JP3129371B2 - Bath agent - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a bath preparation, and more particularly to a bath preparation containing guava seed essence.

[0002]

2. Description of the Related Art The Japanese are known as bath ethnic groups. However, bathing habits are not limited to Japanese people, but since the Roman era, they have been widely practiced in the West, and even now, in Germany, they are called Kurhauss. There are many places that include birds that mean hot springs, suggesting that the joy that baths have provided to humanity is not small.

[0003] The effect of the bath, which has been favored by human beings, is largely due to inorganic substances such as salt dissolved in hot springs and the like. Therefore, in recent years, many bath agents having a salt component modeled on these hot spring components have been sold.
Also, reflecting the herb boom of one time, those that blend herbal essences are also commercially available,
Basically, it was largely dependent on inorganic salts.

The effects of these inorganic salts are mainly the promotion of blood circulation and the effect of keeping warm. It can be said that the conventional bath preparation is obtained by adding an herb extract or the like as a softening agent. Therefore, it can be said that there was no bath agent that escaped from the effect of a mere inorganic salt.

[0005]

DISCLOSURE OF THE INVENTION The present invention has been made in view of the above circumstances, and has a highly safe bathing agent, which has both a blood circulation promoting action and a warming effect of an inorganic salt and a skin metabolism activating action. The purpose is to provide.

[0006]

Means for Solving the Problems The present inventors have intensively searched for a substance which can be added to a bath agent and has a strong metabolic activation action on the skin, and as a result, found the action in guava seed essence. Completed the invention.

The guava of the present invention is a tropical plant belonging to the family Myrtaceae, and its fruits are widely marketed and used for food in Japan. In the present invention, the essence of guava seeds is used. Examples of methods for obtaining essence from guava seeds include a squeezing method and a solvent extraction method.

[0008] In this method, essence is obtained from guava seeds by squeezing.
Pressurization may be performed, and if necessary, heating may be performed.

In this method, essence is obtained from guava seeds by solvent extraction. Examples of the solvent used include alcohols such as methanol and ethanol, halogenated hydrocarbons such as chloroform and dichloromethane, diethyl ether and isopropyl ether. And one or more selected from ethers, ketones such as acetone and methyl ethyl ketone, and hydrocarbons such as normal hexane, cyclohexane and petroleum ether. In addition, the extraction may be continuous or batch type, and even when heated,
It may be at room temperature or cooled. Moreover, you may add stirring suitably. As pretreatment of the seed, drying or the like may be performed in advance.
After the extraction operation, insoluble matter is removed by filtration, and then the mixture is concentrated to obtain an essence.

The preferred amount of guava seed essence in the bath is 0.1 to 10% by weight. This is because if the compounding amount is less than 0.1% by weight, the effect cannot be expected, and 10% by weight
This is because the effect has ceased even if it exceeds.

In the bath preparation of the present invention, in addition to guava seed essence, optional ingredients generally used in bath preparations, for example, inorganic salts such as sodium sulfate and sodium carbonate, surfactants, fungicides, fragrances and herbal extracts. , Humectants, polyhydric alcohols and the like can be blended.

[0012]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to these examples. In addition, in the following formulation examples
All component amounts are% by weight.

Embodiment 1 FIG. Production Example 1 After 1 kg of dried guava seeds was finely ground, 2 l of normal hexane was added thereto, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 131 g of a pale yellow liquid.

Embodiment 2 FIG. Production Example 2 After 1 kg of dried guava seeds was finely ground, 2 l of dichloromethane was added thereto, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 145 g of a pale yellow liquid.

Embodiment 3 FIG. Production Example 3 After 1 kg of dried guava seeds was finely ground, 2 l of diethyl ether was added thereto, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 152 g of a pale yellow liquid.

Embodiment 4 FIG. Production Example 4 After 1 kg of dried guava seeds was finely ground, 2 l of acetone was added thereto, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 104 g of a pale yellow liquid.

Embodiment 5 FIG. Production Example 5 After 1 kg of guava seeds were finely ground, 2 l of a 50% ethanol-chloroform solution was added, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 102 g of a pale yellow liquid.

Embodiment 6 FIG. Production Example 6 1 kg of dried guava seeds was squeezed with a press at 450 kg while heating to 80 ° C. to obtain 43 g of a pale yellow liquid.

Embodiment 7 FIG. Acute toxicity Acute toxicity was examined using ICR mice (male, 5 weeks old, 25 to 35 g). That is, 6 animals per group, Production Examples 1 to
Each of 6 guava seed essences was orally administered at 1 g / Kg. On the 14th day after the administration, survival was determined and the LD50 value was determined. None of the animals died, and therefore the LD50
The value seems to be 1 g / Kg or more. This indicates that the safety of the essence of the present invention is high.

Embodiment 8 FIG. Local toxicity Hartley white guinea pig (female, 300-350
g) The backs of the six animals were shaved to create six 1 mm square parts. The 0.03 m l of guava seed essence of Examples 1-6 to each of the sites once daily 5 consecutive days of administration was determined based on a skin reaction in Japan patch test criteria on day 6. That is,-: no reaction, ±: false positive reaction, +: positive reaction, ++: criterion for reaction accompanied by edema. The judgment was that there was no reaction at any site. This indicates that the guava seed essence of the present invention has low local toxicity to the skin.

Embodiment 9 FIG. Keratin turnover speed promotion effect The skin activation effect was measured as the turnover promotion effect as Merckmar. After shaving the back of each group of 6 guinea pigs, 10 of the essences of Examples 1 to 5 were used.
% Liquid paraffin solution and apply 80% with a BLB lamp.
Ultraviolet light was irradiated at a light amount of W / cm ² for 30 minutes. This was continued once a day for 5 days, then dansyl chloride was applied, and the number of days until the fluorescence of dansyl chloride disappeared was measured. As a comparison, a 10% liquid paraffin solution of vitamin A, which is known as a turnover accelerator, was used. Table 1 shows the results. This indicates that the guava seed essence of the present invention has an excellent keratin turnover promoting effect. Therefore, this can be expected to activate the skin.

[0022]

[Table 1]

Embodiment 10 FIG. Formulation Example The following components were weighed into a kneader and kneaded to obtain a bath agent. Sodium sulfate 97 Essence of Example 1 2 Fragrance 0.5 POE (60) hydrogenated castor oil 0.5

Embodiment 11 FIG. Formulation Example The following components were weighed into a kneader and kneaded to obtain a bath agent. Sodium sulfate 50 Sodium bicarbonate 40 Fragrance 0.5 POE (100) hydrogenated castor oil 0.5 Essence of Example 2 4 Essence of Example 3 5

Embodiment 12 FIG. Formulation Example The following components were weighed into a kneader and kneaded to obtain a bath agent. Sodium sulfate 50 Sodium hydrocarbon 40 Fragrance 0.5 Essence of Example 0.5 Propylene glycol 5 Polyethylene glycol (4000) 4

Example 13 Formulation Example The following ingredients were weighed, heated and stirred, dissolved, and then cooled to obtain a bath agent. Coconut oil fatty acid diethanolamide 1 butyl paraben 0.05 methyl paraben 0.1 stearic acid 0.1 ethanol 15 propylene glycol 10 essence of Example 6 10 water 63.75

Embodiment 14 FIG. Use test An actual use test was performed on the bath agent of Example 13. That is, the bath preparation of Example 13 and the bath preparation of Example 13 in which the essence of Example 6 was replaced with olive oil (comparative)
Example) was used by 20 people one week at a time, and the questionnaire was answered. Table 2 shows the results. This indicates that the bath agent of the present invention is excellent.

[0028]

[Table 2]

[0029]

EFFECT OF THE INVENTION The bath preparation of the present invention is very useful because it has excellent heat retention and blood circulation promoting effects, is highly safe, and has a skin activating effect.

──────────────────────────────────────────────────続 き Continuation of the front page (51) Int.Cl. ⁷ Identification code FI A61P 17/00 A61P 17/00 (72) Inventor Yoshikazu Hirai 27-1 Takashimadai, Kanagawa-ku, Kanagawa-ku, Yokohama-shi, Japan Yokohama Research Laboratory (72) Inventor Norie Muramatsu 271-1 Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa Prefecture Pola Chemical Industry Co., Ltd. Yokohama Research Laboratory (72) Inventor Masaki Yagi 271-1 Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa No. Polar Research Institute, Yokohama Research Institute (72) Inventor Toshiyuki Fukuda 27-1, Takashimadai, Kanagawa-ku, Kanagawa-ku, Kanagawa-ken, Japan Polar Research Institute Yokohama Research Laboratory (56) References JP-A-6-305978 ( JP, A) JP-A-6-206814 (JP, A) JP-A-5-246837 (JP, A) JP-A-3-151315 (JP, A) JP-A-1-14506 3 (JP, A) (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (3)

(57) [Claims] 1. A bath preparation containing 0.1 to 10% by weight of guava seed essence. 2. The bath preparation according to claim 1, wherein the guava seed essence is a guava seed squeezed product. 3. The bath preparation according to claim 1, wherein the guava seed essence is an organic solvent extract of guava seed.