JP2998287B2 - グリチルレチン酸誘導体 - Google Patents

グリチルレチン酸誘導体

Info

Publication number
JP2998287B2
JP2998287B2 JP3128799A JP12879991A JP2998287B2 JP 2998287 B2 JP2998287 B2 JP 2998287B2 JP 3128799 A JP3128799 A JP 3128799A JP 12879991 A JP12879991 A JP 12879991A JP 2998287 B2 JP2998287 B2 JP 2998287B2
Authority
JP
Japan
Prior art keywords
compound
present
ascorbic acid
reaction
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP3128799A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04330088A (ja
Inventor
一美 緒方
恭三 山本
玲子 松田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Priority to JP3128799A priority Critical patent/JP2998287B2/ja
Priority to TW081101804A priority patent/TW201750B/zh
Priority to US07/849,574 priority patent/US5229378A/en
Priority to EP92104149A priority patent/EP0503582B1/en
Priority to DE69223827T priority patent/DE69223827T2/de
Priority to ES92104149T priority patent/ES2112870T3/es
Priority to CA002062652A priority patent/CA2062652A1/en
Priority to AT92104149T priority patent/ATE161848T1/de
Priority to SU925011293A priority patent/RU2065864C1/ru
Priority to KR1019920004158A priority patent/KR0185717B1/ko
Publication of JPH04330088A publication Critical patent/JPH04330088A/ja
Application granted granted Critical
Publication of JP2998287B2 publication Critical patent/JP2998287B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP3128799A 1991-03-13 1991-03-13 グリチルレチン酸誘導体 Expired - Lifetime JP2998287B2 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP3128799A JP2998287B2 (ja) 1991-03-13 1991-03-13 グリチルレチン酸誘導体
US07/849,574 US5229378A (en) 1991-03-13 1992-03-10 Glycyrrhetic acid derivatives
TW081101804A TW201750B (enExample) 1991-03-13 1992-03-10
DE69223827T DE69223827T2 (de) 1991-03-13 1992-03-11 Glycyrrheticsäurederivate
ES92104149T ES2112870T3 (es) 1991-03-13 1992-03-11 Derivados de acido glicirretico.
CA002062652A CA2062652A1 (en) 1991-03-13 1992-03-11 Gylcyrrhetic acid derivatives
EP92104149A EP0503582B1 (en) 1991-03-13 1992-03-11 Glycyrrhetic acid derivatives
AT92104149T ATE161848T1 (de) 1991-03-13 1992-03-11 Glycyrrheticsäurederivate
SU925011293A RU2065864C1 (ru) 1991-03-13 1992-03-12 Производные глицирретовой кислоты и способ их получения
KR1019920004158A KR0185717B1 (ko) 1991-03-13 1992-03-13 글리시레틴산 유도체

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3128799A JP2998287B2 (ja) 1991-03-13 1991-03-13 グリチルレチン酸誘導体

Publications (2)

Publication Number Publication Date
JPH04330088A JPH04330088A (ja) 1992-11-18
JP2998287B2 true JP2998287B2 (ja) 2000-01-11

Family

ID=14993725

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3128799A Expired - Lifetime JP2998287B2 (ja) 1991-03-13 1991-03-13 グリチルレチン酸誘導体

Country Status (10)

Country Link
US (1) US5229378A (enExample)
EP (1) EP0503582B1 (enExample)
JP (1) JP2998287B2 (enExample)
KR (1) KR0185717B1 (enExample)
AT (1) ATE161848T1 (enExample)
CA (1) CA2062652A1 (enExample)
DE (1) DE69223827T2 (enExample)
ES (1) ES2112870T3 (enExample)
RU (1) RU2065864C1 (enExample)
TW (1) TW201750B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254321B (it) * 1992-04-10 1995-09-14 Kemiprogress S R L Composizione farmaceutica per il trattamento e la prevenzione delle infiammazioni cutanee e della mucosa orale.
US5519008A (en) * 1992-09-10 1996-05-21 Glycomed Incorporated Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin)
US5527890A (en) * 1993-04-16 1996-06-18 Glycomed Incorporated Derivatives of triterpenoid acids and uses thereof
CN1034334C (zh) * 1993-08-14 1997-03-26 贵州省中医研究所 齐酞酸钠及其药物组合物
US5951990A (en) * 1995-05-15 1999-09-14 Avon Products, Inc. Ascorbyl-phosphoryl-cholesterol
US5922335A (en) * 1995-05-15 1999-07-13 Avon Products, Inc. Uses for ascorbyl-phosphoryl-cholesterol in topical compositions
US6162450A (en) * 1995-05-15 2000-12-19 Avon Products, Inc. Uses of ascorbyl-phosphoryl-cholesterol and compositions for practicing same
US5866147A (en) * 1995-05-15 1999-02-02 Avon Products, Inc. Ascorbyl-phosphoryl-cholesterol
US5607968A (en) * 1995-06-07 1997-03-04 Avon Products, Inc. Topical alkyl-2-O-L-ascorbyl-phosphates
AU6377096A (en) * 1996-05-14 1997-12-05 Avon Products Inc. Ascorbyl-phosphoryl-cholesterol
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US7151082B2 (en) * 1999-02-11 2006-12-19 The Feinstein Institute For Medical Research Antagonists of HMG1 for treating inflammatory conditions
KR100986225B1 (ko) * 2001-02-16 2010-10-07 아스비오파마 가부시키가이샤 Ａｏｐ－１ 유전자 또는 ａｏｐ－１의 발현 감소를수반하는 질환의 치료 방법 및 상기 질환의 치료약
US7304034B2 (en) * 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US7696169B2 (en) * 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
AU2004272607B2 (en) * 2003-09-11 2008-11-06 Cornerstone Therapeutics Inc. Monoclonal antibodies against HMGB1
WO2007011606A2 (en) * 2005-07-18 2007-01-25 Critical Therapeutics, Inc. USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS
US20080311122A1 (en) * 2005-11-28 2008-12-18 Medimmune, Llc Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof
RU2623876C2 (ru) * 2014-11-10 2017-06-29 Александр Владимирович Диковский Фармацевтическая композиция для лечения гиперлипидемии
RU2611362C1 (ru) * 2015-11-26 2017-02-21 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Водорастворимая композиция, обладающая противоопухолевой активностью и способ ее получения
CN115813859B (zh) * 2022-12-13 2024-05-17 五邑大学 一种甘草次酸配体脂质体及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL24113A (en) * 1965-08-08 1969-06-25 Greidinger D Glycyrrhetic acid phosphoric acid ester and salts thereof
GB1093908A (en) * 1965-11-26 1967-12-06 Biorex Laboratories Ltd New derivatives of glycyrrhetinic acid
GB1229562A (enExample) * 1969-01-17 1971-04-28
US3734944A (en) * 1970-05-15 1973-05-22 Biorex Laboratories Ltd Glycyrrhetinic acid esters
GB1476053A (en) * 1975-02-07 1977-06-10 Biorex Laboratories Ltd Glycyrrhetinic acid derivatives
US4939128A (en) * 1988-04-25 1990-07-03 Takeda Chemical Industries, Ltd. Ester of ascorbic acid 2-phosphate and pharmaceutical use

Also Published As

Publication number Publication date
EP0503582B1 (en) 1998-01-07
US5229378A (en) 1993-07-20
DE69223827D1 (de) 1998-02-12
EP0503582A1 (en) 1992-09-16
RU2065864C1 (ru) 1996-08-27
JPH04330088A (ja) 1992-11-18
KR920018062A (ko) 1992-10-21
CA2062652A1 (en) 1992-09-14
DE69223827T2 (de) 1998-06-18
KR0185717B1 (ko) 1999-05-15
ES2112870T3 (es) 1998-04-16
ATE161848T1 (de) 1998-01-15
TW201750B (enExample) 1993-03-11

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Legal Events

Date Code Title Description
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 19991005