JP3143833B2 - Mite control agent for indoor dust mites and method for controlling indoor dust mites - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an agent for controlling house dust mites and a method for controlling house dust mites using the same, and more particularly to a method using an iodopropagyl carbamate derivative as an active ingredient. , With a small amount of spraying and application,
Particularly effective in controlling indoor dust mites that inhabit and propagate indoors and cause problems such as asthma
The present invention relates to a mite control agent for indoor dust mites and a method for controlling indoor dust mites .

[0002]

2. Description of the Related Art Conventionally, drying of tatami mats and jutans has been regarded as the most effective means of controlling ticks generated in a house, but these methods are very difficult to implement spatially and labor-intensively. Therefore, chemical control is generally performed.
And Thus, as the agents that have been used conventionally, is an organic phosphorus-based fenthion, fenitrothion, diazinon, DDVP, trichlorfon, pyrethroid Kurisuron, permethrin, Pro Po box <br/> Le of Carbamate such . However, environments such as tatami or rug that inhabit the house dust mites, it is not a multi-uniform treatment of the drug is difficult.

[0003] Spraying indoors is dangerous.
Therefore, the amount used had to be reduced. However, drugs that have been widely used conventionally described above, have quite a large amount of use and not the house dust mites controlling effect with effective is obtained.

[0004] The present inventors have proposed a use amount that does not pose a danger to the human body.
Against house dust mites, to find a drug that sufficient proof removal effect can be obtained, and extensive research on various drugs, as one of the results, 3-iodo-2-propynyl butyl carbamate indoor It has been found that the mite not only has a remarkable effect in controlling dust mites but also has an ovicidal effect of these mites, which was previously proposed in Japanese Patent Application No. 97090/1990.

The present inventors have found that even small amounts of indoor dust mites
Against class, although making efforts day and night in order to develop drugs that exhibit sufficient anti-vibration effect, iodopropargyl carbamate derivatives is according to the present patent applicant prior application 3-iodo -2
-Indoor dust dust superior to propynyl butyl carbamate
We learned that it has a control effect on duck species .

[0006]

SUMMARY OF THE INVENTION Accordingly, the present invention has been made based on the above-mentioned new finding, and is based on the above-mentioned new finding , for indoor dust mites containing one or more kinds of iodopropagyl carbamate derivatives as an active ingredient . The present invention relates to a method for controlling indoor dust mites using a mite controlling agent and iodopropagyl carbamate derivatives.

[0007] The indoor dust mites mentioned here include Dermatophagoides farinae, Dermatophagoides farinae, Dermatophagoides farinae, Dermatophagoides farinae, Dermatophagoides farinae, Dermatophagoides farinae, Dermatophagoides farinae, Scots mite, Cyperus spp. The tick control agent and the tick control method according to the present invention are excellent in controlling the indoor dust mites described above.

[0008]

DISCLOSURE OF THE INVENTION The present invention provides an iodopropargyl carbamate derivative represented by the following general formula:
It is characterized by containing one or more species as active ingredients.

That is, the gist of the present invention is as follows: (1) The following general formula:

Embedded image (Wherein R is a phenyl group; one to three of H in the phenyl group is a halogen atom, a lower alkyl group, a nitro group, a cyano group, a halo-lower alkyl group, a lower alkoxy group, a lower alkoxy-lower alkyl group, a lower alkenyl) Mite control for indoor dust mites characterized by containing an iodopropargyl carbamate derivative represented by the formula (1) as an active ingredient: a group selected from the group consisting of a group substituted by an oxy group or a lower alkynyloxy group. Agent. (2) house dust mites controlling method which comprises using the house dust mites for mite control agent according to (1). It is in.

The iodopropargyl carbamate derivatives contained in the present invention are compounds represented by the above general formula. By mixing one or more of these compounds, mites, especially conventional mites can be obtained. Indoors showing excellent effect on indoor dust mites that were difficult to completely eliminate with chemicals
A mite control agent for dust mites is obtained.

In the above general formula, R is a phenyl group; one to three of H of the phenyl group is a halogen atom, a lower alkyl group, a nitro group, a cyano group, a halo-lower alkyl group, a lower alkoxy group, a lower alkoxy lower. It is selected from the group consisting of a group substituted by an alkyl group, a lower alkenyloxy group or a lower alkynyloxy group. Many of the compounds represented by the above formula have already been disclosed as fungicides in EP-2578.
88, 258-030 and the like,
It can be easily produced by reacting iodopropargyl alcohol with substituted phenyl isocyanate. Illustrating specific compounds included in the present invention,
3-Iodopropargyl N-phenylcarbamate and 2-chloro, 3-chloro, 4-chloro, 2-methyl,
-From a phenyl group having a methyl, 4-methyl, 2,4-dichloro, 3,4-dichloro, 3-fluoro, 4-fluoro, 3-trifluoromethyl, 4-nitro or 4-methoxy group as a substituent 3-iodopropargyl N-phenylcarbamate.
When the compound of the present invention is actually used as a mite control agent for indoor dust mites, it may be used as it is without adding any other components, but solids used in general chemicals may be used. It can also be mixed with various liquid and gaseous carriers, formulation auxiliaries, baits and the like to produce oils, emulsions, powders, granules, wettable powders, aerosols, sheets and the like.

The carriers used in the preparation may be used alone or in combination. Examples of the solid carrier include powders or granular materials such as talc, clay, bentonite, kaolin, diatomaceous earth, calcium carbonate, urea, ammonium sulfate, white carbon, activated carbon, wood flour, and starch.Examples of the liquid carrier include kerosene, Aliphatic hydrocarbons such as kerosene, aromatic hydrocarbons such as xylene, methylnaphthalene, toluene and benzene, halogenated hydrocarbons such as dichloroethane and trichloroethylene, alcohols such as ethanol, isopropanol and cellosolve, acetone, methyl ethyl ketone and the like Ketones, diethyl ether, ethers such as tetrahydrofuran, esters such as ethyl acetate, nitriles such as acetonitrile, amides such as dimethylformamide, soybean oil, vegetable oils such as cottonseed oil, and the like. For example freon gas, LPG, dimethyl ether. Pharmaceutical auxiliaries include, for example, surfactants such as alkyl sulfates, polyoxyethylene sorbitan esters, and polyoxyethylene alkyl ethers; film-forming agents such as cellulose derivatives and vinyl resins; polyvinyl alcohol; CMC; And the like, a thickener or a dispersant, a foaming agent, a burning agent and the like.

In formulating, the mixing ratio generally includes 0.1% to 50%, preferably 0.1 to 20%, based on the compound of the present invention as% by weight, and 50 to 99.9 as a carrier.
% And 0 to 15% are optimal as auxiliary agents. Further, when actually using the present invention, the method of use, dosage form used,
Of course it is appropriately selected by using the location and the like, 1 m ² per 0.0 as an active ingredient used in an amount
It is desirable to treat with 5 to 5 g, preferably 0.5 to 2 g. Furthermore, a wider range of effects can be expected by mixing and using other insecticides, acaricides, fungicides, insect repellents, fungicides, fragrances, coloring agents and the like.

Hereinafter, the present invention will be described in more detail with reference to Formulation Examples and Test Examples, but the present invention is not limited thereto.

Example 1 Iodopropargyl-2-chlorophenylcarbamate 0.3 g Denatured alcohol 150 ml Propellant 150 ml Total 300 ml Iodopropargyl-2-chlorophenylcarbamate was dissolved in denatured alcohol and put in a 300 ml aerosol can. A propellant (LPG) was charged to produce an aerosol. [Example 2] Iodopropargyl-3-trifluoromethylphenylcarbamate 10 parts by weight Nitrocellulose 50 parts by weight Carboxymethylcellulose 5 parts by weight Mineral powder 100 parts by weight Water was appropriately added to each of the above raw materials and kneaded, After granulation by an extrusion granulator, it was dried and filled in a metal container to produce a smoke agent. Example 3 Iodopropargyl phenyl carbamate 2 parts by weight Clay 10 parts by weight Talc 88 parts by weight 100 parts by weight The above-mentioned raw materials were sufficiently mixed by a powder mixer and a pulverizer to produce a powder. Example 4 Iodopropargyl-4-chlorophenylcarbamate was dissolved in a small amount of ethanol, kneaded with PP and PE, and formed into a sheet to form a sheet.

The following compounds were prepared as comparative examples to compare the mite control effects of house dust mites . [Comparative Example 1] 3-Iodo-2-propynylbutylcarbamate (hereinafter abbreviated as "IPBC"). Comparative Example 2 full E Nchion (Fenthion). [Comparative Example 3] Diazinon.

The following test was carried out to examine the mite control effect of the compound of the present invention and the compound of the comparative example for indoor dust mites according to the present invention. Dermatophagoides farinae and Dermatophagoides farinae were selected as typical indoor dust mites, and they were eliminated by the same method and the results were evaluated by the same evaluation method. [Efficacy against Dermatophagoides farinae] The compound of the present invention is diluted with acetone and adjusted to a predetermined concentration. The diluent was added to a 4.5 cm diameter glass Petri dish.
After dropping 5 ml and air-drying to prepare a dry film, 30 adult adults of Dermatophagoides farinae are inoculated. In addition, an insect repellent adhesive was applied in a strip shape around the bottom of the Petri dish, and the repellent individuals were also evaluated. After 24 hours and 48 hours if necessary, the test insects were categorized into normal individuals, repellent individuals, paralyzed individuals, and dead individuals. [Efficacy against Dermatophagoides farinae] In order to examine the mite control effect of the compound of the present invention and the compound of the comparative example for indoor dust mites , a test was conducted in the same manner as in Dermatophagoides farinae. [Egg Killing Efficacy Test] On a dry film prepared in the same manner as in the efficacy test for adult worms, eggs of Acarina mites within 0 to 48 hours after birth were inoculated, and the hatching rate was examined three weeks later.

The results of the tests are shown in Tables 1-2, 3 and 4.
Are shown together. Tables 1 and 2 show the efficacy against Dermatophagoides farinae, Table 3 shows the efficacy against Dermatophagoides farinae, and Table 4 shows the ovicidal efficacy.

[Table 1]

[Table 2]

[Table 3]

[Table 4] In Tables 1 to 3, (N) indicates a normal individual and (A)
v) shows a repellent individual, (Ab) shows a paralyzed individual, and (D) shows a dead individual.

[0019]

As is clear from the above test results, according to the mite control agent for indoor dust mites of the present invention, indoor dust mites in a tatami mat or a jutan are almost completely prepared at a low dose. It is an excellent thing that can be controlled. In addition, not only adult house dust mites, until eggs house dust mites also can kill almost completely, with effectively a re-occurrence of house dust da <br/> two such Can be prevented.

Continuation of the front page (56) References JP-A-63-264449 (JP, A) JP-A-63-54306 (JP, A) JP-B-46-21917 (JP, B1) JP-B-43-11306 (JP, A) , B1) (58) Field surveyed (Int. Cl. ⁷ , DB name) A01N 47/20

Claims (2)

(57) [Claims] [Claim 1] The following general formula: (Wherein R is a phenyl group; one to three of H in the phenyl group is a halogen atom, a lower alkyl group, a nitro group, a cyano group, a halo-lower alkyl group, a lower alkoxy group, a lower alkoxy-lower alkyl group, a lower alkenyl) Mite control for indoor dust mites characterized by containing an iodopropargyl carbamate derivative represented by the formula (1) as an active ingredient: a group selected from the group consisting of a group substituted by an oxy group or a lower alkynyloxy group. Agent. 2. A house dust mites controlling method which comprises using the house dust mites for mite control agent according to claim 1.