KR19980054662A - Microcapsules composition for cockroach attractant larvae and preparation method thereof - Google Patents
Microcapsules composition for cockroach attractant larvae and preparation method thereof Download PDFInfo
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- KR19980054662A KR19980054662A KR1019960073828A KR19960073828A KR19980054662A KR 19980054662 A KR19980054662 A KR 19980054662A KR 1019960073828 A KR1019960073828 A KR 1019960073828A KR 19960073828 A KR19960073828 A KR 19960073828A KR 19980054662 A KR19980054662 A KR 19980054662A
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Abstract
본 발명은 바퀴벌레 유인독이제용 마이크로캡슐제 조성물에 관한 것이다. 더욱 구체적으로, 본 발명은 유기인계 살충제 또는 카바메이트계 살충제와 탄소수 8 내지 18 의 포화지방산을 포함하는 마이크로캡슐의 소수성 심재료, 벽재료로서 수용성 고분자화합물 및 유화제를 포함하는 바퀴벌레 유인독이제용 마이크로캡슐 조성물, 그의 제조방법 및 이 조성물을 함유하는 바퀴벌레 유인독이제에 관한 것이다. 본 발명의 마이크로캅셀제 조성물은 살충제의 고유한 냄새를 마스킹함으로써 바퀴벌레의 살충제에 대한 기피성을 해소시키고 유인력을 증대시키며, 살충제의 독성발현시간을 연장하여 바퀴의 소화먹이 토함 및 재섭취습성에 의한 연쇄살충효과를 발현시키고, 살충제의 산화 등에 의한 경시변화를 방지하여 살충제의 안정성을 높이는 잇점을 갖는다.The present invention relates to a microcapsule composition for cockroach attractant. More specifically, the present invention is a hydrophobic core material of a microcapsule containing an organophosphorus insecticide or a carbamate insecticide and a saturated fatty acid having 8 to 18 carbon atoms, and a microcapsule for cockroach toxic poisoning agent containing a water-soluble polymer compound and an emulsifier as a wall material. A composition, a method for preparing the same, and a cockroach attractant containing the composition. The microcapsule composition of the present invention masks the intrinsic odor of the insecticide, thereby relieving the repellent of the cockroach insecticide, increasing the attractiveness, and prolonging the toxic expression time of the insecticide, thereby entraining the indigestion of the wheel and re-ingestion. It has the advantage of expressing the insecticidal effect and preventing the change over time due to oxidation of the insecticide, thereby increasing the stability of the insecticide.
Description
본 발명은 바퀴벌레 유인독이제용 마이크로캡슐제 조성물에 관한 것이다. 더욱 구체적으로, 본 발명은 유기인계 살충제 또는 카바메이트계 살충제와 탄소수 8 내지 18 의 포화지방산을 포함하는 마이크로캡슐의 소수성 심재료, 벽재료로서 수용성 고분자화합물 및 유화제를 포함하는 바퀴벌레 유인독이제용 마이크로캡슐 조성물, 그의 제조방법 및 이 조성물을 함유하는 바퀴벌레 유인독이제에 관한 것이다.The present invention relates to a microcapsule composition for cockroach attractant. More specifically, the present invention is a hydrophobic core material of a microcapsule containing an organophosphorus insecticide or a carbamate insecticide and a saturated fatty acid having 8 to 18 carbon atoms, and a microcapsule for cockroach toxic poisoning agent containing a water-soluble polymer compound and an emulsifier as a wall material. A composition, a method for preparing the same, and a cockroach attractant containing the composition.
본 발명에 따르면 바퀴벌레 유인독이제내에 포함되는 살충제를 마이크로캡슐화시켜 살충제의 고유한 냄새를 마스킹함으로써 바퀴벌레의 살충제에 대한 기피성을 해소시키고 유인력을 증대시키며, 살충제의 독성발현시간을 연장하여 바퀴의 소화먹이 토함 및 재섭취습성에 의한 연쇄살충효과를 발현시키고, 살충제의 산화 등에 의한 경시변화를 방지하여 살충제의 안정성을 높이는 잇점을 갖는 바퀴벌레 유인독이제용 마이크로캡슐제 조성물이 제공된다.According to the present invention, by microencapsulating the insecticide contained in the cockroach attractant poisoning agent to mask the inherent odor of the insecticide, the repellency of the cockroach to repellent pesticides and increase the attractiveness, prolongs the toxic expression time of the insecticide to extinguish the wheel digestion Provided is a microcapsule composition for cockroach attractant insects having the advantage of expressing a chain insecticidal effect due to food vomiting and re-ingestion, and preventing the change over time due to oxidation of the insecticide, thereby increasing the stability of the insecticide.
일반적으로 바퀴벌레는 생식력 및 번식력이 강하기 때문에 가정에서나 음식업소에서 박멸하는데 어려움이 많다. 이러한 바퀴의 생식과 번식에 있어서 가장 중요한 요인은 수분, 은신처, 무리, 온도, 먹이 등이 있으며 이러한 조건을 충족시키는 장소에 바퀴가 운집하게 된다. 바퀴벌레가 운집하는 장소에 유인구조를 설치하여 살충제를 혼합한 먹이를 먹게한 후 연속적인 식독작용을 일으키게 함으로써 바퀴벌레를 박멸하는 유인독이제식 살충제가 실용화되어 널리 사용되고 있다. 따라서 바퀴가 유인구조내의 유인독이제를 먹게하기 위해 유인력을 높이고, 연속적인 식독작용을 위해 약효 발현시간을 지연시키고, 장기사용이 가능하도록 약제 안정성을 부여하는 것이 바퀴벌레용 유인독이제식 살충제의 살충효력을 높이며 유지하는데 매우 중요한 요소이다.In general, cockroaches have a high fertility and fertility, so it is difficult to eradicate them at home or in a restaurant. The most important factors in the reproduction and reproduction of these wheels are moisture, hides, herds, temperatures, and food, and the wheels gather in places that meet these conditions. Induction insecticides that exterminate cockroaches have been widely used because they have a decoy structure at the place where cockroaches are gathered to feed prey with insecticides and then cause a continuous poisoning effect. Therefore, to increase the attractive force for the wheel to eat the lure poisoning agent in the lure structure, delay the drug expression time for continuous poisoning action, and to give the drug stability to enable long-term use of insecticidal insecticides for cockroaches It is a very important factor in maintaining and raising the level.
기존의 바퀴벌레 유인독이제는 대상 곤충의 생리적인 특징과 관계없이 범용되고 있는 살충제를 부형제들과 혼합하여 제조하고 있으며, 이에 따라 원하는 살충양상을 얻기 보다는 살충제 특성에 의해 살충양상이 좌우되는 것이 필연적이다. 대표적인 바퀴벌레 유인독이제용 살충제로는 유기인계 살충제(클로르피리포스, 마라치온, 페니트로치온, 트리크로폰, 다이아지논), 카바메이트계 살충제(프로폭슬), 히드라메칠논 등이 사용되고 있으며, 이중 유기인계 살충제 및 카바메이트계 살충제는 약제의 생산비용이 저렴하나 고유냄새가 강해 바퀴벌레의 기피성을 유발하며, 신경전달과정에서 아세틸콜린 에스테라제(acetylcholine esterase)와 길항적으로 결합하는 신경독으로 속효성인 것을 특징으로 하여 섭식후 30 분 이내에 치사하게 되므로, 먹은 음식을 토한 후 여러 개체가 나누어 먹는 바퀴의 습성에 기인한 연쇄살충 효과를 기대할 수 없다.The existing cockroach attractant is manufactured by mixing a common insecticide with excipients irrespective of the physiological characteristics of the target insect, it is inevitable that the insecticide properties are determined by the insecticide properties rather than obtaining the desired insecticide. Representative insecticides for cockroach antagonists include organophosphorus insecticides (chlorpyrphos, maracion, phenytrothion, triclophone, diazinon), carbamate insecticides (propoxyl), hydramcinolone, etc. Phosphorus insecticides and carbamate insecticides are cheaper to produce, but have strong inherent odors, which cause cockroach repellency. They are fast-acting neurotoxins that antagonize acetylcholine esterase during neurotransmission. Because it is characterized in that the fatality within 30 minutes after feeding, the chain insects due to the habit of eating wheels divided by several individuals after vomiting food can not be expected.
반면에 히드라메칠논은 에너지 대사과정에서 사이토크롬(cytochrom) P-450 을 저해함으로써 에너지 대사를 차단하여 바퀴를 치사시키게 되므로 섭식 후 2-4 일에 걸친 에너지 소진에 따라 치사하게 되는 지효성 약제로서, 이 기간동안 바퀴습성상의 연쇄살충 효과를 얻을 수 있는 약제이기는 하나 생산비용이 높은 단점과 주위온도가 16℃ 이하인 경우에는 효력이 없으며 죽어가던 개체도 회복된다는 단점이 있다[참조: J. of Economic Entomology, vol. 79, 1613-1616, 1986].Hydramethinone, on the other hand, inhibits cytochrome P-450 in the process of energy metabolism, which kills the wheel by killing the energy metabolism. Although it is a drug that can obtain a chain insecticidal effect on wheel habits during this period, there are disadvantages of high production cost and ineffectiveness when the ambient temperature is below 16 ° C and recovery of dying individuals [J. of Economic Entomology] , vol. 79, 1613-1616, 1986.
이에 본 발명자들은 살충제 고유냄새에 의한 바퀴벌레 기피성을 방지하여 유인효력을 증대시키고, 유기인계 및 카바메이트계 살충제의 온도독립적 살충효력 및 저렴한 생산비용의 장점 및 히드라메칠논의 지효성에 의한 연쇄살충력의 장점을 모두 살릴수 있는 방법을 개발하기 위해 집중적인 연구를 수행하였다. 그 결과, 본 발명자들은 특정의 수용성 고분자화합물을 벽재료로 사용하여 이하에 정의하는 바와 같은 구성을 갖는 마이크로캡슐제제를 제조하고, 이 마이크로캡술제제가 살충제 냄새의 마스킹과 지효성을 통한 연쇄살충효력 부여 및 살충제 안정성을 획득하여 살충효력을 증대시킬 수 있음을 확인하고 본 발명을 완성하였다.Therefore, the present inventors increase the attracting effect by preventing cockroach repellency due to the intrinsic smell of insecticides, the temperature-independent insecticidal effect of organophosphorus and carbamate insecticides and the low production cost, and the serial insecticidal effect of the hydramethinone sustained efficacy Intensive research was carried out to develop a way to save all of them. As a result, the present inventors manufactured a microcapsule formulation having a composition as defined below using a specific water-soluble high molecular compound as a wall material, and the microcapsule formulation gives a chain insecticidal effect through masking and sustained release of an insecticide odor. And it was confirmed that the insecticidal stability can be increased by obtaining insecticide stability and completed the present invention.
따라서, 본 발명은 유기인계 또는 카바메이트계 살충제와 탄소수 8 내지 18 의 포화지방산을 포함하는 소수성 심재료, 수용성 고분자화합물을 포함하는 벽재료, 및 유화제를 포함하는 살충성 마이크로캡슐제 조성물에 관한 것이다.Accordingly, the present invention relates to an insecticidal microcapsule composition comprising an organophosphorus or carbamate insecticide and a hydrophobic core material containing a saturated fatty acid having 8 to 18 carbon atoms, a wall material containing a water-soluble high molecular compound, and an emulsifier. .
본 발명에 따르는 살충성 마이크로캡슐제 조성물에 있어서, 살충성 성분으로서 사용되는 유기인계 살충제 또는 카바메이트계 살충제의 종류는 특별히 제한되지는 않으나, 바람직하게는 클로르피리포스, 마라치온, 다이아지논, 페니트로치온 및 트리크로폰중에서 선택된 유기인계 살충성 화합물 또는 대표적인 카바메이트계 살충제인 프로폭슬이 사용될 수 있다. 본 발명에서는 이들 살충성 화합물중의 두가지 이상의 성분을 혼합하여 사용할 수도 있다.In the insecticidal microcapsule composition according to the present invention, the type of organophosphorus insecticide or carbamate insecticide used as the insecticidal component is not particularly limited, but preferably chlorpyriphos, marachione, diazinone, penny Organophosphorus insecticides selected from trochion and triclopon or propoxles, which are representative carbamate insecticides, can be used. In the present invention, two or more components of these pesticidal compounds may be mixed and used.
본 발명의 조성물에서 마이크로캡슐의 심재료로 사용되는 탄소수 8 내지 18 의 포화지방산에는 예를들어 카프릴산(C7H15COOH), 카프르산(C9H19COOH), 라우르산(C11H23COOH), 미리스트산(C13H27COOH), 팔미트산(C15H31COOH), 스테아르산(C17H35COOH) 등이 있으며, 바람직하게는 미리스트산, 팔미트산 또는 스테아르산이 사용된다.The saturated fatty acid having 8 to 18 carbon atoms used as the core material of the microcapsules in the composition of the present invention includes, for example, caprylic acid (C 7 H 15 COOH), capric acid (C 9 H 19 COOH), and lauric acid ( C 11 H 23 COOH), myristic acid (C 13 H 27 COOH), palmitic acid (C 15 H 31 COOH), stearic acid (C 17 H 35 COOH), and the like. Mittic acid or stearic acid is used.
본 발명의 마이크로캡슐제 조성물에서 벽재료로 사용되는 수용성 고분자화합물은 바람직하게는 알긴산나트륨과 같은 알긴산염, 식물섬유인 셀룰로즈, 젤라틴, 아라비아검, 아가로즈, 메틸셀룰로즈, 에틸셀룰로즈, 하이드록시프로필셀룰로즈 및 폴리비닐알콜로 구성된 그룹중에서 선택된다. 본 발명에서는 둘 이상의 수용성 고분자화합물을 혼합하여 벽재료로 사용할 수도 있다. 특히 바람직하게는 알긴산염을 벽재료로 사용할 수 있다.The water-soluble high molecular compound used as wall material in the microcapsule composition of the present invention is preferably alginate such as sodium alginate, cellulose which is plant fiber, gelatin, gum arabic, agarose, methylcellulose, ethyl cellulose, hydroxypropyl cellulose. And polyvinyl alcohol. In the present invention, two or more water-soluble high molecular compounds may be mixed and used as a wall material. Especially preferably, alginate can be used as a wall material.
본 발명의 살충성 마이크로캡슐제 조성물에는 또한 유화제가 첨가되는데, 본 발명에서 바람직하게 사용될 수 있는 유화제로는 폴리옥시에틸렌 소르비탄-지방산 에스테르계 유화제, 예를들면 트윈 20(폴리옥시에틸렌(20) 소르비탄 모노라우레이트), 트윈 40(폴리옥시에틸렌(20) 소르비탄 모노팔미테이트), 트윈 60(폴리옥시에틸렌(20) 소르비탄 모노스테아레이트), 트윈 80(폴리옥시에틸렌(20) 소르비탄 모노올리에이트) 등이 포함되며, 특히 바람직하게는 트윈 20 이 사용된다.Emulsifiers are also added to the insecticidal microcapsule compositions of the present invention, and emulsifiers which may be preferably used in the present invention include polyoxyethylene sorbitan-fatty acid ester-based emulsifiers such as Tween 20 (polyoxyethylene (20) Sorbitan monolaurate), Tween 40 (polyoxyethylene (20) sorbitan monopalmitate), Tween 60 (polyoxyethylene (20) sorbitan monostearate), Tween 80 (polyoxyethylene (20) sorbitan Monooleate) and the like, particularly preferably Tween 20.
본 발명에 따른 바퀴벌레 유인독이제용 살충성 마이크로캡슐제 조성물에서 각 구성성분들은 유기인계 또는 카바메이트계 살충제 5 내지 50 중량부, 탄소수 8 내지 18 의 포화지방산 10 내지 50 중량부, 수용성 고분자화합물 30 내지 50 중량부 및 유화제 5 내지 20 중량부의 비로 조성된다.In the insecticidal microcapsules composition for cockroach attractant insecticide according to the present invention each component is 5 to 50 parts by weight of organophosphorus or carbamate insecticide, 10 to 50 parts by weight of saturated fatty acid having 8 to 18 carbon atoms, 30 to water-soluble polymer compound And 50 to 20 parts by weight and an emulsifier of 5 to 20 parts by weight.
본 발명은 또한 상기한 바와 같은 구성을 갖는 조성물로 부터 바퀴벌레 유인독이제용 마이크로캡슐제를 제조하는 방법에 관한 것이다.The present invention also relates to a method for producing a microcapsule for cockroach attractant from the composition having the configuration as described above.
본 발명에 따르면, 탄소수 8 내지 18 의 포화지방산을 융점 이상에서 용융시키고 여기에 유기인계 또는 카바메이트계 살충제를 용해시켜 마이크로캡슐제의 소수성 심재료를 제조하고, 벽재료인 수용성 고분자화합물과 유화제를 용해시킨 수용액에 상기에서 수득한 소수성 심재료를 가하여 강하게 교반하여 O/W 에멀젼을 만들고, 이 에멀젼을 스프레이 드라잉(spray dryin) 방법에 의해 건조시킴으로써 목적하는 마이크로캡슐제를 제조할 수 있다.According to the present invention, a saturated fatty acid having 8 to 18 carbon atoms is melted at a melting point or higher, and an organic phosphorus or carbamate insecticide is dissolved therein to prepare a hydrophobic core material of a microcapsule, and a water-soluble high molecular compound and an emulsifier are used as wall materials. The hydrophobic core material obtained above was added to the dissolved aqueous solution, followed by vigorous stirring to form an O / W emulsion, and the desired microcapsule was prepared by drying the emulsion by a spray dryin method.
상기한 바와 같은 본 발명의 방법을 구체적으로 설명하면 다음과 같다.Referring to the method of the present invention as described above in detail.
본 발명에 따르는 제조방법은 크게 4 단계로 구분될 수 있다. 즉, 본 발명의 방법은 제 1 단계로 유화제가 용해된 수용액에 벽재료를 용해시키는 단계, 제 2 단계로 지방산을 융점 이상에서 용융시키고 여기에 살충제를 용해시키는 단계, 제 3 단계로 제 1 단계에서 생성된 용액내에 제 2 단계에서 생성된 액상의 지방산에 살충제가 용해된 소수성 용액을 유화 및 분산시키는 단계, 및 제 4 단계로 생성된 에멀젼을 스프레이 드라잉하는 단계를 포함한다. 이들 각각의 단계들의 순서는 필요에 따라 임의로 변화시킬 수 있다.The manufacturing method according to the present invention can be largely divided into four steps. That is, the method of the present invention is a step of dissolving the wall material in the aqueous solution in which the emulsifier is dissolved in the first step, melting the fatty acid above the melting point in the second step and dissolving the pesticide therein, the first step in the third step Emulsifying and dispersing the hydrophobic solution in which the pesticide is dissolved in the liquid fatty acid produced in the second step in the solution produced in the step; and spray drying the emulsion produced in the fourth step. The order of each of these steps can be arbitrarily changed as required.
상기한 바와 같이 스프레이 드라잉법에 의해 본 발명의 살충성 마이크로캡슐제 조성물을 마이크로캡슐화시키게 되면 살충제의 냄새를 마스킹하는 효과를 나타내어 바퀴의 기피성을 방지하여 유인효력을 증대시키며, 또한 지효성에 의한 연쇄살충효력을 부여하고, 안정성이 높은 제제를 수득할 수 있다.As described above, when the microcapsule composition of the insecticidal microcapsules of the present invention is sprayed, the effect of masking the odor of the insecticide is masked and the repellency of the wheel is prevented to increase the attraction effect, and also the chain by the sustaining effect. The insecticidal effect can be imparted and a high stability formulation can be obtained.
본 발명에 따라 제조되는 마이크로캡슐제를 실제로 바퀴의 퇴치를 위한 목적으로 이용하고 하는 경우에, 이들은 바퀴벌레 유인독이제에 통상적으로 사용되는 성분, 예를들면 식물성 먹이, 동물성 먹이, 결합제, 당원, 글리세린 등과 함께 배합시켜 바퀴벌레 유인독이제로 제조함으로써 통상의 방법으로 사용할 수 있다. 따라서, 본 발명에는 이와 같은 바퀴벌레 유인독이제도 포함된다.In the case where the microcapsules prepared according to the invention are actually used for the purpose of combating wheels, they are the components commonly used in cockroach attractants, such as plant foods, animal foods, binders, sugars, glycerin It can be used by the conventional method by combining with the same to prepare a cockroach attractant. Therefore, the present invention includes such cockroach attractant.
바퀴벌레 유인독이제내의 살충성 마이크로캡슐제 조성물의 함량은 조성물에 포함된 각각의 살충활성성분에 대하여 보건복지부 고시에서 규정한 함량에 적합하도록 선택하는 것이 바람직하다. 예를들어, 마이크로캡슐제의 혼합비율은 유인독이제 총량 100 중량부당 살충활성성분으로서 계산하여 유기인계 살충제인 클로르피리포스의 경우에는 0.5 내지 1.5 중량부, 마라치온의 경우에는 0.5 중량부 이하, 페니트로치온은 2.0 중량부 이하, 카바메이트계 살충제인 프로폭슬은 2.0 중량부 이하의 비로 혼합시키는 것이 바람직하다.The content of the insecticidal microcapsule composition in the cockroach attractant is preferably selected to suit the content defined in the Ministry of Health and Welfare for each pesticidal active ingredient included in the composition. For example, the mixing ratio of the microcapsule agent is calculated as an insecticidal active ingredient per 100 parts by weight of the detoxifying agent, and 0.5 to 1.5 parts by weight for chlorpyriphos, an organophosphorus insecticide, 0.5 parts by weight or less for marathione, Phenytrothion is preferably 2.0 parts by weight or less, and carbamate-based insecticide propoxyl is preferably mixed in a ratio of 2.0 parts by weight or less.
본 발명은 이하의 실시예에 의거하여 더욱 구체적으로 설명되지만, 본 발명의 기술적 범위가 이들 실시예에 의해 어떤 식으로든 제한되는 것은 아니다.The present invention is described in more detail based on the following examples, but the technical scope of the present invention is not limited in any way by these examples.
실시예 1Example 1
마이크로캡슐제의 총중량(100 중량부)을 기준으로 하여 미리스트산 25 중량부를 용융시킨 다음, 용융된 미리스트산에 프로폭슬 15 중량부를 가하여 용해시켜 심재료를 제조하였다. 알긴산나트륨 50 중량부 및 트윈-20 10 중량부를 용해시킨 수용액 300㎖ 에 상기에서 수득한 심재료를 가하고 강하게 교반하여 에멀젼화시킨 후 스프레이 드라이기로 분사건조하여 프로폭슬을 함유하는 마이크로캡슐제를 제조하였다.A core material was prepared by melting 25 parts by weight of myristic acid based on the total weight of the microcapsules (100 parts by weight), and then adding 15 parts by weight of propoxal to the dissolved myristic acid. The core material obtained above was added to 300 ml of an aqueous solution in which 50 parts by weight of sodium alginate and 10 parts by weight of tween-20 were dissolved, followed by emulsification with vigorous stirring to prepare a microcapsule containing propoxol by spray drying with a spray dryer. .
프로폭슬을 15 중량% 의 농도로 함유하는 마이크로캡슐제 13.3 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 45 중량부와 당원(물엿) 27.5 중량부, 결합제로서 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 바퀴벌레 유인독이제를 제조하였다.13.3 parts by weight of microcapsules containing 15% by weight of propoxol, 45 parts by weight of vegetable food (barley powder, yeast extract) and animal food (anchovy powder, sodium casein sodium) and 27.5 parts by weight of sugar source (starch syrup), binder As a mixture, polyethylene glycol 6000 (trade name: Carbowax, Korea Polyol) and 10 parts by weight of glycerin 6 parts by weight of the cockroach attractant was prepared.
실시예 2Example 2
마이크로캡슐제의 총중량(100 중량부)을 기준으로 하여 팔미트산 25 중량부를 용융시킨 다음, 용융된 팔미트산에 프로폭슬 15 중량부를 가하여 용해시켜 심재료를 제조하였다. 알긴산나트륨 50 중량부 및 트윈-20 10 중량부를 용해시킨 수용액 300㎖ 에 상기에서 수득한 심재료를 가하고 강하게 교반하여 에멀젼화시킨 후 스프레이 드라이기로 분사건조하여 프로폭슬을 함유하는 마이크로캡슐제를 제조하였다.The core material was prepared by melting 25 parts by weight of palmitic acid based on the total weight of the microcapsules (100 parts by weight), and then adding 15 parts by weight of propoxal to the dissolved palmitic acid. The core material obtained above was added to 300 ml of an aqueous solution in which 50 parts by weight of sodium alginate and 10 parts by weight of tween-20 were dissolved, followed by emulsification with vigorous stirring to prepare a microcapsule containing propoxol by spray drying with a spray dryer. .
프로폭슬을 15 중량% 의 농도로 함유하는 마이크로캡슐제 13.3 중량부를 식물성 먹이(보리가루, 효모엑기스) 및 동물성 먹이(멸치분, 카제인나트륨) 45 중량부와 당원(물엿) 27.5 중량부, 결합제로서 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 바퀴벌레 유인독이제를 제조하였다.13.3 parts by weight of microcapsules containing 15% by weight of propoxol, 45 parts by weight of vegetable food (barley flour, yeast extract) and animal food (anchovy powder, sodium casein) and 27.5 parts by weight of sugar source (starch syrup), as a binder Cockroach attractant was prepared by mixing 10 parts by weight of polyethylene glycol 6000 (trade name: Carbowax, Korean Polyol) and 6 parts by weight of glycerin.
실시예 3Example 3
마이크로캡슐제의 총중량(100 중량부)을 기준으로 하여 스테아르산 25 중량부를 용융시킨 다음, 용융된 스테아르산에 프로폭슬 15 중량부를 가하여 용해시켜 심재료를 제조하였다. 알긴산나트륨 50 중량부 및 트윈-20 10 중량부를 용해시킨 수용액 300㎖ 에 상기에서 수득한 심재료를 가하고 강하게 교반하여 에멀젼화시킨 후 스프레이 드라이기로 분사건조하여 프로폭슬을 함유하는 마이크로캡슐제를 제조하였다.A core material was prepared by melting 25 parts by weight of stearic acid based on the total weight of the microcapsules (100 parts by weight), and then adding 15 parts by weight of propoxal to the dissolved stearic acid. The core material obtained above was added to 300 ml of an aqueous solution in which 50 parts by weight of sodium alginate and 10 parts by weight of tween-20 were dissolved, followed by emulsification with vigorous stirring to prepare a microcapsule containing propoxol by spray drying with a spray dryer. .
프로폭슬을 15 중량% 의 농도로 함유하는 마이크로캡슐제 13.3 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 45 중량부와 당원(물엿) 27.5 중량부, 결합제로서 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 바퀴벌레 유인독이제를 제조하였다.13.3 parts by weight of microcapsules containing 15% by weight of propoxol, 45 parts by weight of vegetable food (barley powder, yeast extract) and animal food (anchovy powder, sodium casein sodium) and 27.5 parts by weight of sugar source (starch syrup), binder As a mixture, polyethylene glycol 6000 (trade name: Carbowax, Korea Polyol) and 10 parts by weight of glycerin 6 parts by weight of the cockroach attractant was prepared.
실시예 4Example 4
마이크로캡슐제의 총중량(100 중량부)을 기준으로 하여 미리스트산 25 중량부를 용융시킨 다음, 용융된 미리스트산에 클로르피리포스 15 중량부를 가하여 용해시켜 심재료를 제조하였다. 알긴산나트륨 50 중량부 및 트윈-20 10 중량부를 용해시킨 수용액 300㎖ 에 상기에서 수득한 심재료를 가하고 강하게 교반하여 에멀젼화시킨 후 스프레이 드라이기로 분사건조하여 클로르피리포스를 함유하는 마이크로캡슐제를 제조하였다.A core material was prepared by melting 25 parts by weight of myristic acid based on the total weight of the microcapsules (100 parts by weight), and then adding 15 parts by weight of chlorpyriphos to the dissolved myristic acid. The core material obtained above was added to 300 ml of an aqueous solution in which 50 parts by weight of sodium alginate and 10 parts by weight of tween-20 were dissolved, followed by emulsification with vigorous stirring, followed by spray drying with a spray dryer to prepare microcapsules containing chlorpyrifos. It was.
클로르피리포스를 15 중량% 의 농도로 함유하는 마이크로캡슐제 4.0 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 50 중량부와 당원(물엿) 30 중량부, 결합제로서 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 바퀴벌레 유인독이제를 제조하였다.4.0 parts by weight of microcapsules containing chlorpyrufos at a concentration of 15% by weight, 50 parts by weight of vegetable food (barley flour, yeast extract) and animal food (anchovy powder, sodium casein) and 30 parts by weight of sugar source (starch syrup), A cockroach attractant was prepared by mixing 10 parts by weight of polyethylene glycol 6000 (trade name: Carbowax, Korean Polyol) and 6 parts by weight of glycerin as a binder.
실시예 5Example 5
마이크로캡슐제의 총중량(100 중량부)을 기준으로 하여 팔미트산 25 중량부를 용융시킨 다음, 용융된 팔미트산에 클로르피리포스 15 중량부를 가하여 용해시켜 심재료를 제조하였다. 알긴산나트륨 50 중량부 및 트윈-20 10 중량부를 용해시킨 수용액 300㎖ 에 상기에서 수득한 심재료를 가하고 강하게 교반하여 에멀젼화시킨 후 스프레이 드라이기로 분사건조하여 클로르피리포스를 함유하는 마이크로캡슐제를 제조하였다.The core material was prepared by melting 25 parts by weight of palmitic acid based on the total weight of the microcapsules (100 parts by weight), and then adding 15 parts by weight of chlorpyriphos to the dissolved palmitic acid. The core material obtained above was added to 300 ml of an aqueous solution in which 50 parts by weight of sodium alginate and 10 parts by weight of tween-20 were dissolved, followed by emulsification with vigorous stirring, followed by spray drying with a spray dryer to prepare microcapsules containing chlorpyrifos. It was.
클로르피리포스를 15 중량% 의 농도로 함유하는 마이크로캡슐제 4.0 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 50 중량부와 당원(물엿) 30 중량부, 결합제로서 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 바퀴벌레 유인독이제를 제조하였다.4.0 parts by weight of microcapsules containing chlorpyrufos at a concentration of 15% by weight, 50 parts by weight of vegetable food (barley flour, yeast extract) and animal food (anchovy powder, sodium casein) and 30 parts by weight of sugar source (starch syrup), A cockroach attractant was prepared by mixing 10 parts by weight of polyethylene glycol 6000 (trade name: Carbowax, Korean Polyol) and 6 parts by weight of glycerin as a binder.
실시예 6Example 6
마이크로캡슐제의 총중량(100 중량부)을 기준으로 하여 스테아르산 25 중량부를 용융시킨 다음, 용융된 스테아르산에 클로르피리포스 15 중량부를 가하여 용해시켜 심재료를 제조하였다. 알긴산나트륨 50 중량부 및 트윈-20 10 중량부를 용해시킨 수용액 300㎖ 에 상기에서 수득한 심재료를 가하고 강하게 교반하여 에멀젼화시킨 후 스프레이 드라이기로 분사건조하여 클로르피리포스를 함유하는 마이크로캡슐제를 제조하였다.A core material was prepared by melting 25 parts by weight of stearic acid based on the total weight of the microcapsules (100 parts by weight), and then adding 15 parts by weight of chlorpyriphos to the dissolved stearic acid. The core material obtained above was added to 300 ml of an aqueous solution in which 50 parts by weight of sodium alginate and 10 parts by weight of tween-20 were dissolved, followed by emulsification with vigorous stirring, followed by spray drying with a spray dryer to prepare microcapsules containing chlorpyrifos. It was.
클로르피리포스를 15 중량% 의 농도로 함유하는 마이크로캡슐제 4.0 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 50 중량부와 당원(물엿) 30 중량부, 결합제로서 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 바퀴벌레 유인독이제를 제조하였다.4.0 parts by weight of microcapsules containing chlorpyrufos at a concentration of 15% by weight, 50 parts by weight of vegetable food (barley flour, yeast extract) and animal food (anchovy powder, sodium casein) and 30 parts by weight of sugar source (starch syrup), A cockroach attractant was prepared by mixing 10 parts by weight of polyethylene glycol 6000 (trade name: Carbowax, Korean Polyol) and 6 parts by weight of glycerin as a binder.
실시예 7Example 7
마이크로캡슐제의 총중량(100 중량부)을 기준으로 하여 미리스트산 25 중량부를 용융시킨 다음, 용융된 미리스트산에 페니트로치온 15 중량부를 가하여 용해시켜 심재료를 제조하였다. 알긴산나트륨 50 중량부 및 트윈-20 10 중량부를 용해시킨 수용액 300㎖ 에 상기에서 수득한 심재료를 가하고 강하게 교반하여 에멀젼화시킨 후 스프레이 드라이기로 분사건조하여 페니트로치온을 함유하는 마이크로캡슐제를 제조하였다.The core material was prepared by melting 25 parts by weight of myristic acid based on the total weight of the microcapsules (100 parts by weight), and then adding 15 parts by weight of phenytrothion to the dissolved myristic acid. The core material obtained above was added to 300 ml of an aqueous solution in which 50 parts by weight of sodium alginate and 10 parts by weight of tween-20 were dissolved, followed by emulsification with vigorous stirring to prepare a microcapsule containing phenytrothion by spray drying with a spray dryer. It was.
페니트로치온을 15 중량% 의 농도로 함유하는 마이크로캡슐제 13.3 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 45 중량부와 당원(물엿) 27.5 중량부, 결합제로서 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 바퀴벌레 유인독이제를 제조하였다.13.3 parts by weight of microcapsules containing phenytrothion at a concentration of 15% by weight, 45 parts by weight of vegetable food (barley flour, yeast extract) and animal food (anchovy powder, sodium casein sodium) and 27.5 parts by weight of sugar source (starch syrup), A cockroach attractant was prepared by mixing 10 parts by weight of polyethylene glycol 6000 (trade name: Carbowax, Korean Polyol) and 6 parts by weight of glycerin as a binder.
실시예 8Example 8
마이크로캡슐제의 총중량(100 중량부)을 기준으로 하여 팔미트산 25 중량부를 용융시킨 다음, 용융된 팔미트산에 페니트로치온 15 중량부를 가하여 용해시켜 심재료를 제조하였다. 알긴산나트륨 50 중량부 및 트윈-20 10 중량부를 용해시킨 수용액 300㎖ 에 상기에서 수득한 심재료를 가하고 강하게 교반하여 에멀젼화시킨 후 스프레이 드라이기로 분사건조하여 페니트로치온을 함유하는 마이크로캡슐제를 제조하였다.The core material was prepared by melting 25 parts by weight of palmitic acid based on the total weight of the microcapsules (100 parts by weight), and then adding 15 parts by weight of phenytrothion to the dissolved palmitic acid. The core material obtained above was added to 300 ml of an aqueous solution in which 50 parts by weight of sodium alginate and 10 parts by weight of tween-20 were dissolved, followed by emulsification with vigorous stirring to prepare a microcapsule containing phenytrothion by spray drying with a spray dryer. It was.
페니트로치온을 15 중량% 의 농도로 함유하는 마이크로캡슐제 13.3 중량부를 식물성 먹이(멸치분, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 45 중량부와 당원(물엿) 27.5 중량부, 결합제로서 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 바퀴벌레 유인독이제를 제조하였다.13.3 parts by weight of microcapsules containing phenytrothion at a concentration of 15% by weight, 45 parts by weight of vegetable food (anchovy, yeast extract) and animal food (anchovy, sodium casein) and 27.5 parts by weight of sugar source (starch syrup), A cockroach attractant was prepared by mixing 10 parts by weight of polyethylene glycol 6000 (trade name: Carbowax, Korean Polyol) and 6 parts by weight of glycerin as a binder.
실시예 9Example 9
마이크로캡슐제의 총중량(100 중량부)을 기준으로 하여 스테아르산 25 중량부를 용융시킨 다음, 용융된 스테아르산에 페니트로치온 15 중량부를 가하여 용해시켜 심재료를 제조하였다. 알긴산나트륨 50 중량부 및 트윈-20 10 중량부를 용해시킨 수용액 300㎖ 에 상기에서 수득한 심재료를 가하고 강하게 교반하여 에멀젼화시킨 후 스프레이 드라이기로 분사건조하여 페니트로치온을 함유하는 마이크로캡슐제를 제조하였다.A core material was prepared by melting 25 parts by weight of stearic acid based on the total weight of the microcapsules (100 parts by weight), and then adding 15 parts by weight of phenytrothion to the dissolved stearic acid. The core material obtained above was added to 300 ml of an aqueous solution in which 50 parts by weight of sodium alginate and 10 parts by weight of tween-20 were dissolved, followed by emulsification with vigorous stirring to prepare a microcapsule containing phenytrothion by spray drying with a spray dryer. It was.
페니트로치온을 15 중량% 의 농도로 함유하는 마이크로캡슐제 13.3 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치가루, 카제인나트륨) 45 중량부와 당원(물엿) 27.5 중량부, 결합제로서 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 바퀴벌레 유인독이제를 제조하였다.13.3 parts by weight of microcapsules containing phenytrothion at a concentration of 15% by weight, 45 parts by weight of vegetable food (barley powder, yeast extract) and animal food (anchovy powder, sodium casein powder) and 27.5 parts by weight of sugar source (starch syrup), A cockroach attractant was prepared by mixing 10 parts by weight of polyethylene glycol 6000 (trade name: Carbowax, Korean Polyol) and 6 parts by weight of glycerin as a binder.
비교예 1Comparative Example 1
프로폭슬 원제(99%) 2 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 50 중량부, 당원(물엿) 32 중량부, 결합제인 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 유인독이제를 제조하였다.2 parts by weight of propoxol raw material (99%), vegetable food (barley flour, yeast extract) and animal food (anchovy powder, sodium casein), 50 parts by weight, sugar member (starch syrup) 32 parts by weight, binder polyethylene glycol 6000 (brand name: Carbowax, Korean polyol) and 10 parts by weight of glycerin and 6 parts by weight of the mixture was prepared to attract deodorant.
비교예 2Comparative Example 2
클로르피리포스 원제(99%) 0.6 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 50 중량부, 당원(물엿) 31.4 중량부, 결합제인 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 유인독이제를 제조하였다.0.6 parts by weight of chlorpyrefoss raw material (99%), 50 parts by weight of vegetable food (barley powder, yeast extract) and animal food (anchovy powder, sodium casein), 31.4 parts by weight sugar (starch syrup), polyethylene glycol 6000 (binder) : Carbowax, Korea polyol) 10 parts by weight and glycerin 6 parts by weight was mixed to prepare a detoxifying agent.
비교예 3Comparative Example 3
페니트로치온 원제(99%) 2 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 50 중량부, 당원(물엿) 32 중량부, 결합제인 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 유인독이제를 제조하였다.2 parts by weight of phenytrothion raw material (99%), 50 parts by weight of vegetable food (barley powder, yeast extract) and animal food (anchovy powder, sodium casein), 32 parts by weight of sugar (starch syrup), polyethylene glycol 6000 (binder) : Carbowax, Korea polyol) 10 parts by weight and glycerin 6 parts by weight was mixed to prepare a detoxifying agent.
비교예 4Comparative Example 4
히드라메칠논 원제(99%) 2 중량부를 식물성 먹이(보리가루, 효모엑기스분) 및 동물성 먹이(멸치분, 카제인나트륨) 50 중량부, 당원(물엿) 32 중량부, 결합제인 폴리에틸렌글리콜 6000(상품명: 카보왁스, 한국폴리올) 10 중량부 및 글리세린 6 중량부와 혼합시켜 유인독이제를 제조하였다.2 parts by weight of raw hydramethinone (99%), 50 parts by weight of vegetable food (barley flour, yeast extract) and animal food (anchovy powder, sodium casein), 32 parts by weight of sugar (starch syrup), polyethylene glycol 6000 (binder) : Carbowax, Korea polyol) 10 parts by weight and glycerin 6 parts by weight was mixed to prepare a detoxifying agent.
실험예 1 (살충효력 및 연쇄살충효과 평가)Experimental Example 1 (evaluation of insecticidal effect and serial insecticidal effect)
15ℓ 의 투명 페트리디쉬에 실시예 1 내지 9 에 의해 제조된 마이크로캡슐제-함유 바퀴벌레 유인독이제와 비교예 1 내지 4 에 의해 제조된 살충원제 함유 유인독이제를 각각 1.5g 씩의 양으로 넣고 각각의 페트리디쉬에 바퀴에 적합한 물, 먹이 및 은신처를 제공한 뒤 한국산 독일바퀴(Blatella germanica) 수컷 성충 20 마리씩을 넣어 5 일 동안 유지하여 각각의 유인독이제의 살충효력을 평가하였다. 그후 유인독이제를 제거하고 유인독이제와 접촉하지 않은 새로운 독일바퀴 수컷 성충 20 마리씩을 각각의 페트리디쉬에 투입하여 이후 5 일간 연쇄살충효과를 평가하였다(온도조건 25℃/16℃, 상대습도 80%). 측정된 결과는 살충제의 종류에 따라 각각 다음 표 1 내지 표 3 에 기재하였다.The microcapsule-containing cockroach attractant prepared in Examples 1 to 9 and the insecticide-containing intestinal agent prepared according to Comparative Examples 1 to 4 were added to 15 l of transparent Petri dish in amounts of 1.5 g each. Petri dishes were provided with water, food, and shelter suitable for the wheels, and 20 adult males of Blatella germanica were added to each other and maintained for 5 days. Subsequently, the insects were removed and 20 adult males of the German wheels that did not come into contact with them were put into each petri dish to evaluate the chain insecticidal effect for 5 days (temperature condition 25 ℃ / 16 ℃, relative humidity 80). %). The measured results are shown in the following Tables 1 to 3, respectively, according to the type of pesticide.
[표 1]TABLE 1
마이크로캡슐화 프로폭슬 및 프로폭슬 원제함유 유인독이제 살충효력 비교Comparison of Insecticidal Effects of Microencapsulated Propoxol and Propoxyl Induced Toxins
상기 표 1 에서 KT50 은 처리개체 수의 50% 를 치사시키는데 소요된 시간이다. 상기 표 1 에 기재된 결과로 부터, 마이크로캡슐화된 프로폭슬을 함유하는 실시예 1 내지 3 의 유인독이제는 프로폭슬 원제가 함유된 비교예 1 의 유인제와 비교하여 살충효력은 유사하나 KT50 의 증가로 인한 연쇄치사율이 현저하게 증대되었으며, 히드라메칠논을 함유하는 비교예 4 의 유인독이제에 비해 온도의존성이 없어 높은 살충효력이 있음을 알 수 있다.In Table 1, KT50 is the time taken to kill 50% of the number of treated objects. From the results shown in Table 1 above, the attractant of Examples 1 to 3 containing the microencapsulated propoxol was similar to the attractant of Comparative Example 1 containing the propoxal agent, but with an increase in KT50. Due to the chain mortality is significantly increased, it can be seen that there is no temperature dependence compared to the attractant poisoning agent of Comparative Example 4 containing hydramethanone has a high insecticidal effect.
[표 2]TABLE 2
마이크로캡슐화 클로르피리포스 및 클로르피리포스 원제함유 유인독이제 살충효력 비교Insecticidal Effects of Microencapsulated Chlorpyriphos and Chlorpyriphos-derived Induced Toxins
상기 표 2 에서 KT50 은 처리개체 수의 50% 를 치사시키는데 소요된 시간이다. 상기 표 2 에 기재된 결과로 부터 마이크로캡슐화된 클로르피리포스를 함유하는 실시예 4 내지 6 의 유인독이제는 클로르피리포스 원제가 함유된 비교예 2 의 유인독이제와 비교하여 살충효력은 유사하나, KT50 의 증가로 인한 연쇄치사율이 현저하게 증대되었으며, 히드라메칠논을 함유하는 비교예 4 의 유인독이제에 비해 온도의존성이 없어 높은 살충효력이 있음을 알 수 있다.In Table 2, KT50 is the time taken to kill 50% of the number of treated objects. From the results described in Table 2, micro-encapsulated chlorpyridose containing the toxic poisoning agents of Examples 4 to 6 compared to the toxic poisoning agent of Comparative Example 2 containing the chlorpyriphos raw agent, but KT50 Chain mortality was increased significantly due to the increase in, compared to the toxic poisoning agent of Comparative Example 4 containing hydramcinolone does not have a temperature dependence, it can be seen that there is a high insecticidal effect.
[표 3]TABLE 3
마이크로캡슐화 페니트로치온 및 페니트로치온 원제함유 유인독이제 살충효력 비교Insecticidal Effects of Microencapsulated Phenythrothion and Phenythrothion-derived Induced Toxins
상기 표 3 에서 KT50 은 처리개체 수의 50% 를 치사시키는데 소요된 시간이다. 상기 표 3 에 기재된 결과로 부터 마이크로캡슐화된 페니트로치온을 함유하는 실시예 7 내지 9 의 유인독이제는 페니트로치온 원제가 함유된 비교예 3 의 유인독이제와 비교하여 살충효력은 유사하나, KT50 의 증가로 인한 연쇄치사율이 현저하게 증대되었으며, 히드라메칠논을 함유하는 비교예 4 의 제제에 비해 온도의존성이 없어 높은 살충효력이 있음을 알 수 있다.In Table 3, KT50 is the time taken to kill 50% of the number of treated objects. From the results shown in Table 3, the micro-encapsulated phenytroxion containing Examples 7 to 9 are similar to the insecticidal agent of Comparative Example 3 containing the phenytrothion source, but the insecticidal effect is similar, KT50 Chain mortality was increased significantly due to the increase of, and compared with the formulation of Comparative Example 4 containing hydramethanone there is no temperature dependence, it can be seen that there is a high insecticidal effect.
실험에 2 (유인력 평가)2 on the experiment (attraction evaluation)
100ℓ 의 투명한 플라스틱 상자에 실시예 1 에 의해 제조된 마이크로캡슐제 함유 유인독이제와 비교예 1 및 비교예 4 에 의해 제조된 살충원제 함유 유인독이제를 각각 1.5g 씩의 양으로 동시에 넣고 한국산 독일바퀴 수컷 성충 50 마리를 투입한 후 중앙부에 물, 먹이, 은신처를 제공한 뒤 48 시간 후에 각각의 유인독이제에 유인된 개체수를 포획법으로 평가하였다. 측정된 결과는 다음 표 4 에 기재하였다.Into a 100-liter transparent plastic box, the microcapsule-containing stinging agent prepared according to Example 1 and the pesticide-containing stinging agent prepared according to Comparative Example 1 and Comparative Example 4 were simultaneously added in an amount of 1.5 g each. Fifty male adult males were fed and water, food, and shelter were provided in the center, and 48 hours later, the number of attracted individuals was evaluated by capturing method. The measured results are shown in Table 4 below.
[표 4]TABLE 4
마이크로캡슐화 프로록슬이 함유된 유인독이제와 살충원제 함유 유인독이제의 유인력 비교Comparison of Attraction Forces of Induced Toxins Containing Microencapsulated Prolox and Insecticides Containing Pesticides
상기 표 4 로 부터 마이크로캡슐화된 프로폭슬 제제를 함유하는 실시예 1 의 유인독이제는 비교예 1 의 프로폭슬 원제가 함유된 유인독이제에 비해 유인력이 현저하게 증대되었으며, 히드라메칠논을 함유하는 비교예 4 의 유인독이제에 비해서도 유인력이 증대되어 살충원제가 갖는 특이냄새가 마스킹되어 기피효과가 개선되었음을 알 수 있다.The attractant of Example 1 containing the microencapsulated propoxol preparation from Table 4 has significantly increased the attraction force compared to the attractant containing the propoxal agent of Comparative Example 1, the comparison containing hydramethanone Compared to the attractant poisoning agent of Example 4, the attracting force is increased, and the specific smell of the insecticide is masked, indicating that the repelling effect is improved.
실험예 3 (살충제 안정성 평가)Experimental Example 3 (Pesticide Stability Evaluation)
실시예 1 내지 9 및 비교예 1 내지 4 에 의해 제조된 유인독이제를 상온(25℃/상대습도 80%)에서 3, 6, 9 개월간 방치한 후 살충제의 함량을 HPLC 로 분석하여 초기 함량과 비교함으로써 분해율을 구해 경시변화에 따른 살충제의 안정성을 평가하였다. 측정된 결과는 다음 표 5 에 나타내었다.The detoxifying agents prepared according to Examples 1 to 9 and Comparative Examples 1 to 4 were left at room temperature (25 ° C./relative humidity of 80%) for 3, 6, and 9 months, and then the content of the pesticide was analyzed by HPLC. By comparing the degradation rate, the stability of the pesticides was evaluated according to the change over time. The measured results are shown in Table 5 below.
[표 5]TABLE 5
경시변화에 따른 살충제 분해율(%) 비교Comparison of pesticide degradation rate (%) according to the change over time
상기 표 5 에 기재된 결과로 부터 마이크로캡슐화된 살충제제를 함유하는 실시예 1 내지 9 의 유인독이제는 살충원제를 함유하는 비교예 1 내지 4 의 유인독이제에 비해 경시변화에 따른 살충제 분해율이 낮아 장기처리시에도 살충성분이 안정하게 유지되고 있음을 알 수 있다.From the results shown in Table 5, the detoxifying agents of Examples 1 to 9 containing microencapsulated insecticides had a lower rate of degradation of the pesticides over time than the detoxifying agents of Comparative Examples 1 to 4 containing insecticides. It can be seen that the pesticide component is stably maintained even during the treatment.
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| KR100454236B1 (en) * | 2002-01-29 | 2004-10-26 | 한국과학기술원 | The Water-continuous Emulsion Type Insecticide and Preparation Method of thereof |
| KR100454235B1 (en) * | 2002-01-29 | 2004-10-26 | 한국과학기술원 | The Paste-type Insecticide and Preparation Method of thereof |
| WO2013089925A1 (en) * | 2011-12-12 | 2013-06-20 | Stc. Unm | Microencapsulation as a strategy for implementation and environmental safe-guarding of a paratransgenic approach to control of vector-borne diseases |
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| US5178871A (en) * | 1991-06-26 | 1993-01-12 | S. C. Johnson & Son, Inc. | Stable double emulsions containing finely-divided particles |
| TW241194B (en) * | 1991-12-27 | 1995-02-21 | Takeda Pharm Industry Co Ltd | |
| JPH0624903A (en) * | 1992-04-09 | 1994-02-01 | Nippon Bayeragrochem Kk | Plant treating agent |
| US5362425A (en) * | 1992-10-22 | 1994-11-08 | Technology Unlimited, Inc. | Organic oil spray-drying techniques |
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| KR100454235B1 (en) * | 2002-01-29 | 2004-10-26 | 한국과학기술원 | The Paste-type Insecticide and Preparation Method of thereof |
| WO2013089925A1 (en) * | 2011-12-12 | 2013-06-20 | Stc. Unm | Microencapsulation as a strategy for implementation and environmental safe-guarding of a paratransgenic approach to control of vector-borne diseases |
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