JP2828295B2 - トポイソメラーゼ阻害剤または細胞分化誘導剤としての五環式トリテルペノイド化合物 - Google Patents
トポイソメラーゼ阻害剤または細胞分化誘導剤としての五環式トリテルペノイド化合物Info
- Publication number
- JP2828295B2 JP2828295B2 JP1510077A JP51007789A JP2828295B2 JP 2828295 B2 JP2828295 B2 JP 2828295B2 JP 1510077 A JP1510077 A JP 1510077A JP 51007789 A JP51007789 A JP 51007789A JP 2828295 B2 JP2828295 B2 JP 2828295B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- topoisomerase
- mono
- alkenyl
- nhr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/02—Saturated compounds containing hydroxy or O-metal groups
- C07C62/06—Saturated compounds containing hydroxy or O-metal groups polycyclic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23590388A | 1988-08-24 | 1988-08-24 | |
| US235,903 | 1988-08-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04500209A JPH04500209A (ja) | 1992-01-16 |
| JP2828295B2 true JP2828295B2 (ja) | 1998-11-25 |
Family
ID=22887334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1510077A Expired - Fee Related JP2828295B2 (ja) | 1988-08-24 | 1989-08-24 | トポイソメラーゼ阻害剤または細胞分化誘導剤としての五環式トリテルペノイド化合物 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0431076B1 (OSRAM) |
| JP (1) | JP2828295B2 (OSRAM) |
| KR (1) | KR100187738B1 (OSRAM) |
| CN (1) | CN1041204C (OSRAM) |
| AU (1) | AU630374B2 (OSRAM) |
| CA (1) | CA1330944C (OSRAM) |
| DE (1) | DE68909947T2 (OSRAM) |
| DK (1) | DK31391A (OSRAM) |
| TW (1) | TW225990B (OSRAM) |
| WO (1) | WO1990001937A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4201903B4 (de) * | 1992-01-24 | 2004-04-15 | Hermann P.T. Prof. Dr.Med. Ammon | Pharmazeutische Verwendung von Boswelliasäuren |
| DE4444288A1 (de) * | 1994-12-13 | 1996-06-20 | Rainer Dr Med Etzel | Verwendung von Weihrauch zur Behandlung der Alzheimer-Krankheit |
| DE4445728A1 (de) * | 1994-12-21 | 1996-06-27 | Simmet Th Prof Dr | Verwendung von Boswelliasäure zur Behandlung von Hirntumoren |
| DE19531067A1 (de) † | 1995-08-23 | 1997-02-27 | Hermann P T Prof Dr Med Ammon | Verwendung von Boswelliasäure und ihren Derivaten zur Hemmung der normalen und gesteigerten Leukozytenelastase- oder Plasminaktivität |
| CA2372772A1 (en) * | 1999-04-30 | 2000-11-09 | Sabinsa Corporation | Compositions of boswellic acids derived from boswellia serrata gum resin, for treating lymphoproliferative and autoimmune conditions |
| WO2002085921A2 (de) * | 2001-03-01 | 2002-10-31 | Johann Jauch | Einfaches verfahren zur synthese von boswelliasäuren und derivaten davon |
| CN1304007C (zh) * | 2002-02-04 | 2007-03-14 | 中国医学科学院药物研究所 | 乙酰乳香酸在制备肿瘤转移抑制剂中的应用 |
| US8028292B2 (en) | 2004-02-20 | 2011-09-27 | Sony Computer Entertainment Inc. | Processor task migration over a network in a multi-processor system |
| CN101796182B (zh) * | 2007-06-25 | 2013-10-16 | 植物生物科学有限公司 | 涉及三萜合成的酶 |
| DE102008015607A1 (de) * | 2008-03-26 | 2009-10-15 | Universität Tübingen | Verwendung von Boswelliasäuren und synthetischen Boswelliasäurederivaten zur Hemmung der mikrosomalen Prostaglandin E2 Synthase und des Cathepsin G |
| WO2010105821A1 (de) | 2009-03-17 | 2010-09-23 | Herta Ertelt | Verfahren zur extraktion von pflanzlichen harzen sowie dadurch gewonnene extraktionsprodukte und deren verwendung |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501734A (en) * | 1981-03-06 | 1985-02-26 | Wakunaga Yakuhin Kabushiki Kaisha | Promotion of absorption of drugs administered through the alimentary system |
-
1989
- 1989-08-17 CA CA000608654A patent/CA1330944C/en not_active Expired - Fee Related
- 1989-08-24 KR KR1019900700818A patent/KR100187738B1/ko not_active Expired - Fee Related
- 1989-08-24 EP EP89910793A patent/EP0431076B1/en not_active Expired - Lifetime
- 1989-08-24 AU AU43033/89A patent/AU630374B2/en not_active Ceased
- 1989-08-24 CN CN89107605A patent/CN1041204C/zh not_active Expired - Fee Related
- 1989-08-24 WO PCT/US1989/003581 patent/WO1990001937A1/en not_active Ceased
- 1989-08-24 DE DE89910793T patent/DE68909947T2/de not_active Expired - Fee Related
- 1989-08-24 JP JP1510077A patent/JP2828295B2/ja not_active Expired - Fee Related
-
1990
- 1990-06-09 TW TW079104733A patent/TW225990B/zh active
-
1991
- 1991-02-22 DK DK031391A patent/DK31391A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW225990B (OSRAM) | 1994-07-01 |
| WO1990001937A1 (en) | 1990-03-08 |
| DE68909947D1 (de) | 1993-11-18 |
| EP0431076A4 (en) | 1992-01-15 |
| EP0431076A1 (en) | 1991-06-12 |
| AU4303389A (en) | 1990-03-23 |
| DK31391D0 (da) | 1991-02-22 |
| JPH04500209A (ja) | 1992-01-16 |
| AU630374B2 (en) | 1992-10-29 |
| KR900701280A (ko) | 1990-12-01 |
| DK31391A (da) | 1991-02-22 |
| CA1330944C (en) | 1994-07-26 |
| KR100187738B1 (ko) | 1999-06-01 |
| DE68909947T2 (de) | 1994-02-24 |
| CN1041204C (zh) | 1998-12-16 |
| CN1043131A (zh) | 1990-06-20 |
| EP0431076B1 (en) | 1993-10-13 |
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