JPH0532506A - Agent for preventing mite and method therefor - Google Patents

Abstract

PURPOSE:To provide a mite-preventing agent exhibiting a remarkable controlling effect on indoor dusty mites by the spraying or application of a small amount of the agent, the mites living and multiplying especially indoors and causing troubles such as asthma. CONSTITUTION:A mite-preventing agent contains an iodopropargyl carbamate derivative of the formula [R is phenyl having one to three substituents (e.g. halogen, lower alkyl, NO2, CN, lower haloalkyl, lover alkoxy, lover alkoxy lower alkyl, lower alkenyloxy, lower alkinyloxy)], e.g. iodopropargyl-2- chlorophenyl carbamate, as an active ingredient. The mite-preventing agent can almost perfectly control indoor dusty mites in a low dose of 0.05-5g, preferably effectively prevent the re-infestation of the mites because can effectively prevent the re-infestation of the mites because of enabling to kill not only the imagines but also the eggs.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a mite control agent and a mite control method, and more specifically, it uses an iodopropargyl carbamate derivative as an active ingredient and can be spread especially indoors by applying a small amount of it. The present invention relates to a mite control agent and a mite control method, which are particularly effective in controlling indoor dust mites that cause problems such as breeding and causing asthma.

[0002]

2. Description of the Related Art Conventionally, as a means for controlling mites generated in a house, drying of tatami mats and jutan has been the most effective, but these methods are very difficult in terms of space and labor. Therefore, it is generally controlled by chemicals.
Thus, the conventionally used agents include organic phosphorus-based phenthion, fenitrothion, diazinon, DDVP, trichlorfon, pyrethroid-based chrysulon, permethrin, carbamate-based provoxur, and the like. However, in environments such as tatami mats and jutan, where indoor dust mites live, it is often difficult to uniformly treat the chemicals, and it is dangerous to spray the chemicals indoors. I didn't get it.

However, the above-mentioned agents which have been widely used until now cannot obtain an effective effect of controlling ticks unless they are used in a considerably large amount.

The present inventors have been researching various drugs in order to find a drug that can obtain a sufficient tick control effect in a dose that is not harmful to the human body, and one of the achievements is 3-iodo. It was found that -2-propynyl butyl carbamate is not only very effective in controlling indoor dust mites, but also has an ovicidal effect on these mites. Proposed as No. 97090.

The present inventors have been working day and night to develop a drug exhibiting a sufficient tick control effect even in a small amount, but iodopropargyl carbamate derivatives are related to the prior application of the applicant of the present invention. It has been found that it has a tick control effect superior to that of iodo-2-propynylbutylcarbamate.

[0006]

Therefore, the present invention is based on the above new findings, and a tick control agent and iodopropa containing one or more of iodopropargyl carbamate derivatives as an active ingredient. The present invention relates to a method for controlling ticks using Gilkerbamate derivatives.

The indoor dust mites referred to here include Dermatophagoides farinae, Dermatophagoids mosquitoes, Dermatophagoides farinae, Plutella xylostella, Dermatophagoides farinae, Acanthophoridae, Sato mites, stag beetle mite, Keracaropsis spp. The mite controlling agent and the mite controlling method according to the present invention are excellent in controlling the above indoor dust mites.

[0008]

The present invention provides one of iodopropargyl carbamate derivatives represented by the following general formula.
It is characterized by containing one kind or two or more kinds as an active ingredient.

That is, the gist of the present invention is that (1) The following general formula

[Chemical 2] (In the formula, R is a phenyl group; one or three of H of the phenyl group is a halogen atom, a lower alkyl group, a nitro group, a cyano group, a halo lower alkyl group, a lower alkoxy group, a lower alkoxy lower alkyl group, a lower alkenyl. And a lower alkynyloxy group-substituted group.), An agent for controlling ticks, comprising an iodopropargyl carbamate derivative represented by the formula (1) as an active ingredient. (2) A method for controlling ticks, which comprises using the tick controlling agent according to (1) above. It is in.

The iodopropargyl carbamate derivatives contained in the present invention are compounds represented by the above general formula, and by mixing one or more of these compounds, mites, particularly conventional ones, can be used. It is possible to obtain a tick control agent that is effective against indoor dust mites, which were difficult to completely control with chemicals.

In the above general formula, R is a phenyl group; one to three of H of the phenyl group are halogen atom, lower alkyl group, nitro group, cyano group, halo lower alkyl group, lower alkoxy group, lower alkoxy lower group. It is selected from the group consisting of a group substituted with an alkyl group, a lower alkenyloxy group or a lower alkynyloxy group. Many of the compounds represented by the above formula have already been used as fungicides in EP-257888, 258.
-030 and the like, which are known substances, can be easily produced by reacting iodopropargyl alcohol with substituted-phenyl isocyanate. Examples of specific compounds included in the present invention include 3-iodopropargyl N-phenylcarbamate and 2-chloro, 3
-Chloro, 4-chloro, 2-methyl, 3-methyl, 4-
Methyl, 2,4-dichloro, 3,4-dichloro, 3-fluoro, 4-fluoro, 3-trifluoromethyl, 4-
3-iodopropargyl N-phenylcarbamate composed of a phenyl group having a nitro or 4-methoxy group as a substituent can be mentioned. Incidentally, when actually using the compound of the present invention as a tick control agent,
It may be used as it is without adding any other ingredients,
Oils, emulsions, powders, granules, wettable powders, aerosols, sheets, etc., which are appropriately mixed with solid, liquid, and gaseous carriers and auxiliary agents for preparations, baits, etc. used for general drugs. It can also be manufactured.

The carriers used in the preparation may be used alone or in combination. Examples of the solid carrier include talc, clay, bentonite, kaolin, diatomaceous earth, calcium carbonate, urea, ammonium sulfate, white carbon, activated carbon, wood flour, starch, and other powders or granules.The liquid carrier includes, for example, kerosene, Aliphatic hydrocarbons such as kerosene, aromatic hydrocarbons such as xylene, methylnaphthalene, toluene and benzene, halogenated hydrocarbons such as dichloroethane and trichloroethylene, alcohols such as ethanol, isopropanol and cellosolve, acetone, methyl ethyl ketone, etc. Ketones, diethyl ether, ethers such as tetrahydrofuran, esters such as ethyl acetate, nitriles such as acetonitrile, amides such as dimethylformamide, soybean oil, vegetable oil such as cottonseed oil, and the like, and the gas carrier is For example freon gas, LPG, dimethyl ether. Examples of the auxiliaries for preparation include surfactants such as alkyl sulfate ester salts, polyoxyethylene sorbitan esters and polyoxyethylene alkyl ethers, cellulose derivatives, film forming agents such as vinyl resins, polyvinyl alcohol, CMC, gum arabic. Examples thereof include thickeners or dispersants, foaming agents, combustion agents and the like.

In formulating, the mixing ratio is generally 0.1% to 50%, preferably by weight of the compound of the present invention.
The optimum content is 0.1 to 20%, the carrier is 50 to 99.9%, and the auxiliary agent is 0 to 15%. Further, when the present invention is actually used, it is natural that it is appropriately selected depending on the method of use, dosage form, place of use, etc., but the amount used is preferably 0.05 to 5 g per 1 m ² as an active ingredient.
Treatment with 0.5 to 2 g is desirable. Furthermore, a wider range of effects can be expected by mixing with other insecticides, acaricides, bactericides, pest repellents, antifungal agents, fragrances, coloring agents and the like.

Hereinafter, the present invention will be described in more detail with reference to formulation examples and test examples, but the present invention is not limited thereto.

[Example 1] Iodopropargyl-2-chlorophenylcarbamate 0.3 g Denatured alcohol 150 ml Propellant 150 ml Total 300 ml Iodopropargyl-2-chlorophenylcarbamate was dissolved in denatured alcohol to prepare an aerosol can for 300 ml. Then, it was filled with a propellant (LPG) to prepare an aerosol. [Example 2] Iodopropargyl-3-trifluoromethylphenylcarbamate 10 parts by weight Nitrocellulose 50 parts by weight Carboxymethyl cellulose 5 parts by weight Mineral fine powder Remainder 100 parts by weight Water was appropriately added to each of the above materials and kneaded. After granulating with an extrusion granulator, it was dried and filled in a metal container to produce a smoking agent. [Example 3] Iodopropargyl phenylcarbamate 2 parts by weight Clay 10 parts by weight Talc 88 parts by weight 100 parts by weight The above raw materials were thoroughly mixed by a powder mixer and a pulverizer to produce a powder. [Example 4] Iodopropargyl-4-chlorophenylcarbamate was dissolved in a small amount of ethanol to give PP, P.
It was kneaded into E and molded into a sheet to prepare a sheet agent.

To compare the effect of controlling ticks, the following compounds were prepared as comparative examples. [Comparative Example 1] 3-iodo-2-propynylbutylcarbamate (hereinafter, abbreviated as "IPBC"). [Comparative Example 2] Fenthion. [Comparative Example 3] Diazinon.

The following tests were conducted in order to investigate the effect of controlling the ticks according to the present invention and the compounds of Comparative Examples. Dermatophagoides farinae and Dermatophagoides farinae were selected as typical indoor dust mites, exterminated by the same method, and the results were evaluated by the same evaluation method. [Effect on Dermatophagoides farinae] The compound of the present invention is diluted with acetone and adjusted to a predetermined concentration. Add 0.5 ml of the dilution liquid to a glass dish with a diameter of 4.5 cm and let it air dry.
After creating the dry film,
Inoculate to 30 heads. Insect repellents were also evaluated by applying a strip of insect repellent adhesive around the bottom of the dish. After 24 hours and, if necessary, after 48 hours, the test insects were classified into normal individuals, repellent individuals, paralyzed individuals, and dead individuals and investigated. [Efficacy against acarid mite] In order to investigate the mite controlling effect of the mite controlling agent of the present invention and the compound of the comparative example, a test was carried out in the same manner as in the case of Dermatophagoides farinae. [Eggicidal efficacy test] On a dry film prepared in the same manner as in the efficacy test for adults, the eggs of Acarina pallidum within 0 to 48 hours after birth were inoculated, and the hatching rate was investigated 3 weeks later.

The results of the above tests are shown in Tables 1-2, Table 3 and Table 4
Are shown together. Tables 1 and 2 show the efficacy against Dermatophagoides farinae, Table 3 shows the efficacy against Dermatophagoides farinae, and Table 4 shows the ovicidal efficacy.

[Table 1]

[Table 2]

[Table 3]

[Table 4] In Tables 1 to 3, (N) indicates a normal individual, (Av) indicates a repellent individual, (Ab) indicates a paralyzed individual, and (D) indicates a dead individual.

[0019]

As is clear from the above test results, the tick control agent of the present invention can control almost completely even indoor dust mites in tatami mats and jutan with a low dosage. It is excellent. Furthermore, not only adults of mites but also eggs of mites can be killed almost completely,
Therefore, the reoccurrence of mites can be effectively prevented.

Claims (2)

[Claims] 1. The following general formula: (In the formula, R is a phenyl group; one or three of H of the phenyl group is a halogen atom, a lower alkyl group, a nitro group, a cyano group, a halo lower alkyl group, a lower alkoxy group, a lower alkoxy lower alkyl group, a lower alkenyl. And a lower alkynyloxy group-substituted group.), An agent for controlling ticks, comprising an iodopropargyl carbamate derivative represented by the formula (1) as an active ingredient. 2. A method for controlling ticks, which comprises using the tick control agent according to claim 1.