JP2845346B2 - 骨形成具 - Google Patents

骨形成具

Info

Publication number
JP2845346B2
JP2845346B2 JP2515578A JP51557890A JP2845346B2 JP 2845346 B2 JP2845346 B2 JP 2845346B2 JP 2515578 A JP2515578 A JP 2515578A JP 51557890 A JP51557890 A JP 51557890A JP 2845346 B2 JP2845346 B2 JP 2845346B2
Authority
JP
Japan
Prior art keywords
sequence
bone
protein
matrix
osteogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2515578A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04502336A (ja
Inventor
オパーマン,ハーマン
クベラサンパス,サンガヴェル
ルージャー,デーヴィッド・シー
オズカイナック,エンジン
パング,ロイ・エイチ・エル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/483,913 external-priority patent/US5171574A/en
Application filed by Stryker Corp filed Critical Stryker Corp
Publication of JPH04502336A publication Critical patent/JPH04502336A/ja
Application granted granted Critical
Publication of JP2845346B2 publication Critical patent/JP2845346B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608Bone, e.g. demineralised bone matrix [DBM], bone powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003Not used, see subgroups
    • A61C8/0004Consolidating natural teeth
    • A61C8/0006Periodontal tissue or bone regeneration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00365Proteins; Polypeptides; Degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Prostheses (AREA)
JP2515578A 1989-10-17 1990-10-15 骨形成具 Expired - Lifetime JP2845346B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US42269989A 1989-10-17 1989-10-17
US422,699 1989-10-17
US07/483,913 US5171574A (en) 1989-02-23 1990-02-22 Bone collagen matrix for implants
US483,913 1990-02-22
US56992090A 1990-08-20 1990-08-20
US569,920 1995-12-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP9177440A Division JPH10114673A (ja) 1989-10-17 1997-07-02 骨形成具

Publications (2)

Publication Number Publication Date
JPH04502336A JPH04502336A (ja) 1992-04-23
JP2845346B2 true JP2845346B2 (ja) 1999-01-13

Family

ID=27411374

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2515578A Expired - Lifetime JP2845346B2 (ja) 1989-10-17 1990-10-15 骨形成具
JP9177440A Withdrawn JPH10114673A (ja) 1989-10-17 1997-07-02 骨形成具
JP2000254562A Expired - Lifetime JP3368260B2 (ja) 1989-10-17 2000-08-24 骨形成具
JP2002008070A Withdrawn JP2002281976A (ja) 1989-10-17 2002-01-16 骨形成具
JP2003348890A Withdrawn JP2004041236A (ja) 1989-10-17 2003-10-07 骨形成具
JP2005274803A Withdrawn JP2006068018A (ja) 1989-10-17 2005-09-21 骨形成具

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP9177440A Withdrawn JPH10114673A (ja) 1989-10-17 1997-07-02 骨形成具
JP2000254562A Expired - Lifetime JP3368260B2 (ja) 1989-10-17 2000-08-24 骨形成具
JP2002008070A Withdrawn JP2002281976A (ja) 1989-10-17 2002-01-16 骨形成具
JP2003348890A Withdrawn JP2004041236A (ja) 1989-10-17 2003-10-07 骨形成具
JP2005274803A Withdrawn JP2006068018A (ja) 1989-10-17 2005-09-21 骨形成具

Country Status (11)

Country Link
EP (1) EP0448704B1 (cg-RX-API-DMAC7.html)
JP (6) JP2845346B2 (cg-RX-API-DMAC7.html)
AT (1) ATE167486T1 (cg-RX-API-DMAC7.html)
CA (1) CA2042577A1 (cg-RX-API-DMAC7.html)
DE (1) DE69032424T2 (cg-RX-API-DMAC7.html)
DK (1) DK0448704T3 (cg-RX-API-DMAC7.html)
ES (1) ES2118723T3 (cg-RX-API-DMAC7.html)
GR (1) GR3027722T3 (cg-RX-API-DMAC7.html)
LU (1) LU90855I2 (cg-RX-API-DMAC7.html)
NL (1) NL300062I2 (cg-RX-API-DMAC7.html)
WO (1) WO1991005802A1 (cg-RX-API-DMAC7.html)

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US5459047A (en) 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
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US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
CA2030518C (en) * 1989-03-28 2000-03-21 Elizabeth A. Wang Osteoinductive compositions
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US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
US6194376B1 (en) 1991-03-11 2001-02-27 Creative Biomolecules, Inc. Method for modulating inflammatory response comprising administering morphogen
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
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US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US5631159A (en) * 1993-09-22 1997-05-20 Creative Biomolecules, Inc. Lipid-modified serum free media
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ATE378407T1 (de) * 1994-04-29 2007-11-15 Curis Inc Morphogene protein-spezifische zelloberflächenrezeptoren und ihre verwendungen
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US6846906B1 (en) 1998-10-07 2005-01-25 Stryker Corporation Modified proteins of the TGF-β superfamily, including morphogenic proteins
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Title
Proc.Natl.Acad.Sci.USA,Vol.86,p.4554−4558(1989)

Also Published As

Publication number Publication date
GR3027722T3 (en) 1998-11-30
DK0448704T3 (da) 1999-04-06
JPH10114673A (ja) 1998-05-06
JP2006068018A (ja) 2006-03-16
JP2002281976A (ja) 2002-10-02
JP2004041236A (ja) 2004-02-12
JPH04502336A (ja) 1992-04-23
AU648997B2 (en) 1994-05-12
WO1991005802A1 (en) 1991-05-02
NL300062I2 (nl) 2002-02-01
AU6648190A (en) 1991-05-16
NL300062I1 (nl) 2001-12-01
JP2001095591A (ja) 2001-04-10
LU90855I2 (en) 2002-01-24
EP0448704B1 (en) 1998-06-17
JP3368260B2 (ja) 2003-01-20
DE69032424D1 (de) 1998-07-23
EP0448704A1 (en) 1991-10-02
EP0448704A4 (en) 1992-07-08
ES2118723T3 (es) 1998-10-01
CA2042577A1 (en) 1991-04-18
DE69032424T2 (de) 1999-02-04
ATE167486T1 (de) 1998-07-15

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