi, Medicinal Pepo Pumpkin Seed Extract and Soy Germ Extract Extract, General Clinical Trial for Night Frequent Urination, Medicine and Pharmacy, Natural Sciences, November 2001, 45, No. 5, p. 728-738 Mark Blumenthal, Werner Busse, Alicia Goldberg, Joerg Gruenwald, Tara Hall, Chance W. Riggins, Robert S. Rister, Sigrid Klein, "The Complete German Commission E Monographs", Published November 30, Revised January 17, 1991. "The American Botanical Council", Published in cooperation with Integrative Medicine Communications, Boston, Massachusetts 1998, Pumpkin seed p.193

  The purpose of the present invention is dysuria due to benign prostatic hyperplasia, frequent urination / urinary incontinence resulting from climacteric disorder in women, stress urinary incontinence observed in many women, overactive bladder and urinary tract observed in both men and women An object of the present invention is to provide a tea bag that is effective for urination disorders derived from infectious diseases, and that can be taken easily, safely, and continuously for a long time.

  The present inventors attempted to isolate and purify a composition that can be expected to have a positive effect on urological diseases, can be easily obtained, and can be safely taken for a long time from Cucurbita pepo seeds. . As a result, it was found that the composition obtained by water-extracting the seeds of Cucurbita pepo has a significantly stronger pharmacological activity than the conventionally reported 60% ethanol extract. And as a result of examining the form which can take easily the active ingredient with which the prevention and / or treatment effect of a urological system disease is acquired, the knowledge that the form of a tea bag was the most suitable was acquired.

  The present invention has been made based on such knowledge, and the contents are stored in the bag, and the water-soluble components effective for the prevention and / or treatment of urological diseases are removed from the contents by immersing in the water. An elution tea bag, characterized in that the contents are made from Cucurbita seeds as a raw material.

  According to the tea bag of the present invention, the water-soluble component that has been immersed in water (or hot water) and eluted out of the bag is urinary dysfunction resulting from benign prostatic hyperplasia, frequent urination and / or urine derived from female climacteric disorder It exhibits excellent preventive or ameliorating effects on urinary tract diseases such as incontinence, stress urinary incontinence observed in many women, and overactive bladder and urinary dysfunction caused by urinary tract infections observed in both men and women.

  Since this invention has the form of a tea bag, an active ingredient can be easily extracted just by immersing in water or hot water like a well-known tea bag. Moreover, it can be taken as a drink like tea, and has a high immediate effect on urological diseases.

  Furthermore, unlike conventionally known medicines for traditional urological diseases, traditional Chinese medicines, etc., the beverage produced with the tea bag of the present invention has few side effects and can be used for a long time.

1 is a perspective view of a tea bag 1 according to the present invention. It is an example of the content 12 accommodated in the bag 10, Comprising: They are (A) pumpkin genus seed 4, (B) defatted pumpkin seed 2, and (C) pumpkin seed powder 3, respectively. It is a figure which shows the process of manufacturing the tea bag from the pumpkin seed.

  FIG. 1 is a perspective view of a tea bag 1 according to the present invention. In the tea bag 1 of the present invention, the contents 12 are stored in the bag 10, and the water-soluble components effective in the prevention and / or treatment of urological diseases are eluted from the contents 12 by immersing them in water. It is the tea bag 1, Comprising: The content 12 uses a pumpkin (Cucurbita) seed as a raw material.

  In this embodiment, “water” means any of tap water, distilled water, purified water, ion exchange water, ultrafiltration water, reverse osmosis water, ultrapure water, and well water unless otherwise specified. To do.

  Specific examples of urinary diseases include, for example, dysuria resulting from benign prostatic hyperplasia, frequent urination and / or urinary incontinence resulting from female climacteric disorder, overactive bladder, stress urinary incontinence, urinary tract infection Dysuria derived from can be mentioned.

  The water-soluble component eluted from the tea bag 1 of the present invention with water has excellent preventive and / or therapeutic effects on these urological diseases, and improves the patient's quality of life (QOL), It relieves mental and physical distress. In addition, unlike pharmaceuticals, herbal medicines, etc., there are few side effects and easy intake, so long-term continuous use is possible. Furthermore, since the pharmacological activity is stronger than that of the existing 60% alcohol extract, a high clinical effect can be expected even with a small dose. From the viewpoint of cost, there is also an advantage that the active ingredient can be extracted with water and can be manufactured easily and inexpensively.

  The seeds of the genus Cucurbita are not limited to their varieties, but are preferably seeds of pepo pumpkin (Cucurbita pepo) or western pumpkin (Cucurbita maxima).

  The pumpkin (Cucurbita) seeds stored in the tea bag 1 of the present invention can be used as a whole. However, the storage stability of the pumpkin (Cucurbita) seeds and the ease of water extraction are considered. In this case, it is preferable to use a defatted pumpkin seed having a low fat content after oil is collected from the seed of the genus Cucurbita. Specifically, the fat content after removing the oil is preferably about 10% by weight or less of the seed weight, more preferably the seed of the genus Cucurbita from which the fat content is removed to about 1% by weight or less. .

  Moreover, in order to obtain the water extract of the genus Cucurbita, it is not limited to the shape of a seed. For example, it may be used as it is with a thin husk (Cucurbita) seed, or it may be divided into more than 20% with a thick husk. Moreover, the squeezed rice cake which remained after the oil extraction of the pumpkin (Cucurbita) seed can also be used, and the pumpkin (Cucurbita) seed powder which grind | pulverized it can also be used. The particles should be as coarse as possible considering the oxidative stability of the fats and oils contained in the seeds of the genus Cucurbita, but it is desirable that the particles be fine to some extent when considering the extraction efficiency of the active ingredient. Specifically, the proportion of particles of 500 μm or less in the pulverized particle size is preferably 50% by weight or more.

  FIG. 2 is an example of the contents 12 stored in the bag 10, (A) Cucurbita seed 4, (B) defatted pumpkin seed 2 after squeezing Cucurbita seed, (C) Pumpkin seed powder 3 obtained by further pulverizing (B).

  The pumpkin genus (Cucurbita) seed 4, the defatted pumpkin seed 2 or the pumpkin seed powder 3 stored in the tea bag 1 of the present invention is preferably subjected to sterilization treatment. Since gram-negative pathogenic bacteria (for example, Salmonella) can be substantially sterilized by the sterilization treatment, the safety of the tea bag 1 can be increased.

  Specifically, for example, the sterilization treatment is performed by passing the pumpkin seed 4, the defatted pumpkin seed 2 or the pumpkin seed powder 3 through the superheated steam at 110 ° C. for several seconds with a superheated steam sterilizer. Can do. Moreover, it can also sterilize using a microwave sterilizer.

  The Cucurbita seed 4, the defatted pumpkin seed 2 or the pumpkin seed powder 3 stored in the tea bag 1 of the present invention requires a heat history at 55 ° C. for 10 minutes or under wet heat as a pathogen. In addition, microbial growth countermeasures during the manufacturing process such as water extraction are 80 ° C, 30 minutes or equivalent conditions as the upper limit temperature condition for preventing the preventive and / or therapeutic effect activity against urological diseases. Preferably, the heat history is below or below the moist heat. If a heat history exceeding this range is given, the preventive and / or therapeutic effect on urological diseases may be reduced. Therefore, if there is no problem of pathogen contamination in the distribution process of genus Cucurbita seeds, defatted pumpkin seeds or pumpkin seed powder, sterilization treatment is unnecessary.

  Since the tea bag 1 of the present invention can be obtained by water extraction of water-soluble components effective for the prevention and / or treatment of urinary system diseases, it is extracted with water or hot water after being extracted with water or hot water like tea in a conventionally known tea bag. Can be taken as is.

  In the tea bag 1 of the present invention, the material of the bag 10 for wrapping the contents 12 can be selected as appropriate. When packaging the Cucurbita seeds 4 as they are, the mesh is such that the contents 12 do not leak. Paper, nets, and non-woven fabrics can be used, and when defatted pumpkin seeds 2 and pumpkin seed powders 3 are packaged, it is preferable to use non-woven fabrics.

  Further, if the handle thread 14 is coupled to the bag 10 of the tea bag 1 and the grip paper 16 is coupled to the tip of the handle thread 14, the tea bag 1 can be easily taken out from the immersed water or hot water. preferable.

  The tea bag 1 of the present invention is made up of contents 12 such as pigeon, oolong tea, hub tea, hawthorn, malt, strawberry tea, amadokoroko, gymnema sylvestre, safflower, daidai, green tea, brown rice, Oolong tea, kelp, mugwort, ganoderma, wolfberry, bamboo shoots, bamboo shoots, shiitake mushrooms, citrus peel, eriko (sebisu grass seeds), beach tea, morohaya, yunaka, licorice, biwaha, banca, ginseng, rooibos, Amachazuru, too much, roasted tea, puer tea, gold flower tea, green tea extract, beakless fruit, ginger, jujube, thin load, evening primrose, guava leaf, banaba leaf, kawara kemei, shrimp, morohaya, plantain, mugwort, wolfberry leaf, Mulberry Leaf, Ginkgo, Honeysuckle, Oyster, Mate Leaf, Vulture, Perilla, Artichoke, Echinacea, Elderflower, Orega , Orange peel, orange blossom, chamomile, cardamom, clove, kuwan grass, genus pepper, comfrey, safflower, summer savory, sium, cinnamon, jasmine, juniper berry, stevia, sage, serpirum, st jones, turmeric, thyme, dandelion , Nettle, Hibiscus, Basil, Passion Flower, Vanilla Beans, Valerian, Hyssop, Feverfu, Fennel, Hop, Marjoram, Marigold, Mallow, Peppermint, Meadow Sweet, Yarrow, Eucalyptus, Lavender, Licorice, Linden, Lemongrass, Lemon You can combine one or more of Verbena, Lemon Balm, Lemon Peel, Rose, Rosehips, Rosemary, Wild Strawberry etc. wear.

  When taking the tea bag 1 of the present invention as a beverage for prevention and / or treatment of urological diseases, the daily dose for adults is preferably 500 mg to 1000 mg in terms of solid content of the water extract. It is recommended to take 1 to 3 doses after meals. Therefore, it is preferable that the weight of the content 12 accommodated in a tea bag is 5g-10g.

  The tea bag 1 of the present invention uses water as an extraction solvent, and can be dissolved in the extraction solvent to elute water-soluble components of the genus Cucurbita seeds.

  Conventionally known methods for extracting the active ingredient of the genus Cucurbita are mainly lipophilic fractions such as fatty acids (linoleic acid, oleic acid, palmitic acid), carotenoids, tocopherols, Δ-5 and Δ-7 phytosterols. An aqueous ethanol solution was used as the extraction solvent to extract the minutes. In contrast, the present inventors have found that the active ingredient is contained in the water-soluble fraction. Thus, water is used as an extraction solvent to form a tea bag most suitable for producing a peppo pumpkin seed drink excellent in preventive and / or therapeutic effects on urological diseases.

  The method of using the tea bag 1 of the present invention is to wrap Cucurbita seeds or pulverized Cucurbita seeds in tea bags and extract them in a pot containing water for a certain period of time. In a method such as putting a tea bag in a container such as a mug and extracting it with hot water or warm water for a short time to make a drink, and a cold water tea drink that is immersed in water and immersed in a refrigerator for several hours There is a way.

  FIG. 3 is a diagram showing a process for producing a tea bag from a seed of the genus Cucurbita. The pumpkin (Cucurbita) seed 4 which is the raw material of the contents is squeezed and defatted in order to enhance the storage stability against oxidation. Specifically, by crushing the genus Cucurbita seed 4 and heat-treating at 140 ° C. for 20 to 40 minutes (S1), pressurizing the crushed material with a press or the like, and extracting water and oil (S2 ) To obtain defatted pumpkin seeds 2.

  The defatted pumpkin seed 2 is further subjected to a pulverizer to obtain a powdered pumpkin seed powder 3 (S3). The pumpkin seed powder 3 is preferably a powder in which the proportion of particles of 500 μm or less in the pulverized particle size is 50% by weight or more.

  The pumpkin seed powder 3 may then be sterilized by passing it through 110 ° C. superheated steam for several seconds using a superheated steam sterilizer or the like (S4). Thereby, Gram negative pathogenic bacteria (for example, Salmonella) can be substantially sterilized. If there is no problem of contamination in the distribution process of pumpkin seeds, defatted pumpkin seeds or pumpkin seed powder, sterilization is not necessary.

  The sterilized pumpkin seed powder 3 is packed in a tea bag (S5). That is, by sterilizing the pumpkin seed powder 3 (content 12) in a bag 10 such as a non-woven fabric, the handle thread 14 is coupled to the bag 10, and the grip paper 16 is coupled to the tip of the handle thread 14. The desired tea bag 1 is obtained.

  Since the pumpkin seed 4, the defatted pumpkin seed 2 or the pumpkin seed powder 3 contained in the tea bag 1 of the present invention contains fat, for example, when making a tea bag with a long shelf life of more than six months Is preferably housed in a packaging bag that can be sealed even with low fat together with an oxygen scavenger. In addition, the packaging bag may be a packaging bag in which the above tea bags are individually mounted, or a packaging bag in which a plurality of tea bags are accommodated.

  In addition, although the example which used the pumpkin seed powder 3 as the content 12 was shown here, it can replace with the pumpkin seed powder 3, and can also use the pumpkin genus (Cucurbita) seed 4 or the defatted pumpkin seed 2. FIG.

  Next, the present invention will be described in detail with reference to examples, but the present invention is not limited to this.

1. Production of tea bags Cucurbita pepo seeds were used as seeds of the genus Cucurbita. First, 1 kg of pepo pumpkin seeds were crushed, then water and a small amount of sodium chloride were added to the crushed material and kneaded and heated at 140 ° C. for 30 minutes. And the defatted pumpkin seed was obtained by pressurizing crushed material with a press machine and extracting water and oil.

  This defatted pumpkin seed was dried and applied to a pulverizer to obtain a powdered powder in which the proportion of particles of 500 μm or less in the pulverized particle size was 50% by weight or more (hereinafter referred to as “low-fat pumpkin seed powder”) Called). By these operations, about 320 g of oil of Cucurbita pepo seed and 430 g of low-fat pumpkin seed powder were obtained. A tea bag was manufactured by storing 5 g of this low-fat pumpkin seed powder in a non-woven fabric, binding handle yarn to the bag, and binding grip paper to the tip of the handle yarn.

2. Evaluation test Pour 180 ml of hot water into one tea bag produced as described above, steam for 30 minutes or more to elute the water-soluble components of low-fat pumpkin seed powder into hot water, and prepare a beverage in the form of tea. (Peppo pumpkin tea). Four middle-aged men aged 65-75 years who have overactive bladder symptoms (frequent urination symptoms) who have more than 2 urinations during the night have taken about 180 ml of tea before going to bed for 4 days. It was.

  As a result, the number of urinations during the night was improved in the 2 patients from the first day (the number of urinations during the night decreased by 1 or more), and the other 2 patients did not change. Furthermore, on the 3rd and 4th day of taking the drug, the improvement in the number of urinations during the night was confirmed in all four patients, and the effect of improving the urinary excretion during urination was also observed. In addition, the method of administration in this clinical study also demonstrated that the drug effect by the water extract is immediate. None of the subjects had any side effects.

DESCRIPTION OF SYMBOLS 1 ... Tea bag 2 ... Degreasing pumpkin seed 3 ... Pumpkin seed powder 4 ... Pumpkin seed 10 ... Bag 12 ... Contents 14 ... Handle thread 16 ... Grip paper

Claims (8)

A tea bag in which the contents are stored in a bag, and the water-soluble components effective in the prevention and / or treatment of urological diseases are eluted from the contents by immersing them in water.
The content is characterized in that the raw material is a pumpkin (Cucurbita) seed,
Tea bag.   The tea bag of claim 1, wherein the Cucurbita seed is a Cucurbita pepo seed.   The tea bag of Claim 1 or 2 whose fat content of the said seed is 10 weight% or less.   The tea bag according to any one of claims 1 to 3, wherein the seed is a powder having a pulverized particle size in which particles of 500 µm or less account for 50 wt% or more.   The urological disorder is dysuria resulting from benign prostatic hyperplasia, frequent urination and / or urinary incontinence resulting from climacteric disorder in women, overactive bladder, stress urinary incontinence, dysuria resulting from urinary tract infection The tea bag of any one of Claims 1-4.   The tea bag according to any one of claims 1 to 5, wherein the bag is a nonwoven fabric.   The tea bag according to any one of claims 1 to 6, wherein a handle thread is coupled to the bag.   A sealable packaging bag containing the tea bag according to any one of claims 1 to 7 and an oxygen scavenger.