DE68909947D1 - Pentacyclische triterpenoid-verbindungen als topoisomerase-inhibitoren oder zell-differenzierungs-induktoren. - Google Patents

Pentacyclische triterpenoid-verbindungen als topoisomerase-inhibitoren oder zell-differenzierungs-induktoren.

Info

Publication number
DE68909947D1
DE68909947D1 DE89910793T DE68909947T DE68909947D1 DE 68909947 D1 DE68909947 D1 DE 68909947D1 DE 89910793 T DE89910793 T DE 89910793T DE 68909947 T DE68909947 T DE 68909947T DE 68909947 D1 DE68909947 D1 DE 68909947D1
Authority
DE
Germany
Prior art keywords
cell differentiation
topoisomerase inhibitors
pentacyclic triterpenoid
triterpenoid compounds
differentiation inductors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89910793T
Other languages
English (en)
Other versions
DE68909947T2 (de
Inventor
Yue-Wei Research Triangle Lee
Qi-Cheng Institute Of Mat Fang
Zhen-Guo Chang Baishan In Wang
De-Hua Chang Baishan Instit Li
C Cook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RES TRIANGLE INST RESEARCH TRI
Research Triangle Institute
Original Assignee
RES TRIANGLE INST RESEARCH TRI
Research Triangle Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RES TRIANGLE INST RESEARCH TRI, Research Triangle Institute filed Critical RES TRIANGLE INST RESEARCH TRI
Application granted granted Critical
Publication of DE68909947D1 publication Critical patent/DE68909947D1/de
Publication of DE68909947T2 publication Critical patent/DE68909947T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/02—Saturated compounds containing hydroxy or O-metal groups
    • C07C62/06—Saturated compounds containing hydroxy or O-metal groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE89910793T 1988-08-24 1989-08-24 Pentacyclische triterpenoid-verbindungen als topoisomerase-inhibitoren oder zell-differenzierungs-induktoren. Expired - Lifetime DE68909947T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23590388A 1988-08-24 1988-08-24

Publications (2)

Publication Number Publication Date
DE68909947D1 true DE68909947D1 (de) 1993-11-18
DE68909947T2 DE68909947T2 (de) 1994-02-24

Family

ID=22887334

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89910793T Expired - Lifetime DE68909947T2 (de) 1988-08-24 1989-08-24 Pentacyclische triterpenoid-verbindungen als topoisomerase-inhibitoren oder zell-differenzierungs-induktoren.

Country Status (10)

Country Link
EP (1) EP0431076B1 (de)
JP (1) JP2828295B2 (de)
KR (1) KR100187738B1 (de)
CN (1) CN1041204C (de)
AU (1) AU630374B2 (de)
CA (1) CA1330944C (de)
DE (1) DE68909947T2 (de)
DK (1) DK31391D0 (de)
TW (1) TW225990B (de)
WO (1) WO1990001937A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4201903B4 (de) * 1992-01-24 2004-04-15 Hermann P.T. Prof. Dr.Med. Ammon Pharmazeutische Verwendung von Boswelliasäuren
DE4444288A1 (de) * 1994-12-13 1996-06-20 Rainer Dr Med Etzel Verwendung von Weihrauch zur Behandlung der Alzheimer-Krankheit
DE4445728A1 (de) * 1994-12-21 1996-06-27 Simmet Th Prof Dr Verwendung von Boswelliasäure zur Behandlung von Hirntumoren
DE19531067A1 (de) † 1995-08-23 1997-02-27 Hermann P T Prof Dr Med Ammon Verwendung von Boswelliasäure und ihren Derivaten zur Hemmung der normalen und gesteigerten Leukozytenelastase- oder Plasminaktivität
AU4450600A (en) * 1999-04-30 2000-11-17 Sabinsa Corporation Compositions of boswellic acids derived from boswellia serrata gum resin, for treating lymphoproliferative and autoimmune conditions
WO2002085921A2 (de) * 2001-03-01 2002-10-31 Johann Jauch Einfaches verfahren zur synthese von boswelliasäuren und derivaten davon
CN1304007C (zh) * 2002-02-04 2007-03-14 中国医学科学院药物研究所 乙酰乳香酸在制备肿瘤转移抑制剂中的应用
US8028292B2 (en) 2004-02-20 2011-09-27 Sony Computer Entertainment Inc. Processor task migration over a network in a multi-processor system
CA2687559A1 (en) * 2007-06-25 2009-04-02 Plant Bioscience Limited Enzymes involved in triterpene synthesis
DE102008015607A1 (de) * 2008-03-26 2009-10-15 Universität Tübingen Verwendung von Boswelliasäuren und synthetischen Boswelliasäurederivaten zur Hemmung der mikrosomalen Prostaglandin E2 Synthase und des Cathepsin G
WO2010105821A1 (de) 2009-03-17 2010-09-23 Herta Ertelt Verfahren zur extraktion von pflanzlichen harzen sowie dadurch gewonnene extraktionsprodukte und deren verwendung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501734A (en) * 1981-03-06 1985-02-26 Wakunaga Yakuhin Kabushiki Kaisha Promotion of absorption of drugs administered through the alimentary system

Also Published As

Publication number Publication date
AU4303389A (en) 1990-03-23
EP0431076B1 (de) 1993-10-13
AU630374B2 (en) 1992-10-29
CN1041204C (zh) 1998-12-16
EP0431076A1 (de) 1991-06-12
DE68909947T2 (de) 1994-02-24
CN1043131A (zh) 1990-06-20
WO1990001937A1 (en) 1990-03-08
JPH04500209A (ja) 1992-01-16
KR100187738B1 (ko) 1999-06-01
JP2828295B2 (ja) 1998-11-25
CA1330944C (en) 1994-07-26
DK31391A (da) 1991-02-22
TW225990B (de) 1994-07-01
EP0431076A4 (en) 1992-01-15
KR900701280A (ko) 1990-12-01
DK31391D0 (da) 1991-02-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee