CA2121900A1 - Utilisation de composes nitroso aromatiques se liant a l'adenosine-diphosphoribose-polymerase comme agents antitumoraux et anti-retroviraux - Google Patents

Utilisation de composes nitroso aromatiques se liant a l'adenosine-diphosphoribose-polymerase comme agents antitumoraux et anti-retroviraux

Info

Publication number
CA2121900A1
CA2121900A1 CA002121900A CA2121900A CA2121900A1 CA 2121900 A1 CA2121900 A1 CA 2121900A1 CA 002121900 A CA002121900 A CA 002121900A CA 2121900 A CA2121900 A CA 2121900A CA 2121900 A1 CA2121900 A1 CA 2121900A1
Authority
CA
Canada
Prior art keywords
nitroso
group
compound
compounds
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002121900A
Other languages
English (en)
Inventor
Ernest E. Kun
Jerome Mendeleyev
William G. Rice
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octamer Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2121900A1 publication Critical patent/CA2121900A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002121900A 1991-10-22 1991-11-26 Utilisation de composes nitroso aromatiques se liant a l'adenosine-diphosphoribose-polymerase comme agents antitumoraux et anti-retroviraux Abandoned CA2121900A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78080991A 1991-10-22 1991-10-22
US780,809 1991-10-22

Publications (1)

Publication Number Publication Date
CA2121900A1 true CA2121900A1 (fr) 1993-04-29

Family

ID=25120767

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002121900A Abandoned CA2121900A1 (fr) 1991-10-22 1991-11-26 Utilisation de composes nitroso aromatiques se liant a l'adenosine-diphosphoribose-polymerase comme agents antitumoraux et anti-retroviraux

Country Status (5)

Country Link
EP (1) EP0609211A4 (fr)
JP (1) JP3070767B2 (fr)
AU (1) AU676992B2 (fr)
CA (1) CA2121900A1 (fr)
WO (1) WO1993007868A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
US5652260A (en) * 1991-10-22 1997-07-29 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compound useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5464871A (en) 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
CA2148455A1 (fr) * 1992-11-02 1994-05-11 Ernest Kun Composes nitrosoaromatiques lies a l'adenosine-diphosphoribose-polymerase, utiles comme agents anti-retroviraux et anti-tumeurs
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
JP2008543786A (ja) * 2005-06-10 2008-12-04 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ調節因子及び癌の治療
US20080076778A1 (en) * 2006-09-05 2008-03-27 Bipar Sciences, Inc. Methods for designing parp inhibitors and uses thereof
EP3655418A4 (fr) 2017-06-22 2021-05-19 Triact Therapeutics, Inc. Procédés de traitement d'un glioblastome
WO2019067991A1 (fr) 2017-09-29 2019-04-04 Triact Therapeutics, Inc. Formulations d'iniparib et leurs utilisations

Also Published As

Publication number Publication date
AU676992B2 (en) 1997-04-10
JPH07502975A (ja) 1995-03-30
AU1260992A (en) 1993-05-21
JP3070767B2 (ja) 2000-07-31
EP0609211A4 (fr) 1995-02-01
WO1993007868A1 (fr) 1993-04-29
EP0609211A1 (fr) 1994-08-10

Similar Documents

Publication Publication Date Title
US5652260A (en) Adenosine diphosphoribose polymerase binding nitroso aromatic compound useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5482975A (en) Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5516941A (en) Specific inactivators of "retroviral" (asymmetric) zinc fingers
US5473074A (en) Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54
US5262564A (en) Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
US5464871A (en) Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US5877185A (en) Synergistic compositions useful as anti-tumor agents
US5874444A (en) Poly (ADP-ribose) polymerase inhibitors to treat diseases associated with cellular senescence
EP2295053B1 (fr) Nouveaux 2H-Chromen-2-one-3-carboxamides pour applications médicales
US6306889B1 (en) Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
WO1996022791A9 (fr) Nouvelles compositions synergiques antitumorales et antiretrovirales
EP2305246A1 (fr) Inhibiteurs du facteur de nécrose tumorale
EP0622076B1 (fr) Inhibiteur de restenose apres arterioplastie coronarienne percutanee
CA2121900A1 (fr) Utilisation de composes nitroso aromatiques se liant a l'adenosine-diphosphoribose-polymerase comme agents antitumoraux et anti-retroviraux
JPH06234635A (ja) インターロイキン１ベータを阻害するためのレフルノミドの使用
EP0610519B1 (fr) Medicament anti-vih
EP0877614A1 (fr) Procede d'induction de la mort des cellules neoplasiques par utilisation de derives d'oxyrane de piperazine
JP3276762B2 (ja) イソキノリン誘導体を含有する医薬組成物
JPH10504517A (ja) 抗レトロウイルス剤および抗腫瘍剤として有用なアデノシンジホスホリボースポリメラーゼ結合性ニトロソ芳香族化合物
JPS5849315A (ja) 抗腫瘍剤
EP2114410B1 (fr) Dérivés de n-amino tétra hydrothiazine, procédé de fabrication et utilisation
CH677610A5 (fr)
WO2001012198A1 (fr) Medicaments diriges contre l'infarctus du myocarde

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead