JP3070767B2 - 抗腫瘍及び抗―レトロウィルス剤として有用なアデノシンジホスホリボースポリメラーゼ結合性ニトロソ芳香族化合物 - Google Patents

抗腫瘍及び抗―レトロウィルス剤として有用なアデノシンジホスホリボースポリメラーゼ結合性ニトロソ芳香族化合物

Info

Publication number
JP3070767B2
JP3070767B2 JP4505220A JP50522092A JP3070767B2 JP 3070767 B2 JP3070767 B2 JP 3070767B2 JP 4505220 A JP4505220 A JP 4505220A JP 50522092 A JP50522092 A JP 50522092A JP 3070767 B2 JP3070767 B2 JP 3070767B2
Authority
JP
Japan
Prior art keywords
nitroso
benzopyrone
compounds
cells
nobp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP4505220A
Other languages
English (en)
Japanese (ja)
Other versions
JPH07502975A (ja
Inventor
カン，アーネスト
メンデレイエブ，ジェローム
ジー． ライス，ウィリアム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Publication of JPH07502975A publication Critical patent/JPH07502975A/ja
Application granted granted Critical
Publication of JP3070767B2 publication Critical patent/JP3070767B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP4505220A 1991-10-22 1991-11-26 抗腫瘍及び抗―レトロウィルス剤として有用なアデノシンジホスホリボースポリメラーゼ結合性ニトロソ芳香族化合物 Expired - Lifetime JP3070767B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78080991A 1991-10-22 1991-10-22
US780,809 1991-10-22
PCT/US1991/008902 WO1993007868A1 (fr) 1991-10-22 1991-11-26 Composes aromatiques nitreux liant l'adenosine-diphosphoribose polymerase efficaces en tant qu'agents antitumoraux et anti-retrovirus

Publications (2)

Publication Number Publication Date
JPH07502975A JPH07502975A (ja) 1995-03-30
JP3070767B2 true JP3070767B2 (ja) 2000-07-31

Family

ID=25120767

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4505220A Expired - Lifetime JP3070767B2 (ja) 1991-10-22 1991-11-26 抗腫瘍及び抗―レトロウィルス剤として有用なアデノシンジホスホリボースポリメラーゼ結合性ニトロソ芳香族化合物

Country Status (5)

Country Link
EP (1) EP0609211A4 (fr)
JP (1) JP3070767B2 (fr)
AU (1) AU676992B2 (fr)
CA (1) CA2121900A1 (fr)
WO (1) WO1993007868A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464871A (en) 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US5753674A (en) * 1991-10-22 1998-05-19 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
AU5298693A (en) * 1992-11-02 1994-05-24 Emory University Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-retroviral agents and anti-tumor agents
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
CA2612979A1 (fr) * 2005-06-10 2006-12-21 Bipar Sciences, Inc. Modulateurs de parp et traitement du cancer
EP2059802A4 (fr) * 2006-09-05 2010-09-08 Bipar Sciences Inc Procedes de conception d'inhibiteurs de parp et leurs utilisations
WO2018237327A1 (fr) 2017-06-22 2018-12-27 Triact Therapeutics, Inc. Procédés de traitement d'un glioblastome
WO2019067991A1 (fr) 2017-09-29 2019-04-04 Triact Therapeutics, Inc. Formulations d'iniparib et leurs utilisations

Also Published As

Publication number Publication date
AU1260992A (en) 1993-05-21
AU676992B2 (en) 1997-04-10
WO1993007868A1 (fr) 1993-04-29
JPH07502975A (ja) 1995-03-30
EP0609211A1 (fr) 1994-08-10
EP0609211A4 (fr) 1995-02-01
CA2121900A1 (fr) 1993-04-29

Similar Documents

Publication Publication Date Title
US5516941A (en) Specific inactivators of "retroviral" (asymmetric) zinc fingers
US5482975A (en) Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5473074A (en) Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54
US5262564A (en) Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
US5753674A (en) Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
JP3042711B2 (ja) 細胞静止及び抗ウィルス剤として有用な新規５−ヨード−６−アミノ−１，２−ベンゾピロン及びそれらの類似体
JPH08510452A (ja) 抗ウイルス剤および抗腫瘍剤として有用な新規な芳香族ニトロおよびニトロソ化合物およびそれらの代謝物
US5877185A (en) Synergistic compositions useful as anti-tumor agents
ES2385831T3 (es) Compuestos para el tratamiento de enfermedades celulares proliferativas
EP1857443B1 (fr) Composés thérapeutiques morpholino substitués
JP2008505937A (ja) インドールアミン２，３−ジオキシゲナーゼ（ｉｄｏ）阻害剤
JP3070767B2 (ja) 抗腫瘍及び抗―レトロウィルス剤として有用なアデノシンジホスホリボースポリメラーゼ結合性ニトロソ芳香族化合物
WO1996022791A9 (fr) Nouvelles compositions synergiques antitumorales et antiretrovirales
JPS621952B2 (fr)
JP4121151B2 (ja) 抗新生物薬および抗レトロウイルス薬として有用なアクリドンから誘導された化合物
KR20020043238A (ko) Ｐｄｅ４ 억제제로서의 테트라히드로티오피란프탈라지논유도체
JP2012504588A (ja) ピリミド誘導体およびその製薬学的用途
JPH10506410A (ja) 抗腫瘍剤及び抗ウイルス剤としてのビス−（２−ハロエチル）アミノフェニル置換ジスタマイシン誘導体
US6229048B1 (en) Helianthrone derivatives as anti-cancer agents
US20070060600A1 (en) 4-Anilinequinazolines with adenosine-kiase inhibitor properties
JPH10504517A (ja) 抗レトロウイルス剤および抗腫瘍剤として有用なアデノシンジホスホリボースポリメラーゼ結合性ニトロソ芳香族化合物
JPH10507446A (ja) ビス−２−アミノピリジン類、その製造方法及び寄生虫感染を制御するためのその用途
EP1313459B1 (fr) Dianthraquinones polycycliques utilisees comme agents anticancereux et anti-angiogeniques
JP2767176B2 (ja) 抗癌剤
WO2018067842A1 (fr) Composés de naphtoquinone d'aziridinyle et d'amino dimère et leur utilisation pour la leucémie myéloïde aiguë

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090526

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090526

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100526

Year of fee payment: 10

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110526

Year of fee payment: 11

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110526

Year of fee payment: 11

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120526

Year of fee payment: 12

EXPY Cancellation because of completion of term
FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120526

Year of fee payment: 12