JP3021651B2 - アロマターゼ阻害剤としての２β，１９−メチレンアミノ架橋ステロイド類 - Google Patents

アロマターゼ阻害剤としての２β，１９−メチレンアミノ架橋ステロイド類

Info

Publication number
JP3021651B2
JP3021651B2 JP03518609A JP51860991A JP3021651B2 JP 3021651 B2 JP3021651 B2 JP 3021651B2 JP 03518609 A JP03518609 A JP 03518609A JP 51860991 A JP51860991 A JP 51860991A JP 3021651 B2 JP3021651 B2 JP 3021651B2
Authority
JP
Japan
Prior art keywords
methyleneamino
aromatase
compounds
androst
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP03518609A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06509543A (ja
Inventor
ジェイ． オニール ジョンストン，
ノートン ピー． ピート，
ジョセフ ピー． バークハート，
Original Assignee
メレルダウファーマスーティカルズ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メレルダウファーマスーティカルズ インコーポレイテッド filed Critical メレルダウファーマスーティカルズ インコーポレイテッド
Publication of JPH06509543A publication Critical patent/JPH06509543A/ja
Application granted granted Critical
Publication of JP3021651B2 publication Critical patent/JP3021651B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP03518609A 1990-11-30 1991-10-17 アロマターゼ阻害剤としての２β，１９−メチレンアミノ架橋ステロイド類 Expired - Lifetime JP3021651B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/621,183 US5126488A (en) 1990-11-30 1990-11-30 2β,19-methyleneamino bridged steroids as aromatase inhibitors
US621,183 1990-11-30
PCT/US1991/007810 WO1992009619A1 (en) 1990-11-30 1991-11-17 2β,19-METHYLENEAMINO BRIDGED STEROIDS AS AROMATASE INHIBITORS

Publications (2)

Publication Number Publication Date
JPH06509543A JPH06509543A (ja) 1994-10-27
JP3021651B2 true JP3021651B2 (ja) 2000-03-15

Family

ID=24489088

Family Applications (1)

Application Number Title Priority Date Filing Date
JP03518609A Expired - Lifetime JP3021651B2 (ja) 1990-11-30 1991-10-17 アロマターゼ阻害剤としての２β，１９−メチレンアミノ架橋ステロイド類

Country Status (15)

Country Link
US (1) US5126488A (OSRAM)
EP (1) EP0559706B1 (OSRAM)
JP (1) JP3021651B2 (OSRAM)
KR (1) KR100200462B1 (OSRAM)
AT (1) ATE154606T1 (OSRAM)
AU (1) AU647226B2 (OSRAM)
CA (1) CA2096020C (OSRAM)
DE (1) DE69126622T2 (OSRAM)
DK (1) DK0559706T3 (OSRAM)
ES (1) ES2104736T3 (OSRAM)
FI (1) FI932446A7 (OSRAM)
GR (1) GR3024298T3 (OSRAM)
HU (1) HU213608B (OSRAM)
NO (1) NO302123B1 (OSRAM)
WO (1) WO1992009619A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510340A (en) * 1992-06-12 1996-04-23 Sri International Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
AU630008B2 (en) * 1989-12-20 1992-10-15 Merrell Dow Pharmaceuticals Inc. 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors

Also Published As

Publication number Publication date
FI932446A0 (fi) 1993-05-28
HUT64365A (en) 1993-12-28
HU213608B (en) 1997-08-28
ES2104736T3 (es) 1997-10-16
WO1992009619A1 (en) 1992-06-11
EP0559706B1 (en) 1997-06-18
JPH06509543A (ja) 1994-10-27
NO931951D0 (no) 1993-05-28
DE69126622T2 (de) 1997-10-23
US5126488A (en) 1992-06-30
CA2096020A1 (en) 1992-05-31
DK0559706T3 (da) 1997-09-08
FI932446L (fi) 1993-05-28
DE69126622D1 (de) 1997-07-24
EP0559706A1 (en) 1993-09-15
FI932446A7 (fi) 1993-05-28
ATE154606T1 (de) 1997-07-15
CA2096020C (en) 2003-06-17
KR100200462B1 (ko) 1999-06-15
GR3024298T3 (en) 1997-10-31
AU647226B2 (en) 1994-03-17
EP0559706A4 (OSRAM) 1994-02-09
NO931951L (no) 1993-05-28
NO302123B1 (no) 1998-01-26
AU9027991A (en) 1992-06-25

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