JP2858229B2 - Pest antibacterial repellent composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pest and antibacterial repellent composition.

[0002]

2. Description of the Related Art Sterilization and disinfection of bacteria causing food poisoning and hospital-acquired infectious diseases, and fungi that occur in humid places and cause discomfort, etc., and insecticides of sanitary and unpleasant pests, Research on capture has made great progress and has contributed to the purification and beautification of environmental sanitation in recent years. Accordingly, various drugs have been developed and have been well received.

For example, chlorxylenol (CMX, C
₈ H ₉ ClO = 156.61) is decades epidemic prevention, preservatives have been used in various fields as a fungicide. This chlorxylenol was developed in the UK as a fungicide for cuts, wounds and abrasions, and is inactive against bacterial spores, but is effective against gram-negative and gram-positive bacteria, and is effective against black mold, blue mold, black mold, etc. It has been used for the control of pathogenic bacteria such as wood rots such as molds, Japanese quail and blue germs, Staphylococcus aureus and Escherichia coli.

Further, sulfamethoxypyridazine (SM)
DP, C ₁₁ H ₁₂ N ₄ O ₃ S = 280.31) was developed as a long-acting sulfamine antibacterial agent, and has recently been widely used as an animal drug, particularly as a dairy cow breast injection.

[0005] Trimethoprim (TMP, C ₁₄ H ₁₈
N ₄ O ₃ = 290.32) is frequently used as an antifolate antibacterial agent used in food-producing animals, but has recently been used as a component of an enhanced sulfa drug. In particular, a combination with sulfadoxine (SDOX), sulfadimethoxine (SDMX), sulfadiazine (SDZ), sulfamethoxazole (SMX), and sulfaclopyridazine (SCPD) is used as an antifolate antiprotozoal.

[0006] Ivermectin (IVM) is a macrolide anthelmintic insecticide, 22,23-dihydroavermectin B _1a (C ₄₈ H ₇₄ O ₁₄ = 875.11) and B
_1b (C ₄₇ H ₇₂ O ₁₄ = 861.08)
b = 8: 2).

[0007]

However, these drugs have a low preventive effect on desired places, tools, and areas, and can be said to be drugs as post-action measures. For example, kitchen,
Pests are remarkably inhabited in places such as food factories and hospitals,
At present, disinfection is performed once or twice every several months, and the cost for such disinfection is also high, and there is a problem that the effect persistence is short.

[0008] Systems utilizing selective toxic agents of sterilization, sterilization, disinfection and insecticide have undergone a stage of defense against pests by a mechanism of multidrug resistance,
There is also the problem that the economic burden is increasing for the development of new drugs. In addition, the world's desire to prevent environmental pollution is becoming increasingly severe every year.

[0009] Until now, unlike pesticides for agricultural use, hygienic pest control agents and unpleasant pests that require various special actions are safe and rich in storage stability.
Furthermore, no satisfactory products have yet been found for sanitary control agents which maintain their effect characteristics such as a flushing-out effect on cockroaches and a knockdown effect on mosquitoes, flies and cockroaches.

In view of the above, the present invention has been made in view of the above, and is not a development of an agent to be killed such as a knockdown effect which has been conventionally targeted, but has an antibacterial effect and a repellent effect on a wide range of pests. It is an object of the present invention to provide a pest antibacterial repellent composition which is safe for humans and animals, has a long lasting effect, and is highly stable.

[0011]

The configuration of the present invention for solving the above-mentioned object will be described.

[0012] pest antimicrobial repellent composition according to claim 1 is chloroxylenol, sulfamethoxazole methoxy pyridazine, the active ingredient consisting of trimethoprim and ivermectin, polyoxyethylene polyoxypropylene glycol, of isopropanol and acetic acid neutralized And a dissolution aid prepared with sterilized purified water.

[0013] The pesticidal antibacterial repellent composition according to claim 2 comprises at least one of petroleum solvents, chlorinated hydrocarbons, alcohols, ether derivatives and water, and has a vapor pressure at room temperature which is lower than the injection pressure. It is characterized in that it is in the form of an aerosol using a solvent.

[0014] The pest antibacterial repellent composition according to claim 3 has a form in which it is attached to a carrier selected from fibers, papers, rubbers, synthetic resins, mortar, concrete and paint. It is a feature.

[0015]

According to the pest antibacterial repellent composition of claim 1, chlorxylenol (CMX), sulfamethoxypyridazine (SMDP) and trimethoprim (TM)
By mixing with P) and / or ivermectin (IVM), a synergistic effect is exerted on the effect of the single product, and in a small amount, it has an antibacterial action against bacteria, mold, and algae, and has an antibacterial action against pests and the like. Has a repellent effect.

In addition, if a single product is used, the onset of resistance is quick and the drug effect is short. However, since the active ingredients are mixed, the onset of resistance is delayed and the effect lasts long. The nature becomes high.

Further , the mixture of the four active ingredients broadens the antibacterial spectrum and the anti-insect spectrum, and is effective against a wide range of pests.

This composition is effective when recrystallized, whether it is water-based, solvent-based or paint-based. Since the crystallized composition does not volatilize and does not dissolve in water or a solvent, the effect of the crystallized composition is antibacterial and repellent only by contact between the pest and the composition. The term "antimicrobial activity" as used herein refers to the activity of inhibiting the growth of microorganisms, and the composition inhibits the process of converting para-aminobenzoic acid to folic acid, which is necessary for nucleic acid synthesis of cells, thereby preventing cell division. It is not an action to kill microorganisms. The term "repellent effect" means that the contact is prevented and the food to which the composition is adhered in a closed system is not allowed to eat even if starved. The edible material is thought to prevent cell division of symbiotic protozoa residing in the pest, and to avoid it as it seems to die as an individual without being decomposed.

These active ingredients (CMX, SMDP, T
MP, IVM) can be dissolved or dispersed in a desired liquid, or directly mixed or adsorbed with a desired solid carrier, and if necessary, wettable powders, emulsions, dispersants, oils, powders, granules, sprays, etc. Agents, aerosols, coating agents, paints, etc. may be appropriately adjusted and used, and those kneaded with resins, rubbers, mortar concretes may be molded and used, or formed into sheets, films or tapes. Can be used.

In preparing the antibacterial repellent of the present invention into an appropriate dosage form, various commonly used film-forming agents, emulsifiers, stabilizers, dyes, fragrances and the like may be added or blended as required. And may be further blended with conventionally used pest repellents, insecticides, insecticide synergists, rodenticides and repellents, fungicides, herbicides, fertilizers, and the like as appropriate. These may be used in combination.

According to the pest antibacterial repellent composition of claim 2, the active ingredient (CMX, SMDP, TMP,
IVM) can also be in the form of an aerosol.

At room temperature, a solvent whose vapor pressure is substantially equal to or lower than the injection pressure is, for example, hexane, 2,3,4-
Petroleum solvents such as trimethylnanone, cyclohexane, kerosene, naphtha, normal paraffin, isoparaffin, liquid paraffin, chlorinated hydrocarbons such as dichloroethane and trichloroethane, alcohols and ether derivatives such as ethyl alcohol, isopropyl alcohol and ethylene glycol, and water Examples of the propellant include chlorofluorocarbons (CFC-12, CFC-142b, CFC-152a, CFC-123, CFC-134a, CFC-22, CFC-133, etc.), liquefied petroleum gas, dimethyl ether, carbon dioxide gas, and the like. Can be used alone or as a mixture.

According to the pest antibacterial repellent composition of claim 3, the active ingredient (CMX, SMDP, TMP,
IVM) may have a form attached to a carrier.

As the solid carrier, for example, mineral powders such as kaolin, diatomaceous earth, talc and calcium carbonate, and vegetable powders such as wood flour, soy flour and starch can be used.

As the carrier resin, for example, polyvinyl chloride, polyethylene, chlorinated polyethylene, polypropylene, polyamide, ethylene-vinyl acetate copolymer resin,
Synthetic resins such as phenolic resin, urea resin, polyvinyl alcohol, epoxy resin, and silicone resin, and natural resins such as rosin and guaiac resin can be used.

Examples of the carrier rubbers include synthetic rubbers such as polybutadiene, polychloroprene, and polyisobutylene, and natural rubbers.

[0027]

Embodiments of the present invention will be described below in detail.

<Example 1> The pest and antimicrobial repellent composition of this example includes chlorxylenol (CMX, C ₈ H ₉ C ₁₀ = 156.61) and sulfamethoxypyridazine (SMDP, C ₁₁ H ₁₂ N).
₄ O ₃ S = 280.31), trimethoprim (TMP,
(C ₁₄ H ₁₈ N ₄ O ₃ = 290.32) and an active ingredient consisting of ivermectin (IVM) and a neutralizing dissolution aid consisting of polyoxyethylene polyoxypropylene glycol, isopropanol and acetic acid. It was prepared with purified water.

The polyoxyethylene polyoxypropylene glycol comprises, for example, Pulllock L-31 and Pullock P123.

Four active ingredients (CMX, SMDP, TM
P, IVM) is CMX: SMD
P: TMP: IVM = 14-72: 14-43: 11
43: 2 to 15.

The mixing ratio (wt%) of the whole component is CM
X: SMDP: TMP: IVM: Pulllock L-31:
Pulllock P123: isopropanol: acetic acid: purified water = 5 to 25: 5 to 20: 4 to 15: 1 to 5: 5 to 25:
6 to 25:20 to 25: 4 to 10: 7 to 35.

Next, the manufacturing method of the first embodiment will be described.

Four active ingredients (CMX, SMDP, TM
P, IVM) is extremely insoluble in water, so CMX
And an aqueous solution of polyoxyethylene (3) polyoxypropylene (17) glycol (Pulloc L-31) to prepare a mixed solution (I), which was used for SMDP, TMP and IVM.
Acetic acid is added to the mixture to increase the water solubility of SMDP, TMP, and IVM, and to use polyoxyethylene (4
2) A mixed solution (II) containing isopropanol was prepared by adding an aqueous solution of polyoxypropylene (67) glycol (Pulloc P123), and then mixed solution (I) and mixed solution (II)
Are heated and mixed to obtain the aqueous preparation of this example.

Next, effects of the first embodiment will be described.

(1) There is a repellent effect against German cockroaches. Hereinafter, this effect is shown in Tables 1 and 2.
This will be described with reference to FIG.

[0036]

[Table 1]

Table 1 above shows the composition ratio of the composition to be tested.

The compositions of the present invention (Samples Nos. 5 to 12) and Comparative Examples (Samples Nos. 1 to 4) were prepared, and Table 1 Composition 1
wt% paint (acrylic rubber emulsion 70w
(t%, color pigment 10 wt%, extender pigment 10 wt%, film forming aid 7 wt%, dispersant 2 wt%, Table 1 composition 1 wt%)
, A repellent effect test for German cockroaches was performed.

That is, the adjustment paint was applied to 5 inner walls of a plywood box (inner size 10 cm × 15 cm × 2 cm) having an inlet inner size of 2 cm × 10 cm so as to be 5 g / m ^2.
After natural drying for a week, each of the obtained test boxes was allowed to stand overnight (12 hours) in a rearing case holding 400 German cockroaches after a predetermined number of days had passed since preparation, and the number of German cockroaches invading the above test boxes Is counted. The pest repellent effect of each test sample was determined from the number of residents according to the criteria shown in Table 2 below. Table 2 shows the results.

[0040]

[Table 2]

In Table 2, Table 1 was used as a control (blank).
The results of a similar test performed using a test box made by bonding a paint containing no composition (Experiment No. 13) and no sample applied (Experiment No. 14) plywood are also shown.

As is clear from Table 2, the comparative example (sample N
o. In 1 to 4), the number of German cockroaches invading and inhabiting after 1 to 3 months is 1 to 10 or more. According to the use of the composition of the present invention (sample Nos. 5 to 12), Even after 6 months, the number of invading houses is 0, and a remarkable repellent effect can be maintained for a long time.

(2) It has a remarkable antibacterial repellent action against pests that adhere to and infest humans, animals and plants.
Effective pests include not only the German cockroach but also the following:

Examples of fungi include Clodosporium, Aureobasidium, Alternaria, Fusarium, Trichoderma, Mucor, Rhizopus, Absidsia, Kusarecoke mold, Aspergillus, Penicillium, Monascus, Neurospora, Gibberella, Botrytis, and the like.

The bacteria include Pseudomonas, Acetobacter, Escherichia, Corynebacterium, Brevihacterium, Bacillus, Clostridium, Micrococcus, Staphylococcus, Vibrio, Proteus,
Salmonella, Serratia, Streptococcus, Potulinum, Escherichia coli, Campylobacter, Bacillus, etc.

Examples of algae include melosila, cyclocera, asterella nerella, mougeotia, spirogilla, urothrix, chlamydomonas, microcystis, ossilatoria, chlorella and the like.

Examples of the sanitary pests include flies (house flies), mosquitoes (Kodaka mosquitoes, Anopheles japonicus, Aedes aeruginosa), cockroaches (Black cockroaches, Yamato cockroaches, German cockroaches, American cockroaches, Japanese cockroaches),
There are lice (head lice, body lice, lice, bed bugs), blackflies, fleas, stag beetles, black scallops, ants, bees, blue stag beetles, mites (Scarab mites, Scarab ticks, Scared mites, Scared mites, Acarina mites, and other mites).

Examples of unpleasant pests include millipedes, geese, dung beetles, stink bugs, leopard bugs, midges, and fly flies.

Examples of the clothing pests include Iga, Yuiga, Zyutanga, Katsuobushimushi, Himekabushiushimushi, and spots.

[0050] Examples of food pests include Acarina mites, Katsuobushi beetles, Harajiro beetles, moths, spots and weevil.

Examples of horticultural pests include aphids, brown beetles, white-spotted beetles, scale insects, spider mites (spotted spider mite, Kanzawa spider mite), slugs, snails,
Usukamaimaimai etc.

As the wood pests, there are wood-penetrating pests (Hirata bark beetle, Nagasin beetle, Shibanmushi, Longhorn beetle, Weevils), termites (Yet termite, Yamato termite, Daikoku termite) and the like.

(3) It is extremely stable and can be used for controlling various pests, and can be used without problems in applications where there is a high possibility of contact with humans. For example, closet, drawer closet, clothes box, kitchen, carpet, tatami, pillar, under floor,
It can be used for inner walls and outer walls, etc., to prevent damage to sanitary pests, unpleasant pests, wood pests, grain storage pests, horticultural pests and microorganisms.

[0054]

The effect was confirmed in a combination of two or three before the mixture of CMX , SMDP , TMP and IVM. However, the effect was improved as compared with the single product.
Some exhibited antibacterial action.

Further, SMDP has been used as an effective agent for bacterial infections susceptible to sulfa drugs.
It has been found that when mixed with X at a ratio of 1: 1 (% by weight) or the like, not only molds, yeasts and bacteria which are not effective as a single product but also algae are widely used.

For example, Aspergillus sp.
108 species such as us niger and Aurobasidium sp.
eobasidium pullulans and two other species, Chaetomium sp.
68 species including Chaetomium globosum, Cladosporium sp.
Glioc, 23 species such as Cladosporium cladosporioides
In ladium sp., 9 species such as Gliocladium virens, Myrot
In hecium sp., 5 species such as Myrothecium verrucaria, P
In enicillium sp., 188 such as Penicillium citrinum
Species, such as Rhizopus stolonifer in Rhizopus sp.
The species, Trichophyton mentagroph in Trichophyton sp.
It is effective against fungi such as 11 species such as ytes, and 18 bacteria such as Bacillus cereus in Bacillus sp.
Species, Escherichia coli, Klebsiella pneumoniae, Psendo
In monas sp., 36 species such as Pseudomonds aeruginosa, Sa
In lmone sp., three species such as Salmone enteritidis, Vibr
io sp. is effective against two species such as Vibrio parahaemolyticus, and yeast is Candida sp.
Albicans and 135 other species are effective.

Although CMX and SMDP each have no effect on insects or the like when used alone, high concentrations of a combination of the two have an effect of repelling mites as sanitary pests. When TMP and / or IVM are combined with the two, a repellent effect is observed at a lower concentration of the ternary combination than the two.

Further, 5 of CMX, SMDP and IVM:
At a weight ratio of 5: 1, an effect comparable to a four-member combination was obtained in a repellent test for mites (Pterocarpus mites, Dermatophagoides farinae, house dust mites, etc.).

Also, CMX, SMDP and TMP 4:
Significant repelling movement was observed at an application of 20 g / m ² against unpleasant pests such as millipedes and geese at a ratio of 4: 1 by weight.

A repellent test for pests was conducted using a combination of TMP and IVM. As a result, the insecticidal effect was exhibited at a high concentration as in the case of the single product, and no effect was observed at a low concentration. Thus, the combination of CMX , SMDP , TMP , and IVM provides a broader and lower concentration of safe pest antimicrobial repellents.

Example 2 50 parts by volume of each of the compositions prepared in Table 1 (samples Nos. 5, 7, 9 and 11) and 50 parts by volume of a mixture of liquefied petroleum gas and dimethyl ether (50:50 by volume) And the pressure can for aerosol (content 4
(35 ml) to a total volume of 300 ml, attached to a jetting device and sealed to obtain the pest repellent composition of the present invention in the form of an aerosol.

Using these aerosols, Example 1
When a similar pest repellent effect test was performed, the same results as in Example 1 were obtained.

Example 3 Each of the compositions prepared in Table 1 (samples Nos. 6, 8, 10, and 12) was 100 g /
m ² unbleached kraft paper, linter 500 microns, nonwoven (polyethylene 3: cotton 1) 300 microns and cotton 500 microns
In addition, the mortar plate is spray impregnated with 5 g / m ² into 5 cm, and then dried to obtain a sample of the present invention in a form held by a sheet-like substrate.

When these samples were applied to the inner wall 5 of the veneer box of the shape used in Example 1 and subjected to the same test, the same results as in Example 1 were obtained.

Example 4 A paste prepared by mixing 60% by weight of PVC powder (PCM-12 manufactured by Kaneka Chemical Industry Co., Ltd.) and 10% by weight of DOP with 10% by weight of the composition prepared in Table 1 was mixed at 140 ° C. for 10 minutes. Heating was performed to obtain an antibacterial repellent-containing sheet having a thickness of 1 mm.

Using the obtained circularly formed sheet as a control, a circular sheet having a thickness of 1 mm and a diameter of 15 cm containing no active ingredient and a length of 30 cm, a width of 40 cm and a height of 20 c
m in a veneer box, a plastic petri dish (diameter: 10 cm, height: 1 cm) containing vegetables (cabbage and cabbage) in the center of each circular sheet,
Next, 30 slugs were released in the box, and the number of slugs on a plastic petri dish containing vegetables three days after standing was measured. Table 3 shows the results.

[0068]

[Table 3]

As is evident from Table 3, slugs do not stick to vegetables left on the sheet impregnated with the antibacterial repellent, and all of the slugs contained on the sheet not impregnated with the active ingredient of the present invention. Recognized above.

Example 5 A paste obtained by mixing 60% by weight of PVC powder (PCM-12 manufactured by Kaneka Chemical Industry Co., Ltd.) and 10% by weight of DOP with 10% by weight of the composition prepared in Table 1 was mixed at 140 ° C. for 10 minutes. Heating was performed to obtain a 5 mm-thick antibacterial repellent-containing sheet.

As a control sheet, sample N shown in Table 1 was used.
o. A sheet containing 10% by weight of the composition containing only the neutralization and dissolution aid of No. 5 and a sheet containing no additive were prepared.

Holes having a diameter of 5 mm were formed at both ends of a sheet formed into a square (100 × 100 × ^t 5 mm), and a nylon rope was placed 1 m below the water surface of an industrial water tank ( ^L 20 × ^W 25 × ^H 10 m) of Sagamigawa Hydrogen. And suspended, and algae and the like adhering to the sheet surface were observed. Table 4 shows the results.

[0073]

[Table 4]

The test was conducted from late March to mid-October. When the deposits were identified after 6 months, Table 4
As is clear from FIG. Comparative examples (samples Nos. 1 to 5) include chlorophylls and hormidium, green alga, anabaena and uremo, alga fungi, and zooglare, a bacterium, which were hardly observed in 5-12.
In 4), many were observed.

Example 6 The composition prepared in Table 1 was added to 0.1%
A fungus solution of mold or yeast was applied to an agar plate medium to which 1% by weight was added and cultured, and then the presence or absence of bacterial growth was examined. As a control, Table 1 No. The same test was conducted for the case where only 5% by weight of the neutralization dissolution aid was added and 1% by weight was not added.

The number of mold spores and the number of yeast cells are 10 ⁶ / ml
Apply the test strain adjusted so that it becomes
And the yeast were cultured at 25 ° C. for 2 days. Table 5 shows the growth results of the bacteria.

[0077]

[Table 5]

As is clear from Table 5, the sample N of the present invention
o. No. 5 to 12 showed no growth of the fungus.

<Example 7> The composition prepared in Table 1 was added to 0.1%.
The plate was cultured for 20 hours on an agar plate for sensitivity measurement to which 1% by weight was added, and then diluted with the same medium so that the number of cells became about 10 ⁶ / ml. For 18 to 20 hours, and the presence or absence of bacterial growth was observed. The control was also tested in the same manner as in Example 6. Table 6 shows the results.

[0080]

[Table 6]

As is clear from Table 6, the sample N of the present invention
o. In Nos. 5 to 12, no growth of bacteria was observed.

Example 8 The aerosol used in Example 2 was sprayed on a 70 × 70 × 70 cm glass box. Immediately after spraying and at the time of drying, the face was put in this glass box, and sample No. When the irritation of 5 to 12 was observed, no irritation was felt with the composition of the present invention. Slight phenolic odor was observed in the wet state immediately after spraying, but no odor was observed after drying.

<Example 9> 250 g of each of the compositions shown in Table 1 was placed in a polyethylene container with an inner stopper.
It stood still at the temperature of 0 degreeC. After 1 month, 3 months, 6 months and 12 months after standing, the content of the active ingredient was measured.
o. There was almost no change as in the case of Nos. 1 to 4.

Example 10 Composition 10 prepared in Table 1
Volume and dimethyl ether and liquefied petroleum gas mixture (5
90 parts by volume (0:50 volume ratio) in a pressure-resistant can for aerosol (contents: 435 ml) so as to have a total volume of 300 ml, attached to an injection device and sealed, and then the pest repellent composition of the present invention in the form of an aerosol agent Get things.

When these dogs were sprayed with these aerosols, it was observed that many fleas jumped out of the hair and repelled. It was also confirmed that lice and mite eggs had died. No harm was found when the dog licked the solution. In addition, the skin disease in which the hair of a dog comes off healed in a short period of time, and the hair grew again. Comparative Example (Sample N
o. The above results were not obtained in 1-4).

<Example 11> Sample No. of the composition in which the cleaning of the horse body was adjusted as shown in Table 1 was performed. Sample Nos. 5, 7, 9, 11 and Comparative Example 3 was performed by adding 5% by weight to a commercially available detergent.

The removal of the fleas, lice and ticks on the horse body
For about one month thereafter, insects such as mites that attacked the horse body were repelled and kept away. However, the sample No. of the comparative example. In No. 3, no sufficient effect was observed.

Example 12 Sample No. of the composition prepared in Table 1 for cleaning dairy cows Sample Nos. 6, 8, 10, 12 and Comparative Examples 4 was performed by adding 3% by weight to the cleaning agent.

When the composition was allowed to remain after washing with water, the number of insects that touched the bovine as well as blood-sucking insects such as lice, fleas and ticks was significantly reduced. Milk output increased. However, no effect was observed in the sample N0.4 of the comparative example.

Example 13 0.1 ml of the composition prepared in Table 1 and commercially available dilute solutions of isopropanol of DEET were cut in half with 30 mm diameter filter paper.
Each was treated dropwise and air-dried. Filter paper of the same type of untreated section and 1
Pairs are set in a plastic petri dish having a diameter of 40 mm, and 0.2 ml of distilled water is dropped on each filter paper to release the house termites (10 termites and 2 termites). Approximately 30 minutes later, the sample was capped and allowed to stand in a constant temperature room, and after a predetermined period of time, the state of the test insects and the state of damage to the filter paper were examined. The results are shown in Table 7 (36
The number of termites on the treated paper in the head, the repellent rate, and the state of damage to the treated paper are shown.

The test was carried out in three groups of 12 animals per section.
As a control, the sample No. of the composition was used. The same test was performed for only the neutralization dissolution aid No. 5.

[0092]

[Table 7]

As is clear from Table 7, the composition of the present invention has a sample No. 5 to 12 and DEET were able to completely repel the feeding damage of the termites up to the 0.1% group.

The termite repellent of the present invention has an excellent repellent effect against termites such as termites, house termites, and termites, and can be avoided from damaging buildings and communication cables.

Example 14 The composition prepared in Table 1 and the sample No. 1% by weight of the neutralizing dissolution aid of No. 5 was mixed with a urethane resin and an emulsion, and the mixture was applied to the inside and outside of the ABS telephone body with a brush. Inside the phone inside the food factory
The cockroaches seemed to be comfortable to live in, and the contact and parts of the conventional equipment, corrosion, poor conductivity, etc. were often significantly impaired within a month after the new installation, but the function deteriorated even after 6 months after application Was not observed in the composition of the present invention.

Before the application and in the control group (neutralizing dissolution aid and blank), living bodies and dead bodies such as mites and cockroaches inside the telephone were found to have a volume of 10 to 20 cc in three months. Similarly, the sample No. of the present invention. 8 to 1 in 1-4
2cc was recognized.

<Example 15> A circular filter paper (diameter 9c) was placed in a Petri dish (diameter 9cm, height 2cm) in a constant temperature room at 25 ° C.
m) laid, dropping the compositions prepared in Table 1 at a rate of 1 m ² per 25 ml. 30 minutes after air drying, mackerel fillet (20 × 2
0 × 5 cm) is left at the center, and 2 cc of a 10% dilution of the same composition is dropped. Sterile purified water was used as a control.
After 30 minutes from the air drying, 10 female adults of the housefly to be tested are released, the state of contact with the filter paper and the mackerel cut is recorded on a video tape, and the number of contacts for 4 hours is counted.

In the comparative examples (sample Nos. 1 to 4), the number of times of contact with the filter paper was 22 to 29 times, and the cuts were 12 to 15 times, and in the control section (blank), the filter papers and the cuts were recognized for a long time. . In the composition of the present invention (Sample Nos. 1 to 12),
The house fly, when approaching the filter paper or the fillet, did not come into contact with it and only stopped on the lid of the petri dish. The petri dish used for the test was made of a transparent plastic, and a very shallow incision (1 × 1 mm) was formed on the lid, and then the petri dish was used for the test. In the composition of the present invention as well, the mortality was zero and the repellent effect was observed.

<Example 16> A repellent test was carried out on a red mite, Acarina mites using a sample attraction method. Powder feed (mice, for lard breeding, manufactured by CLEA Japan) 15 on the bottom of a polybat 11 cm high, 40 cm wide and 30 cm long
Spread 0g as evenly as possible and place 10x10cm
Specimens cut into pieces of the size 1 were placed one by one on the left and right. One of the left and right specimens was prepared by mixing one of the compositions prepared in Table 1 with water.
A filter paper treated twice and diluted 5.0 ml / 100 cm ² , and the other was treated as a control filter paper treated with water. On this sample,
2.5g of powdered feed (15% moisture) without tick in a container of 1.4cm height and 2.8cm diameter in the center
After one day, the number of mites that had invaded the feed was counted by a saline suspension method.

In the saline floating method, 0.5 g of a mite-infested feed is thoroughly stirred, taken out, placed in a Wildman flask, and the mites are suspended using 20% saline, and the upper layer of water is removed. It was transferred onto a filter paper fitted with a suction device, filtered, and the filter paper was stained with a 0.1% methylene blue aqueous solution.
By this operation, only the filter paper was dyed blue, and the mites were not dyed and appeared to be yellowish white. The whole number was counted under a stereoscopic microscope.

The experiment was performed at room temperature 25 ± 2 ° C. and humidity 70-80%.
Table 8 shows the results obtained in the range described above. The density of Dermatophagoides farinae in the feed spread on each polypad bottom was 357 (300, 424, 348) per 0.5 g of feed.
Each sample was subjected to three repeated experiments. Table 8 shows the results.

[0102]

[Table 8]

In this test method, it can be considered that if the repellency of 80% or more is obtained, the effect is actually exhibited.
As is clear from Table 8, in the composition of the present invention section (sample Nos. 5 to 12), an extremely high repellent effect of 94% or more of repellent rate is recognized by the treatment of 500 μl per 1 m ² .

<Example 17> A repellent performance test of clothing pests was performed using middle-aged larvae of the horned beetle.
A nonwoven fabric (70% polypropylene, 30% pulp) and a wool fabric were immersed in an 8-fold dilution of the composition prepared in Table 1 and dried to prepare a test piece. The residual solid matter of the dried test piece is 18.3 g / m ^{2 for} nonwoven fabric and 5 for wool fabric.
6.2 g / m ² .

Experiment 1 When the treatment material is nonwoven fabric The nonwoven fabric of the sample was cut into a circle having a diameter of 40 mm, and each was placed on the bottom surface of a glass Petri dish (40 mm in inner diameter). Then, a 100% wool cloth (unprocessed product) of the same size was overlaid on the nonwoven fabric. Each of these petri dishes was fed with 20 individual beetles. For comparison with the treated section of the invention section and the comparative section, a section using an untreated nonwoven fabric was used as a control section. The number of test repetitions for each sample was three. Stored at room temperature (25-28 ° C). The repellent effect was determined by comparing the weight loss of the wool cloth with the control after the test was completed, and dead individuals were also confirmed.

Experiment 2 When the treatment material is wool cloth The wool cloth of the sample was cut into a circle having a diameter of 40 mm, and each was placed on the bottom surface of a glass petri dish (inner diameter 40 mm). Each of these petri dishes was fed with 20 individual beetles. For comparison with the treated section, a section using an untreated wool cloth in the above-described experimental setting was used as a control section. The number of test repetitions for each sample was three. Stored at room temperature (25-28 ° C). The repellent rate is based on the following equation.

Repellent rate (%) = ｛(weight loss of control group−
Table 9 and Table 10 show the results after 4 weeks of weight loss of treated group) / weight loss of control group x 100.

[0108]

[Table 9]

[0109]

[Table 10]

As is clear from Tables 9 and 10, a high repellency was observed in the plot of the present invention. Only one dead animal was identified in two wool cloth samples (60 individuals tested: 1.7%), and there were no dead individuals in the other treatment groups and the control group. Of course, in the repellent effect, since the occurrence of dead individuals is not so bad, it is necessary to reduce the amount of addition.

Example 18 2 of the composition prepared in Table 1
Commercially available pantyhose is treated with 25 ml of 0% aqueous solution, and after air-drying, the arm is covered with a tubular portion (elbow and below fingertips), inserted into a 25 × 25 × 25 cm cage containing adult female Aedes albopictus, and is removed every minute. The number of flying insects to the arm and the test insects after 10 minutes were collected, and the blood sucking number was counted, and the blood sucking flying number and the blood sucking rate were calculated. In addition, the amount immersed in only the dilution water was used as a control. Table 11 shows the results.

[0112]

[Table 11]

As is clear from Table 11, in the control group, a slight repellent effect was observed even in the sense that the blood did not fly after the initial blood sucking, but in the control group of the present invention, even if the hand was brought closer to the test insects. No blood-sucking behavior was shown.

[0114]

According to the present invention, as described in detail above, the following effects can be obtained.

[0115] According to the present invention described in claim 1, for 4's mixing of the active ingredient, very low toxicity to humans and animals, resistant expressed rich stability delayed effect lasting longer, its It has a wide range of effects and is a safe insect repellent with a wide spectrum of insect repellents, including insects such as mosquitoes, flies, cockroaches, or mites such as house dust mites, house dust mites, dust mites, and mites such as slugs, or slugs. It has a broad antibacterial spectrum against microorganisms such as fungi , bacteria and algae.

Further, the active ingredient and the like are contained or adhered to various materials to easily provide a great effect of antibacterial property and repellent insect repellent, and the effect of the present invention is extremely large.

Therefore, prevention of pests before they inhabit in human spheres of living, especially living quarters, food factories, hospitals, food warehouses, etc., or after-disinfection completion, prevent after-disinfection, and prevent the growth of pests as well as dressing. can do.

In addition, conventional fungicides, insecticides, etc. are prescriptions for killing pests, whereas the present invention does not kill unnecessary pests. A pest antibacterial repellent composition that does not contaminate water or soil can be provided.

According to the second aspect of the present invention, the active ingredient (CMX, SMDP, TMP, IVM) can be in the form of an aerosol. It can exhibit antibacterial properties and repellency against pests.

According to the third aspect of the present invention, the active ingredient (CMX, SMDP, TMP, IVM) can be in the form of being attached to a carrier. It can exhibit antibacterial properties and repellency against living organisms.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ identification symbol FI // (A01N 43/58 31:08 43:54 43:90) (58) Investigated field (Int.Cl. ⁶ , DB name) ) A01N 43/58 A01N 25/02 A01N 25/06 A01N 25/10 A01N 25/34 A01N 31:08 A01N 43:54 A01N 43:90 CA (STN) REGISTRY (STN) WPIDS (STN)

Claims (3)

(57) [Claims] 1. A chloroxylenol, sulfamethoxazole methoxy pyridazine was prepared with active ingredients consisting of trimethoprim and ivermectin, polyoxyethylene polyoxypropylene glycol, and neutralizing the solubilizing agent consisting of isopropanol and acetic acid in sterile purified water A pest / antibacterial repellent composition, characterized in that: 2. A form of an aerosol using a solvent comprising at least one of petroleum solvents, chlorinated hydrocarbons, alcohols, ether derivatives and water and having a vapor pressure of not more than an injection pressure at room temperature. Claim 1 characterized by the following:
The pest antibacterial repellent composition according to the above. 3. The antibacterial pest repellent according to claim 1, characterized in that it has a form in which it is attached to a carrier selected from fibers, papers, rubbers, synthetic resins, mortar, concrete and paint. Composition.